Prevention of Neural Tube Defects and proper folate periconceptional supplementation
Testo completo
(2) Prevention of Neural Tube Defects and proper folate periconceptional supplementation. N AL I. The use of folinic acid (calcium levofolinate) in preventing NTDs is inappropriate.. References. 3.. 4.. IO. 2.. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991;338(8760):131-7. Wald NJ, Law MR, Morris JK, Wald DS. Quantifying the effect of folic acid. Lancet 2001;358(9298):2069-73. ACMG. American College of Medical Genetics Statement on Folic Acid: fortification and supplementation. Am J Med Genet 1998;78:381. Truswell AS, Kounnavonq S. Quantitative response of serum folate to increasing intakes of folic acid in healthy women. Eur J Clin Nutr 1997;51(12):839-45.. AZ. 1.. ©. C. IC. ED. IZ. IO. N. II N. TE. R. N. prevention has never been claimed by Manufacturers. It should be reminded that all data from scientific research in NTDs prevention are based on folic acid only, and folinic acid has never been cited in that field. Moreover, folic acid and folinic acid supplementation achieve different effects in preventing NTDs in some experimental models (transgenic mice). Also, no data are available on the exact dose of folinic acid that corresponds to the dose of folic acid before mentioned. Furthermore, in Italy the lower dose of folinic acid tablests is 4.0 mg, that could be hardly justified in the general population. Daily cost of folic acid use varies from Euro 0.05 (Folico tablets) to 0.12 (Folidex, Fertifol, Folina tablets), while daily cost of folinic acid is four to ninefold higher (Euro 0.30-0.45).. Journal of Prenatal Medicine 2008; 2 (4): 40-41. 41.
(3)
Documenti correlati
Le due considerate come variabili dipendenti nell’analisi sono la variabile binomiale del completamento dei corsi corrispondente al download dell’attestato (CERTIFICATE) e il rate
The system boundaries include the electricity used to treat the gas, the production of any reagents used, the amount of biogas that is upgraded, the amount of methane lost during
The analysis has been per- formed through a computational pipeline that (i) re-annotates microarray probes into GB (gene based) and TB custom CDFs; (ii) predicts miRNA targets
(2) by means of the direct measurement of the heat flow meters], temperature variation (T, measured by temperature sensors in the two faces of the wall) and mass (m, measured in
Nel passare infine dalle tecniche di governance e dai loro effetti alle pratiche discorsive che le sorreggono, l’attenzione si sposta sulle concezioni di Costituzione che i
Use of all other works requires consent of the right holder (author or publisher) if not exempted from copyright protection by the applicable
Aim: To compare need for bone augmentation, surgical complications, periodontal, radiographic, aesthetic and patient reported outcomes in subjects receiving implant placement at
В Италии авенариусов ский эмпириокритицизм имел успех в первое десятилетие XX века, о чем свидетельствуют работы Аурелио Пелацца (среди