 Barthe L, Woodley J & Houin G. Gastrointestinal absorption of drugs:

(1)

Bibliografia

 Acra SA, Ghishan FK. Methods of investigating intestinal transport. J Parenter Enteral Nutr 1991; 15: 93S–98S.

 Barthe L, Woodley J & Houin G. Gastrointestinal absorption of drugs:

methods and studies. Fundamental and Clinical Pharmacology 1999;

13:154-168.

 Barthe L, Woodley J, Kenworthy S, Houin G. An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine. Eur J Drug Metab Pharmacokinet 1998; 23:

313–323.

 Burton PS, Conradi RA, Hilgers AR & Ho NF. Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells.

Biochemical and Biophysical Research Communications 1993; 190:760- 766.

 Canaparo R, Finnstrom N, Serpe L, Nordmark A, Muntoni E, Eandi M, Rane A, Zara GP. Expression of CYP3A4 isoforms and P-glycoprotein in human stomach, jejunum and ileum. Clin Exp Pharmacol Physiol 2007; 34:1138-44.

 Carreno-Gomez B, Duncan R. Everted rat intestinal sacs: a new model

for the quantitation of P-glycoprotein mediated-efﬂux of anticancer

agents. Anticancer Res 2000; 20:3157–3161

(2)

 Cheema KJ, Scoﬁeld AM. Intestinal absorption of glucose in rats after continuous challenge with larvae of Nippostrongylus brasiliensis. J Helminthol1984; 58:263–266.

 Chen Ts, Currier GJ and Wabner CL. Intestinal transport during the life span of the mouse. J Gerontol 1990; 45:B129–B133

 Chung YH, Nishigaki R, Iga T, Hanano M. The mechanism of intestinal transport of sulfamethoxazole and the effect of chlorpromazine in rat everted intestine. J Pharmacobiodyn1985; 8:142–149.

 Colabufo NA, Perrone R, Berardi F, Paradiso A. Multidrug resistance:

Biological and pharmaceutical advances in antitumour treatment. 2008;

5:261-262

 Emoto C, Yamazaki H, Yamasaki S, Shimada N, Nakajima M, Yokoi T..

Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro. Xenobiotica 2000; 30:971–

982.  Fromm MF. Importance of P-glycoprotein at blood tissue barriers.

Trends Pharmacol Sci 2004; 25:424-9

 Fujioka Y, Mizuno N, Morita E, Motozono H, Takahashi K, Yamanaka Y and Shinkuma D. Effect of age on the gastrointestinal absorption of acyclovir in rats. J Pharm Pharmacol 1991; 43:465–469.

 Goodman & Gilman. Le basi farmacologiche della terapia. 2012.

(3)

 Gottesman MM, Germann UA, Aksentijevich I, Sugimoto Y, Cardarelli, C.O., and Pastan, I. Gene transfer of drug resistance genes. Implications for cancer therapy. Ann. N.Y. Acad. Sci., 1994; 716:126-138.

 Gottesman MM, Ling V. The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett., 2006;

580: 998.

 Hauer-Jensen M, Wilson HD and Schedl HP. Morphological and functional recovery of rat small intestine following localized hyperthermia. Int J Hyperthermia 1988; 4:527-535

 Higuchi S, Rongqian Wu, Mian Zhou, Corrado P. Marini, Thanjavur S, Ravikumar, Ping Wang . Gut hyperpermiability after ischemia and reperfusion: attenuation with adrenomedullin and its binding protein treatment. Int J Clin Exp Pathol 2008; 1: 409– 418.

 Hunter J, Hirst BH & Simmons NL. Drug absorption limited by P- glycoprotein-mediated secretory drug transport in human intestinalepithelial Caco-2 cell layers. Pharmaceutical Research 1993;

10: 743-749.

 Khemiss F, Ahmadi S, Massoudi R, Ghoul-Mazgar S, Safta S, Moshtaghie AA, Saïdane D. Effect of in vitro exposure to Vibrio vulniﬁcus on hydroelectrolytictransportandstructural changes of sea bream (Sparus aurata L.) intestine. Fish Physiol Biochem2009; 35:541–

549.

(4)

 Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ & Wilkinson GR. Interrelationship between substrates and hinibitors of human CYP3A and P-glycoprotein. Pharm. Res., 1999; 16:408-414.

 Kleinow KM, Johnston BD, Holmes EP, McCarrol ME. Rhodamine 123 permeability through the catﬁsh intestinal wall: relationship to thermal acclimation and acute temperature change. Comp Biochem Physiol C Toxicol Pharmacol 2006; 144:205–215.

 Koning J, Muller F, Fromm MF. Transporters and drug-drug interactions: important determinants of drug disposition and effects.

