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(1)A trans-resveratrol B vehicle Supplementary Figure S1

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(1)

A

trans-resveratrol

B

vehicle

Supplementary Figure S1. Effect of resveratrol stereoisomers on tumor angiogenesis. Female C57BL/6N mice were given trans- or cis-resveratrol in the drinking water (30 Pg/mL in 0.15%

ethanol) throughout the whole experimental period starting 4 days before the subcutaneous transplantation of murine B16 melanoma cells (1.5x105 cells per graft). At day 18 after grafting, frozen tumor sections were immunostained with a rat monoclonal anti-mouse CD31 antibody. Note the significant reduction in CD31+ tumor vascularization following trans-resveratrol administration (A) when compared to vehicle (B). Original magnification: x200. Quantification of the results are shown in Figure 6B.

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