UNIVERSITA’ DEGLI STUDI DI PISA FACOLTA’ DI FARMACIA
CORSO DI LAUREA SPECIALISTICA IN CHIMICA E TECNOLOGIA FARMACEUTICHE
TESI DI LAUREA
Rational Design, Synthesis, and Pharmacological
Evaluation of Carboxamide Derivatives as Selective
Cannabinoid-2 Receptor Ligands
RELATORE: RELATORE: Prof.ssa Clementina Manera Prof.ssa Paola Nieri
CANDIDATO: Valentina Lucchesi
Index:
• Introduction
2-29o Endocannabinoid System (ECS)
o Cannabinoid receptors
o Endogenous ligands of cannabinoid receptors
o Signal transduction activated by cannabinoid receptors o Biochemistry of endocannabinoid system
o Physiological function of ECS and cannabinoid
treatments
o Other functions of the ECS
o Pharmacological role of CB2 receptors o Pain
o Amyotrophic lateral sclerosis o Bone mass
o Prevention of Alzheimer’s disease
o Inhibition of tumor angiogenesis by cannabinoids o Effect of cannabinoid drugs in experimental models of
colon cancer and clinical data
• Introduction of Experimental Part
31-44• Pharmacological Experimental Section
46-49• Scheme of Synthesis
51-52 o Scheme 1o Scheme 2
