Infertilità di coppia: diagnosi citogenetica e risposta ai trattamenti di procreazione medicalmente assistita di II livello

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

(6)

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" #!$ + $ % 6 . , " ! " # " !$ " --#6 6 6 - 6 ! % ; . # " 6 6 ! " #6 " ! > $ , L = 9 &3 3?= , % , ! % F ! , , + ! " # " ! # -- + 6 95<9 , !% )9'< ! ! , ! " # " # ##% > !% ! , 6 6 - ; ! ! , 19& <? &9 < ! ! , - % # " > !% ! , 6 6 - ; , 19& <? >J $ # = =9 &335?= ! " # " !$ 6 ## -% , # %" !$ # % % , ! " # " =

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, #- % ,% # ! , , . # " ! 6 ,% 8 " 8 - " " " 8 " > -=&?= , #- % ,% - " - # + "" 9 # !$ # . + !$ 6 " # ! , , . # 9 6 ,% 8 # "6 ! % " = , #- % ! " , + " # - + " , " # ! #" 9 , ,

% - ! % " ! % %6 , # ## , . ,% =

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

! "6 >GQ ## M= =9 &344E %! J= = = &3 1E % %R M= =9 &3 &E % = =9 &3 ? :% 9 # // ! % 6 " !$ , , . ,% G + # NNO9 % 6 !$ ## . # NO9 , ! , 6 , 6 " ! , ! " # " N # . %" = !$ - # %, #% 6 ) 9NNO , ! !$ ! % ) 9NNO , 6 , ! " # " N # . %" !$ 6 !$ # ## . # ! % )4 NO= F %" , % 6 , ! " # " !$ ## . -#6 " , 6 # , .% , " ! , , #- % 9 + . , F "/ # ! > G= =9 &333?= 6 - ! " # " !$ %" !$ $ ++ # " " . / #% + 8= ! 6 0122 # 6%I #! # # -- " #6 " ! !$ &95< , - #6 " ! = F - , F ; 6 F .. 6 ! 6 " ,% # ! , , . # " ! >J ! /# = = , ## , = J=9 &33'?= !$ 6 :% # 6 # # # -% #6 " ,

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#%-#6 " , - # %, # . ! !$ # 7&< , - #6 " 6 # 6 6 , , ! " # " , # ## ')NN ')NO > $ D= , = =9 '111?= 6 " # %, " ! #% 6 ) 9NOO #%-- #! !$ ! " # " O # . %" . 6 # 6 " , F , 6 ! ## " ! > LP J= =9 &343E . # = = =9 &3 1?= ! 9 # %, #%!! ## . 9 #% 6 % " 9 , " # !$ ! % - " ) 9NOO 6 ## " # 9 , F ## . ,

6 !$ NOO >M% - L = =9 &3 3E M $ # J= 0= =9 &35&E 6 , = = =9 &33&E M ! J= =9 &33 ?= % !$ %6 , % # " !$ ! "6 / ! . # # " & ># , " , % 6 / / 8 , # 6 .. . #! ; '95<?9 # " &5 ># , " , ,H ,# 6 / / 8 , # 6 .. . #! ; 9)<? # " '& ># , " , H 6 / / 8 , # 6 .. . #! ; ''9&<? >J ! /# = = , ## , = J=9 &33 ?= :% # # # " '& ! # , -- % - F 8 6 ,% . ! ++ . / #% + 89 + 6 6 # % F , #6 " - # , # . - #6 " F #6 " 9 , " , - , . / ! , 6 ! - > 6 , = =9 &33&?=

! " # " !$ # % %

" / ! " # " ! . %# #6 ! + ! " 6 , + % " , + ! # % % , ! " # " 9 ! # -% % = + " 6%I ## % # ! " # " 6%I ! . - 6 C ! " # " " -$ = 6 " ! # # , # -% &= , 9 !$ ! # # 6 , , % 6 , ! " # " E 6%I ## " 9 # -% , % # % 9 66% # 9 # -% , ,% % = '= ,%6 ! 9 !$ ! # # 6 , % # -" ! " # " ! = = 7 . # 9 , " - , ,% % ! , &51S , # -" ! " # " ! ! "6 # ## = # -" . ! %,

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# -# (% !# &#''( "+-$++$-( ( ,- ,#

