Nealey, and C. J. Murphy, Biological length scale topography enhances cell- substratum adhesion of human corneal epithelial cells, J. Cell Science, vol.

(1)

[1] T.D. Barbara Nguyen-Vu, Hua Chen, Alan M. Cassel, Russel Andrews, Meyya Meyyappan, and Jun Li, Vertically Aligned Carbon Nanofiber Arrays: An Advanced toward Electrical-neural Iinterfaces, 2006

[2] N.W. Karuri, S. Liliensiek, A. I. Teixeira, G. Abrams, S. Campbell, P. F.

Nealey, and C. J. Murphy, Biological length scale topography enhances cell- substratum adhesion of human corneal epithelial cells, J. Cell Science, vol.

117, pp. 3153-3164, 2004.

[3] Ke Wang , Harvey A. Fishman, Hongjie Dai, and James S. Harris, Neural Stimulation with a Carbon Nanotube Microelectrode Array, 2006

[4] 21. T.D.B. Nguyen-Vu, H. Chen, A. M. Cassell, R. Andrews, M.

Meyyappan, and J. Li, “Vertically-Aligned Carbon Nanofiber Arrays: An Advance toward Electrical-Neural Interfaces”, Small, vol. 2, pp. 89-94, 2006.

[5] W.L.C. Rutten, Selective Electrical Interfaces with the Nervous System, Annu. Rev. Biomed. Eng., vol. 4, pp. 407-452, 2002.

[6] T.J. Webster, M.C. Waid, J. L. McKenzi, R.L. Price, and J.U. Ejiofor, Nano-biotechnology: carbon nanofibers as improved neural orthopedic implants, Nanotechnology, vol. 15, pp. 48-45, 2004.

[7] 12. M. Meyyappan, Carbon Nanotubes Science and Applications. CRC Press, Boca Raton, FL, 2005.

[8] S. Iijima, Helical microtubles of graphitic carbon,1991

(2)

[9] Tamir Gabay, Moti Ben-David, Itshak Kalifa, Raya Sorkin, Ze’ev R Abrams, Eshel Ben.Jacob, YaelHanein Electrochimical and Biological properties of carbon nanotubes based multi-electrode array, 2006

[10] Nancy A. Monteiro-Riviere, PhD, Alfred o:Inman, MS, Yung Y. Wang, PhD, Robert J.Nemanich, PhD, Surfactatnt effect on carbon nanotubi interaction with human Keratinocytes, 2005

[11] Frank A.Witzmann, Nancy A. Monteiro-Riviere, PhD Multiwalled carbon nanotubi exposure alters protein expression in human Keratinocytes, 2006

[12] S.K.Smart, A.I. Cassady, G.Q.Lu, D.J. Martin, The biocompatibility of carbon nanotube, 2006

[13] T.D. Barbara Nguyen-Vu, Hua Chen, Alan M. Cassel, Russel Andrews, Meyya Meyyappan, and Jun Li, Vertically Aligned Carbon Nanofiber Architecture as a Multifunctional 3D Neural Electrical Interface,

[14] D.E. Discher, P. Janmey, and Y.L.Wang, Tissue Cells Feel and Respond to the Stiffness of Their Substrate, Science, vol. 310, pp. 1139-11343, 2005.

[15] A. Brock, E. Chang, C.-C. Ho, P. LeDuc, X. Jiang, G. M. Whitesides, and D. E. Ingber, Geometric Deteminats of Directional Cell Motility Revealed Using Mircocontact Printing, Langmuir, vol. 19, pp. 1611-1617, 2003.

[16] A.I. Teixeira, G.A. Abrams, P.J. Betrics, C.J. Murphy, and P.F. Nealey, Epithelial contact guidance on well-defined micro- and nanostructured substrates, J. Cell Science,vol. 116, pp. 1881-1892, 2003.

[17] N.W. Karuri, S. Liliensiek, A. I. Teixeira, G. Abrams, S. Campbell, P.

F. Nealey, and C. J. Murphy, Biological length scale topography enhances

(3)

cell-substratum adhesion of human corneal epithelial cells, J. Cell Science, vol. 117, pp. 3153-3164, 2004.

[18] Simpson N.E., Stablerb C.L., Simpsona C.P., Sambanisc A., Constantinidis I, The role of the CaCl

2

-guluronic acid interaction on alginate encapsulated βTC3 cells, Biomaterials 25,13: 2603-2610,2003.

