• Non ci sono risultati.

Pectin-honey hydrogel: Characterization, antimicrobial activity and biocompatibility

N/A
N/A
Protected

Academic year: 2021

Condividi "Pectin-honey hydrogel: Characterization, antimicrobial activity and biocompatibility"

Copied!
19
0
0

Testo completo

(1)

19 July 2019

AperTO - Archivio Istituzionale Open Access dell'Università di Torino

Pectin-honey hydrogel: Characterization, antimicrobial activity and biocompatibility / Giusto, Gessica; Beretta, Giangiacomo; Vercelli, Cristina; Valle, Emanuela; Iussich, Selina; Borghi, Roberta; Odetti, Patrizio; Monacelli,

Fiammetta; Tramuta, Clara; Grego, Elena; Nebbia, Patrizia; Robino, Patrizia; Odore, Rosangela; Gandini, Marco. - In: BIO-MEDICAL MATERIALS AND ENGINEERING. - ISSN 0959-2989. - 29:3(2018), pp. 347-356.

Original Citation:

Pectin-honey hydrogel: Characterization, antimicrobial activity and biocompatibility

Published version:

DOI:10.3233/BME-181730

Terms of use:

Open Access

(Article begins on next page)

Anyone can freely access the full text of works made available as "Open Access". Works made available under a Creative Commons license can be used according to the terms and conditions of said license. Use of all other works requires consent of the right holder (author or publisher) if not exempted from copyright protection by the applicable law.

Availability:

This is the author's manuscript

(2)

! !"#$%&'()&"* (*+,)-"./ #(0,0#$",%10$%)&2 0&$%3%#,)4%0. 0#$%5%$* 0&+ 4%)#)360$%4%.%$*

! "

#$%%&'( #&)%*+(, #&(-.&('+/+ 0$1$**(2, 31&%*&-( 4$1'$55&(, 6/(-)$5( 4(55$(, 7$5&-( 8)%%&'9(,

:

;+2$1*( 0+1.9&', <(*1&=&+ >?$**&', @&(//$**( A+-('$55&', 35(1( B1(/)*((, 65$-( #1$.+(, <(*1&=&(

C

D$22&((, <(*1&=&( ;+2&-+(, ;+%(-.$5( >?+1$(, A(1'+ #(-?&-&(

E F

(G$H(1*/$-* +I 4$*$1&-(1J 7'&$-'$%, K-&L$1%&*J +I B)1&-, M(1.+ <(+5+ 01(''&-& "NE, !OOPE

Q

#1).5&(%'+ RB>S, 8*(5J T

2G$H(1*/$-* +I <9(1/('$)*&'(5 7'&$-'$% G87@U;A, K-&L$1%&*J +I A&5(-, 4&( A(-.&(.(55& "E,

P

"O!:: A&5(-+ RA8S, 8*(5J !O

'G$H(1*/$-* +I 8-*$1-(5 A$?&'&-$ (-? A$?&'(5 7H$'&(5*&$%, K-&L$1%&*J +I #$-+(, 4&(5$ 0$-$?$**+

!!

V4 F, !F!:" #$-+L( R#6S, 8*(5J !"

!: !C

U??1$%% '+11$%H+-?$-'$ *+ G1W #(-?&-& (* /(1'+W.(-?&-&X)-&*+W&* I1+/ *9$ G$H(1*/$-* +I !E

4$*$1&-(1J 7'&$-'$%, K-&L$1%&*J +I B)1&-, M(1.+ <(+5+ 01(''&-& "NE, !OOPE #1).5&(%'+ RB>S, !F 8*(5J, H9+-$ Y:PO!!FQOTTF! !Q !T !P "O "! "" ": "C

(3)

" 748$,0#$

"E

90#:-,);&+/ D+L$5 H$'*&-N9+-$J 9J?1+.$5% 9(L$ 2$$- ?$L$5+H$? (-? '9(1('*$1&=$? (% /$?&'(5 "F

?$L&'$W 8?$(55J, ( Z+)-? ?1$%%&-. %9+)5? /(&-*(&- +H*&/(5 I5)&? (II&-&*J, H$1/&* /+&%*)1$ "Q

$L(H+1(*&+-, H1+*$'* *9$ Z+)-? I1+/ /&'1+2$%, (-? 9(L$ %9(H$N'+-I+1/(2&5&*J, 2&+'+/H(*&2&5&*J, "T

(-? (-*&2('*$1&(5 ('*&L&*JW <4="#$%5"/ U -+L$5, %&/H5$ (-? I(%* /$*9+? *+ H1+?)'$ H$'*&-N9+-$J "P

Z+)-? ?1$%%&-.% &% ?$%'1&2$?W >"$()+8/ B9$ H1+H$1*&$% +I *9$%$ H$'*&-N9+-$J 9J?1+.$5% Z$1$ :O

&-L$%*&.(*$?, &-'5)?&-. %Z$55&-. (2&5&*J, Z(*$1 L(H+)1 *1(-%/&%%&+- 1(*$, 9J?1+.$- H$1+[&?$ :!

H1+?)'*&+-, /$*9J5.5J+[(5 '+-*$-* (-? (-*&2('*$1&(5 ('*&L&*JW 0&+'+/H(*&2&5&*J Z(% (%%$%%$? 2J :"

H1+5&I$1(*&+- (%%(J% )%&-. ')5*)1$? I&21+25(%* '$55% (-? 2J !" #!#$ %*)?J Z&*9 %)2')*(-$+)% (-? ::

&-*1(H$1&*+-$(5 &/H5(-*(*&+- &- 1(*%W ?"8;.$8/ \J?1+.$5 %9+Z$? ( .++? Z(*$1 L(H+)1 *1(-%/&%%&+-:C

1(*$, I5)&? )H*(]$ (-? Z$1$ -+* 'J*+*+[&' I+1 I&21+25(%*%W B9$ 9J?1+.$5 ?$/+-%*1(*$? .++? :E

(-*&2('*$1&(5 ('*&L&*J *+Z(1? '5&-&'(55J 1$5$L(-* H(*9+.$-%, &-'5)?&-. %& '()*(+ (-? ,& -$.!W :F

0&+'+/H(*&2&5&*J Z(% '+-I&1/$? 2J *9$ /$(%)1$/$-* +I H5(%/( 5$L$5% +I &-*$15$)]&- R8MS! 2$*(, :Q

8MNF, *)/+)1 -$'1+%&% I('*+1 RBD@S (5H9(, (-? H1+%*(.5(-?&- R<#S6"W D+ 9&%*+5+.&'(5 '9(-.$% :T

Z$1$ +2%$1L$?W @)&#.;8%)&8/ B9$ H1$%$-'$ +I ( -(*)1(5 ('*&L$ '+/H+-$-*, '+-I+1/(2&5&*J, (-? :P

'+/H5$*$ 1$%+12(2&5&*J (1$ *9$ /(&- '9(1('*$1&%*&'% +I *9&% -$Z 2&+'+/H(*&25$ 2&+/(*$1&(5 *9(* &% CO

Z$55 *+5$1(*$? 2J *9$ 2+?J, H+%%&25J &/H1+L$% 9$(5&-., /(J 2$ )%$? I+1 %)1.&'(5 '+/H5&'(*&+-% C!

H1$L$-*&+-, Z&*9 ( %&/H5$ (-? &-$[H$-%&L$ H1+?)'*&+- H1+'$%%W C"

C:

A"*B),+8^ 2&+'+/H(*&2&5&*J, 2&+/(*$1&(5, H$'*&-N9+-$J 9J?1+.$5%, Z+)-? ?1$%%&-., /$?&'(5 CC ?$L&'$ CE CF CQ CT

(4)

: C&$,)+;#$%)&

CP

\$(5&-. Z+)-?% (1$ %&*$% *9(* (1$ $(%&5J (**(']$? 2J 2('*$1&(, Z9&'9 5$(?% *+ *9$ I+1/(*&+- +I ( EO

2&+I&5/ *9(* ?$L&*(5&%$% *&%%)$% _!`W B9$ ?$L$5+H/$-* +I ( -$Z Z+)-? ?1$%%&-. &% ( I+')% (1$( I+1 E!

/(-J 1$%$(1'9$1% %&-'$ *9$ ?1$%%&-. '(- '1$(*$ ( 2(11&$1 (.(&-%* &-I$'*&+- Z9&5$ /(&-*(&-&-. ( E"

H9J%&+5+.&'(5 $-L&1+-/$-* &- '+-*('* Z&*9 *9$ Z+)-? _"N:`W B9$%$ ?1$%%&-.% 9$5H *+ /(&-*(&- ( E:

/+&%* $-L&1+-/$-* (* *9$ Z+)-? %&*$, H1+/+*$ *&%%)$ 9$(5&-., (-? 1$?)'$ &-I$'*&+-, H(&-, (-? EC

'+%*% _!, CNE`W U-*&/&'1+2&(5 (.$-*% H5(J (- &/H+1*(-* 1+5$ &- 1$?)'&-. 2('*$1&(5 '+-*(/&-(*&+-, EE

2)* *9$ 1$%&%*(-'$ +I H(*9+.$-% *+ *9$%$ %)2%*(-'$% 9(% 5$? *+ ( ?$'1$(%$ &- *9$ $II&'('J +I EF

(-*&2&+*&'%W ;$%$(1'9$1% 9(L$ *9$1$I+1$ (?L&%$? (.(&-%* *9$ )%$ +I %J%*$/&' (-*&/&'1+2&(5 (.$-*% EQ

I+1 *9$ *1$(*/$-* +I Z+)-?% _!, F`W ET

4(1&+)% Z+)-? ?1$%%&-.% '+-%&%*&-. +I L$.$*(25$ I&21$%, H1+*$'*&L$ I&5/%, 9J?1+.$5%, (-? 9J?1+.$5 EP

$-1&'9$? Z&*9 -&*1+.$- +[&?$% (1$ (L(&5(25$ '+//$1'&(55J _!N", E, Q`W \J?1+.$5% (1$ 1$H+1*$? *+ 2$ FO

%)&*(25$ I+1 )%$ &- 9$(5&-. Z+)-?% 2)* *9$J 9(L$ 5&/&*(*&+-% &- ')11$-* )%$, Z9&'9 &-'5)?$ ( F!

