Teresa Pellegrino
Curriculum Vitae et Studiorum
1. Informazioni personali
Nome: Teresa Pellegrino
Indirizzo Ufficio: Istituto Italiano di Tecnologia via Morego 30, Genova,16163
eMail: teresa.pellegrino@iit.it
numero di telefono: + 39 010 2896730 Fax: +39 010 71 781 236
Nazionalità: Italiana
2. Formazione
2000 Laurea in Chimica, Dipartimento di Chimica, Università di Bari, Italia
2005 Dottorato (Ph.D.) in Chimica, Dipartimento di Tecnologie Farmacaceutiche, Università di Bari, Italia
3. Carriera Scientifica
3.1 Formazione professionale:
Febbraio 2014-corrente Team leader del gruppo di Nanomateriali per la Biomedicina presso la Fondazione Istituto Italiano di Technologie, Genova (contratto a tempo indeterminato)
Febbraio 2008- Febbraio 2014 Ricercatore dell’istituto di Nanoscienze del CNR, Lecce (Italia), con contratto a tempo indeterminato nel periodo da febbraio 2010 a gennaio 2014
3.2 Formazione Post-dottorato:
2004-2007 Contratto Post‐Dottorato Laboratorio Nazionale di Nanotecnologie Lecce (Italia)
3.3 Periodi all’estero:
07/2019- 08/2019 Visiting scientist presso la Molecular Foundry, Lawrence Berkeley Lab., Berkeley, CA (USA)
07/2018- 08/2018 Visiting scientist presso la Molecular Foundry, Lawrence Berkeley Lab., Berkeley, CA (USA)
07/2017- 08/2017 Visiting scientist presso la Molecular Foundry, Lawrence Berkeley Lab., Berkeley, CA (USA)
06/2016- 08/2016 Visiting scientist presso la Molecular Foundry, Lawrence Berkeley Lab., Berkeley, CA (USA)
03/2003-08/2004 Marie Curie Fellowship presso il Centro di Nanoscienze, gruppo del Prof. W.J.
Parak, Monaco (Germania)
07/2001-02/2003 Visiting Student presso il Dipartmento di Chimica, gruppo del Prof. P.
Alivisatos, Università della California, Berkeley
10/1999-10/2000 Stage nel laboratorio di Chimica Analitica, Università di Bari
Relatori della mia formazione di dottorato: Prof. Paul Alivisatos (Università di Berkeley, California), Prof.
Wolfgang J. Parak (Università di Marburg, Germania); Prof. Giovanni Natile (Università di Bari, Italia);
3.4 Finanziamenti apportati da progetti nazionali e internazionali (progetti in corso di validità)
2018‐2022 Principal Investigator per il progetto AIRC (Italian Association of Cancer Research), Individual Grant, Advancing glioblastoma therapy: nanoparticles for magnetic hyperthermia, heat‐mediated drug delivery and tumor targeting, (N. 20709) (762000 euros complessivi previa valutazione al terzo anno del progetto)
2016‐2020 Starting European Research Council (ERC)‐Individual Grant, “Colloidal Inorganic Nanostructures for Radiotherapy and Chemotherapy”, (ICARO, N. 678109) (1160000 euro per IIT, progetto di durata di 58 mesi, inizio marzo 2016)
2020‐2024 Horizon 2020, EU: H2020‐MSCA‐ITN‐2019, PI scientifico del partner IIT, ” Heating triggered drug release from nanometric inorganic‐metal organic framework composites” (HeatNMof – 691185, coordinator Patricia Horciada) (522999 euro per IIT, progetto di durata di 4 anni, inizio: 1 marzo 2020)
2020‐2021 –PI del progetto scientifico H2020 ERC Proof of Concept “Gram scale production of ferrite nanocubes and thermo‐responsive polymer coated nanocubes for medical applications and further exploitation in other hyperthermia fields” (Hypercube, 158000 euro per IIT durata di 18 mesi)
2019‐2021 Supervisor scientifico della borsa Marie Curie Individual Fellowship assegnata a Stefano Persano (call EU: H2020‐MSCA‐IF‐2018) per il progetto “MHT‐Immuno Enhancer: Stimuli‐Responsive Nanoplatform to Combine Magnetic Hyperthermia with Immunemodulators Delivery for Glioblastoma Treatment” (183473 euro per IIT, durata biennale)
(finanziamenti passati)
2014‐2017 Fondazione Cariplo, Scientific PI come partner IIT per il progetto coordinato da Delia Mezzanzaniga, Istituto Nazionale dei Tumori, Milano“Disease recurrence in
epithelial ovarian cancer: deciphering miRNA‐driven regulatory networks related to drug sensitivity/cellular plasticity and exploring nanomaterial‐based targeted delivery of identified key molecules for therapeutic purposes” (120 000 euro per IIT)
2012‐2017: European Marie Curie Training Networks (ITN) – PI per il partner IIT
(MAG(NET)ICFUNFunctionalized Magnetic Nanoparticles and their Application in Chemistry and Biomedicine, contract number 290248) (590234 euro per IIT)
2014‐2016 Principal Investigator per il progetto AIRC (Italian Association of Cancer Research), Individual Grant, Stimuli‐Responsive Nanoparticles for eradicating different subsets of cancer cells within
tumors, (Acronimo NanoCures) (270000 euro per IIT)
2011‐2013: Partner scientifico del gruppo CNR del progetto AIRC “miRNA profile associated to clinical
response in ovary cancer: biological/clinical implications” ‐ cod. 10302., coordinato dal P.I.: Silvana Canevari, Istituto Nazionale dei Tumori, Milan (Italy) (40 000 euro per CNR)
2009‐2013: Coordinatore di progetto Europeo, FP7 SMALL, (Magnetic Nanocontainers for Combined Hyperthermia and Controlled Drug Release MAGNIFYCO, contract n. 228622, dal titolo: Magnetic nanocontainers for combined hyperthermia and controlled drug release) (3 400 000 euros contributo totale Europeo, di cui 327 720 euros per IIT e 388 707 euro per il CNR )
2005‐2006: Partner scientifico del gruppo CNR del progetto Italiano PRIN “New types of contrast agents for magnetic resonance imaging and tissue targeting: brain damage in animal model” finanziato dal ministro dell’università e della ricerca (30 000 euro).
