Enrichment dei GO-term (biological process) dei 62 geni associabili alla CFT 171 e di cui è stato possibile rinvenire i codici identificativi Uniprot. I p-value sono corretti con il metodo Bonferroni, il
livello di significatività di soglia usato è stato pari a un p-value di 5·10
-2. A sinistra sono elencati i GO-term, seguiti da una loro descrizione. Il campo "Geni" indica il numero di geni annotati per il
termine corrispondente. "Classe" indica il numero totale di geni annotati per lo stesso termine nell'intero database di riferimento (NET-GE). I termini sono ordinati in ordine di p-value crescente.
GO-term Descrizione Geni Classe P-value
GO:0030182 neuron differentiation 19 911 8,78E-13 GO:0031326 regulation of cellular biosynthetic process 36 6987 3,80E-10 GO:0009889 regulation of biosynthetic process 36 7051 5,06E-10 GO:0010468 regulation of gene expression 36 7158 8,09E-10 GO:0019219 regulation of nucleobase-containing compound metabolic process 37 7797 1,72E-09 GO:0051171 regulation of nitrogen compound metabolic process 37 7927 2,91E-09 GO:0032774 RNA biosynthetic process 25 3250 2,97E-09 GO:2000112 regulation of cellular macromolecule biosynthetic process 34 6579 3,03E-09 GO:0048869 cellular developmental process 26 3694 6,66E-09 GO:0009887 organ morphogenesis 20 1719 6,83E-09 GO:0010556 regulation of macromolecule biosynthetic process 34 6784 7,40E-09 GO:0051252 regulation of RNA metabolic process 33 6360 7,65E-09 GO:0006355 regulation of transcription, DNA-templated 32 6146 1,92E-08 GO:0006351 transcription, DNA-templated 23 2949 2,47E-08 GO:2001141 regulation of RNA biosynthetic process 32 6249 3,02E-08 GO:0009059 macromolecule biosynthetic process 27 4344 3,84E-08 GO:0030154 cell differentiation 21 2446 4,34E-08 GO:0031323 regulation of cellular metabolic process 39 9728 5,40E-08 GO:0080090 regulation of primary metabolic process 39 9808 7,06E-08 GO:0034654 nucleobase-containing compound biosynthetic process 25 3760 7,21E-08 GO:0016070 RNA metabolic process 27 4467 7,34E-08 GO:0048598 embryonic morphogenesis 18 1566 1,36E-07 GO:0019438 aromatic compound biosynthetic process 25 3919 1,76E-07 GO:0018130 heterocycle biosynthetic process 25 3931 1,88E-07 GO:0044271 cellular nitrogen compound biosynthetic process 25 3991 2,60E-07 GO:0019222 regulation of metabolic process 40 10848 3,41E-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter 23 2989 4,34E-07 GO:1901362 organic cyclic compound biosynthetic process 25 4099 4,59E-07 GO:2000113 negative regulation of cellular macromolecule biosynthetic process 25 3633 5,30E-07 GO:0090304 nucleic acid metabolic process 29 5696 6,07E-07 GO:0060255 regulation of macromolecule metabolic process 36 8942 6,97E-07 GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25 3691 7,42E-07 GO:0048468 cell development 20 2280 1,07E-06 GO:0001501 skeletal system development 12 620 1,13E-06 GO:0010558 negative regulation of macromolecule biosynthetic process 25 3771 1,17E-06 GO:0051172 negative regulation of nitrogen compound metabolic process 25 3798 1,36E-06 GO:0048731 system development 21 2612 1,65E-06 GO:0006357 regulation of transcription from RNA polymerase II promoter 19 2379 1,67E-06 GO:0051094 positive regulation of developmental process 23 3200 1,67E-06 GO:0034645 cellular macromolecule biosynthetic process 24 4013 1,84E-06 GO:0010629 negative regulation of gene expression 24 3561 2,22E-06 GO:0045892 negative regulation of transcription, DNA-templated 23 3247 2,23E-06 GO:0009653 anatomical structure morphogenesis 27 4591 2,40E-06 GO:1902679 negative regulation of RNA biosynthetic process 23 3295 2,97E-06 GO:0048523 negative regulation of cellular process 27 5279 3,26E-06
