Nanoparticles Based on Fructose and Alkaly-Earth Halogenides with Second Harmonic Generation properties for applications as bio-sensors and for Radiotherapy.

(1)

This is the author's final version of the contribution published as:

Domenica Marabello, Paola Antoniotti, Alessandro Barge, Paola Benzi, Valentina

Boscaro, Carlo Canepa, Margherita Gallicchio, Elena Peira, Leonardo Lo Presti,

Nanoparticles Based on Fructose and Alkaly-Earth Halogenides with Second

Harmonic Generation properties for applications as bio-sensors and for

Radiotherapy, XLVI Annual Meeting of the Italian Crystallographic Association,

Abstract and Programme Book, Perugia 26-29/6/2017

The publisher's version is available at:

http://www.cristallografia.org/congresso2017/eng/detail.asp?idn=2911

When citing, please refer to the published version.

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Nanoparticles Based on Fructose and Alkaly-Earth Halogenides with Second Harmonic

Generation properties for applications as bio-sensors and for Radiotherapy.

Domenica Marabello,a,d_{Paola Antoniotti,}a,d_{Alessandro Barge,}b_{Paola Benzi,}a,d_{Valentina Boscaro,}b_{Carlo Canepa,}a Margherita Gallicchio,b_{Elena Peira,}b_{Leonardo Lo Presti}c

a_{Dipartimento di Chimica, Università degli Studi di Torino, Torino, Italy}

b_{Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Torino, Italy.}

c_{Dipartimento di chimica, Università degli Studi di Milano, Milano, Italy}

d_{CRISDI, Center for Crystallography, University of Torino, Torino, Italy. [email protected]}

In recent years, some Metal Organic Frameworks (MOFs) with Second Harmonic Generation (SHG) properties, based on fructose and alkali-earth alogenides, were investigated to understand the effect of cation size and anion polarizability on crucial quantities correlated to the non-linear optical (NLO) response, such as hyperpolarizability and optical susceptibility [1,2]. The compounds studied are interesting for biomedicine applications, as they combine high biocompatibility, due to their non-toxic components, and significant SH emission, that can permit exploitation for in vitro bio-imaging.

Right now, a possible application in radiotherapy is under investigation. To these purposes we synthetized nanoparticles of some MOFs, based on fructose and SrX2 salts (X=Cl, I). The compounds were characterized by single-crystal and powder XRD, IR and RAMAN spectroscopy and the second-order susceptibility were estimated from theoretical calculations, both in vacuo and in the solid state. Furthermore, we attempted to assess the reduction of the SH intensity for small quantities of nano-crystals, in order to ascertain the possibility of applications in biological systems.

The nanoparticles were encapsulated in a phospholipidic shell and characterized by Dynamic light scattering technique (DLS). Preliminary activity studies on target cells are in progress.

Figure 1. Crystal packing of Sr(fructose)I2·H2O.

[1] D. Marabello, P. Antoniotti, P. Benzi, C. Canepa, E. Diana, L. Operti, L. Mortati, M. P. Sassi J. Mater. Sci., 2015, 50 (12), 4330- 4341

[2] D. Marabello, P. Antoniotti, P. Benzi, C. Canepa, L. Mortati, M. P. Sassi Acta Cryst. B, accepted

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