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DIETARY COMPLIANCE IN DIABETES PREVENTION PROJECT IN FINLAND

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DIETARY COMPLIANCE IN DIABETES PREVENTION PROJECT IN FINLAND

Sonja Bärlund

1

, Ulla Uusitalo

1

, Päivi Kleemola

1

, Mikael Knip

2

, Hans K.

Åkerblom

2

, Suvi M. Virtanen

1

1

Department of Epidemiology and Health Promotion, National Public Health Institute,

2

Hospital for Children and Adolescents, Uni

2

versity of Helsinki, Helsinki, Finland

Introduction:

Diabetes Prevention Project is an international, randomised, double-blinded trial. The hypothesis to be tested is whether hydrolysed infant formula compared to cow's milk based formula decreases the risk of developing type 1 diabetes in children with HLA conferred genetic disease susceptibility.

Methods:

During the first 6-8 months of life the infant will be given Study Formula if additional milk is needed. According to the protocol the infant should use Study Formula daily for at least 2 months before the age of 8 months. During the intervention period cow’s milk, beef and foods containing these have to be avoided. Dietary compliance is monitored with dietary interviews every month of intervention. For the present study we used the data collected in Finland by the end of November 2003 (altogether 149 children at different stages of the intervention).

Results:

At 2 weeks of age 96% of the infants were breastfed and 39% were exclusively breastfed, at the 3-month interview 83% and 29%, and at the 6-month interview 60% and 2%, respectively. At 9 months of age 48% of the children were breastfed. During the first 2 weeks of life 33% of the infants received Study Formula daily, between 2 and 3 months of age 38%, and between 5 and 6 months of age 62%. Among the first 76 children to reach the end of the intervention 60 (79%) had received Study Formula for at least 2 months, 10 y (13%) less than 2 months and 6 (8%) not at all. Of the children 22% had used food not recommended during the intervention (on average 1.2 deviations/child). The most common deviations were use of hydrolysed formula other than the Study Formula (9%), milk-based formula (8%) and lactic acid bacteria that may contain trace amounts of milk protein (5%).

Conclusions

The dietary compliance among the studied children was good, 79% had received Study Formula according to the study protocol.

Keywords: hydrolysed infant formula, cow's milk based infant formula, randomised clinical trial, dietary compliance

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