CELLULA STAMINALE LINFOIDE CELLULA STAMINALE TOTIPOTENTE CENTROBLASTO CENTROCITO B-MEMORIA PRECURSORE B CELLULA STAMINALE MIELOIDE LINFOMA DELLA ZONA MARGINALE •Extra nodale •Splenico •nodale LINFOMA LINFOPLASMOCITICO LINFOMA A CELLULE MANTELLARI LINFOMI B DIFFUSI A GRANDI CELLULE LINFOMA FOLLICOLARE B- naïve (IgM+/IgD+) LINFOMA DI BURKITT
linfonodo
tessuti extra-nodali/ LINFOMI T PERIFERICI PRECURSORE Ttimo
centro germinativo zona mantellare zona marginalemidollo osseo
Hairy cell leukemia L prolinfocitica LEUCEMIA LINFATICA ACUTA a T-cellule LEUCEMIA LINFATICA ACUTA a B-cellule MIELOMA LEUCEMIA LINFATICA CRONICA
Angiocentric NHL
Intestinal NHL
Cell origin of T-lymphoid neoplasia
T-ALL
BM
T-precursor
cell
THYMUS
Pe
rip
he
ral
bl
oo
d
ALCL
PTCL
Mycosis fungoides
Sezary’s syndrome
T-cell CLL/PLL CD4+ lymphocytes CD8+ lymphocytes LGL expansion Germinal centreHepato-splenic
γδ NHL
L
y
mph
node
Sp
le
en
liver
AITL
Follicular helper T-cellsLymphoid neoplasias
ACUTE (bone marrow)
Lymphoblastic leukemia B-cell
T-cell
CHRONIC-MATURE (peripheral lymphoid organs)
CHRONIC LYMPHOPROLIFERATIVE DISORDERS B-cells
Chronic lymphocytic leukemia Prolymphocytic leukemia
Splenic lymphoma with circulating villous lymphocytes (splenic marginal zone B-cell lymphoma)
Hairy cell leukemia T-cells
CLL/ Prolymphocytic leukemia
Large granular lymphocyte expansion (T8 / NK phenotype)
Non-Hodgkin’s lymphoma
Hodgkin’s lymphoma
Lymphoid neoplasias
ACUTE (bone marrow)
Lymphoblastic leukemia B-cell
T-cell
CHRONIC-MATURE (peripheral lymphoid organs)
CHRONIC LYMPHOPROLIFERATIVE DISORDERS
Non-Hodgkin’s lymphoma
Hodgkin’s lymphoma
Leukocytosis
PB blast cells
Malaise
Anemia
Thrombocytopenia
fever
Presenting symptoms Rapidly evolving diseasePresenting symptoms Usually smoldering disease
Leukocytosis
PB mature cells (monoclonal) Only in advanced stages:
adenopathy Anemia
Thrombocytopenia Splenomegaly Fever
Leukopenia in hairy cell leukemia