Pharmacol Rev 2013; 65:944-66

 Kumar YS, Ramesh S, Rao YM, Paradkar AR.. Effect of rifampicin pretreatment on the transport across rat intestine and oral pharmacokinetics of ornidazole in healthy human volunteers. Drug Metabol Drug Interact 2007; 22:151–163.

 Lacombe O, Woodley J, Solleux C, Delbos JM, Boursier-Neyret C &

Houin G. Localisation of drug permeability along the rat small intestine,using markers of the paracellular, transcellular and some transporter routes.EurJPharmSci 2004; 23:385– 391.

 Le Ferrec E, Chesne C, Artusson P, Brayden D, Fabre G, Gires P,

Guillou F, Rousset M, Rubas W and Scarino ML. In vitro models of the

intestinal barrier. ATLA 2001; 29:649-668.

(5)

 Lindi C, Marciani P, Faelli A, Esposito G. Intestinal sugar transport during ageing. Biochim Biophys Acta 1985; 816:411-414.

 Liu XD, Wang XL, Xie L, Wang GJ. Different effect of erythromycin on absorption kinetics of nimodipine in male and female rats. Eur J Drug Metab Pharmacokinet 2005; 30:69–73.

 Maurer HH, Rump AF. Intestinal absorption of gabapentin in rats.

Arzneimittelforschung 1991; 41:104– 106.

 Muller F, Fromm MF: Transporters and drug-drug interactions:

important determinants of drug disposition and effects. Pharmacol Rev 2013; 65:944-66.

 Ogawa N, Takahashi M, Ishidoh K, Katunuma N. Inhibition of collagenolytic cathepsin by beta-Lactoglobulin in milk and its suppressive on bone resorption. J Nutr Sci Vitaminol 2009; 55:264-270.

 Pento JT, Mousissian GK. Time-dependent deterioration of active transport in duodenal segments of rat intestine. J Pharmacol Methods 1988; 20:9-14.

 Rajnarayana K, Venkatesham A and Krishna DR. Inﬂuence of some bioﬂavonoids on the transport of nitrendipine. Drug Metabol Drug Interact 2008; 23:299–310.

 Said HM, Ghishan FK, Murrell JE. Intestinal transport of 5-

methyltetrahydrofolate in streptozotocin-induced diabetes mellitus in the

rat. Diabetes Res 1986; 3:363–367.

(6)

 Said HM, Sharifian A, Bagherzadeh A. Transport of biotin in the ileum of sukling rats: characteristics and ontogeny. Pediatr Res 1990; 28:266- 269.

 Scuetz EG, Beck WT and Schuetz JD. Modulators and substrates of P- glycoprotein and cytochrome P4503A coordinateli up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 1996a; 49:311- 318.

 Schuetz EG, Schinkel AH, Relling MV and Schuetz JD. P-glycoprotein:

A major determinant of rifampicin-inducible expression of cytochrome P4503A4 in mice and humans. Proc Natl Acad Sci USA 1996b; 93:4001- 4005

 Soderholm JD, Hedman L, Artursson P, Franzen L, Larsson J, Pantzar N, Permert J & Olaison G. Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber. Acta Physiologica Scandinavia 1998; 162: 47-56.

 Tian R, Koyabu N, Takanaga H, Matsuo H, Ohtani H and Sawada Y.Effects of grapefruit juice and orange juice on the intestinal efﬂux of P-glycoprotein substrates. PharmRes 2002; 19:802–809

 Trapani A, Laquintana V, Denora N, Lopedota A, Cutrignelli A, Franco

M, Trapani G, Liso G. Eudragit RS 100 microparticles containing 2-

hydroxypropyl-beta-cyclodextrin and glutathione: physicochemical

characterization, drug release and transport studies. Eur J Pharm Sci

2007; 30:64–74.

(7)

 Ugolev AM, Bagiian AA & Ekkert LG. New method of studying membrane hydrolysis and transport as well as metabolic processes in the small intestine in vitro (everted small intestinal sac with bilateral oxygenation).Fiziol Zh SSSR Im I M Sechenova 1980; 66:1674– 1677.

 Ussing HH & Zerhan K. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiologica Scandinavia 1951; 23:110-127.

 Valinietse MY, Bauman VK, Galvanovsky YY. Absence of alkaline phosphatase-linked inorganic phosphate transport in the chick jejunum .Digestion 1985; 31:182–188.

 Wattanasirichaigoon S. Temperature dependency of bidirectional flux in the rat intestine subjected to graded ischemia. J Med Assoc Thai 2009;

92:S15-S23

 Wilson TH, Wiseman G. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. J Physiol 1954; 123:116–125.

 Yuasa H, Matsuda K & Watanabe J. Influence of anesthetic regimens on intestinal absorption in rats. Pharmaceutical Research 1993; 10:884-888.

 Barthe L, Woodley J & Houin G. Gastrointestinal absorption of drugs:

Bibliografia

 Acra SA, Ghishan FK. Methods of investigating intestinal transport. J Parenter Enteral Nutr 1991; 15: 93S–98S.

