Aiello E.A., Clement-Chomienne O., Sontag D.P., Walsh M.P., Cole W.C., 1996, Proteine kinase C inhibits delayed rectifier K+ current in rabbit vascular smooth muscle cells, Am. J. Physiol., 271, 109-119.

(1)

BIBLIOGRAFIA

Adelman J.P., Shen K.Z., Kavanaugh M.P., Warren R.A., Wu Y.N., Lagrutta A., 1992, Calcium-activated potassium channels expressed from cloned complementary DNAs, Neuron., 9, 209-216.

Aguilar-Bryan L., Clement J.P.I.V., Gonzales G., Kunjilwar K., Babenko A., Bryan J., 1998, Toward understanding the assembly and structure of KATP channels, Physiol. Rev., 78, 227-245.

Aiello E.A., Clement-Chomienne O., Sontag D.P., Walsh M.P., Cole W.C., 1996, Proteine kinase C inhibits delayed rectifier K+ current in rabbit vascular smooth muscle cells, Am. J. Physiol., 271, 109-119.

Amberg G.C., Santana L.F., 2003, Downregulation of the BK channel β1-subunit in genetic hypertension, Circ. Res., 93, 965-971.

Amberg G.C., Bonev A.D., Rossow C.F., Nelson M.T., Santana L.F., 2003, Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension, J. Clin. Invest., 112, 717-724.

Ashcroft F.M., Gribble F.M., 2000, New windows on the mechanism of action of KATP channel openers, Trends Pharmacol. Sci., 21, 439-445.

Ashcroft S.J.H., 2000, The β-cell KATP channel, J. Membr. Biol., 176, 187-206.

Atkinson N.S., Robertson G.A., Ganetzky B., 1991, A component of calcium- activated potassium channels encoded by the Drosophila slo locus, Science, 253, 551-555.

Attali B., Romey G., Honorè E., Schmild-Allina A., Mattei M.G., Lesage F., Ricard P., Barhanin J., Lazdunski M., 1992, Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes, J. Biol. Chem., 267, 8650-8657.

Bang L., Nielsen-Kudsk J.E., Gruhn N., Trautner S., Theilgaard S.A., Olesen S.P., Boesgaard S., Aldershvile J., 1998, Hydralazine-induced vasodilatation involves opening of high conductance Ca2+-activated K+ channels, Eur. J. Pharmacol., 361, 43-49.

Biagi G., Giorgi I., Livi O., Scartoni V., Barili P.L., Calderone V., Martinotti E.,

2001, New 5-substituted-1-(2-hydroxybenzoil)-benzotriazoles, potassium channel

activators.IV, Il Farmaco, 56, 827-834.

(2)

Biagi G., Giorgi I., Livi O., Nardi A., Calderone V., Martelli A., Martinotti E., Le Roy Salerni O., 2004, Synthesys and biological activity of novel substituted benzanilides as potassium channel activators, Eur. J. Med. Chem., 39, 491-498.

Bolotina V.M., Najibi S., Palacino J.J., Pagano P.J., Cohen R.A., 1994, Nitric Oxide directly activates calcium-dependent potassium channels in vascular smooth muscle, Nature, 368, 850-853.

Brenner R., Perez G.J., Bonev A.D., Eckman D.M., Kosek J.C., Wiler S.W., 2000, Vasoregulation by the beta 1 subunit of the calcium-activated potassium channel, Nature 407, 870-876.

Brenner R., Jegla T.J., Wickenden A., Liu Y., Aldrich R.W., 2000, Cloning and functional characterization of a novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4, J. Biol. Chem. 275, 6453-6461.

Brugnara C., de Franceschi L., Alper S.L., 1993, Inhibition of Ca+2-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivates, J. Clin. Invest., 92, 520-526.

Butera J.A., Antane S.A., Hirth B., Lennox J.R., Sheldon J.H., Norton N.W., Warga D., Argentieri T.M., 2001, Synthesis and potassium channel opening activity of substituted 10 H benzo (4,5) furo (3,2-b) indole-and 5,10-dihydro- indeno (1,2-b) indole-1-carboxilic acids, Bioorg. Med. Chem. Lett., 11, 2093- 2097.

Butler A., Tsunoda S., McCobb D.P., Wei A., Salkoff L., 1993, mSlo a complex mouse gene encoding maxi calcium-activated potassium channels, Science 261, 221-224.

Calderone V., Baragatti B., Rossi S., Nieri P., Martinotti E., 1999, Role of potassium channels in the GABA inhibitory action on the purinergic response to electrical field stimulation in rat isolated vas deferens, Pharm. Pharmacol.

