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ADRENOMEDULLIN IN

CARDIOVASCULAR DISEASE

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BASIC SCIENCE FOR THE CARDIOLOGIST

1. B. Swynghedauw (ed.): Molecular Cardiology for the Cardiologist. Second Edition. 1998 ISBN 0-7923-8323-0 2. B. Levy, A. Tedgui (eds.): Biology of the Arterial Wall. 1999

ISBN0-7923-8458-X 3. M.R. Sanders, J.B. Kostis (eds.): Molecular Cardiology in Clinical

Practice. 1999 ISBN 0-7923-8602-7 4. B.Ostadal, F. Kolar (eds.): Cardiac Ischemia: From Injury to Protection. 1999

ISBN 0-7923-8642-6 5. H. Schunkert, G.A.J. Riegger (eds.): Apoptosis in Cardiac Biology. 1999

ISBN 0-7923-8648-5 6. A. Malliani, (ed.): Principles of Cardiovascular Neural Regulation in Health

and Disease. 2000 ISBN 0-7923-7775-3 7. P. Benlian: Genetics of Dyslipidemia. 2001 ISBN 0-7923-7362-6 8. D. Young: Role of Potassium in Preventive Cardiovascular Medicine. 2001

ISBN 0-7923-7376-6 9. E. Carmeliet, J. Vereecke: Cardiac Cellular Electrophysiology. 2001

ISBN 0-7923-7544-0 10. C. Holubarsch: Mechanics and Energetics of the Myocardium. 2002

ISBN 0-7923-7570-X 11. J.S. Ingwall: ATP and the Heart. 2002 ISBN 1-4020-7093-4 12. W.C. De Mello, MJ. Janse: Heart Cell Coupling and Impuse Propagation in

Health and Disease. 2002 ISBN 1 -4020-7182-5 13. P.P.-Dimitrow: Coronary Flow Reserve - Measurement and Application: Focus

on transthoracic Doppler echocardiography. 2002 ISBN 1 -4020-7213-9 14. G.A. Danieli: Genetics and Genomics for the Cardiologist. 2002

ISBN 1-4020-7309-7

15. F.A. Schneider, I.R. Siska, J.A. Avram: Clinical Physiology of the Venous System.

2003. ISBN 1-4020-7411-5 16. Can Ince: Physiological Genomics of the Critically III Mouse. 2004

ISBN 1-4020-7641-X 17. Wolfgang Schaper, Jutta Schaper: Arteriogenesis. 2004

ISBN 1-4020-8125-1 elSBN 1-4020-8126-X

18. Nico Westerhof, Nikos Stergiopulos, Mark I.M. Noble: Snapshots of Hemodynamics:

An aid for clinical research and graduate education. 2005

ISBN 0-387-23345-8 elSBN 0-387-23346-6 19. Toshio Nishikimi: Adrenomedullin in Cardiovascular Disease, 2005

ISBN 0-387-25404-8

elSBN 0-387-25405-6

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ADRENOMEDULLIN IN CARDIOVASCULAR DISEASE

edited by

TOSHIO NISHIKIMI

Department of Hypertension and Cardiorenal Medicine

Dokkyo University School of Medicine Tochigi, Japan

fyj Springer

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Toshio Nishikimi, MD, PhD

Department of Hypertension and Cardiorenal Medicine Dokkyo University School of Medicine

Mibu, Tochigi Japan

Library of Congress Cataloging-in-Publication Data A C.I.P. Catalogue record for this book is available from the Library of Congress.

ISBN-10: 0-387-25404-8 e-ISBN 0-387-25405-6 Printed on acid-free paper.

ISBN-13: 978-0387-25404-3 e-ISBN 978-0387-25405-0

© 2005 Springer Science+Business Media, Inc.

All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now know or hereafter developed is forbidden.

The use in this publication of trade names, trademarks, service marks and similar terms, even if the are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.

Printed in the United States of America.

9 8 7 6 5 4 3 2 1 SPIN 11053873 springeronline.com

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CONTENTS

Introduction Toshio Nishikimi

Chapter 1. Biochemistry of Adrenomedullin Kazuo Kitamura, Kenji Kangawa, and Tanenao Eto

Chapter 2. Adrenomedullin Receptor and Signal Transduction

Takanobu Yoshimoto and Yukio Hirata

17

Chapter 3. Adrenomedullin Gene

Toshihiko Ishimitsu, Kohju Tsukada, Junichi Minami, Hidehiko Ono, and Hiroaki Matsuoka

41

Chapter 4. Adrenomedullin Expression and Secretion

Naoto Minamino

61

Chapter 5. Biological Action of Adrenomedullin Takeshi Horio and Fumiki Yoshihara

83

Chapter 6. Circulating Adrenomedullin Toshio Nishikimi

105

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Chapter 7. Role of Adrenomedullin in Cardiovascular Disease Johji Kato and Tanenao Eto

131

Chapter 8. Adrenomedullin as an Adipokine Kazuhiro Takahashi

155

Chapter 9. Adrenomedullin Knockout Mouse and Transgenic Mouse

Takayuki Shindo

167

Chapter 10. Pleiotropic Effect of Adrenomedullin:

Lessons from Pure Adrenomedullin Knockout Mouse

Tatsuo Shimosawa, Katsuyuki Ando, and Toshiro Fujita

175

Chapter 11. Therapeutic Application of Adrenomedullin

Toshio Nishikimi, Noritoshi Nagaya, Kenji Kangawa, and Hiroaki Matsuoka

187

Chapter 12. Therapeutic Potentials of

Adrenomedullin for Heart Failure and Pulmonary Hypertension

Noritoshi Nagaya, Toshio Nishikimi, and Kenji Kangawa

199

Index 215

VI

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Contributing Authors

Ando, Katsuyuki Eto, Tanenao

Department of Nephrology and First Department of Internal Endocrinology, University of Tokyo, Medicine, Miyazaki Medical Tokyo, Japan College, University of Miyazaki,

Kiyotake, Miyazaki, Japan.

Fujita, Toshiro Hirata, Yukio

Department of Nephrology and Department of Clinical and Endocrinology, University of Tokyo, Molecular Endocrinology, Tokyo Tokyo, Japan Medical and Dental University

Graduate School, Tokyo, Japan

Horio, Takeshi

Department of Medicine, National Cardiovascular Center, Osaka, Japan

Ishimitsu, Toshihiko

Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan

Kangawa, Kenji

Department of Biochemistry, National Cardiovascular Research Institute, Osaka, Japan

Kato, Johji

First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan.

Kitamura, Kazuo

First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan.

Matsuoka, Hiroaki

Department of Hypertension and

Cardiorenal Medicine, Dokkyo

University School of Medicine,

Tochigi, Japan

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Minami, Junichi

Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan

Minamino, Naoto

Department of Pharmacology, National Cardiovascular Research Institute, Osaka, Japan

Nagaya, Noritoshi

Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Research Institute, Osaka, Japan

Nishikimi, Toshio

Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan

Ono, Hidehiko

Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan

Shimosawa, Tatsuo

Department of Nephrology and Endocrinology, University of Tokyo, Tokyo,Japan

Shindo, Takayuki

Department of Cardiovascular Medicine, University of Tokyo, Tokyo,Japan

Takahashi, Kazuhiro

Department of Molecular Biology and Applied Physiology,Tohoku University School of Medicine, Sendai, Japan

Tsukada, Kohju

Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan

Yoshimoto, Takanobu Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

Yoshihara, Fumiki

Department of Medicine, National Cardiovascular Center, Osaka, Japan

vill

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