La procedura sperimentale adottata ha garantito contemporanei spostamenti e condizioni ambientali per le cellule esposte alle radiazioni e per quelle di controllo, tuttavia soltanto il microscopio confocale era munito di atmosfera a flusso controllato di CO2 al 5% con temperatura tenuta costante di 37°C. Per contro il setup per l'esposizione
al laser terahertz era privo di atmosfera controllata e si è svolto a temperatura ambiente di circa 20 °C. Dunque, sebbene le medesime condizioni ambientali contingenti presenti nel laboratorio al momento degli esperimenti siano state garantite per trattati e controlli, non è stato possibile assicurare valori ottimali di temperatura e CO2 durante l'esposizione al
laser,, potenzialmente dando luogo a alterazioni della fisiologia e biologia cellulare dei campioni durante l'irraggiamento.
Un elemento che dovrebbe essere preso in considerazione in futuri studi i quali vogliano ispirarsi al presente, è la diffrazione della radiazione THz nel mezzo acquoso la quale potrebbe influenzare minimamente le cellule di controllo.
La linea cellulare utilizzata è estremamente resistente e sicuramente altre linee non tumorali possono essere considerate migliori modelli per le cellule del corpo umano
Ulteriori studi sono raccomandabili per chiarire elementi così cruciali della interazione di questa parte dello spettro elettromagnetico la quale è destinata ad aumentare negli ambienti in cui viviamo, sia per usi legati alla sicurezza, che per usi in ambiti lavorativi industriali, telecomunicazioni a breve distanza e per applicazioni biomediche di imaging.
B i b l i o g r a f i a
Bibliografia.
1: Michael Rowan-Robinson, Night Vision: Exploring the Infrared Universe . 2: D. H. Barker, D. T. Hodges, T. S. Hartwick, Far Infrared Imagery, Long-Wavelength
Infrared, (1975).
3: Zhao, Li; Hao, Yan-Hui; Peng, Rui-Yun, Advances in the biological effects of terahertz wave radiation, Military Medical Research, (2014).
4: Wallace, Vincent P.; Fitzgerald, Anthony J.; Pickwell, Emma; Pye, Richard J.; Taday, Philip F.; Flanagan, Niamh; Ha, Thomas, Terahertz pulsed spectroscopy of human Basal cell carcinoma, Applied Spectroscopy, (2006).
5: Brun MA, Formanek F, Yasuda A, Sekine M, Ando N, Eishii Y., Terahertz imaging applied to cancer diagnosis., Physics in Medicine and Biology, (2010).
6: Yu, Calvin; Fan, Shuting; Sun, Yiwen; Pickwell-Macpherson, Emma, The potential of terahertz imaging for cancer diagnosis: A review of investigations to date, Quantitative Imaging in Medicine and Surgery, (2012).
7: Truong, Bao C. Q.; Tuan, Hoang D.; Fitzgerald, Anthony J.; Wallace, Vincent P.; Nguyen, Hung T., A dielectric model of human breast tissue in terahertz regime, Breast; Computer Simulation; Female; Humans; Image Interpretation, Computer- Assisted; Models, Biological; Scattering, Radiation; Terahertz Imaging; Terahertz Radiation, (2015).
8: Fitzgerald, Anthony J.; Pinder, Sarah; Purushotham, Anand D.; O'Kelly, Padraig; Ashworth, Philip C.; Wallace, Vincent P., Classification of terahertz-pulsed imaging data from excised breast tissue, Journal of Biomedical Optics, (2012).
9: St Peter, Benjamin; Yngvesson, Sigfrid; Siqueira, Paul; Kelly, Patrick; Khan, Ashraf; Glick, Stephen; Karellas, Andrew, Development and testing of a single frequency terahertz imaging system for breast cancer detection, IEEE journal of biomedical and health informatics, (2013).
10: Fitzgerald, Anthony J.; Wallace, Vincent P.; Jimenez-Linan, Mercedes; Bobrow, Lynda; Pye, Richard J.; Purushotham, Anand D.; Arnone, Donald D., Terahertz pulsed imaging of human breast tumors, Radiology, (2006).