Commun., 5, 407-409.

Calderone V., Chericoni S., Martinelli C., Testai L., Nardi A., Morelli I., 2004, Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels, Naunyn Schmiedebergs Arch Pharmacol. 370, 290-298.

Calderone V., 2002, Large-conduttance, Ca(2+)-activated K(+) channels:

function, pharmacology and drugs, Curr. Med. Chem., 9(14), 1385-1395.

Calderone V., Martelli A., Testai L., Martinotti E., Breschi M.C., 2007,

Functional contribution of the endothelial component to the vasorelaxing effect of

resveratrol and NS-1619, activators of the large-conductance calcium-activated

potassium channel, Naunyn Schmiedebergs Arch Pharmacol., 375, 73-80.

(3)

Calderone V., Fiamingo F.L., Amato G., Giorgi I., Livi O., Martelli A., Martinotti E., 2008, New amido derivates as potential BKCa potassium channel activators, European J. Of Med. Chem., 43, 792-799.

Calderone V., Fiamingo F.L., Amato G., Giorgi I., Livi O., Martelli A., Martinotti E., 2008, 1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators, European J. Of Med. Chem., 43, 2618-2626.

Campos Rosa J., Galanakis D., Piergentili A., Bhandari K., Ganellin C.R., Dunn P.M., Jenkinson D.H., 2000, Synthesis, molecular modeling and pharmacological testing of bis-quinolinium cyclophanes: potent, non peptidic blockers of the apamin-sensitive Ca+2-activated K+ channel, J. Med. Chem., 43, 420-431.

Candia S., Garcia M.L., Latorre R., 1992, Mode of action of iberiotoxin, a blocker of the large conductance Ca2+-activated K+ channel, Biophys. J., 63, 583-590.

Chandy K.G., Gutman G.A., 1995, Voltage-gated potassium channels. In Ligand and Voltage-Gated Ion Channels, North, A., Eds., CRC Press: Boca Raton, FL, 1- 71.

Chang T.C., Wu L., Wang R., 2006, Altered expression of BK channel β1-subunit in vascular tissues from spontaneously hypertensive rats, Am. J. Hyper., 19, 678- 685.

Chen M.L., Hoshi T., Wu C.F., 1996, Heteromultimeric interactions among K+

channel subunits from Shaker and eag families in Xenopus oocytes, Neuron.

17(3), 535-542.

Choi K.L., Aldrich R.W., Yellen G., 1991, Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels, Proc. Natl. Acad. Sci. U.S.A., 88(12), 5092-5095.

Clement J.P., Kunjilwar K., Gonzales G., Schwanstecher M., Panten U., Aguilar- Bryan L., Bryan L., 1997, Association and stoichiometry of KATP channel subunits, Neuron., 18, 827-838.

Coghlan M.J., Carrol W.M., Gopalakrishnan M., 2001, Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress, J. Med. Chem., 44,1627-1653.

Cook N.S., 1990, K+ channels: structure, classification, function and therapeutic potential, Ellis Horwood Limited: Suthampton.

Cook S.J., Archer K., Martin A., Buchheit K.H., Fozard J.R., Muller T., Miller A.J., Elliott K.R., Foster R.W., Small R.C., 1995, Evidence that K+ channel opening is not important in the tracheal relaxant action of SCA-40, Br. J.

Pharmacol., 114, 143-151.

(4)

Covarrubias M., Wei A.A., Salkoff L., 1991, Shaker, Shal, Shab, and Shaw express independent K+ current systems, Neuron, 7(5), 763-773.

Da Silva-Santos E.J., Assreuy J, 1999, Long lasting changes of rat blood pressure to vasocostrictors and vasodilators induced by nitric oxide donor infusion:

involvement of potassium channels, J. Pharmacol. Exp. Ther., 290, 380-387.

Deutsch C., Price M., Lee S., King V.F., Garcia M.L., 1991, Characterization of high affinity binding sites for charybdotoxin in human T lymphocytes. Evidence for association with the voltage-gated potassium channel, J. Biol. Chem., 266, 3668-3674.

Dimitropoulou C., White R.E., Fuchs L., Zhang H., Catravas J.D., Carrier G.O., 2001, Angiotensin II relaxes microvessels via the AT (2) receptor and Ca2+

activated K+ (BKCa) channels, Hypertension, 37, 301-307.

Dimitropoulou C., Han G., Miller A.W., Molero M., Fuchs L.C., White R.E., 2002, Potassium BKCa currents are reduced in microvascular smooth muscle cells from insulin-resistant rats, Am. J. Physiol. Heart Circ. Physiol., 282, 908- 917.