GO-term Descrizione Geni Classe P-value
GO:0044767 single-organism developmental process 30 6740 6,67E-06 GO:0051960 regulation of nervous system development 20 2584 9,33E-06 GO:0032502 developmental process 31 7299 9,55E-06 GO:0045935 positive regulation of nucleobase-containing compound metabolic process 17 2060 9,67E-06 GO:0006139 nucleobase-containing compound metabolic process 31 7311 9,95E-06 GO:0030855 epithelial cell differentiation 14 1135 1,13E-05 GO:1901576 organic substance biosynthetic process 28 6037 1,27E-05 GO:0051173 positive regulation of nitrogen compound metabolic process 17 2108 1,36E-05 GO:0048519 negative regulation of biological process 27 5756 2,19E-05 GO:0045664 regulation of neuron differentiation 17 1894 2,20E-05 GO:0009058 biosynthetic process 28 6217 2,45E-05 GO:0021953 central nervous system neuron differentiation 9 365 2,58E-05 GO:0045165 cell fate commitment 10 501 2,74E-05 GO:0007275 multicellular organismal development 16 1673 2,75E-05 GO:0044249 cellular biosynthetic process 27 5837 2,96E-05 GO:0046483 heterocycle metabolic process 31 7642 2,97E-05 GO:0006725 cellular aromatic compound metabolic process 31 7662 3,17E-05 GO:0009888 tissue development 19 2570 5,46E-05 GO:0031327 negative regulation of cellular biosynthetic process 15 1764 6,11E-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter 18 2314 6,60E-05 GO:0034641 cellular nitrogen compound metabolic process 31 7912 6,93E-05 GO:0009890 negative regulation of biosynthetic process 15 1786 7,19E-05 GO:0003006 developmental process involved in reproduction 18 2335 7,58E-05 GO:1901360 organic cyclic compound metabolic process 31 8010 9,33E-05 GO:0050767 regulation of neurogenesis 18 2377 9,96E-05 GO:0060284 regulation of cell development 20 2979 1,03E-04 GO:0048729 tissue morphogenesis 14 1359 1,08E-04 GO:0006807 nitrogen compound metabolic process 32 8714 1,71E-04 GO:0010628 positive regulation of gene expression 15 1919 1,83E-04 GO:0048856 anatomical structure development 22 4289 1,94E-04 GO:0003002 regionalization 12 988 1,98E-04 GO:0045597 positive regulation of cell differentiation 18 2514 2,33E-04 GO:0060429 epithelium development 12 1006 2,40E-04 GO:0009893 positive regulation of metabolic process 20 3630 2,86E-04 GO:0010604 positive regulation of macromolecule metabolic process 19 3285 3,03E-04 GO:0044260 cellular macromolecule metabolic process 36 11069 3,05E-04 GO:0007389 pattern specification process 14 1481 3,12E-04 GO:0048522 positive regulation of cellular process 25 5768 4,88E-04 GO:0001763 morphogenesis of a branching structure 10 690 5,40E-04 GO:0009954 proximal/distal pattern formation 5 79 5,53E-04 GO:0048666 neuron development 9 539 7,08E-04 GO:0051254 positive regulation of RNA metabolic process 14 1838 7,11E-04 GO:0010605 negative regulation of macromolecule metabolic process 16 2452 7,36E-04 GO:0031324 negative regulation of cellular metabolic process 16 2479 8,52E-04 GO:0031328 positive regulation of cellular biosynthetic process 15 2177 9,16E-04
GO-term Descrizione Geni Classe P-value