[19] Elisabeth Smela, Microfabbrication of PPy microactuators and other conjugated polymer device; 1998

[20] Russelì J. Hill, Temescal, Division of The BOC Group, Inc Physical Vapour Deposition, 1986

[21] M. Madou, Fundamental of Microfabbrication, p. 99

[22] Aluminium thin films and phisical deposition in VLSI

,

p. 335 (sputter deposition for VLSI)

[23] Wayne R. Gombots, Siow Fong Wee, Protein release from alginate matrice, 1998

[24] Campbell Dwek, Biological spettroscopy, 1987

[25] Skoog, West, Chimica analitica

[26] Reyntjens S, Puers R J, Micromech Microeng 11:287, 2001

[27] Vasile MJ, Nassar R, Xie J, Guo H Micron 30:235, 1999

[28] Raffa V., Castrataro P., Menciassi. A, Dario P., “Focused Ion Beam as a

Scanning Probe: Methods and Applications in Applied Scanning Probe

Methods”, Vol. II, to be published by Springer-Verlag

(4)

[29] Prewett P.D., Mair G.L.R. “Focused ion beams from liquid metal ion sources”, Research Studies Press Ltd., Taunton, Somerset, UK; Ishitani T, Ohnishi T, Madokor Y, Kawanami Y (1991) J. Vac. Sci. Technol. B 9:2633

[30] Twonsend PD, Kelly JC, Hartlemy New “Ion Implantation, Sputtering and their Applications”, Academic Press, London, UK (1997)

[31] Phaneuf MW, Micron 30:277,(1999)

[32] Thornell G, Johansson S (1998) J. Micromech. Microeng. 8:251;

Johansson S Schweitz JA, Westberg H, Boman M J. Appl. Phys. 72:5956, 1992

[33] C. Chretien, J.C. Chaumeil, Release of a macromolecular drug from alginate-impregnated microspheres, 2005

[34] Dash A.K., Cudworth G.C. Therapeutic application of implantable drug delivery systems, Journal of Pharmacological and Toxicological Methods - 40: 1-12, 1998.

[35] Majeti N. V., Ravi Kumar, Nano and microparticles as controlled drug delivery devices , J. Pharm. Pharmaceut. Sci. 3: 234-258,2000.

**[36] Go¨ran Frenning*, A° sa Tuno´n, Go¨ran Alderborn, Modelling of drug** release from coated granular pellets,2003

[37] X. Cui, J. Wiler, M. Dzaman, R. A. Altschuler, and D. C. Martin, In vivo studies of polypyrrole/peptide coated neural probes, Biomaterials, vol.

24, pp. 177-787, 2003

[38] Brannon-Peppas L. Polymers in controlled drug delivery Medical Plastics and Biomaterials 4: 34-44 (1997).

[39] Parisa Aslani, Ross A. Kennedy,. Diffusion characteristics of calcium

alginate gels. Biotechnol. Bioeng. 65, 605–610,1999

(5)

[40] G.Ciofani, Studio teorico e sperimentale di un sistema per il controllo della rigenerazione neuronale, 2004

[41] Arne Mikkeisen, Arnoljot Elgsaeter, , Density Distribution of Calcium- Induced Alginate Gels. A Numerical Study Biomaterials, 1995

[42] Amsden, B., Turner, N.,. Studies on diffusion in alginate gel. Effect on cross-linking with calcium or zinc ions on diffusion of acetaminophen,1996

[43] N.E. Simpson, The role of the CaCl2-guluronic acid interaction on alginate encapsulated bTC3 cells, Biomaterials, 2003

[44] M. Abidian, D. H. Kim, and D. C. Martin, Conducting-Polymer Nanotubes for Controlled Drug Release, Adv. Mater., vol. 18, pp. 405-409, 2006.

[45] R. Wadhwa, C.F. Lagenaur, and X. T. Cui, “Electrochemically controlled realease of dexamethasone from conducting polymer polypyrrole coated electrode”, J. Controlled Release, vol. 110, pp. 531-541, 2005.

[46] Mauri, Fenomeni di Trasporto (PLUS, Pisa University Press, 2003).

[47] G. Ciofani, V.Raffa, A.Menciassi.,S.Micera, P.Dario, A drug delivery system based on alginate microspheres: Mass-transport test and in vitro validation,2007

[48] J.H. Chen, Z.P. Huang, D.Z. Wang, S.X. Yang, W.Z. Li, J.G. Wen, and Z.F. Ren, Electrochemical synthesis of polypyrrole films over each well- aligned carbon nanotubes ,Synthetic Metals, vol. 125, pp. 289-294, 2002.

[49] Thuy-Duong Barbara Nguyen-Vu, Hua Chen, Alan Cassel, Jessica

Koehene, Hadeep Purewal, M.Meyyppan, Russel Andrews, and Jun Li

Carbon Nanofiber Nanoelectrode Array for closed-loop electrical

stimolatiom, 2005

(6)

[50] A. Laca, L.A. Garcia, F. Argueso, and M. Diaz, J. Industr. Microbiol.

Biotechnol. 23, 155, 1999.