1$a)&1$/$-* I+1 9&.9 I1$a)$-'J +I (HH5&'(*&+-, &-('*&L(*&+- 2J Z+)-? I5)&?%, (-? I+1/(*&+- +I F"

$%'9(1% _E`W B9$ 1$a)&1$/$-* I+1 ( -$Z (-*&/&'1+2&(5 %)2%*(-'$ 5$? *+ 1$L(5)(*&+- +I (-'&$-* F:

1$/$?&$%, &-'5)?&-. *9$ )%$ +I 9+-$J _TNP`W FC

\+-$J 9(% 2$$- )%$? (5+-$ +1 &- '+/2&-(*&+- Z&*9 +*9$1 '+/H+)-?% I+1 /$?&'(5 )%$ %&-'$ FE

(-'&$-* *&/$%W \+-$J &% ( 9$*$1+.$-$+)% %)2%*(-'$, 9(% (-*&/&'1+2&(5 ('*&L&*J, (-*&N&-I5(//(*+1J FF

$II$'*% (-? &-'1$(%$ *9$ 9$(5&-. H1+'$%% I+55+Z&-. %]&- +1 H$1&*+-$(5 ?(/(.$ _T, !O`W 8* '+-*(&-% FQ

9&.9 5$L$5% +I .5J'&-$, /$*9&+-&-$ (-? H1+5&-$ Z9&'9 (1$ (55 I)-?(/$-*(5 I+1 '+55(.$- I+1/(*&+-FT

(-? I&21+25(%* ?$H+%&*&+-, Z9&'9 (1$ *9$ /(&- I('*+1% I+1 Z+)-? 9$(5&-. _!!`W FP

A(-)]( 9+-$J, H1+?)'$? &- D$Z b$(5(-?, &% *9$ /+%* %*)?&$? 9+-$J 9(L&-. (-*&2('*$1&(5 QO

H1+H$1*&$% (.(&-%* /(c+1 ($1+2&' (-? (-($1+2&' 2('*$1&( %H$'&$% _!"N!:`W Q!

(5)

C 7$L$1(5 '+/H+-$-*% (1$ ]-+Z- *+ '+-*1&2)*$ (-*&2('*$1&(5 ('*&L&*J +I 9+-$JW B9$ +%/+*&' $II$'* +I Q"

*9$ %).(1% &- 9+-$J (-? &*% '9(1('*$1&%*&'(55J ('&?&' H\ (1$ ]-+Z- I('*+1% 9&-?$1&-. 2('*$1&(5 Q:

/)5*&H5&'(*&+-W ;$'$-*5J, *Z+ '+/H+-$-*% +I 9+-$J, 9J?1+.$- H$1+[&?$ R\">"S (-? QC

/$*9J5.5J+[(5 RA#>S, 9(L$ 2$$- &?$-*&I&$? (% $II$'*&L$ (-*&2('*$1&(5% _!CN!F`W QE

U- &?$(5 Z+)-? ?1$%%&-. &% J$* *+ 2$ ?$L$5+H$?W 8?$(55J, ( Z+)-? ?1$%%&-. %9+)5? /(&-*(&-QF

+H*&/(5 I5)&? (II&-&*J, H$1/&* /+&%*)1$ $L(H+1(*&+-, H1+*$'* *9$ Z+)-? I1+/ I+1$&.- /&'1+2$%, (-? QQ

9(L$ %9(H$N'+-I+1/(2&5&*J, 2&+'+/H(*&2&5&*J, (-? (-*&2('*$1&(5 ('*&L&*J _",CNE,!Q`W QT

0(%$? +- *9$%$ H1$/&%$%, *9$ (&/ +I *9$ H1$%$-* %*)?J Z(% *+ ?$%'1&2$ (-? '9(1('*$1&=$ *9$ QP

H1+H$1*&$% +I H$'*&-N9+-$J 9J?1+.$5% R<\\%S I+1 Z+)-? 9$(5&-. (-? *+ (%%$%% *9$&1 TO

2&+'+/H(*&2&5&*J *91+).9 (- &- L&*1+ (-? &- L&L+ (%%(JW T!

>0$",%0. 0&+ 3"$()+8 T"

!"#$%&"'(

T:

\+-$J Z(% H)1'9(%$? I1+/ A(-)]( \$(5*9 RFF d$+-( 3+)1*,B$ UZ(/)*) :TOO, D$Z b$(5(-?S TC

(-? H$'*&- I1+/ U1?$* %W1W5W RB+1&-+, 8*(5JSW 3)5*)1$ /$?&(, *9(* &%, *1JH*+-$ %+J (.(1 RB7US, TE

*1JH*+-$ %+J 21+*9 RB70S, H$H*+-$ Z(*$1, (-? Ee %9$$H 25++? (.(1, Z$1$ H)1'9(%$? I1+/ >[+&? TF

RA&5(-, 8*(5JSW 6%'9$1&'9&( '+5& RB)1&- %*1(&-S (-? 7*(H9J5+'+'')% ()1$)% RB)1&- %*1(&-S &%+5(*$? TQ

I1+/ '(-&-$ Z+)-?% Z$1$ )%$? I+1 *9&% Z+1]W TT

)%$*"%"#&+, +- )..(

TP

B9$ H1$H(1(*&+- /$*9+? Z(% /+?&I&$? (I*$1 *9$ H1+'$?)1$ ?$%'1&2$? 2J d(5]$1W Rd(5]$1, !PC"S PO

_!T` 01&$I5J, *9$ H$'*&-N9+-$J 9J?1+.$5% Z$1$ H1$H(1$? %*(1*&-. I1+/ ( %+5)*&+- R!^! LfLS +I 5&a)&? P!

9+-$J RA(-)]( \$(5*9, D$Z b$(5(-?S (-? %*$1&5$ ?$&+-&=$? Z(*$1W B9$ %(/$ L+5)/$ +I H$'*&-P"

H+Z?$1 RU;G6B %W1W5W, 8*(5JS Z(% *9$- (??$? (-? Z&*9 '+-*&-)+)% %*&11&-. )-*&5 *9$ /&[*)1$ Z(% P:

9+/+.$-$+)%W B9$ 1$%)5*&-. .$5 Z(% %H1$(? &-*+ " // *9&'] I&5/% (-? 9+* (&1 ?1&$? (* COYfN OWE PC

g3 I+1 F 9W B9$- &* Z(% ')* &-*+ %a)(1$% +I E [ E '/ (-? I)1*9$1 '+-?&*&+-$? &- (- (&1 ?1&$1 (* "EYfN PE

(6)

E ! g3 I+1 E ?(J%W B9$ I&5/% Z$1$ *9$- '+55$'*$? (-? H(']$? &- H+5J$*9J5$-$ )-?$1 L('))/ PF

'+-?&*&+-%W U55 /$/21(-$% Z$1$ %*$1&5&=$? 2J .(//(N&11(?&(*&+- (* "E h#1(J (* *9$ 7*$1&.$-&'% PQ

8*(5J R7*$1&.$-&'% 8*(5J, A&-$12&+ R0>S, 8*(5JS _!P`W PT

/'0&1 0*#"2$ #$(# 345$''&,6 #$(#7

PP

B+ &-L$%*&.(*$ *9$ I5)&? %Z$55&-. 1(*&+ +I <\\%, %(/H5$% Z$1$ ')* &-*+ ?&%]% Z&*9 ( ?&(/$*$1 +I !OO

(HH1+[&/(*$5J "E //W B9$ ?1J Z$&.9*% Rd?1JS +I *9$ /$/21(-$% Z$1$ /$(%)1$? (-? 1$'+1?$?W !O!

UI*$1Z(1?%, H1$NZ$&.9$? ?1J %(/H5$% Z$1$ &//$1%$? &- <07 %+5)*&+-, H\ QWC, (* :Qg3W B9$ !O"

Z$&.9*% +I *9$ %Z+55$- <\\% Z$1$ ?$*$1/&-$? $L$1J E /&- %)2%$a)$-*5J 2J %(-?Z&'9&-. *9$ !O:

/$/21(-$% 2$*Z$$- *Z+ H(H$1 *+Z$5% *+ 1$/+L$ $['$%% Z(*$1 +- *9$ %)1I('$, (-? *9$- Z$* !OC

Z$&.9*% RdZ$*S Z$1$ /$(%)1$?W U55 $[H$1&/$-*% Z$1$ H$1I+1/$? &- *1&H5&'(*$W B9$ %Z$55&-. !OE

1(*&+% Z$1$ '(5')5(*$? (% *9$ (L$1(.$ L(5)$ (''+1?&-. *+ *9$ I+55+Z&-. I+1/)5(^ !OF G7 i _RdZ j d?Sfd?` ! !OO !OQ d9$1$ dZ (-? d? 1$H1$%$-* *9$ Z$&.9*% +I Z$* (-? ?1J %(/H5$%, 1$%H$'*&L$5JW !OT 8"#$% 9"*+0% #%",(:&((&+, %"#$ 38;<=7 !OP

B9$ /+&%*)1$ H$1/$(2&5&*J +I *9$ <\\ Z(% ?$*$1/&-$? 2J /$(%)1&-. *9$ d4B;W U H&$'$ +I *9$ !!O

%H$'&/$- Z(% I&[$? +L$1 *9$ *+H +I ( *)2$ R?&(/$*$1, :C //S '+-*(&-&-. !O /M <07W B9$ *)2$ !!!

Z(% *9$- H5('$? &- (- &-')2(*+1 (* :Qg3 (-? :Ee 1$5(*&L$ 9)/&?&*JW B9$ /$/21(-$% Z$1$ !!"

Z$&.9$? (* 1$.)5(1 &-*$1L(5% +I *&/$ (-? *9$ Z$&.9* 5+%% Z(% 1$'+1?$? (-? H5+**$? +- ( .1(H9 !!:

L$1%)% *&/$W B9$ d4B; Z(% '(5')5(*$? I1+/ *9$ %5+H$ +I *9$ .1(H9 2J *9$ I+55+Z&-. I+1/)5(^ !!C

d4B; . R/"f?(JS i R%5+H$ ! "CSfU !!E

d9$1$ U &% (1$( +I *9$ %(/H5$ R/"SW 6[H$1&/$-*% Z$1$ H$1I+1/$? &- *1&H5&'(*$W !!F

.>?> ","'@(&(

!!Q

B9$ (-(5J%&% +I \">"I1+/ 9+-$J (-? <\\% Z(% '(11&$? +)* (''+1?&-. *+ *9$ /$*9+? 1$H+1*$? 2J

!!T

M+-. R!PPPS _"O` RI$11+)% &+- +[&?(*&+-N[J5$-+5 +1(-.$ _@>V` (%%(JS, Z&*9 /&-+1 /+?&I&'(*&+-%W !!P

(7)

F B9$ %*+'] 1$(.$-*% Z$1$ (% I+55+Z%^ 1$(.$-* !, CWC /A 2)*J5(*$? 9J?1+[J *+5)$-$ R0\BS &-!"O

\<M3N.1(?$ /$*9(-+5k 1$(.$-* ", ! /A [J5$-+5 +1(-.$ (-? "WEF /A (//+-&)/ I$11+)% !"!

%)5H9(*$ &- "EO /A \"7>Ck Z+1]&-. 1$(.$-*^ +-$ L+5)/$ +I 1$(.$-* " (??$? *+ -&-$ L+5)/$% +I

!""

1$(.$-* !W UHH1+[&/(*$5J "OO /. +I 9+-$J Z$1$ ?&5)*$? Z&*9 ?$&+-&=$? Z(*$1 *+ *9$ 1(*&+ "Oe !":

ZfZ (-? &//$?&(*$5J ]$H* &- ( *9$1/+%*(* (* B i :Q g3, (-? !OON"M (5&a)+*% Z$1$ (??$? *+ POO !"C

"5 +I @>V Z+1]&-. 1$(.$-*W UI*$1 "O /&- +I &-')2(*&+- (* 1++/ *$/H$1(*)1$, (2%+12(-'$ Z(% !"E

/$(%)1$? (* #i EFO -/ (.(&-%* ( 25(-] '+/H1&%&-. POO "M +I Z+1]&-. 1$(.$-* (-? !OON "M !"F

(5&a)+*% +I ?&%*&55$? Z(*$1 R(2%+12(-'$ +I ?&5)*$? 9+-$J Z(% -$.5&.&25$ (* *9$ +H$1(*&L$ !"Q

Z(L$5$-.*9SW \">"Z(% /+-&*+1$? (* E, !O, !E, "O, :O, FO, (-? !"O /&- (-? )H *+ "C (-? CT 9 +I

!"T

&-')2(*&+-W !"P

B+ 1$?)'$ *9$ H1+'$%%&-. *&/$ 1$a)&1$? *+ $[*1('* *9$ Z(*$1N%+5)25$ '+/H+-$-*% I1+/ <\\%, *9$&1 !:O

%&=$ Z(% 1$?)'$? H1&+1 *+ &-')2(*&+- 2J ')**&-. *9$ %H$'&/$-% &-*+ %/(55 H&$'$% Z&*9 *9$ (&? +I ( !:!

%/(55 (-? '5$(- ]-&I$W U5&a)+*% +I !OO "M +I *9$ (a)$+)% 5(J$1 +I *9$ I&-(5 /&[*)1$ RCOe ZfZS !:"

Z$1$ %)2c$'*$? *+ @>V (-(5J%&% (% ?$%'1&2$? (2+L$ I+1 9+-$JW A+-&*+1&-. +I \">" Z(% '(11&$? !::

+)* (* FO /&-, PO /&-, "C 9, (-? CT 9W B9$ @>V (%%(J Z(% '(5&21(*$? )%&-. %*(-?(1? \">" !:C

R/+5(1 $[*&-'*&+- '+$II&'&$-*, C: AN! '/N!k (2%+12(-'$ Z(L$ 5$-.*9 +I \">" # i "CO -/k 5&-$(1 !:E

1(-.$, OjEO "ASW B$- )-&*% +I '(*(5(%$ Z$1$ %)II&'&$-* *+ ?$%*1+J (55 *9$ \">" &//$?&(*$5JW

!:F

3+-*1+5% Z&*9 '(*(5(%$ Z$1$ )%$? *+ $['5)?$ &-*$1I$1$-'$ ?)$ *+ 9+-$J '+-%*&*)$-*%W !:Q

!$#A@'6'@+B"' 3!C?7 ","'@(&(

!:T

A#> Z(% $L(5)(*$? 2J *9$ /$*9+? H1+H+%$? 2J d&5? R"O!"S _"!` Z&*9 %5&.9* /+?&I&'(*&+-%W B9$ !:P

/$*9+? &% 2(%$? +- *9$ 1$('*&+- 2$*Z$$- DN('$*J5NMN'J%*$&-$ R7&./( U5?1&'9S (-? A#> (* 1++/ !CO

*$/H$1(*)1$W 7(/H5$% Z$1$ ?&5)*$? &- Z(*$1 R:CO /.f/5S (-? *9$ 1$('*&+- Z(% H$1I+1/$? &- !OO !C!

/A %+?&)/ ?&9J?1+.$- H9+%H9(*$ 2)II$1 R(?c)%*$? *+ H\ QWO Z&*9 !O A D(>\S (* "" g3W @+1 *9$ !C"

%*(-?(1? ')1L$ +I *9$ 1$('*&+-, ?&II$1$-* '+-'$-*1(*&+-% +I A#> ROWE, !, ", (-? E /AS Z$1$ )%$?W !C:

(8)

Q A#> % R7&./( U5?1&'9S $a)&L(5$-* *+ OWE, ", (-? E /A (-? !O l5 +I $('9 9+-$J %+5)*&+-!CC

R!QO /. \0Af/5 Z(*$1S Z$1$ (??$? )H *+ ( L+5)/$ +I PTO lM Z&*9 %+?&)/ ?&9J?1+.$-!CE

H9+%H9(*$W B9$ 1$('*&+- Z(% %*(1*$? 2J (??&-. "O lM EOO /A DN('$*J5NMN'J%*$&-$, (-? *9$ !CF

(2%+1H*&+- Z(% 1$'+1?$? (I*$1 Q /&-W B9$ '+-?$-%(*&+- H1+?)'*, DN$N('$*J5N7NR!N9J?1+[JN"N+[+N !CQ

H1+HN!NJ5S 'J%*$&-$, Z(% ?$*$1/&-$? 2J 1$'+1?&-. *9$ (2%+1H*&+- (* "TT -/ RK48h>D P":, 0&+N !CT

B$] 8-%*1)/$-*SW ;$%)5*% (1$ .&L$- &- "/+5f/. +I 9+-$JW !CP

)%+#$&, D+,#$,# ","'@(&( +- A+,$@(

!EO

\+-$J %(/H5$% Z$1$ ?&5)*$? &- Z(*$1 (-? *9$ H1+*$&- '+-*$-* Z(% ?$*$1/&-$? )%&-. *9$ 03U !E!