( 6 9 " ! "% , # ! ! 6 ! 9 , 6 ! ## 6

6 - ! " # " ! %" 9 ; +%# ! ! +-("' ,(% !# 5#-+" ! (!( ## ! # # +%# , ,% ! " # " ! ! ! >& 9&)9& 9'&9''? " -$ 9 !$ # "6 "/ ,% ! #6 , , ! " 9 " #% 66 # = % , + "" # + " % % . ! " # " ! # % , / !! % -$ , ,% " - 9 % 6 !! ! " # " ! # % , ,% / !! ! 9 !$ , # . 6 ,% = # -% :% # " 9 !$ $ - " ! # -% + 6 !$ 9 6 / / " 6 !$U " 6 ,% ; - ! " 9 ! , ! " # " ! , F , . ,% . , , % F% 8 > -=4?=

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6 -("' ,(% !# - 5#-+" ! (!( " # # + " % . ! # % , ! " # " 6 , , # ! , ,% ! " # " 9 #6 . " " -$ ,% / !! = - " 6 , 6 ## ## ! " # " ! " " / ! 9 # -% , % # - - 9 #/ ! 6 % # - - , ! > -= ?= = (*#+ #!#" ! $! 4 -+(+ -# & +-("' ,(% !# - 5#-+" ! (!(

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# ! !$ ## ,% ! " # " " -$ # " - . :% F , . ,% !$ ; 6 6 ,%! # - " #/ ! 9 !$ - ! ! 6 " # " ! " # " ! 9 " -- 6 , :% # 8 / = F , . ,% 6 , % # ! ! " # " " -$ 6%I 6 ,% - " #/ ! 9 , " , # - - , ! " # " " ! F " - , % , ,% " !$ ! "6 - = ( - " % , # , % " 9,8 % - , % - 6 , % # " # ! , ! # ## " + # ! !$ , :% 6 " = '= # ! "% 6 ! # # #+ " # , # -" 6 C , ,% ! " # " " -$ = = F # ; % - " % # -% :% % # -" , ! " # " . ! % 6% # , % ! " # " " - = # ## " !! #" 6%I . + ! # #+ " , % - ! " # " ! % 6% , . # , # ## ! " # " :% # 6 , / . !$ " #6 # #$ + = % / ! " # " !$ # ! # -% , % !$ # . + ! 6 #%" / " ,% F + # ! % # , - " 9 !$ . ! " # 9 # , # " ! 9 !$ # " 6 ! 6 " # = D% , F - ; " ! . - " % - " 6 , ! " # " # % % " = D% # % , # - " " + " - :% ! "6 % - # # % % 6 % ! 66 ! " # " ! 9 ! # , % , , % F . # E 66% 6 ,% ! 66 , ! " # " ! # , % # ! ! 6 ! = F - , "% ; # " ! 9 # ! , " # ! ! " # " ! + " , ! % " , ! % 6 ! , - # # % % = D% + :% ! # , # / 6 " 9 :% # ! # -% , , % ! " # " !$ 9 " / 6 ## ## !$ # ! , 9 :% , # ! %# , 6 # # " ! " # " !$ =

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# % % # , ! . 6 C + :% - % " + 9 # 6 % :% ! % # . - #6 " > %++ , = 6 =9&35'E * ##!$ = =9 &334E #!$ , = =9 &335?= - " 6 C + :% 9 !$ ! /% #! ,% + 8 " #!$ 9 # # ! # ! 6 !$ !$ / # > $ , L =9 &35)E M P = , = =9 &33&?= # ! ! 6 !$ ! . - % ! " # " 6 ## .. % # " 9 ! " # " # ##% % # " ! " # " # ##% = # ! ,% % # " ! # % #! % , 6 C + :% #! 6 ! , ++ ! 8 6 ,% . = " #!$ 6 $ % 6 6 ,% . , 6 !$U9 6 ,% % ! %" , - " " :% , , 6 - #/ ! 9 6 # " , 6 ,% %" ! , #6 " = , , " ! # % ! " # " ! , - #6 " , 6 , # ! # ; , ! "6 , " - 6 ! ## " ! #6 # / , - #/ ! " ! " # " ! = D% # # %, , " # !$ T6 T , # - - , ! " # " , 6 , , 6 #6 ! + ! , # ! ! %# !$ 6 ! % , #6 " " / ! #% 6 ! ! )4< :% , - #/ ! 6 )< > = = 6 --# = =9 &33 E 0% / !$ = =9 &33 ?E > %## %R = =9 &33 E , = =9 &333E * ##!$ = =9 &333E # 6 = = =9 &333?= D% # 6 ! % 6%I %" -- " # -% , % ++ ! " # " ! , 6 , ! " # " # ! 9 # 6 % ! ! , ! " # " & '& > %## %R =