 Barthe L, Woodley J & Houin G. Gastrointestinal absorption of drugs:

methods and studies. Fundamental and Clinical Pharmacology 1999;

13:154-168.

 Barthe L, Woodley J, Kenworthy S, Houin G. An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine. Eur J Drug Metab Pharmacokinet 1998; 23:

313–323.

 Burton PS, Conradi RA, Hilgers AR & Ho NF. Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells.

Biochemical and Biophysical Research Communications 1993; 190:760- 766.

 Canaparo R, Finnstrom N, Serpe L, Nordmark A, Muntoni E, Eandi M, Rane A, Zara GP. Expression of CYP3A4 isoforms and P-glycoprotein in human stomach, jejunum and ileum. Clin Exp Pharmacol Physiol 2007; 34:1138-44.

 Carreno-Gomez B, Duncan R. Everted rat intestinal sacs: a new model

for the quantitation of P-glycoprotein mediated-efﬂux of anticancer

agents. Anticancer Res 2000; 20:3157–3161

 Cheema KJ, Scoﬁeld AM. Intestinal absorption of glucose in rats after continuous challenge with larvae of Nippostrongylus brasiliensis. J Helminthol1984; 58:263–266.

 Chen Ts, Currier GJ and Wabner CL. Intestinal transport during the life span of the mouse. J Gerontol 1990; 45:B129–B133

 Chung YH, Nishigaki R, Iga T, Hanano M. The mechanism of intestinal transport of sulfamethoxazole and the effect of chlorpromazine in rat everted intestine. J Pharmacobiodyn1985; 8:142–149.

 Colabufo NA, Perrone R, Berardi F, Paradiso A. Multidrug resistance:

Biological and pharmaceutical advances in antitumour treatment. 2008;

5:261-262

 Emoto C, Yamazaki H, Yamasaki S, Shimada N, Nakajima M, Yokoi T..

Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro. Xenobiotica 2000; 30:971–

982.

 Fromm MF. Importance of P-glycoprotein at blood tissue barriers.

Trends Pharmacol Sci 2004; 25:424-9

 Fujioka Y, Mizuno N, Morita E, Motozono H, Takahashi K, Yamanaka Y and Shinkuma D. Effect of age on the gastrointestinal absorption of acyclovir in rats. J Pharm Pharmacol 1991; 43:465–469.

 Goodman & Gilman. Le basi farmacologiche della terapia. 2012.

 Gottesman MM, Germann UA, Aksentijevich I, Sugimoto Y, Cardarelli, C.O., and Pastan, I. Gene transfer of drug resistance genes. Implications for cancer therapy. Ann. N.Y. Acad. Sci., 1994; 716:126-138.

 Gottesman MM, Ling V. The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett., 2006;

580: 998.

 Hauer-Jensen M, Wilson HD and Schedl HP. Morphological and functional recovery of rat small intestine following localized hyperthermia. Int J Hyperthermia 1988; 4:527-535

 Higuchi S, Rongqian Wu, Mian Zhou, Corrado P. Marini, Thanjavur S, Ravikumar, Ping Wang . Gut hyperpermiability after ischemia and reperfusion: attenuation with adrenomedullin and its binding protein treatment. Int J Clin Exp Pathol 2008; 1: 409– 418.

 Hunter J, Hirst BH & Simmons NL. Drug absorption limited by P- glycoprotein-mediated secretory drug transport in human intestinalepithelial Caco-2 cell layers. Pharmaceutical Research 1993;

10: 743-749.

 Khemiss F, Ahmadi S, Massoudi R, Ghoul-Mazgar S, Safta S, Moshtaghie AA, Saïdane D. Effect of in vitro exposure to Vibrio vulniﬁcus on hydroelectrolytictransportandstructural changes of sea bream (Sparus aurata L.) intestine. Fish Physiol Biochem2009; 35:541–

549.

 Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ & Wilkinson GR. Interrelationship between substrates and hinibitors of human CYP3A and P-glycoprotein. Pharm. Res., 1999; 16:408-414.

 Kleinow KM, Johnston BD, Holmes EP, McCarrol ME. Rhodamine 123 permeability through the catﬁsh intestinal wall: relationship to thermal acclimation and acute temperature change. Comp Biochem Physiol C Toxicol Pharmacol 2006; 144:205–215.

 Koning J, Muller F, Fromm MF. Transporters and drug-drug interactions: important determinants of drug disposition and effects.

Pharmacol Rev 2013; 65:944-66

 Kumar YS, Ramesh S, Rao YM, Paradkar AR.. Effect of rifampicin pretreatment on the transport across rat intestine and oral pharmacokinetics of ornidazole in healthy human volunteers. Drug Metabol Drug Interact 2007; 22:151–163.

