riferimento ai cuori trattati con il solo veicolo. Gli asterischi (*) indicano la significatività statistica rispetto al veicolo.
Come si può notare, la somministrazione di retigabina 30 µM non ha significativamente modificato l’insulto miocardico indotto dal ciclo di ischemia/riperfusione, in quanto i valori percentuali di RPP, dP/dt, CF e Ai/Avs risultano essere non significativamente diversi da quelli ottenuti per i cuori trattati con il solo veicolo; viceversa, la concentrazione superiore dell’attivatore KV7 (100 µM) ha portato ad un marcato e significativo miglioramento di tutti i parametri funzionali e morfologici (Grafico 6-9).
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Per concludere, è importante sottolineare che si tratta del primo lavoro in cui viene valutata sia la presenza di canali KV7 a livello mitocondriale, e in particolare nel tessuto cardiaco, sia gli effetti cardioprotettivi provocati dagli attivatori di tali canali, come ad esempio la retigabina.
Questo lavoro quindi mette in evidenza, per la prima volta, come anche l’attivazione dei canali KV7 sia implicata nel meccanismo di cardioprotezione in
caso di ischemia del miocardio, patologia dove è noto che l’uso di attivatori dei canali mitoK, in particolare mitoKATP e mitoBKCa, ha funzioni protettive.
Pertanto, questo studio pone le basi per l’identificazione di un nuovo, originale e promettente target farmacologico, utile per eventuali strategie anti-ischemiche future e quindi possibile altro protagonista nello scenario della cardioprotezione.
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