Dalla lettura del testo, tenendo conto anche di quanto il-lustrato nel capitolo precedente, emerge la complessità del-l’utilizzo delle evidenze scientifiche relative all’impatto sulla salute umana degli inquinanti presenti in un SIN: tali evi-denze dovranno essere inserite in un quadro che, per esem-pio, affronti in maniera sistematica e approfondita gli aspetti relativi alle vie di esposizione degli inquinanti. Si dovrà inolttre considerare che molto raramente le esposi-zioni sono riferite a una singola sostanza, che le vie di espo-sizione possono essere molteplici e che i potenziali effetti sulla salute possono esprimersi in modo additivo, sinergico o antagonistico.
Tuttavia si ritiene che quanto proposto in questo contri-buto, e nel capitolo che lo precede, rappresenti un ulteriore passo di un percorso iniziato in SENTIERI Mortalità con
la definizione dei siti in termini di tipologie di fonti di
espo-sizioni ambientali, e che tale percorso possa condurre,
at-traverso varie fasi da identificare progressivamente, a una stima dell’esposizione più puntuale e a valutazioni dell’im-patto sulla salute più specifiche.
Il prossimo passo, già richiamato in questo Rapporto nel capitolo Razionale e obiettivi, prevede l’individuazione degli inquinanti indice e delle rispettive sedi tumorali e
or-gani bersaglio per altri SIN di specifico interesse, con ca-ratteristiche informative adeguate.
La formulazione graduale di ipotesi a priori di interesse eziologico secondo un gradiente di persuasività scientifica (evidenza sufficiente, limitata, inadeguata) per alcuni in-quinanti e alcune cause di morte o malattia verrà svilup-pata in modo da poter saggiare le ipotesi in oggetto in maniera sistematica per i diversi siti esistenti.
anno 38 (2) marzo-aprile 2014 • Suppl. 1
e&p
6/ Inquinanti indice e organi bersaglio
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