114
Bibliografia
Abe K and Kimura H. The possible role of hydrogen sulfide as an
endogenous neuromodulator. J Neurosci 1996; 16:1066-1071.
Aguilar-Bryan L and Bryan J. Molecular biology of adenosine
triphosphate-sensitive potassium channels. Endocr Rev. 1999;
20(2):101-35.
Antoine MH, Berkenboom G, Fang ZY, Fontaine J, Herchuelz A, Lebrun P. Mechanical and ionic response of rat aorta to diazoxide. Eur J Pharmacol. 1992; 216(2):299-306.
Arguad L, Gateau-Roesch O, Raisky O, Loufouat J, Robert D, Ovize M. Postconditioning inhibits mitochondrial permeability
transition. Circulation 2005; 111:194-197.
Armstrong JS. The role of the mitocondrial permeability transition
in cell death. Mitocondrion 2006; 6:225-234.
Ashcroft SJ and Ashcroft FM. Properties and functions of
ATP-sensitive K-channel. Cell signal 1990; 2:197-214.
Atwal KS, Grover GJ, Ahmed SZ, Ferrara FN, Harper TW, Kim KS, Sleph PG, Dzwonczyk S, Russell AD, Moreland S, et al.
Cardioselective anti-ischemic ATP-sensitive potassium channel openers. J Med Chem. 1993; 36(24):3971-4.
115
Babiker FA, De Windt LJ, van Eickels M, Grohe C, Meyer R, Doevendans PA. Estrogenic hormone action in the heart:
regulatory network and function. Cardiovasc Res. 2002;
53(3):709-19. Review.
Baczkó I, Jones L, McGuigan CF, Manning Fox JE, Gandhi M, Giles WR, Clanachan AS, Light PE. Plasma membrane KATP
channel-mediated cardioprotection involves posthypoxic
reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia. FASEB J.
2005;19(8):980-2.
Banerjee SK and Maulik SK. Effect of garlic on cardiovascular
disorders: a review. Nutr J 2002; 1:4.
Bathia M, Sidhapuriwala J, Moochhala SM, Moore PK. Hydrogen
sulfide is a mediator of carrageenan-induced hindpaw oedema in the rat. Br J Pharmacol 2005; 145:141-144.
Belosjorow S, Schulz R, Dirge H, Shade FU, Heusch G.
Endotoxin and ischemic preconditioning: TNF-alpha
concentration and myocardial infarct development in rabbits. Am
J Physiol. 1999; 277(6 Pt 2):H2470-5.
Beltowski J, Jamroz A, Borkowska E. Heme oxidase and carbon
monoxide in cardiovascular physiology and pathology. Postepy
116
Benavides GA, Squadrito GL, Millis RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW. Hydrogen
sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci
USA 2007; 104:17977-17982.
Bernardi P. Modulation of the mitochondrial cyclosporine
A-sensitive permeability transition pore by the proton
electrochemical gradient. Evidence that the pore can be opened by membrane depolarization. J.Biol. Chem. 1992; 267:8834-8839.
Bhatia M, Wong FL, Fu D, Lau HY, Moochhala SM, Moore PK.
Role of hydrogen sulfide in acute pancreatitis and associated lung injury. FASEB J 2005; 19:623-625.
Breschi MC, Calderone V, Martelli A, Minutolo F, Rapposelli S, Testai L, Tonelli F, Balsamo A. New benzopyran-based openers of
the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties. J Med Chem. 2006; 49(26):7600-2.
Bugge E and Ytrehus K. Ischaemic preconditioning is protein
kinase C dependent but not through stimulation of alpha adrenergic or adenosine receptors in the isolated rat heart.
Cardiovasc Res. 1995; 29(3):401-6.
Buja LM. Modulation of the myocardial response to ischemia. Lab invest. 1998; 78(11);1345-73.
Buja LM. Myocardial ischemia and reperfusion injury Cardiovasc Pathol. 2005; 14(4):170-5.
117
Buja LM, Hagler HK, Willerson JT. Altered calcium homeostasis
in the pathogenesis of myocardial ischemic and hypoxic injury.
Cell Calcium 1988; 9(5-6):205-17.
Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, Zhu YC. The novel
pro-angiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovasc Res 2007; 76:29-40.
Cain BS, Meldrum DR, Dinarello CA, Meng X, Joo KS, Banerjee A, Harken AH. Tumor necrosis factor-alpha and interleukin-1beta
synergistically depress human myocardial function. Crit Care Med.