 Lacombe O, Woodley J, Solleux C, Delbos JM, Boursier-Neyret C &

Houin G. Localisation of drug permeability along the rat small intestine,using markers of the paracellular, transcellular and some transporter routes.EurJPharmSci 2004; 23:385– 391.

 Le Ferrec E, Chesne C, Artusson P, Brayden D, Fabre G, Gires P,

Guillou F, Rousset M, Rubas W and Scarino ML. In vitro models of the

intestinal barrier. ATLA 2001; 29:649-668.

 Lindi C, Marciani P, Faelli A, Esposito G. Intestinal sugar transport during ageing. Biochim Biophys Acta 1985; 816:411-414.

 Liu XD, Wang XL, Xie L, Wang GJ. Different effect of erythromycin on absorption kinetics of nimodipine in male and female rats. Eur J Drug Metab Pharmacokinet 2005; 30:69–73.

 Maurer HH, Rump AF. Intestinal absorption of gabapentin in rats.

Arzneimittelforschung 1991; 41:104– 106.

 Muller F, Fromm MF: Transporters and drug-drug interactions:

important determinants of drug disposition and effects. Pharmacol Rev 2013; 65:944-66.

 Ogawa N, Takahashi M, Ishidoh K, Katunuma N. Inhibition of collagenolytic cathepsin by beta-Lactoglobulin in milk and its suppressive on bone resorption. J Nutr Sci Vitaminol 2009; 55:264-270.

 Pento JT, Mousissian GK. Time-dependent deterioration of active transport in duodenal segments of rat intestine. J Pharmacol Methods 1988; 20:9-14.

 Rajnarayana K, Venkatesham A and Krishna DR. Inﬂuence of some bioﬂavonoids on the transport of nitrendipine. Drug Metabol Drug Interact 2008; 23:299–310.

 Said HM, Ghishan FK, Murrell JE. Intestinal transport of 5-

methyltetrahydrofolate in streptozotocin-induced diabetes mellitus in the

rat. Diabetes Res 1986; 3:363–367.

 Said HM, Sharifian A, Bagherzadeh A. Transport of biotin in the ileum of sukling rats: characteristics and ontogeny. Pediatr Res 1990; 28:266- 269.

 Scuetz EG, Beck WT and Schuetz JD. Modulators and substrates of P- glycoprotein and cytochrome P4503A coordinateli up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 1996a; 49:311- 318.

 Schuetz EG, Schinkel AH, Relling MV and Schuetz JD. P-glycoprotein:

A major determinant of rifampicin-inducible expression of cytochrome P4503A4 in mice and humans. Proc Natl Acad Sci USA 1996b; 93:4001- 4005

 Soderholm JD, Hedman L, Artursson P, Franzen L, Larsson J, Pantzar N, Permert J & Olaison G. Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber. Acta Physiologica Scandinavia 1998; 162: 47-56.

 Tian R, Koyabu N, Takanaga H, Matsuo H, Ohtani H and Sawada Y.Effects of grapefruit juice and orange juice on the intestinal efﬂux of P-glycoprotein substrates. PharmRes 2002; 19:802–809

 Trapani A, Laquintana V, Denora N, Lopedota A, Cutrignelli A, Franco

M, Trapani G, Liso G. Eudragit RS 100 microparticles containing 2-

hydroxypropyl-beta-cyclodextrin and glutathione: physicochemical

characterization, drug release and transport studies. Eur J Pharm Sci

2007; 30:64–74.

 Ugolev AM, Bagiian AA & Ekkert LG. New method of studying membrane hydrolysis and transport as well as metabolic processes in the small intestine in vitro (everted small intestinal sac with bilateral oxygenation).Fiziol Zh SSSR Im I M Sechenova 1980; 66:1674– 1677.

 Ussing HH & Zerhan K. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiologica Scandinavia 1951; 23:110-127.

 Valinietse MY, Bauman VK, Galvanovsky YY. Absence of alkaline phosphatase-linked inorganic phosphate transport in the chick jejunum .Digestion 1985; 31:182–188.

 Wattanasirichaigoon S. Temperature dependency of bidirectional flux in the rat intestine subjected to graded ischemia. J Med Assoc Thai 2009;

92:S15-S23

 Wilson TH, Wiseman G. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. J Physiol 1954; 123:116–125.

 Yuasa H, Matsuda K & Watanabe J. Influence of anesthetic regimens on intestinal absorption in rats. Pharmaceutical Research 1993; 10:884-888.

 Yumoto R, Murakami T, Nakamoto Y, Hasegawa R, Nagai J, Takano M.

Transport of Rhodamine 123, a Glycoprotein Substrate, across Rat

intestine and Caco-2 cell Monolayers in the Presence of Cytochrome P-

450 3A-Related Compounds. JPET 1999; 289:149-155.