H1+*$&- (%%(J ]&* (''+1?&-. *+ *9$ /(-)I('*)1$1m% &-%*1)'*&+-% R<&$1'$, 03U <1+*$&- U%%(JSW !E"

!&D%+E&+'+6&D"' ","'@(&(

!E:

B9$ %)''$%% +I %*$1&5&=(*&+- Z(% L$1&I&$? 2J *9$ (2%$-'$ +I 2('*$1&(5 .1+Z*9 +- %+5&? /$?&)/ REe !EC

%9$$H 25++? (.(1S (* :Q g3 I+1 "C 9, 2+*9 &- ($1+2&+%&% (-? (-($1+2&+%&%W 7)2%$a)$-*5J, *9$ !EE

(-*&2('*$1&(5 ('*&L&*J +I <\\% Z(% ?$*$1/&-$? (.(&-%* 7W ()1$)% (-? 6W '+5&, Z9&'9 9(? 2$$-!EF

H1$L&+)%5J &%+5(*$? I1+/ '(-&-$ Z+)-? &-I$'*&+-%W B9$ (.(1 .++? ?&II)%&+- /$*9+? Z(% )%$? *+ !EQ

%'1$$- *9$ (-*&/&'1+2&(5 ('*&L&*J +I *9$ A(-)]( <\\% _""`W 35&-&'(5 %*1(&-% Z$1$ .1+Z- +L$1-&.9* !ET

&- B70 (* :Qg3 (-? (?c)%*$? *+ OWE A'@(15(-? %*(-?(1?W 6('9 ')5*)1$ Z(% &-+')5(*$? +- *9$ !EP

%)1I('$ +I <$*1& H5(*$%W 7)2%$a)$-*5J, Z$55% Z&*9 FN// ?&(/$*$1 Z$1$ 2+1$? &-*+ *9$ %)1I('$ +I !FO

*9$ (.(1W B9$ Z$55% Z$1$ I&55$? Z&*9 F // +I ( A(-)]( 9+-$JN2(%$? H(*'9, TO "5 +I ( A(-)]( !F!

9+-$J %(/H5$ !OOe LfL R(% H+%&*&L$ '+-*1+5S, TO "5 +I ( A(-)]( 9+-$J %(/H5$ EOe LfL R(% ( !F"

H+%&*&L$ '+-*1+5 *9(* 1$%$/25$% *9$ '+-'$-*1(*&+- +I 9+-$J H1$%$-* &- <\\%S, (-? F // +I H$'*&-!F:

R(% -$.(*&L$ '+-*1+5SW <5(*$% Z$1$ &-')2(*$? (* :Qg3, (-? (I*$1 "C 9, *9$ ?&(/$*$1% +I *9$ !FC

&-9&2&*&+- =+-$% Z$1$ /$(%)1$?W 6('9 (%%(J Z(% '(11&$? +)* &- *1&H5&'(*$W !FE

F, 9&#%+ D@#+#+B&D&#@ "(("@

(9)

T B9$ 'J*+'+/H(*&2&5&*J +I <\\% Z(% $L(5)(*$? )%&-. MP"P '$55% R/&'$ I&21+25(%*%S R63U33 3$55 !FQ

M&-$%N7&./( U5?1&'9, A&5(-, 8*(5JS *9(* Z$1$ ')5*)1$? &- QE /M I5(%]% '+-*(&-&-. A+?&I&$? !FT

6(.5$% A$?&)/ RA6Ak 7&./( U5?1&'9, A&5(-, 8*(5JS, !Oe I$*(5 2+L&-$ %$1)/ R@07k 7&./( !FP

U5?1&'9, A&5(-, 8*(5JS, "e MN.5)*(/&-$ R7&./( U5?1&'9, A&5(-, 8*(5JS, (-? "e H$-&'&55&-N !QO

%*1$H*+/&'&-N(/H9+*$1&'&- 0 %+5)*&+- R7&./( U5?1&'9S (* :Qg3 Z&*9 Ee 3>", PEe (&1, (-? !Q!

'+/H5$*$ 9)/&?&*JW d9$- ( '+-I5)$-'$ +I TOe Z(% 1$('9$?, '$55% Z$1$ ?$*('9$? )%&-. OW!e !Q"

*1JH%&-f6GBU %+5)*&+- R7&./( U5?1&'9, A&5(-, 8*(5JS, '$-*1&I).$?, (-? '+)-*$? )%&-. B1JH(-!Q:

05)$ %+5)*&+- R7&./( U5?1&'9S Z&*9 ( 0)1]$1 '9(/2$1W 3$55% Z$1$ $&*9$1 1$%)%H$-?$? (* ( !QC

'+-'$-*1(*&+- +I E!!OE '$55%f/M +1 %*+1$? (* NTOg3 I+1 I)1*9$1 (-(5J%&%W B9$ :NRC,EN !QE

?&/$*9J5*9&(=+5N"NJ5SN",EN?&H9$-J5*$*1(=+5&)/ 21+/&?$ RABBS 1$?)'*&+- (%%(J, ( 1+)*&-$ /$*9+? !QF

I+1 a)(-*&IJ&-. '$55 L&(2&5&*J, Z(% )%$? _":`W !QQ

3$55% RE!!OE '$55%f!OO "MS Z$1$ *1(-%I$11$? &-*+ PFNZ$55 H5(*$% &- +1?$1 *+ H$1I+1/ *9$ ABB

!QT

(%%(J (* "C, CT, (-? Q" 9+)1% (I*$1 %$$?&-.W UI*$1 (- +L$1-&.9* &-')2(*&+- (* :Qg3 (-? Ee 3>", !QP

*9$ /$?&)/ Z(% '9(-.$? RA6A, @07 !Oe, (-*&2&+*&' (-? (-*&/J'+*&' %+5)*&+- "e, MN.5)*(/&-$ !TO

"eS, (-? %$1&(5 ?$'1$(%&-. '+-'$-*1(*&+-% +I 9+-$J /$/21(-$% ?&%%+5L$? &- H9+%H9(*$ 2)II$1$? !T!

%(5&-$ R<07S %+5)*&+-, %*(1*&-. I1+/ OW! .f/5, Z$1$ (??$?W UI*$1 (??&-. ABB R7&./( U5?1&'9, !T"

A&5(-, 8*(5JS %+5)*&+- RC /.f/5 &- <07S, *9$ H5(*$% Z$1$ &-')2(*$? (* :Q g3 (-? Ee 3>" I+1 C !T:

9+)1%W U* *9$ $-? +I &-')2(*&+-, *9$ /$?&)/ Z(% 1$/+L$?, (-? !OO "M +I ?&/$*9J5 %)5I+[&?$ !TC

RGA7>k 7&./( U5?1&'9, A&5(-, 8*(5JS Z(% (??$? &- +1?$1 *+ 5J%(*$ *9$ I+1/(=(- '1J%*(5%W B9$ !TE

H5(*$% Z$1$ I)1*9$1 &-')2(*$? I+1 !O /&-)*$% +- ( '+-*&-)+)% %9(]$1 (* 1++/ *$/H$1(*)1$, (-? *9$ !TF

+H*&'(5 ?$-%&*J +I *9$ Z$55% Z(% ?$*$1/&-$? )%&-. ( H5(*$ 1$(?$1 R<+L$1Z(L$ [k 0&+NB$] !TQ

8-%*1)/$-*% 8-'W, d&-++%]&, K7US (* ( Z(L$5$-.*9 +I EQO -/W !TT

F, 9&9+ E&+D+:*"#&E&'&#@ (#01@

(10)

P U55 H1+'$?)1$% Z$1$ (HH1+L$? 2J *9$ 0&+$*9&'(5 3+//&**$$ +I *9$ K-&L$1%&*J +I B)1&- (-? 2J *9$ !PO

8*(5&(- A&-&%*1J +I \$(5*9 RH1+*+'+5 -)/2$1 :OCf"O!EN<;, "OfOCf"O!ESW !P!

U *+*(5 +I :P (?)5* /(5$ 7H1(.)$NG(Z5$J 1(*%, Z$&.9&-. ""EN"EO .1(/%, Z$1$ H)1'9(%$? 2J !P"

\(15(- M(2+1(*+1&$% R8*(5JSW U55 1(*% Z$1$ 9+)%$? &- %&-.5$ '(.$% I+1 Q ?(J% H1&+1 *+ *9$ 2$.&--&-. !P:

+I *9$ $[H$1&/$-*W B9$ 1++/ *$/H$1(*)1$ Z(% %$* (* ":g3 *91+).9+)* *9$ ?)1(*&+- +I *9$ !PC

$[H$1&/$-* (-? '(.$% Z$1$ '5$(-$? ?(&5JW U-&/(5% Z$1$ I$? Z&*9 ( '+//$1'&(5 ?&$* (-? Z(*$1 !PE

Z(% .&L$- (? 5&2&*)/W U-($%*9$%&( Z(% &-?)'$? 2J (?/&-&%*$1&-. E /.f]. +I [J5(=&-$ !PF

R;+/H)/n, 0(J$1 U-&/(5 \$(5*9, 8*(5JS (-? EO /.f]. +I *&5$*(/&-$ (-? =+5(=$H(/ Rb+5$*&5 EO, !PQ

4&12(', 8*(5JS &-*1(/)%')5(15JW U-($%*9$%&( 5(%*$? I+1 (HH1+[&/(*$5J ! 9+)1W K-?$1 (-($%*9$%&(, !PT

25++? %(/H5$% Z$1$ '+55$'*$? I1+/ *9$ '()?(5 L$&- *+ H$1I+1/ 2&+'9$/&'(5 (-(5J%&%W 7++- (I*$1, !PP

*9$ L$-*1(5 9(&1 Z(% %9(L$? (-? *9$ %]&- Z(% H1$H(1$? )%&-. ( :N%*$H &+?+H+L&?+-$ j "OO

'95+19$[&?&-$ %'1)2W B9$ (-&/(5% Z$1$ 1(-?+/5J (%%&.-$? *+ *9$ *1$(*/$-* +1 '+-*1+5 .1+)H%W U "O!