3.5 Progetti Individuali ottenuti all’inizio della carriera
2003-2004: Marie Curie Fellowship presso il Centro di Nanoscienze, Monaco (Germania) (24000 Euro) 3.6 Premi e altri riconoscimenti
2016‐2020 Starting European Research Council (ERC)‐Individual Grant, “Colloidal Inorganic
Nanostructures for Radiotherapy and Chemotherapy”, (ICARO, contract number 678109) e 2020‐2021 ERC proof of Concept Hypercube
2016 Premio Europeo “European award of the European Group of Chemistry and Biology 2016”,14 March, 2016, http://quimicabiologica.es/blog/files/category‐awards.html
2013 Premio regionale “Apulia Women Talent 2012” assegnato dal Lions International Club per il lavoro condotto sul tema “Magnetic Nanocontainers for Combined Hyperthermia and Controlled Drug Release”.
2012 Premio da rivista Chemical Communications come “top emerging investigators in Chemical Sciences” http://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc17223b
2011 La review “From iron oxide nanoparticles towards advanced iron‐based inorganic materials designed for biomedical applications”, Agosto 2010) è risultata la più scaricata della rivista Pharmacological Research nel 2011:
http://www.journals.elsevier.com/pharmacological‐research/most‐cited‐articles/
2009‐2013 Coordinatore di progetto Europeo, FP7 SMALL collaborative, includente 11 gruppi europei (MAGNIFYCO, contract n. 228622, www.magnifyco.eu, magnetic nanocontainers for combined hyperthermia and controlled drug release)
2009 Il lavoro, Pellegrino t et al., Nano Lett. 2004, 4 (4), 703, è stato selezionato dalla rivista ScienceWatch (Thomson Reuters) come “Emerging Research Front Paper in the field of Materials Science”
2009 Premio internazionale “Primo Levi” assegnato dalla Associazione Italiana della Chimica (per giovani ricercatori con età inferiore ai 35), per il lavoro: “Multifuctional Nanostructures Based
on Inorganic Nanoparticles and Oligothiophenes and their Exploitation for Cellular Studies” A.Quarta, R.
Di Corato, L. Manna, S. Argentiere, R Cingolani, G. Barbarella and T. Pellegrino, (Journal of the American Chemical Society, 2008,130, 10545‐10555).
Lavori con assegnazioni di copertine di riviste
2013 Silva K. A. et al ( 2013, Nanoscale, 2013 5 (23), 11374‐11384)
2014 Guardia P. et al (Journal of Materials Chemistry B,2013, 2, 4426‐4434) 2015 Quarta A. et al (Nanoscale, 2013, 7, 2336–2351)
2016 Guardia P. (Journal of Materials Chemistry B, 2017, 5, 4587‐4594)
4. Attività professionali
4.1 Corsi di insegnamento
2015‐2018 Scuola di dottorato IIT, Genoa, corso da 8 ore per studenti di dottorato sul tema
“Nanoparticles for Biomedical Applications”
2007 Scuola Superiore Isufi, Lecce, Italia. 20 ore di corso sul tema: "Fundamentals of organic chemistry"
2006 Scuola Superiore Isufi, Lecce, Italy: 20 ore di corso e 80 ore di laboratorio sul tema:
"Quantum dot and Gold nanoparticles: synthesis, surface modification and cellular studies "
2006 Sanofi‐Aventis S.p.a, Brindisi, Italy: corso da 8 ore sul tema: "Nanomaterials and Nanotechnology"
2001 Dipartimento di ingegneria meccanica, Università di Bari, Italia: 30 ore di corso su:
“esercitazioni di " Chimica generale e inorganica"
4.2 Esperienza di tutoraggio
‐Membri del gruppo: Researcher: Dr. Stefano Persano ; Post Doc:Dr. Helena Gavilan, Dr. Thanh Binh Mai, Dr. Tamara Fernandes, Dr. Thuin Samantha, Dr. Nisarg Soni, Dr. Niccolò Silvestri, Dr. Sahitya Kumar Avugadda; Dr. Giacomo Mandriota, Dr. Pradip Das, Studenti PhD: John Conteh, Venkatesh.Bollabathini, Giulia Eugenia Paola Nucci, Ana Maria Panaite, Fellow: Giusy Rizzo
- Esperienza di tutoraggio pregressa: ■Sergio Fiorito (PhD 2016‐2020) ■Soraia Fernandes (Post Doc 2017‐2018) ■Ricardo Totovao 2018‐2020 (Post Doc progettpo AIRC) Amira El Merhie Post Doc progetto AIRC (2019‐2020)■ Emille Rodriguez Post Doc progetto ERC (2018‐2019), ■Niccolò Silvestri (stedente PhD 2015‐2018), ■ Studente PhD Sahitya Kumar Avugadda (2016‐2019) ■ Tommaso Avellini: Post Doc su progetto Airc (2014‐2016) ERC(2017‐2018); ■ Markus Barthel: Post Doc su fondi IIT (2014‐2016) eERC (2017‐2018); ■ Studente PhD Preethi Bala(2013‐2018), Studente PhD Thanh Binh Mai (2013‐2017), Studente PhD Marco Cassani (2014‐2018), ■ Dina Niculaes: Studente PhD Marie Curie su progetto magneticfun (2013‐2016); ■ Aidin Lak: Post Doc (2015‐2017); ■Alessia Petrelli: Post Doc su fondi Cariplo (2015‐2016); ■Riccardo DiCorato: CNR‐INFM, Lecce, Italy (2007‐2008)■Angela Fiore: Studente PhD presso CNR‐INFM (2006‐2008) ■Alessandra Quarta: Studente PhD presso CNR‐