1999; 27(7):1309-18.
Calderone V. Large-conductance, Ca2+-Activation K+ Channels: Function, Pharmacology and Drugs. Curr Med Chem 2002;
9:1385-1395.
Calderone V, Testai L, Martelli A, Rapposelli S, Digiacomo M, Balsamo A, Breschi MC. Anti-ischemic properties of a new
spiro-cyclic benzopyran activator of the cardiac mito-KATP channel.
Biochem Pharmacol. 2010; 79(1):39-47.
Calderone V, Testai L, Martelli A, Raposelli S, Breschi MC.
Activators of cardiac mitochondrial ATP-sensitive potassium channels: promising drugs for anti-ischaemic therapy. Current
Topics in Pharmacology Vol. 11,1, 2007.
Caliendo G, Cirino G, Santagada V, Wallance JL. Synthesis and
S-118
releasing drugs as pharmaceuticals. J Med Chem 2010; in press
(DOI: 10.102/jm901638j).
Cannon JG and Dinarello CA. Increased plasma interleukin-1
activity in women after ovulation. Science. 1985;
227(4691):1247-9.
Cavallini D, Modovi B, De Marco C, Sciosciasantoro A. Inhibitory
effect of mercaptoethanol and hypotaurine on the desulfhydration of cysteine by cystathionase. Arch Biochem Biophys 1962;
96:456-457.
Cave AC and Hearse DJ. Ischaemic preconditioning and
contractile function: studies with normothermic and hypothermic global ischaemia J. Mol. Cell Cardiol., 1992; 24:1113- 23.
Chang L, Geng B, Yu F, Zhao J, Jian H, Du J, Tang C. Hydrogen
sulfide inhibits myocardial injury induced by homocysteine in rats.
Amino Acids 2008; 34:573-585.
Cheang WS, Wong WT, Shen B, Lau CW, Xiao YT, Suk YT, Xao X, Chen ZY, Hang Y, 4-Aminopyridine-sensitive K+ channels
contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery. Vascul Pharmacol 2010;
30doi:10.1016/j.vph.
Chen SL, Yang CT, Yang ZL, Guo RX, Meng JL, Cui Y, Lan AP, Chen PX, Feng JQ. Hydrogen sulphide protects H9c2 cells against
119
chemical hypoxia-induced cell injuries. Clin Exp Pharmacol
Physiol in press, DOI:10.1111/j.1440-1681.2009.05289.x.
Chen X, Jhee KH, Kruger WD. Production of the neuromodulator
of H2S by cystathionine beta-synthase via the condensation of
cysteine and homocysteine. J Biol Chem 2004; 279:52082-52086.
Coghlan MJ, Carrol WM, Gopalakrishnan M, Recent developments
in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. J Med Chem 2001;
44:1627-1653.
Cole WC, McPherson CD, Sontag D. ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage.
Circ. Res. 1991; 69:571-581.
Collard CD and Gelman S. Pathophysiology, clinical manifestation, and prevention of ischemia-reperfusion injiury.
Anesthesiology 2001; 94:1133-8.
Conti LR, Radeke CM, Shyng SL, Vandenberg CA.
Transmembrane topology of the sulfonylurea receptor SUR1. J.
Biol. Chem. 2001; 276:(44):41270-8.
Crompton M, Barksby E, Johnson N, Capano M. Mitochondrial
intermembrane junctional complexes and their involvement in cell death. Biochimie 2002; 84:143-152.
120
Crompton M. The mitochondrial permeability transition pore and
its role in cell death. Biochem. J. 1999; 341-233-249.
Cuong DV, Kim N, Joo H, Youm JB, Chung JY, Lee Y, Park WS, Kim E, Park YS, Han J. Subunit composition of ATP-sensitive
potassium channels in mitochondria of rat hearts. Mitochondrion.
2005; 5(2):121-33.
Dahlman-Wright K, Cavailles V, Fuqua SA, Jordan VC, Katzenellenbogen JA, Korach KS, Maggi A, Muramatsu M, Parker MG, Gustafsson JA. International Union of Pharmacology. LXIV.
Estrogen receptors. Pharmacol Rev. 2006; 58(4):773-81.
Daut J, Maier-Rudolph W, von Beckerath N, Mehrke G, Gunther K, Goedel-Meinen L. Hypoxic dilatation regulation, and possible
functions. J. Bioenerg. Biomembr. 1990; 23(4):509-535.