11: Ashworth, Philip C.; Pickwell-MacPherson, Emma; Provenzano, Elena; Pinder, Sarah E.; Purushotham, Anand D.; Pepper, Michael; Wallace, Vincent P., Terahertz pulsed spectroscopy of freshly excised human breast cancer, Optics Express, (2009). 12: Fitzgerald, Anthony J.; Pickwell-MacPherson, Emma; Wallace, Vincent P., Use of
finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue, PloS One, (2014). 13: Hong, Hao; Sun, Jiangtao; Cai, Weibo, Anatomical and molecular imaging of skin
cancer, Clinical, Cosmetic and Investigational Dermatology, (2008).
14: Joseph, Cecil S.; Yaroslavsky, Anna N.; Neel, Victor A.; Goyette, Thomas M.; Giles, Robert H., Continuous wave terahertz transmission imaging of nonmelanoma skin cancers, Lasers in Surgery and Medicine, (2011).
15: Mogensen, Mette; Jemec, Gregor B. E., Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: a review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologies, Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermoscopy; Diagnostic Tests, Routine; Humans; Keratosis; Skin Neoplasms, (2007).
16: Herman, Cila, Emerging technologies for the detection of melanoma: achieving better outcomes, Clinical, Cosmetic and Investigational Dermatology, (2012).
17: Joseph, Cecil S.; Patel, Rakesh; Neel, Victor A.; Giles, Robert H.; Yaroslavsky, Anna N., Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions optical and terahertz skin cancers imaging, Journal of Biophotonics, (2014). 18: Woodward, R. M.; Wallace, V. P.; Arnone, D. D.; Linfield, E. H.; Pepper, M.,
Terahertz pulsed imaging of skin cancer in the time and frequency domain, Journal of Biological Physics, (2003).
19: Woodward, Ruth M.; Cole, Bryan E.; Wallace, Vincent P.; Pye, Richard J.; Arnone, Donald D.; Linfield, Edmund H.; Pepper, Michael, Terahertz pulse imaging in reflection geometry of human skin cancer and skin tissue, Physics in Medicine and Biology, (2002).
20: Woodward, Ruth M.; Wallace, Vincent P.; Pye, Richard J.; Cole, Bryan E.; Arnone, Donald D.; Linfield, Edmund H.; Pepper, Michael, Terahertz pulse imaging of ex vivo basal cell carcinoma, The Journal of Investigative Dermatology, (2003).
21: Rong, Lu; Latychevskaia, Tatiana; Chen, Chunhai; Wang, Dayong; Yu, Zhengping; Zhou, Xun; Li, Zeyu; Huang, Haochong; Wang, Yunxin; Zhou, Zhou, Terahertz in-line digital holography of human hepatocellular carcinoma tissue, Scientific Reports, (2015).
22: Miura, Yasuhiro; Kamataki, Akihisa; Uzuki, Miwa; Sasaki, Tetsuo; Nishizawa, Jun- ichi; Sawai, Takashi, Terahertz-wave spectroscopy for precise histopathological imaging of tumor and non-tumor lesions in paraffin sections, The Tohoku Journal of Experimental Medicine, (2011).
23: Meng, Kun; Chen, Tu-nan; Chen, Tao; Zhu, Li-guo; Liu, Qiao; Li, Zhao; Li, Fei; Zhong, Sen-cheng; Li, Ze-ren; Feng, Hua; Zhao, Jian-heng, Terahertz pulsed spectroscopy of paraffin-embedded brain glioma, Journal of Biomedical Optics, (2014).
24: Chen, Hua; Ma, Shihua; Wu, Xiumei; Yang, Wenxing; Zhao, Tian, Diagnose human colonic tissues by terahertz near-field imaging, Journal of Biomedical Optics, (2015). 25: Ji, Young Bin; Park, Chan Hyuk; Kim, Hyunki; Kim, Sang-Hoon; Lee, Gyu Min;
Noh, Sam Kyu; Jeon, Tae-In; Son, Joo-Hiuk; Huh, Yong-Min; Haam, Seungjoo; Oh, Seung Jae; Lee, Sang Kil; Suh, Jin-Suck, Feasibility of terahertz reflectometry for discrimination of human early gastric cancers, Biomedical Optics Express, (2015). 26: Hou, Dibo; Li, Xian; Cai, Jinhui; Ma, Yehao; Kang, Xusheng; Huang, Pingjie; Zhang,
Guangxin, Terahertz spectroscopic investigation of human gastric normal and tumor tissues, Physics in Medicine and Biology, (2014).