Doyle D.A., Morais Cabral J., Pfuetzner R.A., Kho A., Gulbis J.M., Cohen S.N., Chait B.T., MacKinnon R., 1998, The structure of the potassium channel:

molecular basis of K+ conduction and selectivity, Science (Wash D.C.), 280, 69- 77.

Dumas S., Javoy-Agid F., Hirsch E., Agid Y., Mallet J., 1990, Tyrosine hydroxylase gene expression in human ventral mesencephalon: detection of tyrosine hydroxylase messenger RNA in neuritis, J. Neurosci Res., 25,569-575

Dworetzky S.I., Trojnacki J.T., Gribkoff V.K., 1994, Cloning and expression of a human large-conductance calcium-activated potassium channel, Brain Res. Mol.

Brain Res., 27, 189-193.

Faraci F.M., Heistad D.D., 1998, Regulation of the cerebral circulation: role of endothelium and potassium channels, Physiol. Rev., 78, 53-97.

Feletou M., Vanhoutte P.M., 1999, The third pathway: endothelium-dependent hyperpolarization, J. Physiol. Pharmacol., 50, 525-534.

Ficker E., Taglialatela M., Wible B.A., Henley C.M., Brown A.M., 1994, Spermine and Spermidine as gating molecules for inward rectifier K+ channels, Science, 266, 1068-1072.

Fletcher J.I., Wang X., Connor M., Christie M.J., King G.F., Nicholson G.M., 1999, Spider toxins. A new group of potassium channel modulators, Perspect.

Drug Discovery Des., 15, 61-69.

(5)

Galanakis D., Davis C.A., Ganellin C.R., Dunn P.M., 1996, Synthesis and quantitative Structure-activity relationship of a novel series of small conductance Ca+2 activated K+ channel blockers related to dequalinium, J. Med. Chem., 39, 359-370.

Garcia M.L., Giacobbe R.A., Hensen O.D., Lee S.H., McManus O.B., 1995, Indole diterpene alkaloid compounds, International Patent Application, WO 95/19771.

Ghatta S., Nimmagadda D., Xu X., O’Rourke S.T., 2006, Large conductance, calcium-activated potassium channels: structural and functional implications, Pharmacol. Ther., 110, 103-106.

Goodman S.R., Pace B.S., Shartava A., 1998, New therapeutic approaches to sickle cell disease: targeting RBC membrane oxidative damage, Cell. Mol. Biol.

Lett., 3, 403-411.

Gribkoff V.K., Meanwell N.A., Martin S.W., Hewawasam P., Romine J., Starret J.E., 1998, Diphenylheterocycles as potassium channels modulators, Inter. Patent Applic., WO 9804135.

Gribkoff V.K., Starret J.E., Dworetzsky S.T., 2001, Maxi-K potassium channels:

form, function and modulation of a class of endogenous regulators of intracellular calcium, Neurosc., 7, 166-177.

Hai C.M., Murphy R.A., 1989, Ca2+, crossbridge phosphorylation, and contraction, Annu. Rev. Physiol., 51, 258-298 (a).

Hai C.M., Murphy R.A., 1989, Crossbridge phosphorylation and the energetic of contraction in the swinw carotid media, Prog. Clin. Biol. Res., 315, 253-263 (b).

Hai C.M., Murphy R.A., 1989, Cross-bridge dephosphorylation and relaxation of vascular smooth muscle, Am. J. Physiol., 256, 282-287 (c).

Hanner M., Vianna-Jorge R., Kamassah A., Schmalhofer W.A., Knaus H.G., Kaczorowski G.J., Garcia M.L., 1998, The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding, J. Biol. Chem. 273(26), 16289-16296.

Hermann A., Gorman A.L., 1981, Effects of 4-amminopyridine on potassium currents in a molluscan neuron, J. Gen. Physiol., 78, 63-86.

Herrera G.M., Heppner T.J., Nelson M.T., 2000, Regulation of urinary bladder

smooth muscle contractions by ryanodine receptors and BK and SK channels,

Am. J. Physiol., 279, 60-68.

(6)

Hewawasam P., Starret J.E., Swartz S.G., 1999, Preparation of 4-aryl-3- aminoquinoline-2-ones as potassium channel modulators, International Patent Application, WO9909983.

