SYNTHESIS AND BIOLOGICAL EVALUATION OF ENDOCANNABINOID SYSTEM MODULATORS

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DIDACTIC ACTIVITY

FIRST YEAR

• Metabolismo tumorale: opportunità terapeutiche I – Prof. Filippo Minutolo • Metodi avanzati in Dinamica Molecolare – Prof. Adriano Martinelli • Metabolismo tumorale: opportunità terapeutiche II - Prof. Filippo Minutolo • Caratterizzazione strutturale di molecole di origine naturale mediante tecniche spettroscopiche – Prof.ssa Alessandra Braca • Metabolismo tumorale: opportunità terapeutiche III – Prof. Filippo Minutolo • ASE, LC-MS e OPLC: sviluppo metodiche analitiche per sostanze polari e a polari – Prof.ssa Alessandra Bertoli • Sistemi terapeutici a base di nanoparticelle – Prof.ssa Ylenia Zambito • Analitica Farmaceutica: controllo qualità e attività regolatoria nella produzione dei medicinali e dei prodotti della salute I – Prof. Giuseppe Saccomanni • Terapia anti-angiogenica: bersagli farmacologici e combinazione con farmaci citotossici – Prof. Stefano Fogli • Analitica Farmaceutica: controllo qualità e attività regolatoria nella produzione dei medicinali e dei prodotti della salute II – Prof. Giuseppe Saccomanni • Il Phage Display nella scoperta di nuovi farmaci – Prof.ssa Paola Nieri • Analitica Farmaceutica: controllo qualità e attività regolatoria nella produzione dei medicinali e dei prodotti della salute III – Prof. Giuseppe Saccomanni • Nuovi approcci terapeutici con acidi nucleici – Dr. Lorenzo Citti • ENGLISH FOR WRITING AND PRESENTING SCIENTIFIC PAPERS – Prof. Adrian Wallwork

Seminars:

• “Il cibo della salute, Nutraceutica ed alimenti funzionali” • “Innovative approaches to unveil the mechanisms of action of bioactive natural compounds” Dr. Fabrizio Dal Piaz, Dipartimento di Scienze Farmaceutiche e Biomediche, Università degli Studi di Salerno. • “Phosphoinositides signalling in human diseases” Dr. Tania Maffucci Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London. • “Catalytic organoboron chemistry on a board game” Prof. Maria Elena Fernández Gutiérrez, TECAT - Centre d'Innovació en Catàlisi, Universitat Rovira I Virgili, Tarragona, Spagna.

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• “Membrane proteins - perspectives in drug discovery and therapeutics" Dr Andrea Chicca, Senior Scientist (Oberassistent) Institute of Biochemistry and Molecular Medicine, University of Bern. • "Targeting PDK1 in Cancer" Prof. Marco Falasca, full Professor in Metabolism, School of Biomedical Sciences, Curtin University Perth (Australia) • “Applying NMR to the studying of biological systems” Dott. Marco Tonelli Biochemistry Department, University of Wisconsin-Madison, WI, USA

Conferences:

• ASIS

• SAYCS 2015, RIMINI, October 27th_-29th₂₀₁₅

Summer School:

• Medicinal Chemistry Residential School, Loughborough University, UK, June 21st_-26th₂₀₁₅

SECOND YEAR

Seminars:

• “Bioactive potential of phytochemical extracts” Prof. Joseph Buhagiar; • "CA inhibition mechanisms in the drug design" Prof. Claudiu T. Supuran; • "Computer-aided Drug Design" Prof. Serdar Durdagi; • “Structure, pharmacology and function of cannabinoid receptors” Dr Chicca; • “New potential endocannabinoid-based drugs: from single to multi-target approach” Dr Chicca; • “Organizzazione di un trial clinico nella sperimentazione di un nuovo farmaco” Dr.ssa Luisa Daffonchio, Clinical Development Manager Dompè Farmaceutici-Milano;

Lectures:

• “Approcci chimico-farmaceutici per il disegno e la sintesi di farmaci multifunzionali” Prof.ssa Rapposelli; • “Targeted-therapies” Prof.ssa Rapposelli;

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Course:

• English course in "Scientific Writing and Conference Presentations" Level C1, CLI.

Research Period Abroad:

• University of Aberdeen, Scotland, UK from July 2016 to March 2017;

THIRD YEAR

Lectures

• “Sviluppo e applicazione di probes molecolari per lo studio dei recettori.” Prof. Sabrina Taliani; • “La chimica delle molecole odorose, sensori nasali ed artificiali, sistemi di assorbimento degli odori.” Prof. Cinzia Chiappe; • “I gastrasmettitori e le loro applicazioni in farmacoterapia” Dr. Alma Martelli; • “La chimica del domani tra riduzione di materie materie ed aumento dei rifiuti” Prof. Cinzia Chiappe.

Course:

• English course in "Scientific Writing and Conference Presentations" Level C1 plus, CLI.

Research Periods Abroad:

• University of Aberdeen, Scotland, UK from July 2016 to March 2017; • University of Bern, Switzerland, July-August 2017.

Conferences:

•

International Cannabinoid Research Society, ICRS 2017, 22nd_-26th_June 2017, Montreal, Canada.

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•

European School of Medicinal Chemistry, ESMEC 2017, 2nd-6th July 2017, Urbino, Italy.

• European Federation of Medicinal Chemistry, EFMC 2017, 27th_-31st_August 2017, Vienna, Austria.

• European Federation Medicinal Chemistry – Young Medicinal Chemistry Symposium EFMC – YMCS 2017, 31st August – 1st September 2017, Vienna, Austria.

Posters:

• Flash Presentation at EFMC-YMCS in Vienna: Synthesis and Pharmacological evaluation of allosteric modulators of cannabinoid receptors. • Poster at the European Federation of Medicinal Chemistry (EFMC 2017) in Vienna: “Synthesis and Pharmacological evaluation of allosteric modulators of cannabinoid receptors.” Sept. 2017 • Poster at the European School of Medicinal Chemistry in Urbino: “New allosteric modulator of the CB2 receptor and its potential application in neuropathic pain.” July 2017 • Poster at ICRS in Montreal: “Identification of a new lead compound as an allosteric modulator of the CB2 receptor.” June 2017 • Poster at SAYCS in Rimini: “Rational design and synthesis of analogs of 2-oxo-1,2- dihydropyridine-3-carboxamide derivatives as CB2R ligands.” Oct. 2015 • Poster at the National Meeting in Medicinal Chemistry in Salerno: “Antiproliferative activity of oleocanthal in human malignantcutaneus melanoma cells.” Sept. 2015

Flash Poster Presentation:

• Flash Presentation at EFMC-YMCS in Vienna: “Synthesis and Pharmacological evaluation of allosteric modulators of cannabinoid receptors.” Sept. 2017.

Award

: • Student Travel Award "International Cannabionoid Reasearch Society" ICRS 2017, Montreal, Canada.

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Publications:

• Identification of the first synthetic allosteric modulator of the CB2 receptors and evidence of its efficacy for neuropathic pain relief submitted to Angewandte Chemie International Edition, January 2018. • Polypharmacological Profile of 1,2-Dihydro-2-Oxopyridine-3-Carboxamides in the Endocannabinoid System, submitted to European Journal of Medicinal Chemistry, January 2018. • Diarylurea-based allosteric modulators of cannabinoid CB1 receptor, Bioorganic & Medicinal Chemistry Journal, 2017 Dec 15; 25(24):6427-6434. • Cytotoxic activity of oleocanthal isolated from virgin olive oil on human melanoma cells, Nutrition and Cancer: An international Journal; 68 (5): 873-7.