=9 &33 E * %"" =9 &33 E M ! J= =9 &335E = =9 &335E ! = =9 &335E , = =9 &333E * - K= =9 '111?= ( ! 6 " # ! % ! " # " , # ## , % % # " = " #!$ # ! N % # " 9 " 9 ! %# #6 " ! % # 6 ! ! , " # #6 " - # # , , 6 !$ > !$" , = % =9 &33'?= !$ # ! O % # " # 6 ## ## , # ,% ! - 9 / # 6 , % # " ! . = 6 " - %66 66 - # ! 6 , # , / !! % - , ! " # " O / !! ! , % ! " # " ! ! ! = 0 " :% # # / ! $ % ++ #% + 8= # ! , ! - ! "6 , # ! ! " # " O :% # # % # " = 6% , %

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6 ## ## , # /% % - % ! " # " O= # ! O % # " # - - " , . 9 ! %# , + 8 F51< , ! # = %, #% # - - " ! , " # !$ ! %# , F + 8 6 " . ; - , % # , #6 " - # 6 " , . # " ! = !! # " 9 !% ! % - " 6 ## ! % , . # " ! + # , , #6 " , > # P J= =9 &335?= + # # # ! N O !$ .. - . , - 6# %, % # " ! 6 " , / !! ! , ! " # " # ##% = D% # 6 , # ! ; #6 # / , " #!$ NN ! % + 6 # " G + 9 6 # ! , % # -" , ! " # " O ! O >+ , " , # ! ? #% F N > % (= =9 &354E - = = =9 &35 E -%# " $ = = =9 &331?= + :% , " #!$ NN ; 9 & #% '1=111

> # J= # =9 &3 ?=

6 6 - + :% , , . ,% 6 , % # !

/ # ; , & &=111= :% # 6 C + :% # >& :E&):? >&):E'&:? ! % 6 ! % 9 #6 . " 9 6 1913 V 191'1V > # J= , K $ =9 &33&?= - , . ,% + :% # 6 ! % %" , . . #6 :% , 6 6 - = # ! / # # 6 C ! "% - - #6 " ! #6 " ! ! % + :% , 7 &94< , 1913< #6 . " = 9 # ! / # $ % % !$ 6 / . 8= %, ! #%- #6 " , " #!$ 6 , % # ! / # , " # !$ + :% , - " #/ ! . , ' <9 +% , #6 ! + ! # ! >M P K= , = =9 &35 E # = =9 &35 E = =9 &355E = =9 &33 E - H = =9 '111?=

>& :E&):? 6 ! % , #6 " #/ ! ; , &3 ' < > #!%, = =9 '111?9 " 6 >&):E'&:? ; , 7 && &'< > %## %R = =9 &33 E , = =9 '111?= D% # # %, #% ! # % ! " # " ! , - #6 " , 6

, # ! / # " # !$ + " 6 . , # - - ;

:% > ) 34<?9 !$ 6 - " ! ! " # " " / ! 9 #6 :% , ! > ' <?9 !$ 6 #6 " #/ ! > %## %R =

(20)

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

(21)

+ :% , " ! " # " !$ F + 8 + "" ; . / 9 " # 6%I # " < > #!$ , = =9 &335E 0 P # J= =9 '11&?= '95<

, 6 + "" , ! 66 + 6 # %" !$ , ! " # " # ##% 9 " '9&< $ " # % % , - % # " >0 P # J= =9 '11&?= + 6 , , ++ , / ! " # " !$ # ##% ; " . / 9 # " , - # , !$ , ! # !$ # " !$ =

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# #! + / # 6 . , + ! >K ## =9 &3 &E = =9 &335E . =9 &333?= , ! + " , " # ! #" 6 # 9 6%/ 89 , . ! % %"

(22)

. " / ## , + ! '< #! , % - . , >0 / O= , # / - =9 &3 E . P = = =9 &33 E . 1=9&333?=

!&- *# & $-!#-6 - ! " # " !$ %" !$ $ ++ # " " . / #% + 8= + "" ) 9NNN9 , #"6 9 6 ## 6 # " 6 " # ! , 66% ## + = !$ !% ! # , + "" ! ) ! " # " N9 ! 9 - " , + 6 " + 89 " ! - . , " =

