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Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 alpha/beta pathways

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Received: 24 September 2018

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Revised: 23 January 2019

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Accepted: 18 February 2019 DOI: 10.1002/mc.23001

R E S E A R C H A R T I C L E

Junctional adhesion molecule-A is down-regulated in

anaplastic thyroid carcinomas and reduces cancer cell

aggressiveness by modulating p53 and GSK3 / pathways

α β

Francesca Maria Orlandella

1

|

Raffaela Mariarosaria Mariniello

2,3

|

Paola Lucia

Chiara Iervolino

1

|

Luigi Auletta

1

|

Anna Elisa DeStefano

3

|

Clara Ugolini

4

|

Adelaide Greco

5,6

|

Peppino Mirabelli

1

|

Katia Pane

1

|

Monica Franzese

1

|

Maria Denaro

7

|

Fulvio Basolo

7

|

Giuliana Salvatore

1,2

1IRCCS SDN, Napoli, Italy

2Dipartimento di Scienze Motorie e del

Benessere, Università Parthenope , Napoli, Italy

3CEINGE Biotecnologie Avanzate S.c.a.r.l.,

— Napoli, Italy

4Dipartimento di Area Medica, Azienda

Ospedaliero Universitaria pisana, Pisa, Italy

5

Abstract

Junctional adhesion molecule A (JAM A) is a transmembrane protein that contributes to different biological process, including the epithelial to mesenchymal transition (EMT). Through an EMT profiler array, we explored the molecular players associated with human thyroid cancer progression and identified JAM A as one of the genes mostly deregulated. The quantitative real time polymerase chain reaction and

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