Hewawasam P., Gribkoff V.K., Dworetzky S.I., Ortiz A.A., Kinney G.G., Boisard C.G., Post-Munson D.J., Trojnacki J.T., Huston K., Signor L.J., Lombardo L.L., Reid S.A., Hibbard J.R., Myers R.A., Moon S.L., Wiener H.L., Thalody G., Yeleswaram K., Pajor L.M., Knipe J.O., Meanwell N.A., Johnson G., Molinoff P.B., Starret J.E., Gao Q., 2000, Discovery of openers of large conductance, calcium-activated potassium channels: a new approach to stroke neuroprotection.

219

^th

ACS National Meeting, San Francisco, March 25-29.

Hille B., 1992, Ionic channels of excitable membranes, 2

^nd

ed., Sinauer Associates: Sunderland, MA.

Hoshi T., Zagotta W.N., Aldrich R.W., 1990, Biophysical and molecular mechanism of Shaker potassium channel inactivation, Science, 250(4980), 533- 538.

Hu S., Fink C.A., Kim H.S., Lappe H.W., 1997, Novel and potent BK channel openers: CGS-7181 and its analogs, Drug Dev. Res., 41, 10-21.

Ikebe M., Koretz J., Hartshorne D.J., 1988, Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the proerties and conformation of smooth muscle myosin, J. Biol. Chem., 263, 6432-6437.

Ikemoto Y., Yoshida A., Oda M., 1992, Blockade by trifluoperazine of the Ca(2+)-activated K+ canne in rat hippocampal pyramidal neurons, Eur. J.

Pharmacol., 216(2), 191-198.

Imaizumi Y., Sakamoto K., Yamada A., Hotta A., Susumu O., Muraki K., Uchiyama M., Ohwada T., 2002, Molecular bases of pimazone compounds as novel activator of large-conductance Ca2+-activated K+channel alpha subunit, Mol. Pharmacol., 62, 836-846.

Ishii T.M., Silvia C., Hirschberg B., Bond C.T., Adelman J.P., 1997, Maylie J., A human intermediate conductance calcium-activated potassium channel, Proc.

Natl. Acad. Sci. U.S.A., 94(21), 11651-11656.

Isomoto S., Kondo C., Yamada M., Matsumoto S., Higashiguchi O., Horio Y., Matsusawa Y., Kurachi Y., 1996, A novel sulphonylureareceptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel, J. Biol. Chem., 271, 24321-24324.

Jacob M.K., White R.E., 2000, Diazepam, gamma-aminobutyric acid, and progesterone open K+ channels in myocytes from coronary arteries, Eur. J.

Pharmacol., 403, 209-219.

(7)

Jaggar J.H., Porter V.A., Lederer W.J., Nelson M.T., 2000, Calcium sparks in smooth muscle, Am. J. Physiol. Cell. Physiol., 278, 235-236.

Jensen B.S., Odum N., Jorgensen N.K., Christophersen P., Olesen N.P., 1999, Inhibition of T cell proliferation by selective block of Ca+2 activated K+

channels, Proc. Natl. Acad. Sci. USA, 96, 10917-10921.

Jiang Z., Wallner M., Meera P., Toro L., 1999, Human and rodent maxi-K channel beta-subunit genes: cloning and characterization, Genomics, 55, 57-67.

Jiang Y., Pico A., Cadene M., Chait B.T., MacKinnon R., 2001, Structure of the RCK domain from the E.Coli K+ channel and demonstration of its presence in the human BK channel, Neuron., 29, 593-601.

Jiang Y., Lee A., Chen J., Cadene M., Chait B.T., MacKinnon R., 2002, Crystal structure and mechanism of a calcium-gated potassium channel, Nature, 417, 515-522.

Joiner W.J., Wang L.Y., Tang M.D., Kaczmarek L.K., 1997, hSK4, a member of novel subfamily of calcium-activated potassium channels, Proc. Natl. Acad. Sci.

U.S.A., 94(20), 11013-11018.

Kaczorowski G.J., Knaus H.G., Leonard R.J., McManus O.B., Garcia M.L., 1996, High-conductance calcium-activated potassium channels; structure, pharmacology, and function, J. Bioenerg. Biomembr., 28(3), 255-267.

Kaczorowski G.J., Garcia M.L., 1999, Pharmacology of voltage-gated and calcium-activated potassium channels, Current. Opin. Chem. Biol., 3, 448-458.

Knaus H.G., Folander K., Garcia-Calvo M., Garcia M.L., Kaczorowski G.J., Smith M., 1994, Primary sequenze and immunological characterization of beta- subunit of high conductance Ca+2-activated K+ channel from smooth muscle, J.

Biol. Chem., 269, 17274-17278.