27: Mitobe, Kazutaka; Manabe, Motomu; Yoshimura, Noboru; Kurabayashi, Toru, Imaging of epithelial cancer in sub-terahertz electromagnetic wave, Conference
proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, (2005).
28: Hisazumi, Jin; Suzuki, Tatsuya; Wakiyama, Naoki; Nakagami, Hiroaki; Terada, Katsuhide, Chemical mapping of hydration and dehydration process of theophylline in tablets using terahertz pulsed imaging, Chemical & Pharmaceutical Bulletin, (2012). 29: Sim, Yookyeong Carolyn; Ahn, Kang-Min; Park, Jae Yeon; Park, Chan-Sik; Son, Joo-
Hiuk, Temperature-dependent terahertz imaging of excised oral malignant melanoma, IEEE journal of biomedical and health informatics, (2013).
30: Oh, Seung Jae; Kang, Jinyoung; Maeng, Inhee; Suh, Jin-Suck; Huh, Yong-Min; Haam, Seungjoo; Son, Joo-Hiuk, Nanoparticle-enabled terahertz imaging for cancer diagnosis, Cell Line, Tumor; Contrast Media; Equipment Design; Gold; Humans; Infrared Rays; Lasers; Metal Nanoparticles; Nanotechnology; Nanotubes; Neoplasms; Optical Phenomena; Surface Plasmon Resonance, (2009).
31: Bigourd, Damien; Cuisset, Arnaud; Hindle, Francis; Matton, Sophie; Fertein, Eric; Bocquet, Robin; Mouret, Gaël, Detection and quantification of multiple molecular species in mainstream cigarette smoke by continuous-wave terahertz spectroscopy, Optics Letters, (2006).
32: Bessou, Maryelle; Chassagne, Bruno; Caumes, Jean-Pascal; Pradère, Christophe; Maire, Philippe; Tondusson, Marc; Abraham, Emmanuel, Three-dimensional terahertz computed tomography of human bones, Applied Optics, (2012).
33: Stringer, M. R.; Lund, D. N.; Foulds, A. P.; Uddin, A.; Berry, E.; Miles, R. E.; Davies, A. G., The analysis of human cortical bone by terahertz time-domain spectroscopy, Physics in Medicine and Biology, (2005).
34: Kamburoğlu, K.; Yetimoĝlu, N. Ö; Altan, H., Characterization of primary and permanent teeth using terahertz spectroscopy, Dento Maxillo Facial Radiology, (2014).
35: Crawley, David; Longbottom, Christopher; Wallace, Vincent P.; Cole, Bryan; Arnone, Don; Pepper, Michael, Three-dimensional terahertz pulse imaging of dental tissue, Journal of Biomedical Optics, (2003).
36: Lancaster, P.; Carmichael, F.; Britton, J.; Craddock, H.; Brettle, D.; Clerehugh, V., Surfing the spectrum - what is on the horizon?, British Dental Journal, (2013). 37: Pickwell, E.; Cole, B. E.; Fitzgerald, A. J.; Pepper, M.; Wallace, V. P., In vivo study of
human skin using pulsed terahertz radiation, Physics in Medicine and Biology, (2004). 38: Parrott, Edward P. J.; Sy, Stanley M. Y.; Blu, Thierry; Wallace, Vincent P.; Pickwell-
Macpherson, Emma, Terahertz pulsed imaging in vivo: measurements and processing methods, Journal of Biomedical Optics, (2011).
39: Titova, Lyubov V.; Ayesheshim, Ayesheshim K.; Golubov, Andrey; Rodriguez-Juarez, Rocio; Woycicki, Rafal; Hegmann, Frank A.; Kovalchuk, Olga, Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?, Scientific Reports, (2013).
40: Feldman, Yuri; Puzenko, Alexander; Ben Ishai, Paul; Caduff, Andreas; Agranat, Aharon J., Human skin as arrays of helical antennas in the millimeter and submillimeter wave range, Physical Review Letters, (2008).
