p • ACNE AND RELATED DISORDER5
P33 - Prevenlion of relapses in patients previously treated with oral isotrelinoin for severe acne. Resulls of a multicentre, randomized, retrospective, sponsor-free sludy
S, Vera/di " M, BarfJareschi , A. Ferla Lodigiani , S, Cavicchini' , R. Schianchi2
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l Dipartlmenlo di AnestesIologia, Terapia Intensiva e SCienze Dermatologiche. Umversità degli Studi di Milano. Fondazione I.R.C.C.S.• Cà Granda Ospedale Maggiore Policlinico. Milan, ltaly,2European Inslitute of Dermatology, Milan, ltaly
Introduction: After a systemic trealment with oraI isotretinoin. acne therapy must be continued with topical products in order to avoid possible relapses. The aim of this study was to assess whether a topical retinoid is an effective choice in the prevention of relapses.
Methods: Patients who were successfully treated with oral isotrelinoin for severe acne, allhe end of lhe therapy were randomized Inlo !WO groups: lha firsl one was lrealed wilh a topical relinoid (0.05% trelinoin or 0.05% isotrelinoin or 0.1 % adapalene, 1 applicalion/day for 6·8 monlhs); lhe second group was nollrealed (only delergents and moislurizers were allowed). Follow up was >6 monlhs.
Results: Allhe end of lhe sludy, 2/37 palients (5.4%) lrealed with lopical' retinoids developed a relapse; in lhe group of palients who were noi treated, 7/31 palients (22.6%) developed a relapse (p< 0.05).
Conclusions: On lhe basis of lha resulls of this study, lopical relinoids are helpful in lhe prevenlion of relapses of acne in palienls previously trealed wilh oral isolrelinoin.
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