! " # " !$ # % %

# , " , % ; 6 C ! "% ! " # " ! , + 9 " # 6 ## #! ! % ! + :% !$ , . # / # % % % # " !$ = % # 6%// ! 6 !$ ! . ! " # " !$ #! / , + 9 ! "% :% , :% # . # . ! !$ 6 C ! "% # # ! ! 6 !$ > % # "

(23)

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

(24)

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

(25)

! !$ , . . 6 ! ,% , + ! , ## # 6 . , % + ! , R ! 6 ! + " , "/ . , #%!! ## . #+ " F , F% " = D% # ! !$ 6 ## ## , , . # 6 6 C ! "% # * > ! , * #+ " % , - "/ ?E > , # - 6 " # , 6 #" ! , F . ! #+ " % , F "/ ?=

# "

# " # , % # , " , !$ . # :% # " " #!$ . , 6 # , ++ , F 66 + "" 6 - . ! ! 6 " = D% , # " 66 6 9 F # " ; , + " - 9 :% , . %# # " , % , ; , + - = D% # 7% " ; . , -- = F # " . - " # -% 6 " , ! # , + 8 #6 - 9 :% + ! - # ; # " ! "6 " ## 9 % "/ ,% %/ # 6 . 6 " # " 66 " = ! ! , , F .% 9 6 " #!$ . !$ # 6 ,% , % ! "6 # " !$ 9 , 6 66 % " 6 #6 " ! 6 ! 9 . #+ " % ! ! ! . ! > 9 # " . ! ?9 ! . 8 % > ( 9 # " ( ?9 ! . , %- # > 9 # " ? 9 + 9 %/ > 9 # " %/ ! ?=

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(26)

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

(27)

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

(28)

7 ,=#*( &#' 4 ,?:$4 ) , +(- % ! !$ , + ! , ## # ! "6 # " , 6 . 6 # 6 ! ! - #6 " " / 9 " / 9 # # ! % 6 #" # " 9 ! " 6 # - , 9 , . % ! -% + % , + ! / = F # " . ++ % 6 , ! ! #6 " 6 %

6 , , ! ! &4 &5 > -=&&?=

(29)

* 6 !! F # , F # " 9 , , ! 7 . #! 6 7 .. % + = !F; # + ! , 9 , F . ! # . # / ,% 6 %! 9 + "" " #!$ 9 !$ ! - #6 . " 6 " - ! , , , F% " 9 6 " !$ # + , 6 ! "6 + ! , , . - = D% # 7% " 9 - , 6 + ! , 9 66 ! ,% ! ! ! > 6 %! ?9 !$ ! - " #!$ + "" 9 " ! !$ ! ! , F . ! ; 6 %! , > -=&'?= !F; # 6 %! + "" # - + ! !$ !F; # + ! , 9 " # ! # # - + ! !$ + ! , ; .. % " , " = ( - 6 , 9 !

6 %! !$U ' >,% :% ! 43 ! " # " !$U )4?E 6 !$U # , " - !$ ! "6 / ! #. %66 , % "/ . 9 :% # - # #+ F% = 3 #-+' %%(% !# ! -*('# ># . # / ,% 6 %! 9 % " #!$ , % + "" , ! , + !! ? 9 # - ! !$ " # # - , " + >! ,% 6 %! ,% - /% 6 9 ' 2' M? . - " % ! % 9 ## % "/ , ! #! , -% > !%/ S 9 < ' ?9 6 % ') )5 = % :% # 6 , ! " ! 6 " ## " + # , #. %66 9 , , ! & , . # ! % , , - "/ 9 ! #!% + " , ' 5 ! % =

(30)

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

(31)

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(32)

! " ; # , " # 9 ! # , 6 ! % , #6 " ! " , # " . 9 # ## ! , " ! " # " !$ = !$ ! % "" % 6 ## ## % 9 !$ # # ,%! ## , + = ! ! 6 . , F% , % " ! " 6 9 # %" ! "6 ## . # :% 9 7 6 9 !$ . " ! #! 6 9 #! , "" / 7 . ! , "" / > " % , ! , ?9 #6 , #6 " # ! % % . > -=&)?= #,! ,( !$ :% # ! # 9 . - " % % "/ , ! #! , -% > !%/ S 9 < ' ?9 6 ! ! ') )5 9 # - ! !$ " # ,% 6 %! ,% - /% 6 >+ " ' 2' M?= 0 "/ !$ . % " # #. %66 9 . - # 6 # , % # " " + - ! 9 6 " , #+ " =

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(33)

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(34)

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6 # , - /% 6 9 - , 6 " , . # " ! = > # - , = # =9 " , + ! E + - + , = " =?

