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Handbook of Pediatric

Neuro-Ophthalmology

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Handbook of Pediatric Neuro-Ophthalmology

Edited by

Kenneth W. Wright, MD

Director, Wright Foundation for Pediatric Ophthalmology Director, Pediatric Ophthalmology, Cedars-Sinai Medical Center, Clinical Professor of Ophthalmology, University of Southern California—Keck School of Medicine, Los Angeles, California

Peter H. Spiegel, MD

Focus On You, Inc., Palm Desert, California Inland Eye Clinic, Murrieta, California Children’s Eye Institute, Upland, California

Lisa S. Thompson, MD

Attending Physician, Stroger Hospital of Cook County, Chicago, Illinois

Illustrators

Timothy C. Hengst, CMI Susan Gilbert, CMI Faith Cogswell

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Kenneth W. Wright, MD Peter H. Spiegel, MD Director, Wright Foundation for Focus On You, Inc.

Pediatric Ophthalmology Palm Desert, CA Director, Pediatric Ophthalmology, Inland Eye Clinic

Cedars-Sinai Medical Center, Murrieta, CA Clinical Professor of Children’s Eye

Ophthalmology, University of Institute Southern California—Keck School Upland, CA

of Medicine USA

Los Angeles, CA USA

Lisa S. Thompson, MD Attending Physician

Stroger Hospital of Cook County Chicago, IL

USA

Library of Congress Control Number: 2005932933 ISBN 10: 0-387-27929-6 e-ISBN 0-387-27930-X ISBN 13: 978-0387-27929-9

Printed on acid-free paper.

© 2006 Springer Science+Business Media, Inc.

Reprinted from Wright and Spiegel: Pediatric Ophthalmology and Strabismus, second edition, copyright 2003 Springer Science+Business Media.

All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden.

The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.

While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.

Printed in the United States of America. (BS/EVB) 9 8 7 6 5 4 3 2 1

springer.com

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Preface

Pediatric ophthalmology is a broad field encompassing many diverse topics including embryology, chromosomal abnormali- ties, neurology, craniofacial abnormalities, systemic diseases, retina disease, and strabismus. This variety makes pediatric oph- thalmology interesting, and intellectually stimulating, but at the time somewhat daunting. The handbook series is designed to give the practitioner an easy to understand, succinct yet detailed reference on various subjects related to pediatric ophthalmology.

The Handbook of Pediatric Neuro-Ophthalmology is a prac- tical resource on the diagnosis and management of neurological disorders with ocular manifestations. A broad range of topics are covered including the pediatric neuro-ophthalmology exa- mination, ocular motility disorders, optic nerve anomalies, nystagmus, and neuro-degenerative disease. Children with neurological disorders often have debilitating disease without viable treatment options. In these cases even the seasoned physician can feel uncomfortable when speaking with the family. A beautifully sensitive chapter is included “Breaking the News” that gives practical points to help the physician com- municate with the family.

Chapters in the handbook are reader friendly. They are organized with clear sub-headings that allow the reader to quickly find the area of interest. Excellent color photographs and diagrams illustrate the clinical points and help with disease recognition. Extensive use of tables and information boxes sim- plify and summarize complex topics. Each chapter is fully ref- erenced to provide evidence-based practice guidelines and further in-depth reading.

Another important use of the Handbook of Pediatric Neuro- Ophthalmology is patient and family education. Parents are rightfully concerned about the effects of neurological disease on v

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their child’s eyes. Information including diagrams and photo- graphs from the handbook about the eye manifestations of neu- rological disease can be shared with the families. This important information is often lacking in general texts on ophthalmology and pediatrics.

I hope you will find this book, Handbook of Pediatric Neuro-Ophthalmology, to be an invaluable adjunct to your pedi- atric practice.

Kenneth W. Wright, MD

vi preface

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Contents

Preface . . . . v Contributors . . . . ix 1 Embryology . . . . 1

Cynthia S. Cook, Kathleen K. Sulik, and Kenneth W. Wright

2 Pediatric Neuro-Ophthalmology Examination . . . . 62 Edward G. Buckley

3 The Pediatric Low-Vision Patient . . . . 85 Anne Frances Walonker

4 Breaking the News: The Role of the Physician . . . 92 Nancy Chernus-Mansfield

5 Ocular Motility Disorders . . . . 107 Mitra Maybodi, Richard W. Hertle, and

Brian N. Bachynski

6 Congenital Optic Nerve Abnormalities . . . . 204 Paul H. Phillips and Michael C. Brodsky

7 Cortical Visual Impairment . . . . 247 Susan M. Carden and William V. Good

8 Brain Lesions with

Ophthalmologic Manifestations . . . . 255 Michael X. Repka

9 Nystagmus and Ocular Oscillations in Infancy

and Childhood . . . . 289 Richard W. Hertle

vii

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10 Neurodegenerative Conditions of

Ophthalmic Importance . . . . 324 Mark S. Borchert and Sarah Ying

11 Neurocranial Defects with

Neuro-Ophthalmic Significance . . . . 371 Ronald M. Minzter and Edward G. Buckley

12 Management of Common Pediatric

Neuro-Ophthalmology Problems . . . . 400 James W. McManaway III and Dean J. Bonsall

Index . . . . 435

viii contents

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Contributors

Brian N. Bachynski, MD Dean J. Bonsall, MD Mark S. Borchert, MD Michael C. Brodsky, MD Edward G. Buckley, MD

Susan M. Carden, MBBS, FRACO, FRACS Nancy Chernus–Mansfield

Cynthia S. Cook, DVM, PhD William V. Good, MD Richard W. Hertle, MD, FACS Mitra Maybodi, MD

James W. McManaway III, MD Ronald M. Minzter, MD Paul H. Phillips, MD Michael X. Repka, MD

ix

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Kathleen K. Sulik, PhD Anne Frances Walonker, CO Kenneth W. Wright, MD Sarah Ying, MD

x contributors

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