Kohler M., Hirschberg B., Bond C.T., Kinzie J.M., Marrion N.V., Maylie J., Adelman J.P., 1996, Small-conductance, calcium-activated potassium channels from mammalian brain, Science, 273, 1709-1714.

Kong I.D., Koh S.D., Sanders K.M., 2000, Purinergic activation of spontaneous transient outward currents in guinea pig taenia colonic myocytes, Am. J. Physiol., 278, 352-362.

Kume H., Takai A., Tokuno H., Tomita T., 1989, Regulation of Ca2+-dependent

K+ channel activity in tracheal myocytes by phosphorilation, Nature, 341, 152-

154.

(8)

Kume H., Mikawa K., Takagi K., Kotlikoff M.I., 1995, Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle, Am. J. Physiol., 268, L221-L229.

Laurent F., Michel A., Bonnet P.A., Chapat J.P., Boucard M., 1993, Evaluation of the relaxant effects of SCA-40, a novel charybdotoxin-sensitive potassium channel opener, in guinea pig isolated trachealis, Br. J. Pharmacol., 108, 622-626.

Lawson K., 1996, Potassium channel activation: a potential therapeutic approach, Pharmacol Ther., 70, 39-63.

Lehmann-Horn F., Jurkat-Rott K., 1999, Voltage-gated ion channels and hereditary disease, Physiol. Rev., 79(4), 1312-1372.

Li L., Vapaatalo H., Vaali K., Paakkari I., Kankaanranta H., 1998, Flufenamic and tolfenamic acids and lemakalim relax guinea pig isolated trachea by different mechanism, Life Sci., 62, 303-308.

Li H.F., Chen S.A., Wu S.N., 2000, Evidence for the stimulatory effect of resveratrol on Ca2+ activated K+ current in vascular endothelial cells, Cardiovasc. Res., 45, 1035-1045.

Logsdon N.J., Kang J., Togo J.A., Christian E.P., Airtayrar J., 1997, A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes, J. of Biol. Chem., 272, 32723-32726.

Lopez G.A., Jan Y.N., Jan L.Y., 1994, Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore, Nature, 367(6459), 179- 182.

Lu T., Katakam P.V., VanRollins M., Weintraub N.L., Spector A.A., Lee H.C., 2001, Dihydroxyeicosatrienoic acids are potent activators of Ca2+-activated K+

channels in isolated rat coronary arterial myocytes, J. Physiol., 534, 651-667.

Lu T., He T., Katusic Z.S., Lee H.C., 2006, Molecular Mechanism Mediating Inhibition of Human Large Conductance Ca2+-activated K+ channels by High Glucose, Circ. Res., 99, 607-616.

MacKinnon R., Miller C., 1998, Mechanism of charybdotoxin block of the high conductance, Ca+2-activated K+ channel, J. Gen. Physiol., 91, 335-349.

Mannhold R., 2004, KATP channel openers: structure-activity relationship and therapeutic potential, Med. Res. Rev., 24, 213-266.

Marjiic J., Li Q.X., Nishimaru K., Stefani E., Toro L., 2001, Decreased

Expression of Voltage- and Ca2+-Activated K+ channels in Coronary Smooth

Muscle During Aging, Circ. Res., 88, 210-216.

(9)

McManus O.B., Harris G.H., Giangiacomo K.M., Feigenbaum P., Reuben J.P., Addy M.E., Burka J.F., Kaczorowski G.J., Garcia M.L., 1993, An activator of calcium dependent potassium channels isolated from a medicinal herb, Biochem., 32, 6128-6133.

McManus O.B., Helms L.M., Pallanck L., Ganetsky B., Swanson R., Leonard R.J., 1995, Functional role of the beta subunit of high conductance calcium activated potassium channels, Neuron., 14, 645-650.

Means A.R., VanBerkum M.F.A., Bagchi I., Lu K.P., Rasmussen C.D., 1991, Regulatory functions of calmodulin, Pharmacol. Ther., 50, 255-270.

Meera P., Wallner M., Toro L., 2000, A neuronal beta subunit (KCNMB4) makes the large conductance, voltage and Ca+2-activated K+ channel resistant to charybdotoxin and iberiotoxin, Proc. Natl. Acad Sci USA, 97, 5562-5567.

Merkel L.A., Lappe R.W., Rivera L.M., Cox B.F., Perrone M.H., 1992, Demonstration of vasorelaxant activity with an A

1

-selective adenosine agonist in porcine coronary artery: involvement of potassium channels, Journ. of Pharmacol.

Exper. Therap., 260, 437-443.

Miller C., Moczydlowski E., Latorre R., Philips M., 1985, Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle, Nature, 313, 316-318.