CN'/ /&?5&-$ &-'&%&+- Z(% /(?$ &- *9$ (2?+/&-(5 Z(55W 8- *9$ *1$(*/$-* .1+)H, %)2')*(-$+)% (-? "O"

&-*1(H$1&*+-$(5 &/H5(-*(*&+- +I <\\ Z(% H$1I+1/$? (% H1$L&+)%5J ?$%'1&2$? _"C`W 01&$I5J, +-$ "O:

%a)(1$ $('9 +I <\\ /$(%)1&-. ! ! ! '/ Z(% &/H5(-*$? &-*1(H$1&*+-$(55J )-?$1 *9$ 5$I* "OC

(2?+/&-(5 Z(55 (-? %)2')*(-$+)%5J (* o! '/ 5$I* *+ *9$ /&?5&-$ 2$*Z$$- *9$ /)%'5$ (-? %]&-W 8-"OE

*9$ '+-*1+5 .1+)H, +-5J *9$ %)1.&'(5 H1+'$?)1$ Z(% H$1I+1/$? Z&*9+)* <\\ &/H5(-*(*&+-W 8- 2+*9 "OF

.1+)H%, *9$ /&?5&-$ &-'&%&+- Z(% '5+%$? &- *Z+ 5(J$1%, Z&*9 :NO K7< .5J'+/$1 F:! I+1 *9$ I(%'&(, "OQ

(-? Z&*9 :NO K7< -J5+- I+1 *9$ %]&-W 6('9 %)1.&'(5 H1+'$?)1$ 5(%*$? (2+)* o"O /&-)*$%W "OT

05++? %(/H5$% I+1 *9$ 2&+'9$/&'(5 (-(5J%&% Z$1$ '+55$'*$? I1+/ *9$ '()?(5 L$&-W B9$ 25++? Z(% "OP

'+55$'*$? &-*+ *)2$% 2$I+1$ %)1.$1J (-? (* F 9 RBFS, "C 9 RB"CS, (-? Q" 9 RBQ"S H+%*N%)1.$1J (-? (* "!O

*9$ *&/$ +I $)*9(-(%&(W <5(%/( 5$L$5% +I 8MN!%, 8MNF, BD@N$ (-? <#R6"S Z$1$ /$(%)1$? 2J )%&-. "!!

( '+//$1'&(5 6M87U ]&* R;(* 8M! 2$*( 6M87U ]&*, 0++%*$1 0&+5+.&'(5 B$'9-+5+.Jk ;(* 85NF "!"

(11)

!O 6M87U, U0 @1+-*&$1k ;(* BD@ (5H9( 6M87U, U0 @1+-*&$1k <1+%*(.5(-?&- 6" 6[H1$%% 68U ]&*, "!:

3(J/(- 39$/&'(5SW "!C

U* O, F, "C, Q" 9+)1m% H+%*N%)1.$1J, *91$$ 1(*% I1+/ $('9 .1+)H Z$1$ $)*9(-&=$? (-? *(1.$* +1.(-% "!E

R5&L$1, ]&?-$J, 5$I* (2?+/&-(5 Z(55S Z$1$ '+55$'*$? (-? I&[$? &- Ce I+1/(5?$9J?$W B9$%$ *&%%)$% "!F

Z$1$ %$'*&+-$?, %*(&-$? &- \p6, (-? +2%$1L$? 2J *Z+ H(*9+5+.&%*% &- ( 25&-?$? /(--$1 _"C`W "!Q

4#"#&(#&D"' ","'@(&(

"!T

D+1/(5&*J +I *9$ ?(*( Z(% $L(5)(*$? )%&-. *9$ 79(H&1+jd&5] -+1/(5&*J *$%*W @+1 *9$ &- L&*1+ "!P

'J*+*+[&'&*J (%%(J, (55 $[H$1&/$-*% Z$1$ H$1I+1/$? &- *1&H5&'(*$, (-? *9$ ?(*( (1$ 1$H1$%$-*(*&L$ +I ""O

(* 5$(%* *91$$ &-?$H$-?$-* $[H$1&/$-*%W B9$ 1$%)5*%, $[H1$%%$? (% /$(- q 76A L(5)$%, Z$1$ ""!

(-(5J%$? )%&-. *9$ h1)%](5Nd(55&% *$%* (-? ( G)--m% H+%*N*$%*W """

@+1 H5(%/( 'J*+]&-$ 5$L$5%, (55 $[H$1&/$-*% Z$1$ H$1I+1/$? &- ?)H5&'(*$W @+1 8MN!%, 8MNF, (-? "":

BD@N$, *9$ 1$%)5*% 9(L$ 2$$- $[H1$%%$? (% /$?&(- RPEe 83S L(5)$% (-? Z$1$ (-(5J%$? )%&-. *9$ ""C

+-$NZ(J UD>4U *$%*W @+1 <#R6"S, *9$ 1$%)5*% (1$ $[H1$%%$? (% /$?&(- RPEe 83S (-? Z$1$ ""E

(-(5J%$? )%&-. *9$ @1&$?/(- *$%*W 7*(*&%*&'(5 (-(5J%&% Z(% H$1I+1/$? Z&*9 *9$ #1(H9<(? <1&%/ ""F

FWO! %+I*Z(1$W 4(5)$% Z&*9 H r OWOE Z$1$ '+-%&?$1$? %&.-&I&'(-*W ""Q

?"8;.$8 ""T

/'0&1 0*#"2$ #$(# 3(5$''&,6 #$(#7

""P

B9$ Z$&.9* +I <\\% &//$1%$? &- <07 %+5)*&+- )-?$1 H9J%&+5+.&'(5 /&/&']&-. '+-?&*&+-% RH\ ":O

QWC, :Qg3SW B9$ I5)&? '+-*$-* &-'1$(%$? *+ (2+)* !EOe (I*$1 !TO /&-)*$%W B9$ 1$%)5*% I1+/ *9$ ":!

I5)&? )H*(]$ $[H$1&/$-* 1$L$(5$? *9(* *9$ ?1$%%&-. 9(% Z&?$ '(H('&*J *+ H1$L$-* I5)&? ":"

('')/)5(*&+- &I )%$? +- Z+)-?W "::

8;<=

":C

B9$ *1(-%/&%%&+- +I Z(*$1 L(H+)1 *91+).9 *9$ /$/21(-$% &% (- &/H+1*(-* H(1(/$*$1 I+1 *9$ ":E

$L(5)(*&+- +I *9$&1 $II$'*&L$-$%% (% ( 9J?1(*&+- I('*+1 Z9$- H5('$? +- ( Z+)-?W B9$ d4B; ":F

(12)

!! 1$'+//$-?$? I+1 Z+)-? ?1$%%&-. &% "OOOj"EOO .f/"f?(J &- +1?$1 *+ $-%)1$ H1+H$1 Z+)-? ":Q

/+&%*)1$ Z&*9+)* 1&%] +I ?$9J?1(*&+- +1 $['$%%&L$ H1+?)'*&+- +I $[)?(*$% _!,C`W U .++? d4B; ":T

I('&5&*(*$% *9$ 9$(5&-. H1+'$%% 2$'()%$ &* &/H1+L$% '$55 /&.1(*&+- (-? H1+/+*$% 1$N ":P

$H&*9$5&(5&=(*&+-W "CO

B9$ Z(*$1 5+%% I1+/ ( I)55J 9J?1(*$? ?1$%%&-. +- $[H+%)1$ *+ (&1 Z(% $L(5)(*$?W B9$ /$(-"C!

$L(H+1(*&L$ Z(*$1 5+%% I1+/ <\\% Z(% "FTPWT q !ETWE .f/"f?(JW "C"

.>?>G*%+10D&,6 "D#&9&#@

"C:

U55 *9$ 9+-$J %(/H5$%, 2$I+1$ &-'5)%&+- &- *9$ /$/21(-$%, Z$1$ (25$ *+ H1+?)'$ %&.-&I&'(-* "CC

(/+)-*% +I \">" Z9&5$ -+ \">"?$L$5+H/$-* Z(% +2%$1L$? &- *9$ '(%$ +I '+11$%H+-?&-. <\\%

"CE

R?(*( -+* %9+Z-SW 8- A(-)]( 9+-$J, (* %9+1*$1 &-')2(*&+- *&/$% )H *+ PO /&- +I &-')2(*&+-, *9$ "CF

'+-'$-*1(*&+- +I \">" .$-$1(*$? 2J 9+-$J .5)'+%$ +[&?(%$ Z(% &- *9$ 1(-.$ 1$H+1*$? &- *9$

"CQ

5&*$1(*)1$ I+1 +*9$1 *JH$% +I 9+-$J Z&*9 ?&II$1$-* /$*9+?% +I (-(5J%$% R!j" /A (* :O /&- +I "CT

&-')2(*&+-S _!F, "EN"Q`W 0J '+-*1(%*, A(-)]( 9+-$J %9+Z$? *9$ 5+Z$%* \">"H1+?)'*&+- (* (55

"CP

&-')2(*&+- *&/$%, H1+2(25J 2$'()%$ +I &*% 9&.9 '+-*$-* +I A#>, Z9&'9 9(% H1$L&+)%5J 2$$-"EO

%)..$%*$? *+ 2$ ( .5)'+%$ +[&?(%$N&-9&2&*+1J (.$-* _!F, "E`W U* 5+-.$1 &-')2(*&+- *&/$% R"C (-? "E!