INFM (2006‐2008) ■Maria Ada Malvindi: Studente PhD presso CNR‐INFM (2008) ■Annagrazia Monteduro: studente di laurea presso CNR‐INFM (2008) ■Philomena Piacenza: tecnico (2007‐2009) presso CNR‐INFM, Lecce ■Smitri Rheka Deka: Post Doc (2008‐2009) ■ Manuel Pernia: Post‐Doctoral Fellow at IIT (2010‐2012) ■ Nadja Carola Bigall: Post‐Doctoral Fellow at IIT, Genoa (2009‐2012) ■ Domenico Palumberi: Post‐Doc presso IIT, Genoa (2009‐2010) ■ Graziano Antico: Tecnico, NNL Nanoscienze, CNR (2010‐2012) ■ Hamilton Kakwere: Post‐Doc presso IIT (2012‐2013) ■ Alberto Curcio: Studente PhD presso IIT (2010‐2013)■ Andreas Riedinger: Studente PhD presso IIT (2010‐2013)
■ Pablo Guardia: Post‐Doc presso IIT (2009‐2013) ■ Maria Elena Materia: Studente PhD presso IIT (2012‐2014) and poi Post Doc( 2014‐2017)■ Sara Guerrieri: Studente PhD presso IIT (2012‐2014) - Tutoraggio durante il mio periodo di PhD and Post-Doc: ■Ralph Sperling: studente di laurea, Monaco, Germania (2005) ■Luca Palmirotta: studente di laurea CNR‐INFM (2006) ■Riccardo DiCorato:
studente dilaurea CNR‐INFM , Lecce, (2006) 4.3 Organizzazione di conferenze
2016 ICARO I° Workshop: kick off meeting per il progetto ERC ICARO, Sestri Levante, Italia (06, 2016) 2014 Organizzazione di un Minicolloquim intitolato: "The life‐cycle of nanomaterials in the
(bio)environment: impact on physical properties and toxicity issues" al meeting Condensed Matter, Paris, Francia
2013 Chair della conferenza internazionale del progetto Magnifyco project, Barcellona, Spagna 2013 Organizzatore del Symposium Q all’ e‐MRS meeting: "Bionanomaterials for imaging, sensing and actuating", Nizza, Francia
2011 Organizzatore del Symposium all’ e‐MRS meeting:“Bionanomaterials for imaging, sensing and actuating”, Strasbourg, Francia
2011 Organizzatore del Workshop Internationale “Magnetic Nanocontainers for Combined Hyperthermia
and Controlled Drug Release” at the Italian Institute of Technology, Genova, Italia
4.4 Attività di referee Riviste: JACS, Nature Communications Advanced Materials, Advanced Functional Materials, Nature Materials, Nature Nanotechnology, Nano Letters, Angewandte Chemie, Small, Langmuir, Journal of Materials Chemistry
4.5 Membro valutatore
2019 (settembre 2019) Membro esterno per la commissione di dottorato per la tesi del Dr. Elie Balloul,(Titolo: Magnetic manipulation of intracellular signals) , Pierre et Marie Curie Institute, Paris, France
2017 (marzo): membro esparto del panel di valutazione del progetto Future and Emerging Technology (FET) European program (per il primo periodo sul tema “Neuron stimulation and differentiation using magnetic nanoparticles”).
2016‐ Membro esterno per la commissione di dottorato per la tesi della Dr.ssa Elena González Domínguez (Titolo della tesi: Hierarchical nanostructures for enzymatic catalysis and drug delivery), Università of Vigo, Spagna
2016‐ Membro esperto per la giuria del concorso dii abilitazione "Habilitation à diriger les recherches" in Chimica del Dr. Jerome Fresnais, Sorbonne‐Université ‐ Paris, France
2016‐ Membro esterno per la commissione di dottorato per la tesi della Dr.ssa Soraia Fernandes (Titolo della tesi: From bioremediation to biomedicine: the potential of magnetic nanoparticles in a glance), Università di Regensburg, Germania
2015‐ Membro esterno per la commissione di dottorato per la tesi della Dr.ssa Nadia Licciardello (Titolo della tesi: design, synthesis and functionalization of ultrasmall nanoparticles for bioimaging), CNRS Strasbourg, France
2014‐ Abilitazione nazionale come professore ordinario per l’area "Fondamenti di scienze chimiche e sistemi inroganici per il periodo (23/12/2013 ‐ 23/12/2017)
2013 Membro esterno per la commissione di dottorato per la tesi del Dr. Juan Comenge (Titolo della tesi: Gold NPs as drug delivery agents; detoxifying the antitumoral drug cisplatinum), Instituto Catalano di Nanotecnologie, Spagna
2009 ‐ Membro esterno per la commissione di dottorato per la tesi della Dr.ssa Elena Taboada Cabellos (Titolo della tesi: Synthesis of ϒ‐Fe2O3‐SiO2 composite nanoparticles targeting magnetic resonance imaging and magnetic hyperthermia applications ), Università Autonoma di Barcellona, Spagna 4.5-2 Attività di referaggio di progetti
2016 Israel Science Foundation: Proposal Reviewer 2012 Croatian Science Foundation: Proposal Reviewer 2012 Molecular Foundry, LBL Berkeley: Proposal Reviewer
2008‐2009 Swiss National Science Foundation: Proposal Reviewer 4.6 Altre attività
2017‐BEERC Initiative, In occasione del 10° anniversario della European Research Council (ERC) in Europe, ho participato all’iniziativa organizzata da IIT presentando in un pub a Genova il mio progetto ERC dal titolo: ICARO: “Colloidal Inorganic Nanostructures for Radiotherapy and Chemotherapy”, March 16, 2017, Dallorso il Paradiso della Pinta, Genova (Italia)
2015– “Caffè scientifico”, presentazione di 30 minuti sul tema: ”Magnetic nanoparticles in biomedicine”,7 Genova, 5 marzo, 2015, Pasticceria e Liquoreria, Caffè Marescotti di Cavo.