Nagano N., Imaizumi Y., Hirano M., Watanabe M., 1996, Opening of Ca

²⁺

- dependent K+ channels by nordihydroguaiaretic acid in porcine coronary arterial smooth muscle cells, Jpn. J. Pharmacol., 70, 281-284.

Nakhostine N., Lamontagne D., 1993, Adenosine contributes to hypoxia-induced vasodilation through ATP-sensitive K

⁺

channel activation, Am. J. Physiol., 265, 1289-1293.

Navarro-Antolìn J., Levitsky K.L., Caldéron E., Ordòñez A., Lòpez-Barneo J., 2005, Decreased Expression of Maxi-K+ Channel β1-subunit and Atered Vasoregulation in Hypoxia, Circulation, 112, 1309-1315.

Nelson M.T., Patlak J.B., Worley J.F., Standen N.B., 1990, Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone, Am.

J. Physiol., 259, C3-18.

Nelson M.T., Quayle J.M., 1995, Physiological roles and propertyies of potassium channels in arterial smooth muscle, Am J Physiol., 268, 799-822.

Nichols C.G., 2006, KATP channels as molecular sensor of cellular metabolism,

Nature, 440, 470-476.

(10)

Ocana M., Cendan C.M., Cobos E.J., Entrena J.M., Baeyens J.M., 2004, Potassium channels and pain: present realities and future opportunities, Eur. J.

Pharmacol., 500(1-3), 203-219.

Ogata N., Yoshii M., Narahashi T., 1990, Differential block of sodium and calcium channels by chlorpromazine in mouse neuroblastoma cells, J. Physiol.

Lond., 420, 165-183.

Olesen S.P., Watjen F., 1992, Benzimidazolone derivatives, their preparation and use, European Patent Application, EP 0477819.

Olesen S.P., Munch E., Moldt P., Drejer J., 1994, Selective activation of Ca2+- dependent K+ channels by novel benzimidazolone, Eur. J. Pharmacol., 251, 53-59.

Olesen S.P., Moldt P., Pedersen O., 1994, Urea and amide derivatives and their use in the control of cell membrane potassium channels, International Patent Application, WO9422807.

Papazian D.M., Schwarz T.L., Tempel B.L, Jan Y.N., Jan L.Y., 1987, Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila, Science, 237, 749-753.

Papazian D.M., Timpe L.C., Jan Y.N., Jan L.Y., 1991, Alteration of voltage- dependence of Shaker potassium channel by mutations in the S4 sequence, Nature, 349, 305-310.

Papazian D.M., Timpe L.C., Jan Y.N., Jan L.Y., 1991, Alteration of voltage- dependence of Shaker potassium channel by mutations in the S4 sequence, Nature, 349, 1293-1301.

Papazian D.M., Shao X.M., Seoh S.A., Mock A.F., Huang Y., Wainstock D.H., 1995, Eletrostatic interations of S4 voltage sensor in Shaker K+ channel, Neuron., 14, 1293-1301.

Patterson A.J., Henrie-Olson J., Brenner R., 2002, Vasoregulation at the Molecular Level: A Role for the β1-subunit of the Calcium-Activated Potassium (BK) Channel, Trend Cardiovasc. Med., 12,78-82.

Pérez G., and Toro L., 1994, Differential modulation of large conductance K

Ca

channels by PKA in pregnant and non pregnant myometrium, Am. J. Physiol., 266, C1459-C1463.

Petkova-Kirova P., Gagov H., Krien U., Duridanova D., Noack T., Schubert R., 2000, 4-amminopyridine affects rat arterial smooth muscle BK(Ca) currents by changing intracellular pH, Br. J. Pharmacol., 131, 1643-1650.

Piskorowski R., Aldrich R.W., 2002, Calcium activation of BK(Ca) potassium

channels lacking the calcium bowl and RCK domains, Nature, 420, 499-502.

(11)

Pluger S., Faulhaber J., Furstenau M., Lohn M., Waldschutz R., Gollasch M., 2000, Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca+2 spark/STOC coupling and elevated blood pressure, Circ. Res., 87, 53-60.

Quan L., Sobey C.G., 2000, Selective effects of subarachnoid hemorrhage on vascular responses to 4-aminopyridine in rats, Stroke, 31, 2460-2465.

Quayle J.M., Nelson M.T., Standen N.B., 1997, ATP-sensitive and inwardly rectifying potassium channels in smooth muscle, Physiol. Rev, 77, 1165-1232.

Quast U., 1996, In potassium channels and their modulators: from synthesis to clinical experience, Evans Ed., Taylor and Francis, London, 173-195.

