Bebawy M, Sze DM. Targeting P-glycoprotein for effective oral anti-cancer chemotherapeutics. Curr Cancer Drug Targets, 2008, 8:47-52.

(1)

51

Bibliografia

(2)

52 Avendano C., Menendez JC. Inibithors of multidrug resi stance to antitumor agents (MDR). Curr.Med.,9(2): 159-93 (2002)

Bebawy M, Sze DM. Targeting P-glycoprotein for effective oral anti-cancer chemotherapeutics. Curr Cancer Drug Targets, 2008, 8:47-52.

Brevoort P (1998) The booming U.S. botanical market: a new overview.

HerbalGram. Austin, TX: American Botanical Council and the Herb Research Foundation (44):33-46

Chan LMS, Lowes S, Hirst BH. The ABCs of drug transport in intestine and liver:

efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci, 2004, 21:25-51.

Compagnino Marta, tesi di laurea: Valutazione delle tre specie di

Echinacea sulla generazione, maturazione e attività funzionale delle cellule dendritiche umane 2007.

Dresser GK, McDonald W, Kim RB, Bailey DG. Evaluation of herbal products as potential inhibitors of MDR1. Clin Pharmacol Ther, 2004, 75: 79.

Garrigos M, Mir LM, Orlowski S. Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase: further experimental evidence for a multisite model. Eur J Biochem, 1997, 244:664-73.

Goel V, Chang C, Slama JV, Barton R, Bauer R, Gahler R, Basu TK.

Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats. Int Immunopharmacol, 2002, 2:381-7.

Gupta S. Preferential expression and activity of multidrug resistance gene-1

product (P-glycoprotein, a functionally active efflux pump, in human CD8

⁺

T

cells: a role in cytotoxic effector finction. J Clin Immunol, 1992, 12:451-8.

(3)

53 Hansen TS, Nilsen OG. Echinacea purpurea and P-glyciprotein drug transport in Caco-2 cells. Phytother Res, 2009, 23:86-91.

Hrycyna CA, Ramachandra M, Ambudkar SV, Ko YH, Pedersen PL, Pastan I, Gottesman MM. Mechanism of action of human P-glycoprotein ATPase activity.

Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites. J Biol Chem, 1998, 3:16631-4.

Huls M, Russel GMF, Masereeuw R. The role of ABC transporters in tissue defense and organ regeneration. JPET, 2008, DOI:10.1124.

Johnstone RW, Ruefli AA, Smyth MJ. Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci, 2000, 25:1–6.

Loo TW, Clarke DM. Identification of residues in the drug-binding site of human P-glycoptotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane. J Biol Chem, 1999, 274:35388- 92.

Mizutani T, Masatoshi M, Nakai E, Furumiya K, Togawa H, Nakamura Y, Kawai Y, Nakahira K, Shinkay S, Takahashi K. Genuine Functions of P-Glycoprotein (ABCB1). Curr Drug Metab, 2008, 9:167-174.

Niess JH, Reinecker HC. Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract. Curr Opin Gastroenterol, 2000, 21:687-91.

Okasala O, Salo T, Tammi R, Hakkinen L, Jalkkanen M, Inki P, Larjava H.

Expression of proteoglycans and hyaluronan during wound healing. J.

Histochem. Cytochem., 1995, 43:125-135.

Pendse SS, Behjati S, Schatton T, Izawa A, Sayegh MH, Frank MH. P- Glycoprotein functions as a differentiation switch in antigen presenting cell maturation. Am J Transplan, 2006, 6:2884-93.

Pilarski LM, Paine D, McElhaney J, Cass CE, Belch AR. Multidrag transporter P-

Glycoprotein 170 as a differentiation antigen on normal human lymphocyties and

thhymocities: modulation with differentiation stage and during aging. Amer Journ

of Hemat, 1995, 49:323-35.

(4)

54 Romiti N, Pellati F, Nieri P, Benvenuti S, Andolfi B, Chieli E. P-glycoprotein inhibitory activity of lipophilic constituents of Echinacea pallida roots in a human proximal tubular cell line. Planta Med, 2008, 74:264-6.

Rosenberg MF, Callaghan R, Ford RC, Higgins CF. Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis. J Biol Chem, 1997, 272:10685–94.

Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony- stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J Exp Med, 1994, 179:1109–18.

Sallusto F, Palermo B, Lenig D, Miettinen M, Matikainen S, Julkunen I, Forster R, Burgstahler R, Lipp M, Lanzavecchia A. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol, 1999, 29 5:1617-25

Salmon SE, Grogan TM, Miller T, Scheper R, Dalton WS. Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P- glycoprotein staining. J Natl Cancer Inst, 1989, 81:696-701.

Steinman RM. The control of immunity and tolerance by dendritic cell. Pathol Biol (Paris), 2003, 51:59-60.

Steinmüller C, Roesler J, Gröttrup E, Franke G, Wagner H, Lohmann-Matthes ML. Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes. Int J Immunopharmacol 1993, 15:605-14.

Sun J, He ZG, Cheng G, Wang SJ, Hao XH, Zou MJ. Multidrug resistance P- glycoprotein: crucial significance in drug disposition and interaction. Med Sci Monit, 2004, 10:5-14.

Teodori E, Dei S, Scapecchi S, Gualtieri F. The medicinal chemistry of multidrug

resistance (MDR) reversing drugs. Il farmaco, 2002, 57:385-415.

(5)

55 Thomas H.m Coley H.M. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting P-glycoprotein. Cance control, 10(2): 159-65 (2003)

Ueda K, Yoshida A, Amachi T. Recent progress in P-glycoprotein research.

AntiCancer Drug Des, 1999, 14:115–21.

Van de Ven R, C de Jong M, Reurs WA, Schoonderwoerd AJN, Jansen Gerrit, Hooijberg J, Scheffer GL, D de Gruijl T, Scheper R. Dendritic cells multidrag resistance protein 1 (abcc1) transporter activity for differentiation. J Immun, 2006, 1176:5191-9.

Young JW. Dendritic cells: expansion and differentiation with hematopoietic

growth factors. Curr Opin Hematol, 2001, 6:135-44.