FIGURE 1 P=0.0067P>0.05P=0.029 CDE AB

30 40 50 60 70 80 90 100 110 II-V stages Asym.-I stage Ctrl 30 40 50 60 70 80 90 100 110 I stage Asym. Ctrl II

stage stageIII stageIV-V

20 30 40 50 60 70 80 90 100 110 35 40 45 50 55 60 65 70 75 80 85

CAG repeat expansion in symptomatic patients

20 30 40 50 60 70 80 90 100 110 0 1 2 3 4 5 6 7 8 9 10

Disability scale unit loss per year P=0.0003 P=0.0062 P=0.0003 P=0.005 P=0.017 P=0.04 Serum TG F-β1 levels (n g/ m l) Serum TG F-β1 levels (n g/ m l) Serum TG F-β1 levels (n g/ m l) Serum TG F-β1 levels (n g/ m l)

A

B

CAG repeat expansion in asymptomatic subjects

C

D

E

P=0.0067

P>0.05

P=0.029

FIGURE 1