Ramanathan K., Michael T.H., Fuchs P.A., 2000, Beta-subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells, J. Neurosci., 20, 1675-1684.

Robertson D.W., Steinberg M.I., 1990, Potassium channel modulators: scientific applications and therapeutic promise, J. Med. Chem., 33, 1529-1541.

Roosild K.T., Le and S. Choe, 2004, Cytoplasmic gatekeepers of K+-channel flux: a structural prospective, Trends Biochem. Sci., 35, 99-107.

Schlichter L.C., Pahapill P.A., Schumacher P.A., 1993, Reciprocal regulation of potassium channels by calcium in intact human T lymphocytes, Recept. Channels, 1, 201-215.

Schreiber M. and Salkoff L., 1997, A novel calcium-sensing domain in the BK channel, Biophys. J., 73, 1355-1363.

Scornik F.S., Codina J., Birnbaumer L., Toro L., 1993, Modulation of coronary smooth muscle KCa channels by Gs alpha independent of phosphorilation by protein kinase A, Am. J. Physiol., 265, 1460-1465.

Seoh S.A., Sigg D., Papazian D.M., Bezanilla F., 1996, Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel, Neuron., 16, 1159-1167.

Shi D.H., Guo Z.G., 1996, Inhibitory effect of potassium channel openers on proliferation of cultured rabbit aortic smooth muscle cells, Zhongguo Yao Li Xue Bao, 17(6), 513-515.

Shieh C.C., Coghlan M., Sullivan J.P., Gopalakrishnan M., 2000, Potassium channels: molecular defects, disease and therapeutic opportunities, Pharmacol.

Rev., 52, 557-593.

Shyng S., Nichols C.G., 1997, Octameric stoichiometry of the KATP channel

complex, J. Gen. Physiol., 110, 655-664.

(12)

Shyng S.L., Nichols C.G., 1998, Membrane phospholipid control of nucleotide sensitivity of KATP channels, Science, 282, 1138-1141.

Siemen D., Loupatatzis C., Borecky J., Gulbins E., Lang F., 1999, Ca+2 activated K+ channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line, Biochem. Biophys. Res. Commun., 257, 549-554.

Singh B.S., Goetz M.A., Zink D.L., Dombrowski A.W., Polishook J.D., Garcia M.L., Schmalhofer W., McManus O.B., Kaczorowski G.J., 1994, Maxikdiol: a novel dihydroxysoprimane as an agonist of maxi-K channels, J. Chem. Soc.

Perkin Trans., 1, 3349-3352.

Slesinger P.A., Jan Y.N., Jan L.Y., 1993, The S4-S5 loop contributes to the ion- selective pore of potassium channels, Neuron, 11(4), 739-749.

Sobey C.G., Heistad D.D., Faraci F.M., 1998, K+ channels mediate dilatation of cerebral arterioles in response to arachidonate, Am. J. Physiol., 275, 1606-1612.

Sobey C.G., Faraci F.M., 1999, Inhibitory effect of 4-amminopyridine on responses of the basilar artery to nitric oxide, Br. J. Pharmacol., 126, 1437-1443.

Sobey C.G., 2001, Potassium channel function in vascular disease, Arterioscler Thromb Vasc Biol., 21, 28-38.

Stefani E., Ottolia M., Noceti F., Olcese R., Wallner M., Latorre R., 1997, Voltage-controlled gating in a large conductance Ca+2-sensitive K+ channel (hSlo), Proc. Natl. Acad. Sci. USA, 94, 5427-5431.

Szabo I., Bock J., Jekle A., Soddemann M., Adams C., Lang F., Zoratti M., Gulbins E., 2005, A novel potassium channel in lymphocyte mitochondria, J. Biol.

Chem., 280, 12790-12798.

Taglialatela M., Wible B.A., Caporaso R., Brown A.M., 1994, Specification of pore properties by the carboxyl terminus of inwardly rectifing K+ channels, Science, 264(5160), 844-847.

Tanaka Y., Koike K., Toro L., 2004, Maxi-K channel role in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms, J. Smooth Muscle Res., 40, 125-153.

Tanigichi J., Furukava K., Shigekawa M., 1993, Maxi K+ channels are stimulate by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells, Plügers Archiv., 423, 167-172.

Teramoto N., 2006, Physiological roles of ATP-sensitive K+ channels in smooth

muscle, J. Physiol., 572, 617-624.

(13)

Teuber L., Christophersen P., Strobaek D., Jensen B.S., 2000, Preparation of new benzimidazolones, or benzothiazolones as ion channel modulating agents, International Patent Application, WO200034248.