CT 9S, *9$ *$%*$? 9+-$J %(/H5$% ?&%H5(J$? ( %&.-&I&'(-*5J ?&II$1$-* 2$9(L&+)1^ B9$ ?1(/(*&' 5+%% "E"

+I \">"H1+?)'&-. ('*&L&*J I+)-? I+1 <\\% &-?&'(*$? *9(* *9$&1 H1+?)'*&+- H1+'$?)1$, Z9&'9

"E:

&-'5)?$? ( 9$(*&-. %*$H (* TO g3 (-? $[H+%)1$ *+ &N1(J% I+1 I&-(5 %*$1&5&=(*&+-, &-?)'$? '+/H5$*$ "EC

5+%% +I .5)'+%$ +[&?(%$ ('*&L&*JW B9&% ?$/+-%*1(*$? *9(* *9$ H1$%$1L$? (-*&2('*$1&(5 ('*&L&*J &- *9$ "EE

/&'1+2&+5+.&'(5 *$%*&-. Z(% .$-$1(*$? %+5$5J 2J *9$ ('*&+- +I -+-H$1+[&?$ (.$-*%W "EF

!C? ","'@(&(

"EQ

G&9J?1+[J('$*+-$ RG\US &% ( ?&1$'* H1$')1%+1 +I A# &- A(-)]( 9+-$J _!E`W B9$ A#> "ET

'+-'$-*1(*&+- &- <\\%, ?$*$1/&-$? 2J *9$ DN('$*J5NMN'J%*$&-$ (%%(J, Z(% OW"F q OWOQ "/+5f/. "EP

+I H1+*$&-%W B9$ <\\% 9(? 9&.9$1 A# '+-'$-*1(*&+- *9(- 2)5] 9+-$JW A#> '+-*$-* &% &/H+1*(-* "FO

(13)

!" 2$'()%$ &* '(- %$1L$ (% ( %)&*(25$ a)(5&*J (-? '+%* H(1(/$*$1 I+1 A(-)]( 9+-$JW B9$ \">"(-?

"F!

A# '+-*$-* &% 1$%H+-%&25$ I+1 *9$ (-*&2('*$1&(5 ('*&L&*J +I 9+-$J _"T` (-? <\\% /(&-*(&-"F"

(-*&2('*$1&(5 ('*&L&*J %&/&5(1 *+ *9(* +I 2)5] 9+-$JW "F:

!&D%+E&+'+6&D"' ","'@(&(

"FC

A(-)]( /$/21(-$% ?&? -+* %9+Z 2('*$1&(5 '+-*(/&-(*&+- (I*$1 %*$1&5&=(*&+- 2J .(//(N "FE

&11(?&(*&+-W B(25$ ! +)*5&-$% *9$ (-*&2('*$1&(5 ('*&L&*J 2(%$? +- *9$ '5$(1 =+-$ *9(* Z(% H1+?)'$?W "FF

F, 9&#%+ D@#+#+B&D&#@ "(("@

"FQ

;$%)5*% '+-'$1-&-. *9$ $II$'*% &-?)'$? 2J ?&II$1$-* '+-'$-*1(*&+-% +I ?&%%+5L$? 9+-$J /$/21(-$ "FT

+- L&(2&5&*J +I MP"P '$55% (1$ 1$H1$%$-*$? &- @&.)1$ !W "FP

F, 9&9+ E&+D+:*"#&E&'&#@ (#01@

"QO

B91$$ 1(*% I1+/ *9$ *1$(*$? .1+)H ?&$? +I (%'&*$% &- *9$ I&1%* "C 9+)1%W B9$ .1+%% $L(5)(*&+- &- :F "Q!

1(*% %9+Z$? -+ Z+)-? %&*$ &-I$'*&+- +1 H1$%$-'$ +I (?9$%&+-%W >- H$1I+1/&-. 9&%*+5+.&'(5 "Q"

(-(5J%&% "C (-? Q" 9+)1%m H+%*N%)1.$1J, *9$ *&%%)$ -$(1 *9$ &/H5(-* Z(% I+)-? *+ 2$ '9(1('*$1&=$? "Q:

2J *9$ H1$%$-'$ +I I&21+25(%*% Z&*9 %+/$ '$55)5(1 1$%H+-%$, &-'5)?&-. 5J/H9+'J*$%, /('1+H9(.$%, "QC

(-? -$+L(%')5(1&%(*&+-W D+ 1$('*&+- Z(% +2%$1L$? &- ?&%*(-* +1.(-%W B9)%, *9$ <\\% ?&? -+* "QE

&-?)'$ ( I+1$&.- 2+?J 1$('*&+-W B9$ ?&II$1$-'$% &- *9$ 25++? 5$L$5% +I *9$ 8MN!%, 8MNF, BD@N$ (-? "QF

<#R6"S (* *9$ O, F, "C, (-? Q" 9+)1%m *&/$ H+&-*% Z$1$ -+* %*(*&%*&'(55J %&.-&I&'(-*W B9$ 1$%)5*% (1$ "QQ %)//(1&=$? &- B(25$ "W "QT D%8#;88%)& "QP B9$ -$Z /$/21(-$% /(J 2$ )%$? (% Z+)-? ?1$%%&-.% (% *9$J 9(L$ ( .++? d4B; (-? I5)&? "TO

)H*(]$ (-? %9+Z -+ 'J*+*+[&'&*J *+ I&21+25(%*%k *9$J (5%+ 9(L$ .++? %Z$55&-. '(H(2&5&*J, Z9&'9 &% "T!

(- &/H+1*(-* I('*+1 I+1 1$?)'&-. *9$ 1&%] +I Z+)-? ?$9J?1(*&+-W "T"

"T: "TC

(14)

!: B9$ 1$%)5*% +2*(&-$? 2J *9$ '&*+[&'&*J (%%(J (I*$1 "C 9+)1% I1+/ *9$ %$$?&-., &- H1$%$-'$ +I "TE

?$'1$(%&-. '+-'$-*1(*&+-% +I ?&%%+5L$? 9+-$J /$/21(-$%, 9(L$ %9+Z- ( %*(*&%*&'(55J %&.-&I&'(-* "TF

?$'1$(%$ RHrOWOES +I *9$ '$55% *1$(*$? Z&*9 *9$ 9&.9$%* '+-'$-*1(*&+- ROW! .f/5S '+/H(1$? *+ *9$ "TQ

'+-*1+5 +-$% Z(% +2%$1L$?W U* CT 9+)1% ( *1$-? &- '$55 H1+5&I$1(*&+- Z(% I+)-?^ 9&.9$%* "TT

'+-'$-*1(*&+-% %$$/$? *+ &-?)'$ ( &-9&2&*&+- &- '$55 .1+Z*9 Z9&5$ ?$'1$(%&-. *9$ '+-'$-*1(*&+-, "TP

*9$ '$55 H1+5&I$1(*&+- %$$/$? *+ &-'1$(%$, $L$- &I &* Z(% -+* H+%%&25$ *+ 9&.95&.9* %&.-&I&'(-* "PO

?&II$1$-'$%W U5%+ (* *9&% *&/$ H+&-* &* Z(% H+%%&25$ *+ (HH1$'&(*$ ( %*(*&%*&'(55J %&.-&I&'(-* "P!

?$'1$(%&-. RHrOWOES +I *9$ '$55% *1$(*$? Z&*9 *9$ 9&.9$%* '+-'$-*1(*&+- ROW! .f/5S '+/H(1$? *+ *9$ "P"

'+-*1+5W "P:

UI*$1 Q" 9+)1% +I ')2(*&+-, *9$ 9&.9$%* '+-'$-*1(*&+-% RI1+/ !^" *+ !^FCS '()%$? (- 9&2&*&+- &-"PC

'$55 .1+Z*9 Z9&5$ *9$ 5+Z$%* R!^"EF (-? !^E!"S &-?)'$% ( %*(*&%*&'(55J %&.-&I&'(-* &-'1$(%$ &- '$55 "PE

.1+Z*9 '+/H(1$? *+ *9$ '+-*1+5W G)1&-. *9$ !" #!#$ $[H$1&/$-*%, *1$$ 1(*% ?&$?^ &- ()*9+1%m "PF

+H&-&+-, *9&% Z(% 2$'()%$ +I *9$ $['$%%&L$5J 5(1.$ %9$$* +I /$/21(-$ &/H5(-*$? &-*1(H$1&*+-$(55J "PQ

2$'()%$, &-&*&(55J, ( ?&/$-%&+- +I " ! " '/ Z(% '9+%$-W ;$?)'&-. *9$ ?&/$-%&+- +I *9$ &/H5(-*$? "PT

<\\% *+ ! ! ! '/ ?&? -+* '()%$ (-J &-*1(H$1&*+-$(5 ('')/)5(*&+- +I I5)&?, (% ?$*$1/&-$? I1+/ "PP

/('1+%'+H&' $[(/&-(*&+- (I*$1 $)*9(-(%&( +I *9$ 1$/(&-&-. 1(*%W B9$ *&%%)$ 1$%H+-%$ *+ :OO

&-*1(H$1&*+-$(5 (-? %)2')*(-$+)% &/H5(-*% %9+Z$? ( %&/&5(1 /('1+%'+H&' (-? 9&%*+5+.&'(5 H(**$1-W :O!