D'hahan N, Moreau C, Prost AL, Jacquet H, Alekseev AE, Terzic A, Vivaudou M. Pharmacological plasticity of cardiac
ATP-sensitive potassium channels toward diazoxide revealed by ADP.
Proc Natl Acad Sci U S A. 1999; 96(21):12162-7.
Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate
receptor ion channels. Pharmacol Rev 1999; 51:7-61.
Doeller JE, Isbell TS, Benavides G, Koenitzer J, Patel H, Patel RP, Lancaster JR, Darley-Usmar VM, Kraus DW. Polarographic
measurement of hydrogen sulfide production and consumption by mammalian tissues. Anal Biochem 2005; 341:40-51.
121
Dominy JE and Stipanuk MH. New roles for cysteine and
transsulfuration enzymes: production of H2S, a neuromodulator
and smooth muscle relaxant. Nutr Rev 2004; 62:348-353.
Eichhorn B and Dobrev D. Vascular large conductance
calcium-activated potassium channels: functional role and therapeutic potential. Naunyn Schmiedeberges Arch Pharmacol 2007;
376:145-155.
Fiorucci S, Distrutti E, Cirino G, Wallance JL. The emerging roles
of hydrogen sulfide in the gastrointestinal tract and liver.
Gastroenterology 2006; 131:259-271.
Fryer RM, Hsu AK, Eells JT, Nagase H, Gross GJ. Opioid-induced
second window of cardioprotection: potential role of
mitochondrial KATP channels. Circ Res. 1999; 84(7):846-51.
Fujita A and Kurachi Y. Molecular Aspects of ATP-sensitive K+
channel openers. Pharmacol. Ther. 2000; 85(19):39-53.
Furne J, Springfield J, Koenig T, DeMaster E, Levitt MD.
Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rate tissues: a specialized function of the colonic mucosa. Biochem
Pharmacol 2001; 62:255-259.
Gabel SA, Walker VR, London RE, Steenbergen C, Korach KS, Murphy E. Estrogen receptor beta mediates gender differences in
ischemia/reperfusion injury. J Mol Cell Cardiol. 2005;
122
Garlid KD. Opening mitochondrial K(ATP) in the heart--what
happens, and what does not happen. Basic Res Cardiol. 2000;
95(4):275-9.
Garlid KD, Dos Santos P, Xie ZJ, Costa AD, Paucek P.
Mitochondrial potassium transport: the role of the mitochondrial
ATP-sensitive K(+) channel in cardiac function and
cardioprotection. Biochim Biophys Acta. 2003; 1606(1-3):1-21.
Garlid KD and Paucek P. Mitochondrial potassium transport: the
K(+) cycle. Biochim Biophys Acta. 2003; 1606(1-3):23-41.
Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D’Alonzo AJ, Lodge NJ, Smith MA, Grover GJ.
Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ. Res. 1997; 81:1072-1082.
Garlid KD, Paucek P, Yarov-Yarovoy V, Sun X, Schindler PA.
The mitochondrial KATP channel as a receptor for potassium
channel openers. Biol. Chem. 1996; 271-8796-8799.
Gaudette GR, Krukenkamp IB, Saltman AE, Horimoto H, Levitsky S. Preconditioning with PKC and the ATP-sensitive potassium
channels: a codependent relationship. Ann Thorac Surg. 2000;
70(2):602-8.
123
Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem Biophys Res Commun 2004 b;
318:756-763.
Geng B, Yang J, Qi Y, Zhao J, Pang Y, Du J, Tang C. H2S
generated by heart in rat and its effects on cardiac function.
Biochem Biophys Res Commun 2004 a; 313:362-368.
Gögelein H, Ruetten H, Albus U, Englert HC, Busch AE. Effects of
the cardioselective KATP channel blocker HMR 1098 on cardiac
function in isolated perfused working rat hearts and in anesthetized rats during ischemia and reperfusion. Naunyn
Schmiedebergs Arch Pharmacol. 2001; 364(1):33-41.
Gogvadze V, Robertson JD, Enoksson M, Zhivotovsky B, Orrenius S. Mitichondrial cytocrome C release may occur by
volume-dependent mechanism not involving permeability transition.
Biochem. J., 2004; 378:213-217
Goto M, Liu Y, Yang XM, Ardell JL, Cohen MV, Downey JM.
Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ Res. 1995; 77(3):611-21.
Goubern M, Andriamihaja M, Nubel T, Blachier F, Bouillaud F.