(35)

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

(36)

> -=& ?= #! !%/ 6 ') 6 , " % 8 %! E # , 6 7 # %# , &S - /% 6 # 6%I 6 ! , 7 # " = # " , 89 6 ! % , + ; " / ## = - #+(/("# > ? 7 . ! ; "" % = 6 # 6 C . #! !$ - " 9 " $ ! # %# &S- /% 6 E ! I # , , ! !$ 7% . # . " + # > -=& /?= . ## 6 !%/ 6 &' ') 6 " , 7 # " = - #+(/("# > ? 7 . ! ; " % = * ; ## , . #! ! - " . # / , $ # %# &S- /% 6 > -=& !?= 7 . ! 8 6%I ## !$ 6 # " % &S - /% 6 . # / 9 , - , ! 6 #" 9 , # " - =

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(37)

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0 - # #. %66 # ! , % 6 ! # / 6 ! # = % ,% 6 %! # + , % % ! %! !$ ! 8 )4 ! " # " 9 ' , 6 , , ' , 6 , F% " E 6 % . ! % ! " ! , . , # ! % " # 9 !$ 6 6 !$ - #%6 ! , ! % : • ! ! )5 , 6 + ! , 9 ! ; 'S - , 6 6 !P %69 F "/ ; + " , " ) ! % E • ! ! ' , 6 + ! , 9 ! ; S - , 6 6 !P %69 F "/ ; + " , " 5 ! % E :% # + # - # !$ " " % > T6 !! " T? 6 !$U ; + " , % - %66 , ! % !$ # " - % " E • )S - , 6 + ! , F "/ -- % - # , !$ " " % ! "6 ; + " , &4 ' ! % !$ # % #! " # " #% + " # % ! . 8 6 , :% , 9 !$ " ! . 8 / # ! # ! E • S - , 6 + ! , F "/ , . % / # ! # #% ! % 9 ' 4)9 #" , ## 6 , . , # % # # 9 !$ + " 8 6 ! 9 % # 9 , :% # #. %66 8 F "/ . 6 6 E • 4S S - , 6 + ! , / # ! # "6 # F% E ; % . # " % 6 ! ## ! "6 ## !$ # ! ! %, 8 ! ! &) - , 6 + ! , :% 6% - . , # 8 = ! ## + ! " + - ! , - "/ % 6 ## # ! ; / # #% , ! , % > ! ?= 0 "/ . - @- # A 6 )5 6 " , #+ " = . . 8 :% 8 , 7 "/ . . % ! % !!% # " " + - ! = % " 7 ## . , - "/ . ++ % 6 ! ! , , # "6 6 # !$ %! " " #/ , "6 % 6 !! . , 6 6 ## / !! # -" , 7 "/ =

(38)

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

(39)

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(63)

(5 > #! + 4 ("" , (+ (''# 4 F , *$! (! *(' # ,- * " * ,=# - '#)(+# !#'' !/#-+ ' +< *(",= '# > / %66 9 / - = + 8 , ! 66 ! %# - !$ = 0 , -% -- ( . # a9 * S3 6 '1&1 ! *(' ( ,- * " * ,( #! + 4 ("" , (+ 0112 > , " , G + ? #6 " >5 <? . - #6 " >& <? 0122 > , " ) 9NOO? " 9 !! # " + -("' ,(% ! 5#-+" ! (!# " #6 " , #6 " -("' ,(% ! -#, 4- ,=# " #6 " , #6 " (5 7 !, &#!%( (! *(' # ,- * " * ,=# - '#)(+# !# *(",= ! "+$& 0 ,=# " " (! " ++ 4 "+ ( "4#-* -(**( B!I6 >C0 ! +#-* ! & , !,#!+-(% !# "4#-*(+ ,( ## " , ! ! #6 " ! >N&14_{#6 "} _{2" ?} S 6 ! #6 " - "" > X453? #% ! 6 " ) 9NNO >&? % "4#-* ( >X1? 5 >&9'<? < 8 > 30 E? ) 9NOO >&? #)#-( ' % "4#-* ( >b1 ] ? 4 >39&<? _< 86 > 06E? ) 9NOO >'? ) 9NO9 >& E&)? > ?

