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53 Riferimenti bibliografici

Akamine E.H., Hohman T.C., Nigro D., Carvalho M.H., de Cássia Tostes R., Fortes Z.B. Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42.

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Asano T., Saito Y., Kawakami M., Yamada N., Fidarestat Clinical Pharmacology Study Group. Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients. J. Diabetes Complications. 2002 Mar-Apr;16(2):133-8.

Asano T., Saito Y., Kawakami M., Yamada N., Sekino H., Hasegawa S., Fidarestat Clinical Pharmacology Study Group. Erythrocytic sorbitol contents in diabetic patients correlate with blood aldose reductase protein contents and plasma glucose levels, and are normalized by the potent aldose reductase inhibitor fidarestat (SNK-860). J. Diabetes Complications. 2004 Nov-Dec;18(6):336-42.

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Biadene M., Hazemann I., Cousido A., Ginell S., Joachimiak A., Sheldrick G.M., Podjarny A., Schneider T.R., The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop. Acta. Crystallogr. D. Biol. Crystallogr. 2007 Jun;63(Pt 6):665-72. Epub 2007 May 15.

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Bohren K.M., Brownlee J.M., Milne A.C., Gabbay K.H., Harrison D.H., The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism. Biochim. Biophys. Acta. 2005 May 15;1748(2):201-12.

Bohren K.M., Grimshaw C.E., Lai C.J., Harrison D.H., Ringe D., Petsko G.A., Gabbay K.H., Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme. Biochemistry. 1994 Mar 1;33(8):2021-32.

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Cammarata P.R., Chen H.Q., Yang J., Yorio T., Modulation of myo-[3H]inositol uptake by glucose and sorbitol in culture bovine lens epithelial cells. II. Characterization of high- and low-affinity myo-inositol transport sites, Invest. Ophthalmol. Vis. Sci. 33 (1992) 3572-3580.

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Forman H.J., Torres M., Redox signaling in macrophages, Mol. Aspects Med. 22 (2001) 189-216. Gabbay K.H., Merola L.O., Field R.A. Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes., Science 1966 Jan 14;151(3707):209-10.

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Kato N., Yashima S., Suzuki T., Nakayama Y., Jomori T. Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats. J Diabetes Complications. 2003 Nov-Dec;17(6):374-9.

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Lee J.Y., Je J.H., Kim D.H., Chung S.W., Zou Y., Kim N.D., Ae Yoo M., Suck Baik H., Yu B.P., Chung H.Y., Induction of endothelial apoptosis by 4-hydroxyexenal, Eur. J. Biochem. 271 (2004) 1339-1347.

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