Sulfide, the first inorganic substrate for human cells. FASEB J
124
Gribble FM, Tucker SJ, Ashcroft FM, The essential role of the
Walker Amtifs of SUR1 in KATP channel activation by Mg-ADP and
diazoxide. EMBO J. 1997; 16(6):1145-1418.
Gross GJ and Auchampach JA. Blockade of ATP-sensitive
potassium channels prevents myocardial preconditioning in dogs.
Circ Res. 1992; 70(2):223-33.
Gross GJ and Fryer RM. Sarcolemmal versus mitochondrial
ATPsensitive K+channels and myocardial preconditioning. Cir Res
1999; 84:973-979.
Grover GJ, D'Alonzo AJ, Darbenzio RB, Sewter JC, Hess TA, Sleph PG, Normandin DE, Lodge NJ. A comparison between the
effects of BMS-180448, a novel K+ channel opener, and cromakalim in rat and dog. Eur J Pharmacol. 1995; 294(1):271-80.
Grover GJ, D'Alonzo AJ, Darbenzio RB, Parham CS, Hess TA, Bathala MS. In vivo characterization of the mitochondrial selective
K(ATP) opener
(3R)-trans-4-((4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)dimethyl-2H-1-benzopyran-6-carbonitril
monohydrochloride (BMS-191095): cardioprotective,
hemodynamic, and electrophysiological effects. J Pharmacol Exp
Ther. 2002; 303(1):132-40.
Grover GJ and Atwal KS. Pharmacologic profile of the selective
mitochondrial-K(ATP) opener BMS-191095 for treatment of acute
125
Grover GJ, D’Alonzo AJ, Parham CS, Darbenzio RB.
Cardioprotection with the KATP opener cromakalim is not
correlated with ischemic myocardial action potential duration. J.
Cardiovasc. Pharmacol. 1995a; 26-145-152.
Grover GJ, McCullough JR, D’Alonzo AJ, Sargent CA, Atwal KS.
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448. J. Cardiovasc. Pharmacol.
1995b; 25:40-50.
Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability
transition pore opening during myocardial reperfusion--a target for cardioprotection. Cardiovasc Res. 2004; 61(3):372-85.
Halkos ME, Kerendi F, Corvera JS, Wang NP, Kin H, Payne CS, Sun HY, Guyton RA, Vinten-Johansen J, Zhao ZQ. Myocardial
protection with postconditioning is not enhanced by ischemic preconditioning. Ann. Thorac. Surg. 2004; 78-961-969.
Hamada H, Kim MK, Iwakura A, Ii M, Thorne T, Qin G, Asai J, Tsutsumi Y, Sekiguchi H, Silver M, Wecker A, Bord E, Zhu Y, Kishore R, Losordo DW. Estrogen receptors alpha and beta
mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction.
Circulation. 2006; 114(21):2261-70.
Hausenloy DJ, Wynne A, Duchen M, Yellon D. Transient
126
preconditioning-induced protection. Circulation; 2004;
109:1714-1717.
Henning B and Diener M. Actions of hydrogen sulphide on ion
transport across rat distal colon. Br J Pharmacol 2009;
158:1263-1275.
Hildebrandt TM and Grieshaber MK. Three enzymatic activities
catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 2008; 275:3352-3361.
Holmuhamedov EL, Wang L, Terzic A. ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria. J
Physiol. 1999; 519 Pt 2:347-60.
Holmuhamedov EL, Jahangir A, Oberlin A, Komarov A, Colombini M, Terzic A. Potassium channel openers are
uncoupling protonophores: implication in cardioprotection. FEBS
Lett. 2004; 568(1-3):167-70.
Holmuhamedov EL, Jovanović S, Dzeja PP, Jovanović A, Terzic A. Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial function. Am J Physiol. 1998; 275(5 Pt
2):H1567-76.
Hoorigan FT and Aldrich RW. Coupling between voltage sensor
activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol 2002; 120:267-305.
127
Hsieh YC, Choudhry MA, Yu HP, Shimizu T, Yang S, Suzuki T, Chen J, Bland KI, Chaudry IH. Inhibition of cardiac PGC-1alpha
expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage. FASEB J. 2006; 20(8):1109-17.
Ishii I, Akahoshi N, Yu XN, Kobayashi Y, Namekata K, Komaki G, Kimura H. Murine cystathionine gamma-lyase: complete cDNA
and genomic sequences, promoter activity, tissue distribution and developmental expression. Biochem J 2004; 381:113-123.
