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Nanomaterials-based strategies for piezoelectric cochlear implants

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(1)SYMPOSIUM & 52ND INNER EAR BIOLOGY WORKSHOP. O53 COATED COCHLEAR IMPLANT ELECTRODES TO SUPPRESS INTRACOCHLEAR INFLAMMATORY RESPONSE AND FIBROSIS 4VTBOOF#SBVO +PIBOOFT'JTDIFS1 ,BUIBSJOB/JFEFSNFJFS1, Jochen Steinhoff1,4ÕSFO4DIJMQ 5IPNBT4UBSL1 1 Technical University Munich, Klinikum Rechts der Isar, ENT Department, Munich, Germany; 2MED-EL GmbH Innsbruck, Austria and Starnberg, Germany Objectives. $PDIMFBS JNQMBOU $*  SFTFBSDI DPOUJOVPVTMZ TUSJWFT GPS JNQSPWJOH FMFDUSPEFT BOE JOWFOUJOH OFX FMFDUSPEF UZQFT UP FOBCMFUIFCFTUQPTTJCMFQFSGPSNBODFPG$*SFDJQJFOUT0OFHPBMJT UPNJOJNJ[FJOUSBDPDIMFBSDISPOJDJOáBNNBUJPOBOEàCSPTJTEVFUP GPSFJHOCPEZSFBDUJPOBGUFSJNQMBOUBUJPOUIBUMFBETUPBOJODSFBTFJO FMFDUSPEFJNQFEBODFBOEBEFDSFBTFPGUIFEZOBNJDàUUJOHSBOHFPG MPVEOFTTMFWFMT"EEJUJPOBMMZ DISPOJDJOáBNNBUJPOJOUIFNJEEMFUP MPOHUFSNNBZDBVTFBEFTUSVDUJPOPGTFOTPSJOFVSBMTUSVDUVSFTUIVT JOáVFODJOHUIFQFSGPSNBODFPGJNQMBOUFFTXJUITUBOEBSEJOEJDBUJPOT BT XFMM BT FMFDUSJDBDPVTUJD TUJNVMBUJPO &"4  DBOEJEBUFT EVF UP MPTTPGSFTJEVBMIFBSJOH 8IJMF QIBSNBDPMPHJDBM JOUFSWFOUJPO XJUI HMVDPDPSUJDPJET JT B QSPNJTJOH BQQSPBDI UP EBNQFO QPTUPQFSBUJWF JOáBNNBUPSZ SFBDUJPOT  QSFWFOU àCSPTJT  BOE QSFTFSWF SFTJEVBM IFBSJOH B OPO QIBSNBDPMPHJDBMBQQSPBDIXBTDIPTFO OBNFMZBQBTTJWBUJOHDPBUJOH GPS UIF FMFDUSPEF BSSBZ UIFSFCZ NBLJOH JU MFTT EFUFDUBCMF CZ UIF JNNVOFTZTUFN Methods.  OPSNBM IFBSJOH HVJOFB QJHT %VOLJO )BSUMFZ  XFSF DISPOJDBMMZ JNQMBOUFE XJUI DVTUPNNBEF FMFDUSPEFT .&% &-  FJUIFS DPBUFE XJUI B IJHIMZ CJPDPNQBUJCMF QPMZNFS O $0"5&%  PS DPNNPO TJMJDPOF BSSBZT O /0/$0"5&%  *NQFEBODF BOE "#3NFBTVSFNFOUT XFSF QFSGPSNFE BGUFS           BOE  XFFLT QPTUJNQMBOUBUJPO 5IJT XBT GPMMPXFE CZ IJTUPMPHJDBM FYBNJOBUJPO PG UIF DPDIMFBF &WBMVBUJPO JODMVEFE NFBTVSFNFOU PG àCSPTJT JO UIF DPDIMFB  WBSJPVT JOáBNNBUPSZ NBSLFSTBOEJNNVOPIJTUPMPHJDBMBOBMZTJTPGEFHFOFSBUJPOPGTQJSBM HBOHMJPOOFVSPOT ("1  Results. "MUIPVHI UIFSF XBT OP TJHOJàDBOU EJGGFSFODF CFUXFFO UIF UXP HSPVQT SFHBSEJOH IFBSJOH UISFTIPMET BOJNBMT XJUI DPBUFE JNQMBOUTTIPXFETNBMMFSTIJGUTPGQPTUPQFSBUJWFIFBSJOHUISFTIPMETBU IJHIFSGSFRVFODJFT mL)[ *NQFEBODFNFBTVSFNFOUTSFWFBMFE OP TUBUJTUJDBMMZ TJHOJàDBOU EJGGFSFODF CFUXFFO UIF UXP HSPVQT /P DPSSFMBUJPO XBT PCTFSWFE CFUXFFO QPTUPQFSBUJWF IFBSJOH MPTT BOE JNQFEBODF JODSFBTF )JTUPMPHJDBM BOBMZTJT SFWFBMFE TJHOJàDBOUMZ SFEVDFE DISPOJD MZNQIPQMBTNBUJD JOáBNNBUJPO Q    JO UIF CBTBMUVSOPGDPDIMFBFJNQMBOUFEXJUIDPBUFEJNQMBOUT/PTJHOJàDBOU EJGGFSFODFXBTPCTFSWFEDPODFSOJOHàCSPTJTBOEOFXCPOFGPSNBUJPO *NNVOPIJTUPMPHJDBM ("1 TUBJOJOH EFNPOTUSBUFE B TJHOJàDBOUMZ MPXFS BNPVOU PG EFHFOFSBUFE TQJSBM HBOHMJPO OFVSPOT JO UIF CBTBM UVSOPGUIFDPDIMFBFJNQMBOUFEXJUIDPBUFEFMFDUSPEFT Q  Conclusion. 5IF IJHIMZ CJPDPNQBUJCMF DPBUJOH TFFNT UP CF B QSPNJTJOH JNQSPWFNFOU GPS GVUVSF FMFDUSPEFT QPTTJCMZ JO DPNCJOBUJPOXJUIBOUJJOáBNNBUPSZESVHTMJLFEFYBNFUIBTPOF. O54 NANOMATERIALS-BASED STRATEGIES FOR PIEZOELECTRIC COCHLEAR IMPLANTS Serena Danti1 -VDB#SVTDIJOJ1, Gianni Ciofani .BTTJNJMJBOP -BCBSEJ $BSMPT.PUB1 -VJTB5SPNCJ1 $MBVEJP3JDDJ1 %FMGP %"MFTTBOESP1 (JVTFQQF$(BMMPOF 4UFGBOP#FSSFUUJOJ1 1 OtoLab, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; 2Istituto Italiano di Tecnologia (IIT), Pontedera (PI), Italy; 3Istituto per i Processi Chimico-Fisici, CNR, Pisa, Italy; 4 Dept. of Civil and Industrial Engineering, University of Pisa, Italy "TPGUPEBZ DPDIMFBSJNQMBOUT $*T SFQSFTFOUUIFPOMZPQUJPOGPS EFBG QFPQMF BGGFDUFE CZ QSPGPVOE PS TFWFSF TFOTPSJOFVSBM IFBSJOH MPTT 4/)- "MUIPVHI DPOWFOUJPOBM $*T DBO CSJOH QBUJFOUT CBDL UP BO BDDFQUBCMF IFBSJOH  PO UIF PUIFS IBOE UIFZ TVGGFS GSPN TPNF JNQPSUBOU EJTBEWBOUBHFT JNQBDUJOH UIF RVBMJUZ PG MJGF BOE IFBSJOHBGUFSJNQMBOUBUJPOBOEGPSTVDISFBTPOTBOFXDMBTTPG$*T JT EFTJSBCMF 5IF QIZTJDBM QSPQFSUJFT PG QJF[PFMFDUSJD NBUFSJBMT  XIJDI QPMBSJ[F JO SFTQPOTF