GO:0045596 negative regulation of cell differentiation 16 2226 1,38E-03 GO:0009952 anterior/posterior pattern specification 9 585 1,40E-03 GO:0050794 regulation of cellular process 45 17465 1,45E-03 GO:0048518 positive regulation of biological process 26 6624 1,77E-03 GO:0021954 central nervous system neuron development 5 102 1,98E-03 GO:0009892 negative regulation of metabolic process 16 2679 2,37E-03 GO:0040007 growth 13 1496 2,44E-03 GO:0010557 positive regulation of macromolecule biosynthetic process 14 2042 2,48E-03 GO:0050789 regulation of biological process 46 18486 2,59E-03 GO:0031325 positive regulation of cellular metabolic process 18 3418 2,74E-03 GO:0045893 positive regulation of transcription, DNA-templated 13 1762 2,78E-03 GO:0051239 regulation of multicellular organismal process 18 3432 2,90E-03 GO:0010648 negative regulation of cell communication 19 3347 3,37E-03 GO:0023057 negative regulation of signaling 19 3347 3,37E-03 GO:0048663 neuron fate commitment 5 115 3,60E-03 GO:0048562 embryonic organ morphogenesis 8 484 3,66E-03 GO:1902680 positive regulation of RNA biosynthetic process 13 1811 3,76E-03 GO:0008284 positive regulation of cell proliferation 17 2808 6,06E-03 GO:0048589 developmental growth 9 714 7,19E-03 GO:0002009 morphogenesis of an epithelium 11 1159 8,08E-03 GO:0009968 negative regulation of signal transduction 18 3204 8,15E-03 GO:0048754 branching morphogenesis of an epithelial tube 8 542 8,44E-03 GO:0060537 muscle tissue development 7 387 9,57E-03 GO:0044237 cellular metabolic process 41 15758 1,02E-02 GO:0065007 biological regulation 46 19296 1,15E-02 GO:0060548 negative regulation of cell death 16 2642 1,29E-02 GO:0044702 single organism reproductive process 19 3664 1,30E-02 GO:0001708 cell fate specification 6 264 1,34E-02 GO:0009953 dorsal/ventral pattern formation 6 264 1,34E-02 GO:0048705 skeletal system morphogenesis 7 410 1,40E-02 GO:0060021 palate development 6 269 1,49E-02 GO:0001658 branching involved in ureteric bud morphogenesis 5 155 1,55E-02 GO:0048706 embryonic skeletal system development 5 155 1,55E-02 GO:0051093 negative regulation of developmental process 16 2690 1,63E-02 GO:0007399 nervous system development 10 1018 1,76E-02 GO:0007498 mesoderm development 5 161 1,87E-02 GO:0048638 regulation of developmental growth 8 605 1,88E-02 GO:0048585 negative regulation of response to stimulus 19 3759 1,89E-02 GO:0043170 macromolecule metabolic process 36 12986 2,04E-02 GO:0010975 regulation of neuron projection development 11 1281 2,08E-02 GO:0051726 regulation of cell cycle 16 2760 2,25E-02 GO:0061138 morphogenesis of a branching epithelium 8 624 2,35E-02 GO:0048608 reproductive structure development 10 1062 2,54E-02 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 4 82 2,69E-02 GO:0002065 columnar/cuboidal epithelial cell differentiation 5 175 2,80E-02 GO:0050793 regulation of developmental process 15 2884 2,84E-02 GO:0051240 positive regulation of multicellular organismal process 14 2185 3,04E-02 GO:0021544 subpallium development 2 5 3,05E-02 GO:0007167 enzyme linked receptor protein signaling pathway 15 2504 3,12E-02 GO:0048704 embryonic skeletal system morphogenesis 6 310 3,32E-02 GO:0009880 embryonic pattern specification 5 185 3,66E-02 GO:0048568 embryonic organ development 7 476 3,66E-02 GO:0035295 tube development 8 664 3,68E-02
GO-term Descrizione Geni Classe P-value
GO:0010769 regulation of cell morphogenesis involved in differentiation 10 1115 3,86E-02 GO:0001822 kidney development 7 489 4,35E-02 GO:0014706 striated muscle tissue development 6 333 4,97E-02