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(64)

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(65)

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concentrazione normale concentrazione anormale

0 10 20 30 40 50

DFI vs concentrazione degli spermatozoi

DFI normale DFI anormale # ## " , 9 # ## . . !% ## ! 9 # 6 " + - !$ 6 " 8 #6 " ! ! . , = ( ! "6 , :% , #6 " ! 6 # . " + - . % / = !,#!+-(% !# "4#-*(+ ,( >N &14_? #% # _" b1 ]'1 " ['1 c_{J 7E} > " ? &) )4 c_{K 7E} > " ? ) 3 "+ -(**( )" , !,#!+-(% !# "4#-*(+ ,(

(66)

# -- ! " + - #6 " ! " " 9 6 # . % " " # !% , ++ # - + ! . ^ # , #$ 9 X&9111 > ?_ > /=&'9 + -='4?= #% , " + - #6 " ! 66 # 6 % ! 6 # " #!$ , # 6 7 # !$ . % 7 - 8 , #6 " ! 9 " , # = (5 3 "" , (% !# &#' - "$'+(+ &#'' :+#"+ , ! '( * -/ ' ( "4#-*(+ ,( c _{, ! , + ""} _, ₌

DFI vs morfologia

morfologia normale morfologia anormale 0 20 40 60 DFI normale DFI anormale -/ ' ( "4#-*(+ ,( >< #6 " ! " + " ? #% # " >] 1<? " >[ 1<? c_{J 7E} > " ? ) 4 c_{K 7E} > " ? 4 1 36 "+ -(**( )" * -/ ' ( "4#-*(+ ,(

(67)

# -- !$ 6 # . " 8 #6 " ! " " 9 " # . % " " # !% , ++ # - + ! . ^ # , #$ 9 X&9111 > ?_ > /=& 9 + -=' ?= !$ #% , " 8 #6 " ! 66 # 6 % " , 6 # " #!$ , # 6 , # = (5 "" , (% !# &#' - "$'+(+ &#'' :+#"+ , ! '( * + ' +< "4#-*(+ ,( c _{, ! , + ""} _,

DFI vs motilità degli spermatozoi

motilità normale motilità anomalo 0 10 20 30 40 DFI normale DFI anormale 7 ## , 6 " #6 " ! !$ ! # , # " #!$ , # 6 # 9 6 . % , 7 - 8 , #6 " ! 9 ! ## % . , % 66 + , " 9 !$ # , # %, - %66 , # %, 6 C "6 = + ' +< "4#-*(+ ,( >< #6 " " / ? #% # " >] 1<? " >[ 1<? c_{J 7E} > " ? 1 1 c_{K 7E} > " ? ) 3 "+ -(**( )" * + ' +< "4#-*(+ ,(

(68)

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, 9 7 ## ! - 6 + 6 ; " . , #6 " #!$ 9 6 !$U % , + - " - # ; 6 C , ++ ! , . % #6 " #!$ E % . ; # 6 !$ , ! " & / #6 " # % 6 C ! , , " ! " # " !$ > = 66 9 = = + 8 , ! 66 ! %# - !$ = 0 , -% -- ( . # ==== * S3 6 '1&1?= #% , :% # # %, ! + " # 6 :% # , > /=&)? 7 ! , , " ! " # " !$ ! 66 + 9 . 6 + "" // .% !% / #6 > 9 <E ''24 '?9 ; , ++ , :% #!

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

(69)

51' ! 66 + # %, 9 ! , , ! !$ , , . 9 # >194<? 6 # . % # , 6 / . 89 % ! [ / #6 = " , 6 C # 6 9 # & , :% # ! 66 >'1<? # #! . % " ! " # " ! 9 !$ , 6 %" ! ! ! , ! " # " # ##% > /=&)?= !7; # :% , % #! ! 6 - , " ! " # " !$ #! 6 C + :% " ! 66 ! # , 6 / . 8 # ! , :% 6 % = % . ; ! ## ! % . 6 # ! " 9 ! # %, # ! # % , & # ! 66 . + "" // .% " / #6 " % , ,% 6 // % , + , ! , ! " # " ! 9 6 7 , / 8 , #% ! ## , % . + !$ =