2009 – Coordinatrice e disegnatrice della produzione del calendario annual dell’ Instituto Nazionale di Nanotecnologie del CNR, immagini TEM e SEM.
2008 – Presentazione al pubblico intitolata “Arte e Scienza: immagini TEM, Colouri e inventiva”, “Nano‐
Tech Design dispositivi periferici” event tenuto a Lecce (Italy) at Manifatture Knos exposition center
2016/17/18/19‐ Attività divulgative con studenti della scuola primaria Gilberto Govi, via Felice Cavallotti, 16145 Genova: attività sperimentali volte a spiegare concetti di nanotecnologie, i principi di base della chimica delle molecole, dei cristalli e dei nanomateriali e l’applicazione alla medicina. Si veda il video https://www.youtube.com/watch?v=oZ3cEHcqUXo
4.7 Inviti a seminari/Lezioni/Colloqui, presentazioni a conferenze: 33 presentazioni a conferenze, 20 inviti a seminari, 6 presentazioni su invito a scuole estive tra cui partecipazione a spring eMRS meeting e International Cell Model System summer school in Rome.
5. Scientific output
5.1 Summary. Ho pubblicato 125 lavori su riviste internazionali con sistema peer‐review (6 reviews, 5 lavori come primo autore), 7 capitoli di libri.
Parametri bibliometrici
・ ca. 15000 citazioni, H index 53 (Google Scholar, settembre 2020) 5.2 Brevetti
Nella mia carriera ho generato con IIT 7 famiglie di brevetti(invenzioni) e 18 applicazioni (5 delle quali sono applicazioni PCT), di cui 10 sono state concesse portando a 15 brevetti. Prima del 2009, sono stata coinvolta in altri 5 brevetti di cui quattro sono stati concessi.
Selezione di alcuni dei miei brevetti:
“Chip a trasduzione elettrica per analisi genomiche/proteomiche” (“A nanoelectrode‐based chip for the detection of single biorecognition events for genomics and proteomics applications”), G. Maruccio, E.
Primiceri, P. Marzo, V.Arima, R.Krahne, T.Pellegrino, A. Della Torre, F. Calabi, R. Cingolani, R. Rinaldi, Italian
patent number: TO2007A000341 (15 maggio, 2007).
“Method for separating nanoparticles with a controlled number of active groups” W. H.‐S. Chang, J. K.‐J.
Li,
R. A. Sperling, T. Pellegrino, W. Parak, (US Patent 207/0134679), (14 luglio, 2007).
“Nanocapsule colloidali magnetiche fluorescenti:procedimento per la loro preparazione e loro impiego in
saggi di selezione cellulari”, T. Pellegrino, R. Di Corato, P. Piacenza, L. Manna, R. Cingolan, Italian patent application number: TO2009A000169 ( 6 marzo,2009).
“Nanocristalli di ferrite e loro usi” Italian Patent Application n.ITTO2012A000306, Filing date: 6 aprile, 2012,
Inventori: Pablo Guardia, Andreas Riedinger, Simone Nitti, Teresa Pellegrino, Liberato Manna, Roberto Cingolani. (Methods of making ferrite nanocrystals, US Patent N. US20150064103 A1, 5,marzo 2013)
“Sistema nanoparticellare sensibile al calore” Italian Patent Application n.TO2013A000065, Filing date:
January 28, 2013, Inventori: Andreas Riedinger, Teresa Pellegrino, Pablo Guardia, Alberto Curcio, Roberto
Cingolani, Liberato Manna (Heat‐Sensitive Nanoparticle System; International 28 gennaio, 2014 US Patent N. 2015/0359887) 8
“Procedimento per la sintesi di nanoparticelle magnetiche stimolo‐responsive” Italian patent pending.
Filing date: January 27, 2017, (Document N. 102017000009221 ) Inventori: Teresa Pellegrino, Thanh Binh Mai,Markus Joachim Barthel, Preethi Bala Balakrishnan, Hamilton Kakwere, Roberto Cingolani T. Pellegrino et al, aprile 2019 , “Procedimento per la preparazione alla grammo scala di nanocristalli di forma cubica di ferriti per applicazioni biomediche” filed in April 2019: IT 102019000006469).
5.3 Capitoli di libri
“Measuring Cell Motility Using Quantum Dot Probes” Weiwei Gu; T. Pellegrino; Wolfgang J.
Parak; Rosanne Boudreau; Mark A. Le Gros; A. Paul Alivisatos; Carolyn A. Larabell, (Quantum Dots, Applications in Biology, 2007 (Clifton, NJ), Chapter 11, pp. 125 ‐ 132) .
‘Fluorescent Nanocrystals and Proteins in Nanobioelectronics - for Electronics, Biology and Medicine’, P. P. Pompa, T. Pellegrino and L. Manna,ed. by Andreas Offenhäusser and Ross Rinaldi, Springer 2009.
‘Quantum dot Nanoparticles: Properties, Surface Functionalization, and their applications in biosensoring and imaging’, in ‘Nanostructured Materials for Biomedical Applications’, Ragusa, A.
Zacheo, T. Pellegrino and L. Manna, Edited by M. C. Tan, Transworld Research Network, Kerala, India, 2010.
“Quantum Dots Designed For Biomedical Applications” A. Ragusa, A. Zacheo, A. Aloisi, and T.