41: Tripathi, Saroj R.; Miyata, Eisuke; Ishai, Paul Ben; Kawase, Kodo, Morphology of human sweat ducts observed by optical coherence tomography and their frequency of resonance in the terahertz frequency region, Scientific Reports, (2015).
42: Buersgens, Federico; Acuna, Guillermo; Kersting, Roland, Acoustic phase imaging with terahertz radiation, Optics Express, (2007).
43: Jeong, Kiyoung; Huh, Yong-Min; Kim, Sang-Hoon; Park, Yeonji; Son, Joo-Hiuk; Oh, Seung Jae; Suh, Jin-Suck, Characterization of blood using terahertz waves, Journal of Biomedical Optics, (2013).
44: Zeni, O.; Gallerano, G. P.; Perrotta, A.; Romanò, M.; Sannino, A.; Sarti, M.; D'Arienzo, M.; Doria, A.; Giovenale, E.; Lai, A.; Messina, G.; Scarfì, M. R., Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study, Health Physics, (2007).
45: Kirichuk, V. F.; Tsymbal, A. A., Effects of terahertz irradiation at nitric oxide frequencies on intensity of lipoperoxidation and antioxidant properties of the blood under stress conditions, Bulletin of Experimental Biology and Medicine, (2009). 46: Reid, Caroline B.; Reese, George; Gibson, Adam P.; Wallace, Vincent P., Terahertz
time-domain spectroscopy of human blood, IEEE journal of biomedical and health informatics, (2013).
47: Neelakanta, Perambur S.; Sharma, Bharti, Conceiving THz endometrial ablation: feasibility, requirements and technical challenges, IEEE journal of biomedical and health informatics, (2013).
48: Kim, K.-T. et al. , High-power femtosecond-terahertz pulse induces a wound response in mouse skin, Scientific Reports, (2013).
49: Yoonha Hwang, Jinhyo Ahn, Jungho Mun, Sangyoon Bae, Young Uk Jeong,Nikolay A.Vinokurov, and Pilhan Kim,, In vivo analysis of THz wave irradiation inducedacute inflammatory response in skin by laser-scanning confocal microscopy, Opt Express, (2014).
50: Bondar, N. P.; Kovalenko, I. L.; Avgustinovich, D. F.; Khamoyan, A. G.; Kudryavtseva, N. N., Behavioral effect of terahertz waves in male mice, Bulletin of Experimental Biology and Medicine, (2008).
51: Ivanov AN, Changes in activity of stress-realizing body systems as a result of terahertz irradiation at nitric oxide frequencies in albino rats under conditions of acute stress., Bull Exp Biol Med., (2013).
52: Kirichuck, V. F.; Ivanov, A. N.; Kulapina, E. G.; Krenickiy, A. P.; Mayborodin, A. V., Effect of terahertz electromagnetic irradiation at nitric oxide frequencies on concentration of nitrites in blood serum of albino rats under conditions of immobilization stress, Bulletin of Experimental Biology and Medicine, (2010). 53: Kirichuk, V. F.; Efimova, N. V.; Andronov, E. V., Effect of high power terahertz
irradiation on platelet aggregation and behavioral reactions of albino rats, Bulletin of Experimental Biology and Medicine, (2009).
54: Kirichuck, V. F.; Ivanov, A. N.; Antipova, O. N.; Krenickiy, A. P.; Mayborodin, A. V.; Tupikin, V. D., Sex-specific differences in changes of disturbed functional activity of platelets in albino rats under the effect of terahertz electromagnetic radiation at nitric oxide frequencies, Bulletin of Experimental Biology and Medicine, (2008). 55: Alexandrov, Boian S.; Rasmussen, Kim Ø; Bishop, Alan R.; Usheva, Anny;
Alexandrov, Ludmil B.; Chong, Shou; Dagon, Yossi; Booshehri, Layla G.; Mielke, Charles H.; Phipps, M. Lisa; Martinez, Jennifer S.; Chen, Hou-Tong; Rodriguez, George, Non-thermal effects of terahertz radiation on gene expression in mouse stem cells, Biomedical Optics Express, (2011).
