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EFFECT OF A NEW INFANT FORMULA ENRICHED WITH PREBIOTICS, PROBIOTICS, NUCLEOTIDES AND LC-PUFA ON RECOVERY AFTER INFECTION

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EFFECT OF A NEW INFANT FORMULA ENRICHED WITH PREBIOTICS,

PROBIOTICS, NUCLEOTIDES AND LC-PUFA ON RECOVERY AFTER INFECTION

M. Rivero

1

, A. Roca

2

, R. Chifré

1

, M. Conde

1

, M. Rodriguez

1

, A.

Santamaria

1

, .Gemma Colomé

3

1

Scientific Department, Laboratorios Ordesa, Sant Boi del Llobregat, Barcelona, Spain,

2

Paediatric Area, Hea

2

lth-Service La Florida, Barcelona, Spain,

3

Pediatric Gastroenterology Unit, Hospital Carlos Haya, Málaga, Spain

Introduction: During early life, infections are one of the main causes of disease. The aim of our study was to evaluate the effect of a new infant formula enriched with prebiotics, probiotics, nucleotides and LC-PUFAs with a low lactose content in infant recovery after different kinds of infections (respiratory, digestive...).

Methods: A multicentre, randomised, prospective out-patients clinical trial was conducted. 68 infants aged 12 months and younger, with a non-severe infection were distributed in 2 groups: control group and study (RE) group. Infants younger than 4 months were fed with an infant formula and infants from 5 to 12 months with a follow-on formula. Control group infants were fed standard infant and follow-on formula. RE group infants were fed with infant and follow-on formula enriched with prebiotics (galacto-oligosaccharides, nucleotides and LC- PUFA and with a low level of lactose. Follow-on formula used in the feeding of infants of RE group also contained probiotics (Lactobacillus rhamnosus (( and Bifidobacterium infantis). Clinical symptoms and duration if the infection was recorded at 0, 5, 10 and 15d to know the evolution of infants recovery.

Results: Appetite was recovered by day 6 in infants of RE group and by day 11 in Control group(p<0,001)Weight recovery took place by the 5th day in RE group and by day 12 in the Control group(p<0,0001)... Group RE showed a statistically significant reduction in the duration of digestive symptoms like vomiting and diarrhoea (p=0,04) in comparison with Control group. The mean duration of diarrhoea in Control group was 9 d and 4,8d in RE group. Taken into account all the variables, the global recovery of infants was quicker in group RE than in Control group (7,5 days for group RE and 11,7 days for Control group, p=0,0003).

Conclusions: The new range of infant formula enriched with prebiotics

(galacto-oligosaccharides), probiotics , nucleotides and LC-PUFAs with a low

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EFFECT OF NEW INFANT FORMULA 187 level of lactose has been shown to be useful. It can achieve a complete and fast recovery for infants suffering digestive or respiratory infections.

Keywords: Infant formula, prebiotics, probiotics, nucleotides, LC-PUFAs.

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