Pellegrino, Chapter 10, Edited by C Altavilla and S. Ciliberto, Taylor & Francis Group USA, October 2010
“Immunochemistry, Electron Tomography and Energy Dispersive X-Ray Spectroscopy (EDXS) on Cryosections of Human Cancer Cells Doped with Stimuli Responsive Polymeric Nanogels Loaded with Iron Oxide Nanoparticles” Roberto Marotta, A. Falqui, A. Curcio, A. Quarta, and T.
Pellegrino, in Nanomaterial Interfaces in Biology, Chapter 14, Edited by Kimberly Hamad‐Schifferli, and Paolo Bergese, 2013, XIV, 302 p. a product of Human Press, Springer
“Antibody -Functionalized Inorganic NPs: Mimicking Nature for Targeted Diagnosis and Therapy”; A Quarta, L Manna, T Pellegrino; Book Title: Bioinspired Approaches for Human‐Centric Technologies for Springer, 2014, Editor: R. Cingolani, book Chapter N‐.1, 1‐28
“Magnetic Nanoparticles for Magnetic Hyperthermia and Controlled Drug Delivery”; P. Guardia, A.
Riedinger, H. Kakwere, F. Gazeau, and T. Pellegrino; Book Title: Bio‐ and bioinspired nanomaterials, Wiley , Editors: Daniel Luis‐Molina, Fernando Novio, published in
September 2014, DOI: 10.1002/9783527675821.ch06
5.4 Lista completa dei lavori pubblicatis (* corresponding author):
2020
PB Balakrishnan et al., Exploiting unique alignment of cobalt ferrite nanocubes, mild hyperthermia, and controlled intrinsic cobalt toxicity for cancer therapy, Advanced Materials, 2020, 2003712 (1-11, https://DOI:10.1002/adma.202003712)*
MP Arciniegas et al, Unveiling the Dynamical Assembly of Magnetic Nanocrystal Zig-Zag Chains via In-Situ TEM Imaging in Liquid, Small, volume 26, https://doi.org/10.1002/smll.201907419 *
T. Avellini et al., Cation exchange protocols to radiolabel aqueous stabilized ZnS, ZnSe and CuFeS2 nanocrystals with 64Cu for dual radio- and photo-thermal therapy, Advanced Functional Materials, https://doi.org/10.1002/adfm.202002362, 2020*
BT Mai et al, Photo-induced copper mediated copolymerization of activated-ester methacrylate polymers and their use as reactive precursors to prepare multi-dentate ligands for the water transfer of inorganic nanoparticles, Polymer Chemistry (2020*
2019
Avugadda et al., Esterase-Cleavable 2D Assemblies of Magnetic Iron Oxide Nanocubes: Exploiting Enzymatic Polymer Disassembling To Improve Magnetic Hyperthermia Heat Losses, Chemistry of Materials, (2019) *
MV Zyuzin et al., Confining iron oxide nanocubes inside submicrometric cavities as a key strategy to preserve magnetic heat losses in an intracellular environment, Translation of Magnetic Hyperthermia and Heat-Mediated Chemotherapy, ACS applied materials & interfaces (2019) *
A. Quarta et al, Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles, Nanoscale, (2019)*
T Mai, PB Balakrishnan et al., Thermoresponsive Iron Oxide Nanocubes for an Effective Clinical
Translation of Magnetic Hyperthermia and Heat-Mediated Chemotherapy, ACS applied materials & interfaces 11 (6), 5727-5739 (2019), *
TB Mai, Crosslinked pH-responsive polymersome via Diels-Alder click chemistry: A reversible pH-dependent vesicular nanosystem, Polymer, 19-27 (2018) *
V Calcagno et al, Oil Core–PEG Shell Nanocarrier for In Vivo MRI Imaging, Advanced Healthcare Materials (2019)
2018
Salis B. et al, Polymer Coating and Lipid Phases Regulate Semiconductor Nanorods’ Interaction with Neuronal Membranes: A Modeling Approach, ACS chemical neuroscience (2018)
Lak A. et al., Fe2+ Deficiencies, FeO Subdomains, and Structural Defects Favor Magnetic Hyperthermia Performance of Iron Oxide Nanocubes into Intracellular Environment, Nano Letters (2018) *
Espinosa A. et al, Magnetic (Hyper)Thermia or Photothermia? Progressive Comparison of Iron Oxide and Gold Nanoparticles Heating in Water, in Cells, and In Vivo, Advanced Functional Materials (2018) Balakrishnan P. et al, “Star poly(ε-caprolactone)-based electrospun fibers as drug scaffold for doxorubicin with prolonged drug release activity”, J of Colloids and Surfaces B, (2018)*
Di Corato R. et al, Maghemite nanoparticles with enhanced magnetic properties: one-pot preparation and ultrastable dextran shell, ACS Applied Materials & Interfaces, (2018)
Najafishirtari S et al, Manipulating the morphology of the nano oxide domain in AuCu–iron oxide dumbbell-like nanocomposites as a tool to modify magnetic properties, RSC Advances (2018)
Mai BT et al,, Nanosystems Based on Magnetic Nanoparticles and Thermo- or pH-Responsive Polymers: An Update and Future Perspctives, Accounts of Chemical Research (2018)*
Kakwere H. et al, Dually responsive gold-iron oxide heterodimers: merging stimuli-responsive surface properties to intrinsic inorganic material features, Nanoscale (2018)*
2017