56: Ji, Young Bin; Kim, Sang-Hoon; Jeong, Kiyoung; Choi, Yuna; Son, Joo-Hiuk; Park, Dong Woo; Noh, Sam Kyu; Jeon, Tae-In; Huh, Yong-Min; Haam, Seungjoo; Lee, Sang Kil; Oh, Seung Jae; Suh, Jin-Suck, Terahertz spectroscopic imaging and properties of gastrointestinal tract in a rat model, Biomedical Optics Express, (2014). 57: Arbab, M. Hassan; Dickey, Trevor C.; Winebrenner, Dale P.; Chen, Antao; Klein,
Mathew B.; Mourad, Pierre D., Terahertz reflectometry of burn wounds in a rat model, Biomedical Optics Express, (2011).
58: Lim YL, Taimre T, Bertling K, Dean P, Indjin D, Valavanis A, Khanna SP, Lachab M, Schaider H, Prow TW, Peter Soyer H, Wilson SJ, Linfield EH, Giles Davies A, Rakić AD., High-contrast coherent terahertz imaging of porcine tissue via swept-frequency feedback interferometry, Biomed Opt Express. , (2014).
59: Vaĭsman, N. Ia; Fedorov, V. I.; Nemova, E. F.; Nikolaev, N. A., [Survival and life span of Drosophila melanogaster in response to terahertz radiation], Advances in Gerontology = Uspekhi Gerontologii / Rossiĭskaii͡a Akademiii͡a Nauk, Gerontologicheskoe Obshchestvo, (2013).
60: Fedorov, V. I.; Vaĭsman, N. Ia; Nemova, E. F.; Nikolaev, N. A., Terahertz radiation influence on stressed Drosophila life span, Biofizika, (2014).
61: Fedorov, A. I.; Weĭsman, N. Ia; Nemova, E. F.; Mamrashev, A. A.; Nikolaev, N. A., Terahertz radiation influence on number and development dynamics of offspring F1 of fruit fly females under stress], Biofizika, (2013).
62: Janssens, K.; Dik, J.; Cotte, M.; Susini, J., Photon-based techniques for nondestructive subsurface analysis of painted cultural heritage artifacts, Accounts of Chemical Research, (2010).
63: Walker, Gillian C.; Bowen, John W.; Matthews, Wendy; Roychowdhury, Soumali; Labaune, Julien; Mourou, Gerard; Menu, Michel; Hodder, Ian; Jackson, J. Bianca, Sub-surface terahertz imaging through uneven surfaces: visualizing Neolithic wall paintings in Çatalhöyük, Optics Express, (2013).
64: Ohrström, Lena; Bitzer, Andreas; Walther, Markus; Rühli, Frank Jakobus, Technical note: Terahertz imaging of ancient mummies and bone, Animals; Bone and Bones; Fishes; Hand; History, Ancient; Humans; Mummies; paleopathology; Spine; Terahertz Imaging; Tomography, X-Ray Computed, (2010).
65: Öhrström, Lena; Fischer, Bernd M.; Bitzer, Andreas; Wallauer, Jan; Walther, Markus; Rühli, Frank, Terahertz imaging modalities of ancient Egyptian mummified objects and of a naturally mummified rat, Anatomical Record (Hoboken, N.J.: 2007), (2015). 66: Demming, Anna; Tonouchi, Masayoshi; Reno, John L., Terahertz nanotechnology,
Nanotechnology, (2013).
67: Skryl, Anton S.; Jackson, J. Bianca; Bakunov, Michael I.; Menu, Michel; Mourou, Gerard A., Terahertz time-domain imaging of hidden defects in wooden artworks: application to a Russian icon painting, Applied Optics, (2014).
68: Caumes, Jean-Pascal; Younus, Ayesha; Salort, Simon; Chassagne, Bruno; Recur, Benoît; Ziéglé, Anne; Dautant, Alain; Abraham, Emmanuel, Terahertz tomographic imaging of XVIIIth Dynasty Egyptian sealed pottery, Applied Optics, (2011). 69: Haaser M, Naelapää K, Gordon KC, Pepper M, Rantanen J, Strachan CJ, Taday PF,
Zeitler JA, Rades T., Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging, Eur J Pharm Biopharm. , (2013).
70: Spencer, John A.; Gao, Zongming; Moore, Terry; Buhse, Lucinda F.; Taday, Philip F.; Newnham, David A.; Shen, Yaochun; Portieri, Alessia; Husain, Ajaz, Delayed release tablet dissolution related to coating thickness by terahertz pulsed image mapping, Journal of Pharmaceutical Sciences, (2008).