Nealey, and C. J. Murphy, Biological length scale topography enhances cell- substratum adhesion of human corneal epithelial cells, J. Cell Science, vol.

[1] T.D. Barbara Nguyen-Vu, Hua Chen, Alan M. Cassel, Russel Andrews, Meyya Meyyappan, and Jun Li, Vertically Aligned Carbon Nanofiber Arrays: An Advanced toward Electrical-neural Iinterfaces, 2006

[2] N.W. Karuri, S. Liliensiek, A. I. Teixeira, G. Abrams, S. Campbell, P. F.

Nealey, and C. J. Murphy, Biological length scale topography enhances cell- substratum adhesion of human corneal epithelial cells, J. Cell Science, vol.

117, pp. 3153-3164, 2004.

[3] Ke Wang , Harvey A. Fishman, Hongjie Dai, and James S. Harris, Neural Stimulation with a Carbon Nanotube Microelectrode Array, 2006

[4] 21. T.D.B. Nguyen-Vu, H. Chen, A. M. Cassell, R. Andrews, M.

Meyyappan, and J. Li, “Vertically-Aligned Carbon Nanofiber Arrays: An Advance toward Electrical-Neural Interfaces”, Small, vol. 2, pp. 89-94, 2006.

[5] W.L.C. Rutten, Selective Electrical Interfaces with the Nervous System, Annu. Rev. Biomed. Eng., vol. 4, pp. 407-452, 2002.

[6] T.J. Webster, M.C. Waid, J. L. McKenzi, R.L. Price, and J.U. Ejiofor, Nano-biotechnology: carbon nanofibers as improved neural orthopedic implants, Nanotechnology, vol. 15, pp. 48-45, 2004.

[7] 12. M. Meyyappan, Carbon Nanotubes Science and Applications. CRC Press, Boca Raton, FL, 2005.

[8] S. Iijima, Helical microtubles of graphitic carbon,1991

[9] Tamir Gabay, Moti Ben-David, Itshak Kalifa, Raya Sorkin, Ze’ev R Abrams, Eshel Ben.Jacob, YaelHanein Electrochimical and Biological properties of carbon nanotubes based multi-electrode array, 2006

[10] Nancy A. Monteiro-Riviere, PhD, Alfred o:Inman, MS, Yung Y. Wang, PhD, Robert J.Nemanich, PhD, Surfactatnt effect on carbon nanotubi interaction with human Keratinocytes, 2005

[11] Frank A.Witzmann, Nancy A. Monteiro-Riviere, PhD Multiwalled carbon nanotubi exposure alters protein expression in human Keratinocytes, 2006

[12] S.K.Smart, A.I. Cassady, G.Q.Lu, D.J. Martin, The biocompatibility of carbon nanotube, 2006

[13] T.D. Barbara Nguyen-Vu, Hua Chen, Alan M. Cassel, Russel Andrews, Meyya Meyyappan, and Jun Li, Vertically Aligned Carbon Nanofiber Architecture as a Multifunctional 3D Neural Electrical Interface,

[14] D.E. Discher, P. Janmey, and Y.L.Wang, Tissue Cells Feel and Respond to the Stiffness of Their Substrate, Science, vol. 310, pp. 1139-11343, 2005.

[15] A. Brock, E. Chang, C.-C. Ho, P. LeDuc, X. Jiang, G. M. Whitesides, and D. E. Ingber, Geometric Deteminats of Directional Cell Motility Revealed Using Mircocontact Printing, Langmuir, vol. 19, pp. 1611-1617, 2003.

[16] A.I. Teixeira, G.A. Abrams, P.J. Betrics, C.J. Murphy, and P.F. Nealey, Epithelial contact guidance on well-defined micro- and nanostructured substrates, J. Cell Science,vol. 116, pp. 1881-1892, 2003.

[17] N.W. Karuri, S. Liliensiek, A. I. Teixeira, G. Abrams, S. Campbell, P.

F. Nealey, and C. J. Murphy, Biological length scale topography enhances

cell-substratum adhesion of human corneal epithelial cells, J. Cell Science, vol. 117, pp. 3153-3164, 2004.

[18] Simpson N.E., Stablerb C.L., Simpsona C.P., Sambanisc A., Constantinidis I, The role of the CaCl

-guluronic acid interaction on alginate encapsulated βTC3 cells, Biomaterials 25,13: 2603-2610,2003.