Toro L., Wallner M., Meera P., TanakaY., 1998, Maxi-K a unique member of the voltage gated K channel superfamily, News Physiol. Sci., 13, 112-117.

Tricarico D., Barbieri M., Mele A., Carbonara G., Camerino D.C., 2004, Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK canne of K+-deficient rats, FASEB J., 18(6), 760-761.

Vergara C., Latorre R., Marrion N.V., Adelman J.P., 1998, Calcium-actvated potassium channels, Curr. Opin. Neurobiol., 8, 321-329.

Vogalis F., 2000, Potassium channels in gastrointestinal smooth muscle, J. Auton.

Pharmacol., 20, 207-219.

Vogalis F., Storm J.F., Lancaster B., 2003, SK channels and the varieties of slow after-hyperpolarizations in neurons, Eur. J. Neurosci., 18, 3155-3166.

Volk K.A., Matsuda J.J., Shibata E.F., 1991, A voltage-dependent potassium current in rabbit coronary artery smooth muscle cells, J.Physiol. (Lond.), 439, 751-768.

Wallner M., Meera P., Toro L., 1996, Determinant for beta subunit regulation in high conductance voltage-activated and Ca+2-sensitive K+ channels: an additional transmembrane region at the N-terminus, Proc. Natl. Acad. Sci. USA, 93, 14922-14927.

Wallner M., Meera P., Toro L., 1999, Calcium-activated potassium channels in muscle and brain, Curr. Top. Membr., 46, 117-140.

Wallner M., Meera P., Toro L., 1999, Molecular basis of fast inactivation in voltage and Ca+2 activated K+ channels: a transmembrane beta-subunit homolog, Proc. Natl. Acad Sci USA, 96, 4137-4142.

Wang G., Lemos J.R., 1992, Tetrandine blocks a slow, large-conductance, Ca2+- activated K+ channel besides inhibiting a non-inactivating Ca2+ current in isolated nerve terminals of the rat neurohypophysis, Pflugers Arch., 421, 558-565.

Wang J., Zhou X.B., Wen H., Levitan I.B., 1999, Simultaneous binding of two protein kinases to a calcium-dependent potassium channel, J. Neurosci., 19, RC4.

Wei A., Solaro C., Lingle C., Salkoff L., 1994, Calcium sensitivity of BK type

KCa channels determined by a separable domain, Neuron., 13, 671-681.

(14)

White J.A., McAlpine P.J., Antonarakis S., Cann H., Eppig J.T., Frazer K., Frezal J., Lancet D., Nahmias J., Pearson P., et al., 1997, Guidelines for human gene nomenclature, 45, 468-471.

Woodman O.L., Wongsawatkul O., 2004, Ischaemia enhances the role of Ca2+- activated K+ channels in endothelium-dependent and nitric oxide-mediate dilation of the rat hindquarters vasculature, Clin. Exp. Pharmacol. Physiol., 31, 254-260.

Wu S.N., Li H.F., Shen A.Y., 1999, Activation of large-conductance Ca2+- activated K+ channels by pinacidil in human umbilical vascular endothelial cells, Drug. Dev. Res., 48, 6-16.

Wu S.N., 2003, Large-conductance Ca+2 activated K+ channel: physiological role and pharmacology, Curr. Med. Chem., 10, 649-661.

Xia X.M., Zeng X., Lingle C.J., 2002, Multiple regulatory sites in large- conductance calcium-activated potassium channels, Nature, 418, 880-884.

Yamada M., Isomoto S., Matsumoto S., Kondo C., Shindo C., Horio Y., Kurachi Y., 1997, Sulphonylurea receptor 2B and KIR6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channels, J.Physiol. (Lond.), 499, 715-720.

Zeng X., Xia X.M., Lingle C.J., 2005, Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites, J. Gen. Physiol., 125, 273-286.

ZhaoY.J., Wang J., Rubin L.J., Yuan X.J., 1997, Inhibition of K

V

and K

Ca

channels antagonizes NO-induced relaxation in polmunary artery, Am. J.

Physiol., 272, 904-912.

ZhaoY.J., Wang J., Rubin L.J., Yuan X.J., 1998, Roles of K+ and Cl- channels in cAMP-induced polmunary vasodilation, Exp. Lung. Res., 24, 71-83.

Zhou X.B., Arntz C., Kamm S., Motejlek K., Sausbier U., Wang G.X., 2001, A

molecular switch for specific stimulation of the BKCa channel by cGMP and

cAMP kinase, J. Biol. Chem., 276, 43239-43245.