71: Wagh, M. P.; Sonawane, Y. H.; Joshi, O. U., Terahertz technology: a boon to tablet analysis, Indian Journal of Pharmaceutical Sciences, (2009).
72: Mauritz, Jakob M. A.; Morrisby, Richard S.; Hutton, Roger S.; Legge, Coulton H.; Kaminski, Clemens F., Imaging pharmaceutical tablets with optical coherence tomography, Journal of Pharmaceutical Sciences, (2010).
73: Zeitler, J. Axel; Gladden, Lynn F., In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik e.V, (2009).
74: Kawase, Kodo; Ogawa, Yuichi; Watanabe, Yuuki; Inoue, Hiroyuki, Non-destructive terahertz imaging of illicit drugs using spectral fingerprints, Optics Express, (2003). 75: Wu, Huiquan; Heilweil, Edwin J.; Hussain, Ajaz S.; Khan, Mansoor A., Process
analytical technology (PAT): effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets, International Journal of Pharmaceutics, (2007).
76: Zeitler, J. Axel; Shen, Yaochun; Baker, Colin; Taday, Philip F.; Pepper, Michael; Rades, Thomas, Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging, Journal of Pharmaceutical Sciences, (2007).
77: Ho, Louise; Müller, Ronny; Gordon, Keith C.; Kleinebudde, Peter; Pepper, Michael; Rades, Thomas; Shen, Yaochun; Taday, Philip F.; Zeitler, J. Axel, Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance, Journal of Controlled Release: Official Journal of the Controlled Release Society, (2008).
78: Momose, Wataru; Yoshino, Hiroyuki; Katakawa, Yoshifumi; Yamashita, Kazunari; Imai, Keiji; Sako, Kazuhiro; Kato, Eiji; Irisawa, Akiyoshi; Yonemochi, Etsuo; Terada, Katsuhide, Applying terahertz technology for nondestructive detection of crack initiation in a film-coated layer on a swelling tablet, Results in Pharma Sciences, (2012).
79: Brock, Daniela; Zeitler, J. Axel; Funke, Adrian; Knop, Klaus; Kleinebudde, Peter,
Critical factors in the measurement of tablet film coatings using terahertz pulsed imaging, Journal of Pharmaceutical Sciences, (2013).
80: Lin, Hungyen; Dong, Yue; Shen, Yaochun; Zeitler, J. Axel, Quantifying Pharmaceutical Film Coating with Optical Coherence Tomography and Terahertz Pulsed Imaging: An Evaluation, Journal of Pharmaceutical Sciences, (2015). 81: Niwa, Masahiro; Hiraishi, Yasuhiro; Iwasaki, Norio; Terada, Katsuhide, Quantitative
analysis of the layer separation risk in bilayer tablets using terahertz pulsed imaging, Cellulose; Lactose; Mannitol; Microscopy, Electron, Scanning; Quality Control; Tablets; Tensile Strength; Terahertz Imaging; Tomography, X-Ray Computed, (2013). 82: May, Robert K.; Evans, Michael J.; Zhong, Shuncong; Warr, Ian; Gladden, Lynn F.;
Shen, Yaochun; Zeitler, J. Axel, Terahertz in-line sensor for direct coating thickness measurement of individual tablets during film coating in real-time, Journal of Pharmaceutical Sciences, (2011).
83: Maurer, Lene; Leuenberger, Hans, Terahertz pulsed imaging and near infrared imaging to monitor the coating process of pharmaceutical tablets, International Journal of Pharmaceutics, (2009).
84: Haaser, Miriam; Gordon, Keith C.; Strachan, Clare J.; Rades, Thomas, Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review, International Journal of Pharmaceutics, (2013).