UP NFDIBOJD EFGPSNBUJPO  FOUJUMF UIFN UP SFQMBDF UIF GVODUJPO PG IBJS DFMMT 5IF EFWFMPQNFOU PG B XPSLJOHQJF[PFMFDUSJD$*SFRVJSFTUIBUUIFFMFDUSJDDIBSHFHFOFSBUFE CZ UIF QJF[PNBUFSJBMT NVTU CF TFMGTVGàDJFOU UP TUJNVMBUF UIF DPDIMFBSOFVSPOT'JSTUTUVEJFTVTJOHBCBTJDQJF[PFMFDUSJDQPMZNFS QPMZWJOZMJEFOFáVPSJEF 17%' IBWFTIPXOUIFQSPPGPGDPODFQU  CVUUIFEFWJDFTFOTJUJWJUZXBTTUJMMJOTVGàDJFOU 5IFBJNPGUIJTTUVEZJTUPGBCSJDBUFOPWFMQJF[PFMFDUSJDTVCTUSBUFT CBTFE PO QJF[PQPMZNFST 17%' BOE 17%'5S'&  EPQFE XJUI DFSBNJD OBOPQBSUJDMFT CBSJVN UJUBOBUF OBOPTQIFSFT  DBSCPO OBOPUVCFT  UP PCUBJO DPNQPTJUF NBUFSJBMT XJUI FOIBODFE QFSGPSNBODF4FWFSBMNJDSPGBCSJDBUJPOTUSBUFHJFTXFSFJOWFTUJHBUFE UPQSPEVDFUIJOQJF[PFMFDUSJDQPMZNFSDFSBNJDDPNQPTJUFTDBGGPMET  JO UIF GPSN PG FMFDUSPTQVO OBOPàCFST BOE NJDSPOBOP àMNT UP CF QMBDFE PO UIF CBTJMBS NFNCSBOF  JODMVEJOH TQJO DPBUJOH  IPU QSFTT  BOE DPBYJBM FMFDUSPTQJOOJOH 1SFTFODF PG UIF QJF[PFMFDUSJD DSZTUBMMPHSBQIJD QIBTFT PG UIF DPNQPTJUF NBUFSJBMT XFSF BTTFTTFE WJB9SBZEJGGSBDUJPO5IFQJF[PFMFDUSJDDPOTUBOUTXFSFJOWFTUJHBUFE XJUIBCFODITFUVQJOXIJDIUIFNBUFSJBMEFGPSNBUJPOJTNFBTVSFE VOEFS BO BQQMJFE DVSSFOU 'JOBMMZ  UIF TVCTUSBUFT XFSF DVMUVSFE in vitro XJUI OFVSPOBMMJLF DFMM MJOFT BOE NFTFODIZNBM TUFN DFMMT .4$T  UP BTTFTT UIFJS QPUFOUJBM BCJMJUZ UP JOUFSBDU XJUI JOOFS FBS SFTJEFOUDFMMT 5IFGBCSJDBUJPOQBSBNFUFSTXFSFUVOFEUPPQUJNJ[FUIFQJF[PFMFDUSJD SFTQPOTFPGUIFNBUFSJBMT*ODSFBTJOHCBSJVNUJUBOBUFOBOPQBSUJDMF DPODFOUSBUJPO VQ UP  XX  JO 17%' OBOPàCFS SJCCPOT FOIBODFE JOWFSTF EFGPSNBUJPO  CVU OPU EJSFDU QPMBSJ[BUJPO  QJF[PFMFDUSJD FGGFDU *OUFSBDUJPO XJUI OFVSPOBMMJLF DFMMT XBT OPU BGGFDUFECZCBSJVNUJUBOBUFDPODFOUSBUJPO%JGGFSFOUMZ UIFQSFTFODF PG DBSCPO OBOPUVCFT JO 17%'5S'& àMNT JODSFBTFE QFSGPSNBODF BOE.4$BEIFTJPOXJUISFTQFDUUPQMBJO17%'5S'&àMNT *NQSPWFNFOUT JO QJF[PFMFDUSJD $*T DPVME TVCTUBOUJBMMZ JNQBDU UIF RVBMJUZPGMJGFPGQFPQMFBGGFDUFECZQSPGPVOE4/)-BOESFEVDFUIF IFBMUIDBSFDPTUT. 59.

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