[19] Elisabeth Smela, Microfabbrication of PPy microactuators and other conjugated polymer device; 1998

[20] Russelì J. Hill, Temescal, Division of The BOC Group, Inc Physical Vapour Deposition, 1986

[21] M. Madou, Fundamental of Microfabbrication, p. 99

[22] Aluminium thin films and phisical deposition in VLSI

p. 335 (sputter deposition for VLSI)

[23] Wayne R. Gombots, Siow Fong Wee, Protein release from alginate matrice, 1998

[24] Campbell Dwek, Biological spettroscopy, 1987

[25] Skoog, West, Chimica analitica

[26] Reyntjens S, Puers R J, Micromech Microeng 11:287, 2001

[27] Vasile MJ, Nassar R, Xie J, Guo H Micron 30:235, 1999

[28] Raffa V., Castrataro P., Menciassi. A, Dario P., “Focused Ion Beam as a

Scanning Probe: Methods and Applications in Applied Scanning Probe

Methods”, Vol. II, to be published by Springer-Verlag

[29] Prewett P.D., Mair G.L.R. “Focused ion beams from liquid metal ion sources”, Research Studies Press Ltd., Taunton, Somerset, UK; Ishitani T, Ohnishi T, Madokor Y, Kawanami Y (1991) J. Vac. Sci. Technol. B 9:2633

[30] Twonsend PD, Kelly JC, Hartlemy New “Ion Implantation, Sputtering and their Applications”, Academic Press, London, UK (1997)

[31] Phaneuf MW, Micron 30:277,(1999)

[32] Thornell G, Johansson S (1998) J. Micromech. Microeng. 8:251;

Johansson S Schweitz JA, Westberg H, Boman M J. Appl. Phys. 72:5956, 1992

[33] C. Chretien, J.C. Chaumeil, Release of a macromolecular drug from alginate-impregnated microspheres, 2005

[34] Dash A.K., Cudworth G.C. Therapeutic application of implantable drug delivery systems, Journal of Pharmacological and Toxicological Methods - 40: 1-12, 1998.

[35] Majeti N. V., Ravi Kumar, Nano and microparticles as controlled drug delivery devices , J. Pharm. Pharmaceut. Sci. 3: 234-258,2000.

[36] Go¨ran Frenning*, A° sa Tuno´n, Go¨ran Alderborn, Modelling of drug release from coated granular pellets,2003

[37] X. Cui, J. Wiler, M. Dzaman, R. A. Altschuler, and D. C. Martin, In vivo studies of polypyrrole/peptide coated neural probes, Biomaterials, vol.

24, pp. 177-787, 2003

[38] Brannon-Peppas L. Polymers in controlled drug delivery Medical Plastics and Biomaterials 4: 34-44 (1997).

[39] Parisa Aslani, Ross A. Kennedy,. Diffusion characteristics of calcium

alginate gels. Biotechnol. Bioeng. 65, 605–610,1999

[40] G.Ciofani, Studio teorico e sperimentale di un sistema per il controllo della rigenerazione neuronale, 2004

[41] Arne Mikkeisen, Arnoljot Elgsaeter, , Density Distribution of Calcium- Induced Alginate Gels. A Numerical Study Biomaterials, 1995

[42] Amsden, B., Turner, N.,. Studies on diffusion in alginate gel. Effect on cross-linking with calcium or zinc ions on diffusion of acetaminophen,1996

[43] N.E. Simpson, The role of the CaCl2-guluronic acid interaction on alginate encapsulated bTC3 cells, Biomaterials, 2003

[44] M. Abidian, D. H. Kim, and D. C. Martin, Conducting-Polymer Nanotubes for Controlled Drug Release, Adv. Mater., vol. 18, pp. 405-409, 2006.

[45] R. Wadhwa, C.F. Lagenaur, and X. T. Cui, “Electrochemically controlled realease of dexamethasone from conducting polymer polypyrrole coated electrode”, J. Controlled Release, vol. 110, pp. 531-541, 2005.

[46] Mauri, Fenomeni di Trasporto (PLUS, Pisa University Press, 2003).

[47] G. Ciofani, V.Raffa, A.Menciassi.,S.Micera, P.Dario, A drug delivery system based on alginate microspheres: Mass-transport test and in vitro validation,2007

[48] J.H. Chen, Z.P. Huang, D.Z. Wang, S.X. Yang, W.Z. Li, J.G. Wen, and Z.F. Ren, Electrochemical synthesis of polypyrrole films over each well- aligned carbon nanotubes ,Synthetic Metals, vol. 125, pp. 289-294, 2002.

[49] Thuy-Duong Barbara Nguyen-Vu, Hua Chen, Alan Cassel, Jessica

Koehene, Hadeep Purewal, M.Meyyppan, Russel Andrews, and Jun Li

Carbon Nanofiber Nanoelectrode Array for closed-loop electrical

stimolatiom, 2005

[50] A. Laca, L.A. Garcia, F. Argueso, and M. Diaz, J. Industr. Microbiol.

Biotechnol. 23, 155, 1999.

**[36] Go¨ran Frenning*, A° sa Tuno´n, Go¨ran Alderborn, Modelling of drug** release from coated granular pellets,2003