8- *9$ 5&.9* +I <\\% (-*&2('*$1&(5 ('*&L&*J _!"` (-? %&-'$ (?/&-&%*1(*&+- +I %J%*$/&' (-*&2&+*&'% :O"

?+$% -+* (5Z(J% 5$(? *+ .++? +)*'+/$% &- *$1/% +I^ Z+)-? 9$(5&-., /(*1&[ H$-$*1(*&+- +I *9$ 6<7 :O:

2&+I&5/ (-? (-*&2&+*&' 1$%&%*(-'$, &- *9&% %*)?J Z$ H1+H+%$ *9$ )%$ +I A(-)]( 9+-$J *+ H1$H(1$ :OC

<\\ I+1 Z+)-? ?1$%%&-.%W 8-*$1$%*&-.5J, +)1 /$/21(-$% ?$/+-%*1(*$ ( .++? (-*&2('*$1&(5 ('*&L&*J :OE

*+Z(1? '5&-&'(55J 1$5$L(-* H(*9+.$-&' /&'1++1.(-&%/% %)'9 (% 7W ()1$)% (-? 6W '+5&W :OF

\+-$J /$/21(-$% H+%%$%% ( Z&?$ L(1&$*J +I H1+H$1*&$% *9(* '(- /(]$ *9$/ %)&*(25$ R(% I+1 +*9$1 :OQ

-(*)1(5 /(*$1&(5% %)'9 (% '9&*+%(- 9J?1+.$5%S _", "C, "P`, I+1 L$1J ?&II$1$-* )%$% *9(* Z$ '(-:OT

(15)

!C 9JH+*9$%&%$ 1(-.&-. I1+/ Z+)-? 9$(5&-. *+ (?9$%&+- H1$L$-*&+- *+ ?1). ?$5&L$1JW B9$ H1$%$-'$ :OP

+I -(*)1(5 ('*&L$ '+/H+-$-*%, '+-I+1/(2&5&*J, (-? '+/H5$*$ 1$%+12(2&5&*J (1$ *9$ /(&-:!O

'9(1('*$1&%*&'% +I *9&% -$Z 2&+'+/H(*&25$ 2&+/(*$1&(5 *9(* 1$%H$'*% *9$ H(*9+H9J%&+5+.J +I *&%%)$, :!!

&% Z$55 *+5$1(*$? 2J *9$ 2+?J, H+%%&25J &/H1+L$% 9$(5&-., (-? /(J 2$ )%$? I+1 *9$ H1$L$-*&+- +I :!"

%)1.&'(5 '+/H5&'(*&+-%W @)1*9$1/+1$, *9$ H1+?)'*&+- +I *9$%$ ?$L&'$% &% $[*1$/$5J %&/H5$ (-? :!:

&-$[H$-%&L$W :!C

7#:&)B."+-3"&$8 :!E

B9$ ()*9+1% .1(*$I)55J (']-+Z5$?.$ *9$ I&-(-'&(5 %)HH+1* I1+/ .1(-* <;8D "O!"W :!F

?"E","&#"8 :!Q

!W G(L$ ;D, s+%9& \A, 4$-).+H(5(- 4<W 0&+/$?&'(5 $L(5)(*&+- +I ( -+L$5 -&*1+.$- +[&?$% :!T

1$5$(%&-. Z+)-? ?1$%%&-.W s A(* 7'&^ A(* A$? "O!"k ":^ :OPQj:!OFW :!P

"W 79(9=(? 7, t(1 A, 7&??&a& 7U, A(9/++? D, ;()I U, u)1$%9& bU, $* (5W 39&*+%(-N2(%$? :"O

$5$'*1+%H)- -(-+I+21+)% /(*%, 9J?1+.$5% (-? '(%* I&5/%^ -+L$5 (-*&N2('*$1&(5 Z+)-? :"!

?1$%%&-. /(*1&'$%W s A(*$1 7'& A(*$1 A$? "O!Ek "F^ !:FN!CTW :""

:W b9+) #, ;)9(- U, #$ \, d(-. M, M&) A, d(-. 0, $* (5W ;$%$(1'9 +- ( -+L$5 H+5J RL&-J5 :":

(5'+9+5Sf5J%&-$fL(-&55&- Z+)-? ?1$%%&-.^ 0&+'+/H(*&2&5&*J, 2&+('*&L&*J (-? (-*&/&'1+2&(5 :"C

('*&L&*JW 0)1-% "O!Ck CO^ !FFTN!FQTW :"E

CW U1'9(-( G, 7&-.9 0h, G)**( s, G)**( <hW 39&*+%(-N<4<N-(-+ %&5L$1 +[&?$ Z+)-? :"F

?1$%%&-.^ 8- L&*1+ (-? &- L&L+ $L(5)(*&+-W 8-* s 0&+5 A('1+/+5 "O!Ek Q:, CPjEQW :"Q

EW G(% U, h)/(1 U, <(*&5 D0, 4&%Z(-(*9(- 3, #9+%9 GW <1$H(1(*&+- (-? '9(1('*$1&=(*&+-:"T

+I %&5L$1 -(-+H(1*&'5$ 5+(?$? (/+1H9+)% 9J?1+.$5 +I '(12+[J/$*9J5'$55)5+%$ I+1 &-I$'*$? :"P

Z+)-?%W 3(12+9J?1 <+5J/ "O!Ek !:O/ "ECN"F!W ::O

FW #+?5$$ @W U-*&/&'1+2&(5 1$%&%*(-'$ j (- )-I+5?&-. '(*(%*1+H9$W 01 A$? s "O!:k 012^ ::!

I!FF:W ::"

(16)

!E QW \(1]&-% U, G)1& 7, h5+*9 M3, B1(- 3GW 39&*+%(-N'$55)5+%$ '+/H+%&*$ I+1 Z+)-? ?1$%%&-. :::

/(*$1&(5W <(1* "W U-*&/&'1+2&(5 ('*&L&*J, 25++? (2%+1H*&+- (2&5&*J, (-? 2&+'+/H(*&2&5&*JW s ::C

0&+/$? A(* ;$% <(1* 0^ UHH5 0&+/(* "O!Ck !O"^ !!PPN!"OFW ::E

TW 3++]$ s, G1J?$- A, <(**+- B, 01$--(- s, 0(11$** sW B9$ (-*&/&'1+2&(5 ('*&L&*J +I ::F

H1+*+*JH$ /+?&I&$? 9+-$J% *9(* .$-$1(*$ 1$('*&L$ +[J.$- %H$'&$% R;>7S 9J?1+.$-::Q

H$1+[&?$W 0A3 ;$% D+* "O!Ek T^ !NEW ::T

PW 7(19(- dU, U==(1J A6 R"O!ES \&.9 '+-'$-*1(*&+- 9+-$J '9&*+%(- $5$'*1+%H)-::P

-(-+I&2$1%^ 0&+'+/H(*&2&5&*J (-? (-*&2('*$1&(5 $II$'*%W 3(12+9J?1 <+5J/ "O!Ek !""^ !:EN :CO

!C:W :C!

!OW 6/1$ U, U]&- A, 8%&].+-)5 8, t)]%$5 >, U-(?+5 Ub, 3&I*$1 3W 3+/H(1&%+- +I :C"

&-*1(H$1&*+-$(5 9+-$J (-? %+?&)/ 9J(5)1+-(*$N'(12+[J/$*9J5'$55)5+%$ R7$H1(I&5/vS I+1 :C:

*9$ H1$L$-*&+- +I H+%*+H$1(*&L$ &-*1(N(2?+/&-(5 (?9$%&+-%W 35&- "OOP3 21/ :F:N:FTW :CC

!!W B(- Ah, U?5& G7\, B)/&1(- AU, U2?)55( AU, t)%+II hAW R"O!"S B9$ $II&'('J +I :CE

.$5(/ 9+-$J ?1$%%&-. *+Z(1?% $['&%&+-(5 Z+)-? 9$(5&-.W 6L&? 0(%$? 3+/H5$/$-* :CF

U5*$1-(* A$? "O!"k "O!"^ TOEP:"W :CQ

!"W U1-$ 7, h(& 7, #$1*1)? d, #&%$5( 0, K?+ 0, #)?1)- @W d+)-? '(1$ Z&*9 (-*&2('*$1&(5 :CT

9+-$J RA$?&9+-$JS &- H$?&(*1&' 9$/(*+5+.JN+-'+5+.JW s 7)HH 3(1$ 3(-'$1 "OOFk !C^ P!N :CP

PQW :EO

!:W 7-+Z As, A(-5$JN\(11&% AW >- *9$ -(*)1$ +I -+-NH$1+[&?$ (-*&2('*$1&(5 ('*&L&*J &- D$Z :E!

b$(5(-? /(-)]( 9+-$JW @++? 39$/ "OOCk TC^ !CEN!CQW :E"

!CW w(5(/(] 7, 61?+.?) 3, >=(5H A, K5)2(J1(/ hW 7&5] I&21+&- 2(%$? (-*&2('*$1&(5 :E:

2&+-(-+*$[*&5$% (% Z+)-? ?1$%%&-. /(*$1&(5%W A(* 7'& 6-. 3 "O!Ck C:^ !!j"OW :EC

(17)

!F !EW U*1+** s, \(12$15() 7, \$-5$ BW 7*)?&$% +- *9$ I+1/(*&+- +I /$*9J5.5J+[(5 I1+/

:EE

?&9J?1+[J('$*+-$ &- A(-)]( RM$H*+%H$1/)/ %'+H(1&)/S 9+-$JW 3(12+9J?1(*$ ;$%$(1'9 :EF

"O!"k:F!^Qj!!W :EQ

!FW hZ(]/(- <\7, *$4$5?$ UU, ?$ 0+$1 M, 4(-?$-21+)']$N#1()5% 3A, b((* 7UsW BZ+ :ET

/(c+1 /$?&'&-(5 9+-$J% 9(L$ ?&II$1$-* /$'9(-&%/% +I 2('*$1&'&?(5 ('*&L&*JW <M+7 >D6 :EP

"O!"k F^ $!QQOPW :FO

!QW 79& M, t(-. D, b9(-. \, 39$- M, B(+ M, d$& t, $* (5W U -+L$5 H+5JR!N.5)*(/&' :F!