Quarta A. et al, “Multilayered Magnetic Nanobeads for Delivery of Peptides Molecules Triggered by Intracellular Proteases”, ACS Applied Materials & Interfaces, (2018)*
Dante S. et al, “Selective targeting of neurons with inorganic nanoparticles: revealing the crucial role of nanoparticle surface charge” (2017)*, ACS Nano, accettato, in stampa DOI:
10.1021/acsnano.7b00397
Guardia et al., “Gold-Iron oxide dimers for magnetic hyperthermia: The key role of chloride ions in the synthesis to boost the heating efficiency”, J. of Mater. Chem. B:, 2017, 5, 4587-4594 (2017)*
Vecchioni R. et al, “Oil/Water nano-emulsions loaded with cobalt ferrite oxide nanocubes for photo- acoustic and magnetic resonance dual imaging in cancer: in vitro and preclinical studies”,
Nanomedicine: Nanotechnology, Biology and Medicine, 13 (1), 275-286 (2017)
Cabrera D. et al., “Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes”, Nanoscale, 2017, Advance Article, Nanoscale, 9, 5094-5101: March 21, 2017
Mazuel F. et al, Forced- and Self-Rotation of Magnetic Nanorods Assembly at the Cell Membrane: A Biomagnetic Torsion Pendulum, Small (2017)
Riva Ar et al, Plasmonic/magnetic nanocomposites: Gold nanorods-functionalized silica coated magnetic nanoparticles, Journal of colloid and interface science (2017)
Niculaes D et al,Asymmetric Assembling of Iron Oxide Nanocubes for Improving Magnetic Hyperthermia Performance, ACS Nano (2017)*
2016
Lak A. et al, “Facile transformation of FeO/Fe3O4 core-shell nanocubes to Fe3O4 via magnetic stimulation” in second revision after minor revision comments, Scientific Reports, 6: 33295. (2016)*
S Najafishirtar,”Dumbbell-like Au0. 5Cu0. 5@ Fe3O4 Nanocrystals: Synthesis, Characterization, and Catalytic Activity in CO Oxidation”, ACS Applied Materials & Interfaces, 8 (42), pp 28624 (2016) F Mazuel et al., “Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced
Magnetically at Single Endosome and Tissue Levels”, ACS NANO, DOI: 10.1021/acsnano.6b02876, in press (2016)
S Ghosh, “Colloidal CuFeS2 Nanocrystals: Intermediate Fe d-Band Leads to High Photothermal Conversion Efficiency”,Chemistry of Materials, 28 (13), pp 4848–4858 (2016)*
G. N. Abdelrasoul et al., “PEGylated gold nanorods as optical trackers for biomedical applications: an in vivo and in vitro
comparative study”, Nanotechnology 27 (25), 255101 (2016)
M.F. Casula et al., “Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia”, Phys. Chem. Chem. Phys., 2016, 18, 16848-16855;
doi:10.1039/C6CP02094A (2016)
J Kolosnjaj-Tabi, “Biotransformations of magnetic nanoparticles in the body”, J Kolosnjaj-Tabi, Nano Today, 11, 280—284; doi:10.1016/j.nantod.2015.10.001, (2016)
A Espinosa, “The Duality of Iron Oxide Nanoparticles in Cancer Therapy: Amplification of Heating Efficiency by Magnetic Hyperthermia and Photothermal Bimodal Treatment”, ACS NANO, 10 (2), 2436-2446, DOI: 10.1021/acsnano.5b07249 (2016)
Sathya A., “CoxFe3-xO4 Nanocubes for Theranostic Applications: Effect of Cobalt Content and Particle Size“,Chemistry of Materials, 28 (6), pp 1769–1780, DOI: 10.1021/acs.chemmater.5b04780 (2016)*
2015
B. Spagnolo , "Three-dimensional cage-like microscaffolds for cell invasion studies", Scientific Reports, 5, p 10531 doi:10.1038/srep10531, (2015)
A. Salvetti et al., In vivo biocompatibility of boron nitride nanotubes: Effects on stem cell biology and tissue regeneration in planarians, Nanomedicine, Pages 1-12 doi:10.2217/nnm.15.46, (2015)
Bigall NK et al. "Hollow Iron Oxide Nanoparticles in Polymer Nanobeads as MRI Contrast Agents", J. Phys.
Chem. C,(2015), 119 (11), pp 6246–6253, DOI: 10.1021/jp508951t*
Materia et al. "Mesoscale Assemblies of Iron Oxide Nanocubes as Heat Mediators and Image Contrast Agents",Langmuir, 2015, 31 (2), pp 808–816; DOI: 10.1021/la503930s*
S. Carregal-Romero et al., "Magnetically triggered release of molecular cargo from iron oxide nanoparticle loaded microcapsules", DOI: 10.1039/C4NR04055D, Nanoscale, 2015, 7, 570-576*
Quarta, A. et al. Targeting FR-expressing cells in ovarian cancer with Fab-functionalized nanoparticles: a full study to provide the proof of principle from in vitro to in vivo, Nanoscale 2015, 7, 2336-2351.*
Wang, S. et al. Plasmonic Copper Sulfide Nanocrystals Exhibiting Near-Infrared Photothermal and Photodynamic therapeutic Effects, ACS Nano 2015, 9 (2), pp 1788–1800*
Kakwere H et al., "Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered Drug Delivery", ACS Appl. Mater.
Interfaces, 2015, 7 (19), pp 10132–10145, DOI: 10.1021/am5088117*
Akkerman, Q. A. et al. From Binary Cu2S to Ternary Cu–In–S and Quaternary Cu–In–Zn–S Nanocrystals with Tunable Composition via Partial Cation Exchange,ACS Nano 2015, 9, 521-531.