85: Ho, Louise; Müller, Ronny; Gordon, Keith C.; Kleinebudde, Peter; Pepper, Michael; Rades, Thomas; Shen, Yaochun; Taday, Philip F.; Zeitler, J. Axel, Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating, European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik e.V, (2009). 86: Sakamoto, Tomoaki; Portieri, Alessia; Arnone, Donald D.; Taday, Philip F.;
Kawanishi, Toru; Hiyama, Yukio, Coating and Density Distribution Analysis of Commercial Ciprofloxacin Hydrochloride Monohydrate Tablets by Terahertz Pulsed Spectroscopy and Imaging, Journal of Pharmaceutical Innovation, (2012). 87: Brock D, Zeitler JA, Funke A, Knop K, Kleinebudde P., Evaluation of critical process
parameters for intra-tablet coating uniformity using terahertz pulsed imaging, , (2013). 88: Hisazumi, Jin; Watanabe, Tomoyuki; Suzuki, Tatsuya; Wakiyama, Naoki; Terada,
Katsuhide, Using terahertz reflectance spectroscopy to quantify drug substance in tablets, Multivariate Analysis; Pharmaceutical Preparations; Tablets; Terahertz Spectroscopy, (2012).
89: Bawuah, Prince; Pierotic Mendia, Alessandra; Silfsten, Pertti; Pääkkönen, Pertti; Ervasti, Tuomas; Ketolainen, Jarkko; Zeitler, J. Axel; Peiponen, Kai-Erik, Detection of porosity of pharmaceutical compacts by terahertz radiation transmission and light reflection measurement techniques, International Journal of Pharmaceutics, (2014). 90: Peiponen, Kai-Erik; Bawuah, Prince; Chakraborty, Mousumi; Juuti, Mikko; Zeitler, J.
Axel; Ketolainen, Jarkko, Estimation of Young's modulus of pharmaceutical tablet obtained by terahertz time-delay measurement, International Journal of Pharmaceutics, (2015).
91: Hisazumi, Jin; Suzuki, Tatsuya; Wakiyama, Naoki; Nakagami, Hiroaki; Terada, Katsuhide, Chemical mapping of hydration and dehydration process of theophylline in tablets using terahertz pulsed imaging, Kinetics; Tablets; Temperature; Terahertz Spectroscopy; Theophylline; Water; X-Ray Diffraction, (2012).
92: Sakamoto, T.; Portieri, A.; Taday, P. F.; Takada, Y.; Sasakura, D.; Aida, K.; Matsubara, T.; Miura, T.; Terahara, T.; Arnone, D. D.; Kawanishi, T.; Hiyama, Y., Detection of tulobuterol crystal in transdermal patches using terahertz pulsed spectroscopy and imaging, Die Pharmazie, (2009).
93: Kawase, Masaya; Saito, Tadashi; Ogawa, Masafumi; Uejima, Hideki; Hatsuda, Yasutoshi; Kawanishi, Sonoyo; Hirotani, Yoshihiko; Myotoku, Michiaki; Ikeda, Kenji; Konishi, Hiroki; Iga, Ikumi; Yamakawa, Junji; Nishizawa, Seizi; Yamamoto, Kohji; Tani, Masahiko, Application of terahertz absorption spectroscopy to evaluation of aging variation of medicine, Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry, (2011).
94: Ok, Gyeongsik; Park, Kisang; Kim, Hyun Jung; Chun, Hyang Sook; Choi, Sung- Wook, High-speed terahertz imaging toward food quality inspection, Applied Optics, (2014).
95: Lee, Young-Ki; Choi, Sung-Wook; Han, Seong-Tae; Woo, Deog Hyun; Chun, Hyang Sook, Detection of foreign bodies in foods using continuous wave terahertz imaging, Journal of Food Protection, (2012).
96: Jiusheng, Li, Optical parameters of vegetable oil studied by terahertz time-domain spectroscopy, Applied Spectroscopy, (2010).
97: Baek, Seung Hyun; Lim, Heung Bin; Chun, Hyang Sook, Detection of melamine in foods using terahertz time-domain spectroscopy, Journal of Agricultural and Food Chemistry, (2014).
98: Redo-Sanchez, Albert; Salvatella, Gerard; Galceran, Regina; Roldós, Eva; García- Reguero, José-Antonio; Castellari, Massimo; Tejada, Javier, Assessment of terahertz spectroscopy to detect antibiotic residues in food and feed matrices, The Analyst, (2011).
99: Massaouti, Maria; Daskalaki, Christina; Gorodetsky, Andrei; Koulouklidis, Anastasios D.; Tzortzakis, Stelios, Detection of harmful residues in honey using terahertz time-