('&?Sf%&5]N%$1&'&- 9J?1+.$5 I+1 Z+)-? ?1$%%&-.^ 7J-*9$%&%, '9(1('*$1&=(*&+- (-? 2&+5+.&'(5 :F"

$L(5)(*&+-W A(* 7'& (-? 6-.^ 3 "O!Ek CT^ E::NECOW :F:

!TW d(5]$1 s6W A$*9+? +I H1$H(1&-. 9+/+.$-$+)% 9+-$J H$'*&- '+/H+%&*&+-W <(*$-*$? !PC"k :FC

7$H*$/2$1 TW :FE

!PW 3(1-Z(*9 ;, #1(9(/ 6A, ;$J-+5?% h, <+55+'] <sW B9$ (-*&/&'1+2&(5 ('*&L&*J +I 9+-$J :FF

(.(&-%* '+//+- $a)&-$ Z+)-? 2('*$1&(5 &%+5(*$%W 4$* s "O!Ck !PP^ !!ON!!CW :FQ

"OW M+-. M\, M(- UD0, \%)(- @Bt, \(55&Z$55, 0W #$-$1(*&+- +I 9J?1+.$- H$1+[&?$ 2J :FT

x(-*&+[&?(-*y 2$L$1(.$% (-? *9$ $II$'* +I /&5] (??&*&+-W 8% '+'+( *9$ 2$%* 2$L$1(.$z @1$$ :FP

;(?&' ;$% !PPPk :!^ FQjQ!W :QO

"!W d&5? ;, >+& M, 71&](-*9 4, A{-'9 #WU a)&'], '+-L$-&$-* (-? $'+-+/&'(5 /$*9+? I+1 :Q!

*9$ 1$5&(25$ ?$*$1/&-(*&+- +I /$*9J5.5J+[(5 &- /&55&/+5(1 '+-'$-*1(*&+-%^ *9$ DN('$*J5NMN :Q"

'J%*$&-$ (%%(JW U-(5 0&+(-(5 39$/ "O!"k CO:^ "EQQj"ET!W :Q:

""W 79$15+'] >, G+5(- U, U*9/(- ;, <+Z$1 U, #$*9&- #, 3+Z/(- 7, $* (5W 3+/H(1&%+- +I :QC

*9$ (-*&/&'1+2&(5 ('*&L&*J +I K5/+ 9+-$J I1+/ 39&5$ (-? /(-)]( 9+-$J (.(&-%* :QE

/$*9&'&55&-N1$%&%*(-* 7*(H9J5+'+'')% ()1$)%, 6%'9$1&'9&( '+5& (-? <%$)?+/+-(% :QF

($1).&-+%(W 0A3 3+/H5$/$-* U5*$1- A$? "O!Ok CQ^ :ECj:F!W :QQ

(18)

!Q ":W 4$1'$55& 3, 0(12$1+ ;, ;$ #W B1%&$-* 1$'$H*+1 H+*$-*&(5 4&55+&? ! &- &/(5 *&%%)$^ (-:QT

+L$1L&$Z *+ 9&.95&.9* %&/&5(1&*&$% (-? ?&II$1$-'$% Z&*9 9)/(- %H$'&$%W ;$'$H* 35&- 8-L$%* :QP

"O!Ek "^ !NPW :TO

"CW U=(2 Uh, G+L&-$1 4, >1]&- 0, h5$&-%*$1- s, 71$2-&] A, D&%%(- U, $* (5W :T!

0&+'+/H(*&2&5&*J $L(5)(*&+- +I '1+%%5&-]$? '9&*+%(- 9J?1+.$5% (I*$1 %)2')*(-$+)% (-? :T"

&-*1(H$1&*+-$(5 &/H5(-*(*&+- &- *9$ 1(*W s 0&+/$? A(* ;$% "OOQk T:^ C!CNC""W :T:

"EW A(c*(- s, 0+9+L( s, <1+'9(=]( 6, h5()?&-J sW A$*9J5.5J+[(5 /(J (II$'* 9J?1+.$-:TC

H$1+[&?$ ('')/)5(*&+- &- /(-)]( 9+-$J *91+).9 *9$ &-9&2&*&+- +I .5)'+%$ +[&?(%$W s :TE

A$? @++? "O!Ck !Q^ "POj"P:W :TF

"FW 01)?=J-%]& h, U2)2(]$1 h, 7*NA(1*&- M, 3(%*5$ UW ;$N$[(/&-&-. *9$ 1+5$ +I 9J?1+.$-:TQ

H$1+[&?$ &- 2('*$1&+%*(*&' (-? 2('*$1&'&?(5 ('*&L&*&$% +I 9+-$JW @1+-* A&'1+2&+5 "O!!k "^ !N :TT

PW :TP

"QW 0(-. MA, 0)-**&-. 3, A+5(- <W B9$ $II$'* +I ?&5)*&+- +- *9$ 1(*$ +I 9J?1+.$- H$1+[&?$ :PO

H1+?)'*&+- &- 9+-$J (-? &*% &/H5&'(*&+-% I+1 Z+)-? 9$(5&-.W s U5*$1 3+/H5 A$? "OO:k P^ :P!

"FQj"Q:W :P"

"TW t)%+I D, \(=&I( U, b+9?& ;A, 0(](1 bUW G$L$5+H/$-* +I 9+-$J 9J?1+.$5 ?1$%%&-. I+1 :P:

$-9(-'$? Z+)-? 9$(5&-.W ;(? <9J%&' 39$/ "OOQk QF^ !QFQj!QQOW :PC

"PW b9(-. bM, V) 7d, b9+) VMW <1$L$-*&L$ $II$'*% +I '9&*+%(- +- H$1&*+-$(5 (?9$%&+- &-:PE

1(*%W d+15? s #(%*1+$-*$1+5 "OOFk !"^ CEQ"NCEQQW :PF

F04." ."-"&+ :PQ

B(25$ !^ A$(- =+-$% +I &-9&2&*&+- R?&(/$*$1 _&-'5)?&-. *9(* +I *9$ Z$55`, F //S :PT

B(25$ "^ ;$%)5*% I+1 25++? 5$L$5% +I *9$ 8MN!%, 8MNF, BD@ (5H9( (-? <#R6"S :PP

G%-;," ."-"&+ COO

(19)

!T @&.)1$ !^ ABB (%%(J RDiTS *+ $L(5)(*$ *9$ /+?)5(*&+- +I M"P" '$55% .1+Z*9 (I*$1 *9$ *1$(*/$-* CO!

Z&*9 ?$'1$(%&-. '+-'$-*1(*&+-% +I ?&%%+5L$? 9+-$J /$/21(-$ &- <07 (* ?&II$1$-* $[H$1&/$-*(5 CO"

*&/$ H+&-*% R"C, CT, (-? Q" 9+)1%SW CO:

Riferimenti

Documenti correlati

Se la teologia controversistica è una disciplina che, con l’età della crisi religio­ sa, conosce una formidabile rinascita – al punto di lasciare una profonda e nitida im­

Non riesco a trovare più parole dentro di me, è come se tutto fosse svuotato di senso, mi sento come una scatola priva di ogni cosa, non c’è neanche più la molla

The good agreement with simulation results witnesses the accuracy of the “full-wave” approach, and demonstrates that it can be safely exploited, in spite of much more time-

The free running VCO phase noise has been measured using the IF2 output for a tuning voltage of 1.25V (Fig. 4), the obtained result is better than -76dBc/Hz @ 100kHz from carrier

Can All-Programmable Systems on Chip be used in electrophysiology to study the dynamics of neural circuits by means of high-density microelec- trode arrays, creating a

controller is designed to restore the nominal responses of the augmented helicopter when variations in the identified parameters are considered.. The present thesis was driven by

Queste le conclusioni alle quali è giunta in varie occasioni la Corte Costituzionale, affermando che “nel bilanciamento dei valori costituzionali che il legislatore

ROSALIA alla QUISQUINA: analisi conoscitiva e valutazione della sicurezza statica e sismica Francesco Leto