Bartelmess J. et al., Non-covalent functionalization of carbon nano-onions with pyrene–BODIPY dyads for biological imaging, RSC Adv., 2015,5, 50253-50258,
Jelena Kolosnjaj-Tabi et al.The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice, ACS Nano, 2015, 9 (8),7925-7939,
Yi Xie, Nanoscale Transformations in Covellite (CuS) Nanocrystals in the Presence of Divalent Metal Cations in a Mild Reducing Environment; Chemistry of Materials 27 (21), pp 7531–7537, (2015)
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Barthel M et al., Synthesis of Highly Fluorescent Copper Clusters Using Living Polymer Chains as Combined Reducing gents and Ligands, ACS NANO, (2015)*
2014
Guardia P. et al.,"One pot synthesis of monodisperse water soluble iron oxide nanocrystals with high values of specific absorption rate" J. of Mater. Chem. B, 2, 4426-4434, (2014) * Highligthed by the Journal with the Back Cover assigned
Bogart L. K. et al. “ Nanoparticles for Imaging, Sensing, and Therapeutic Intervention” ACS NANO,; 8 (4), 3107-3122 (2014); DOI: 10.1021/nn500962q
Di Corato R. "Magnetic hyperthermia efficiency in the cellular environment for different nanoparticle designs;"
Biomaterials 35 (24), 6400-6411, (2014)
Kolosnjaj-Tabi J. et al., "Heat-Generating Iron Oxide Nanocubes: Subtle “Destructurators” of the Tumoral Microenvironment" , ACS NANO, 8 (5), 4268–4283 (2014)
2013
Xie, Y. et al., "Dumbbell Nanocrystals. with Tunable Composition by Reduction of Covellite Nanocrystals with Cu+
Ions", JACS. 135, 17630−17637, (2013)
Bigall N. K. et al., “Colloidal Ordered Assemblies in a Polymer ShellA Novel Type of Magnetic Nanobeads for Theranostic Applications” Chemistry of Materials, 25, 1055, 2013,*
Espinosa A. et al., “Magnetic properties of iron oxide nanoparticles prepared 3 by seeded-growth route”, Journal of Nanoparticle Research, 15 (4), 1-132013,(2013) DOI:10.1007/s11051-013-1514-8)
Lartigue, L et al., “Biodegradation of Iron Oxide Nanocubes: High Resolution In Situ Monitoring ACS NANO 7(5), 3939,(2013)
Riedinger A. et al., “Sub-Nanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles”, Nano Letters 13 (6), 2399, (2013)*
K. A. Silva, et al., "Cell-derived Vesicles as a Bioplatform for the Encapsulation of Theranostic Nanomaterials” , Nanoscale 5 (23), 11374-11384, (2013) DOI: 10.1039/C3NR01541F), Highligthed by the Journal with the Front Cover assigned
2012
Fragouli D. et al., “Superparamagnetic cellulose fiber networks via nanocomposite functionalization"
Journal Of Materials Chemistry, 22 (4), 1662-1666,( 2012)
Curcio A. et al., “Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)” Chemical Communications, 48 (18), 2400-2402, (2012) *
Espinosa A. et al., “On the discrimination between magnetite and maghemite by XANES measurements in fluorescence mode”, Measurement Science & Technology, 23 (1), (2012)
Guardia P. et al., “Water-Soluble Iron Oxide Nanocubes with High Values of Specific Absorption Rate for Cancer Cell Hyperthermia Treatment” ACS NANO, 6 (4), 3080-3091 (2012) *
Quarta A. et al., “Polymer coated inorganic nanoparticles: tailoring the nanocrystal surface for designing nanoprobes with biological implications” Nanoscale,4(11), 3319-3334, feature article) (2012)*
Andriola Silva A. et al., “Magnetophoresis at the nanoscale: tracking magnetic targeting efficiency of nanovectors”, Nanomedicine, 7(11), 1713-1727, (2012)
Di Corato R. et al., “'Magnetic nanobeads decorated with silver nanoparticles as cytotoxic agents and photothermal probes” Small, 8 (17) 2731-2742 (2012)*
Pernia M. et al., “Controlled Release of Doxorubicin Loaded within Magnetic Thermo-responsive Nanocarriers under Magnetic and Thermal Actuation in a Microfluidic Channel”, ACS NANO, 6(12), 10535, (2012) *
2011
Bayer I. et al.,“Water-repellent Cellulose Fiber Networks with Multifunctional Properties" Applied Materials and Interfaces, 2011, 3(10), 4024, (2011)
Bigall N. C. et al., “Magnetic Nanocarriers with Tunable pH Dependency for Controlled Loading and Release of Cationic and Anionic Payloads” Advanced Materials, 23(47), 5645, (2011) *
Malvindi M.A. et al.,“Multiple functionalization of fluorescent nanoparticles for specific biolabeling and drug delivery of dopamine” Nanoscale, 3(12), 5110, (2011
Deka S.R. . et al., “Magnetic nanobeads decorated by thermo-responsive PNIPAM shell as medical platforms for the efficient delivery of doxorubicin to tumour cells” Nanoscale, 3 (2), 619 - 629, (2011)*
Di Corato R. . et al., “Multifunctional Nanobeads Based on Quantum Dots and Magnetic Nanoparticles – Synthesis and Cancer Cell Targeting and Sorting” ACS NANO, 5 (2) 1109-1121, (2011)*
George C. . et al., “A Cast-Mold Approach to Iron Oxide and Pt/Iron Oxide Nanocontainers and Nanoparticles with a Reactive Concave Surface” JACS, 133 (7), 2205–2217 (2011)
Zacheo A. . et al., “CdSe/CdS Semiconductor Quantum Rods as Robust Fluorescent Probes for Paraffin-Embedded Tissue Imaging” Transaction on NanoBioscience, 10 (3), pp. 209-215, (2011) *
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Malvindi M. A. . et al., “"Magnetic/Silica nanocomposites as dual-mode contrast agents for combined Magnetic Resonance Imaging and UltraSonography" Advanced Functional Materials, 21 (13), 2548-2555, (2011) 2010
Figuerola A. S. et al., “From Iron Oxide Nanoparticles Towards Advanced Iron-Based Inorganic Materials Designed For Biomedical Applications”Pharmacological Research, 62, 126-143, (2010)*
Deka S. .et al., “Acidic pH-responsive nanogels as cargo system for the simultaneously loading and release of short oligonucleotide and magnetic nanoparticles” Langmuir, 26 (12), 10315-10324, (2010)*
Casciaro S. et al., “Silica nanoparticles for quantitative ultrasound molecular imaging and automatic tissue typing at conventional diagnostic frequencies” Investigative Radiology, 45(11), 715-724, (2010)
2009
Chiodo L. et al., "An ab initio study of the CoPt3-Au interface: implications on the growth of colloidal CoPt3-Au nanocrystal heterodimers"Journal of Physics: Condensed Matter, 21, 1-13, (2009) Deka S. et al.,
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Di Corato R. et al., ‘Magnetic-Fluorescent Colloidal Nano-Beads: Preparation and Exploitation in Cell Separation Experiments’, Macromolecular Bioscience, 9, 952–958 (2009) *
Tortiglione C. et al., “Fluorescent Nanocrystals Reveal Regulated Portals of Entry into and Between the cells of Hydra”Plos One, 4 (issue 11), e7698, 1-14, (2009)
Maruccio G. et al., “A nanoelectrode-based biosensor for the detection of single biorecognition events” Analyst, 134, 2458-2461, (2009)
Arnesano F. et al., “Copper-triggered aggregation of ubiquitin” F. Arnesano, S. Scintilla, V. Calò, E. Bonfrate, C.Ingrosso, M. Losacco, T. Pellegrino, E. Rizzarelli, G. Natile,Plos One4 (issue 9), e7052, 1-11 (2009) Quarta A. et al., “A Bio-conjugation of rod-shaped fluorescent nanocrystals for efficient targeted cell labelling”
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Malvindi M. A. et al., "Rod Shaped Nanocrystals Elicit Neuronal Activity In Vivo " Small, 4(10), 1747–1755, (2008) Quarta A. et al., “Multifuctional Nanostructures Based on Inorganic Nanoparticles and Oligothiophenes and their Exploitation for Cellular Studies” JACS, 130,10545-10555 (2008)*
Di Corato R. et al.,“Water solubilization of hydrophobic nanocrystals by means of poly(maleic anhydride-alt-1- octadecene)” Journal of Materials Chemistry 18, 1991-1996, (2008)*
Figuerola A. et al.,"One-pot Synthesis and Characterization of Size-Controlled Bimagnetic FePt-Iron Oxide Heterodimer Nanocrystals" JACS, 130, 1477-1487 (2008)
Corti M. et al.,"Magnetic properties of novel superparamagnetic MRI contrast agents based on colloidal nanocrystals"
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2007
Quarta A. et al., “Fluorescent-magnetic hybrid nanostructures: preparation, properties and applications in biology”
Transaction on NanoBioscience, 6, 298-308 (2007) topical review*
Tortiglione C. et al., “Synthesis and biological assay of GSH functionalised fluorescent Quantum Dots for staining Hydra vulgaris” Bioconjugate Chemistry, 18, 829-835, (2007)*
Parak W. J. et al.,"Gel Electrophoresis of Gold-DNA Nano-Conjugates" Journal of Biomedicine and Biotechnology, Volume 2007, Article ID 26796, 9 pages (2008), doi:10.1155/2007/26796 2006
Cozzoli P. D: et al., “Synthesis, properties and perspectives of hybrid nanocrystal structures” Chemical Society Review,35: 1195-1208 (2006)
Pellegrino T et al., “Heterodimers based on CoPt3-Au nanocrystals with tunable domain size” JJACS 128 (20):
6690-6698 (2006)*
Sperling R.A. et al., “Electrophoretic Separation of Nanoparticles with a Discrete Number of Functional Groups”
Advanced Functional Materials, 16 (7): 943-948 (2006)
Pompa P:P: et al., “Fluorescence resonance energy transfer induced by conjugation of metalloproteins to nanoparticles”
Chemical Physics Letters 417 (4-6): 351-357,(2006) 2005
Pellegrino T. et al., “On the Development of Colloidal Nanoparticles towards Multifunctional Structures and their Possible Use for Biological Applications, Small 1(1): 8-63, (2005)
Parak W.J. et al., “Labeling of Cells with Quantum Dots” Nanotechnology 16: r9-r25, (2005), topical review.
Gu W.W. et al., “Quantum Dot-Based Cell Motility Assay In Comparison to the Boyden Chamber Invasion Assay”
Science’s STKE, 290/PI5:1-6, (2005) on-line publication)
Pellegrino T. et al., “Biological Applications of Fluorescent Quantum Dots” New Drugs: 14-16, (2005)
Kirchner K. et al., “Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles” Nano Letters 5 (2): 331-338, (2005).
2004
Pellegrino T. et al., “Hydrophobic nanocrystals coated with an amphiphilic polymer shell: a general route to water soluble nanocrystals”, Nano Letters 4 (4): 703-707, (2004).
Caselli M. et al., ”Selective Transition Metal Extraction by Reverse Micelles”, Annali di Chimica 95 (1-2): 33-43, (2004).
2003
Pellegrino T. et al., ”Quantum Dot Based Cell Motility Assay”, Differentiation 71 (9-10): 542-548, (2003).
Parak W.J. et al., ”Biological Applications of Colloidal Nanocrystals” Nanotechnology 14 (7): r15-r27, (2003).
‘Parak W.J. et al.,”Conformation of oligonucleotides attached to gold nanocrystals probed by gel-electrophoresis”
Nano Letters3(1): 33-36, (2003).
2002
Parak W.J. et al., “Conjugation of DNA to silanized colloidal semiconductor nanocrystallinene quantum dots”, Chemistry of Materials 14: 2113-2119, (2002).
Genova, settembre 2020
Dr. Teresa Pellegrino
Team Leader, Italian Institute of Technology, Via Morego 30, Genova 16163, Italy Email: teresa.pellegrino@iit.it