Jabůrek M, Yarov-Yarovoy V, Paucek P, Garlid KD.
State-dependent inhibition of the mitochondrial KATP channel by
glyburide and 5-hydroxydecanoate. J Biol Chem. 1998;
273(22):13578-82.
Jiang B, Tang G, Cao K, Wu L, Wang R. Molecular mechanism
for H2S-induced activation of KATP channels. Antiox Redox Signal
2010; 12:1-2.
Jilkina O, Kuzio B, Grover GJ, Kupriyanov VV. Effects of K(ATP)
channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts. J Mol Cell Cardiol.
2002; 34(4):427-40.
Juhaszova M, Zorov DB, Kim SH, Pepe S, Fu Q, Fishbein KW, Ziman BD, Wang S, Ytrehus K, Antos CL, Olson EN, Sollott SJ.
Glycogen synthase kinase-3beta mediates convergence of protection signalling to inhibit the mitochondrial permeability transition pore. J. Clin. Invest. 2004; 113-1535-1549.
128
Kamoun P. Endogenous production of hydrogen sulfide in
mammals. Amino Acids 2004; 26:243-254.
Kawabata A, Ishiki T, Nagasawa K, Yoshida S, Maeda Y, Takahashi T, Sekiguchi F, Wada T, Ichida S, Nishikawa H.
Hydrogen sulfide as a novel nociceptive messenger. Pain 2007;
132:74-81.
Kerendi F, Kin H, Halkos ME, Jiang R, Zatta AZ, Zhao Z-Q, Guyton RA, Vinten-Johansen J. Remote postconditioning: brief
renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors. Bas. Res. Cardiol. 2005;
100:404-412.
Kimura H. Hydrogen sulfide induces cyclic AMP and modulates
the NMDA receptor. Biochem Biophys Res Commun 2000;
267:129-133.
Kimura Y, Goto Y, Kimura H. Hydrogen sulfide increases
glutathione production and suppresses oxidative stress in mitochondria. Antiox Redox Signal 2010; 12(1):1-13.
Kimura Y and Kimura H. Hydrogen sulfide protects neurons from
oxidative stress. FASEB J 2004; 18:1165-1167.
Kin H, Zatta AJ, Lofye MT, Amerson BS, Halkos ME, Kerendi F, Zhao ZQ, Guyton RA, Headrick JP, Vinten-Johansen J.
129
Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine. Cardiovasc. Res. 2005;
67:124-33.
Kin H, Zhao ZQ, Sun H-Y, Wang NP, Corvera JS, Halkos ME, Kerendi F, Guyton RA, Vinten-Johansen J. Postconditioning
attenuates myocardial ischemiareperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc. Res. 2004;
62:74-85.
Kong X, Tweddell JS, Gross GJ, Baker JE. Sarcolemmal and
mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts. J Mol Cell Cardiol. 2001;
33(5):1041-5.
Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. Proapoptotic cascade activates BID, which oligomerizes BAK
or BAX into pores that result in the release of cytochrome C. Cell
Death Differ. 2000; 7:1166-1173.
Korte T, Fuchs M, Arkudas A, Geertz S, Meyer R, Gardiwal A, Klein G, Niehaus M, Krust A, Chambon P, Drexler H, Fink K, Grohé C. Female mice lacking estrogen receptor beta display
prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarction Circulation. 2005;
130
Kroemer G, Dallaporta D, Resche-Rignon M. The mitochondrial
death/life regulator in apoptosis and necrosis. Ann. Rev. Physiol.
1998; 60:619-642.
Kuo SM, Lea TC, Stipanuk MH. Developmental pattern, tissue
distribution, and subcellular distribution of cysteine:
alpha-ketoglutarate aminotransferase and 3-mercaptopyruvate
sulfurtransferase activities in the rat. Biol Neonate 1983; 43:23-32.
Kurzban GP, Chu L, Ebersole JL, Holt SC. Sulfhemoglobin
formation in human erytrocites by cystalysin, an L-cysteine desulfhydrase from Treponema denticola. Oral Microbiol Immunol
1999; 14:153-164.
Lacraz S, Nicod LP, Chicheportiche R, Welgus HG, Dayer JM.
IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J Clin Invest. 1995;
96(5):2304-10.
Lefer DJ, Nakanishi K, Vinten-Johansen J, Ma X-L, Lefer AM.
Cardiac venous endothelial dysfunction after myocardial ischemia and reperfusion in dogs. Am. J. Physiol. 1992; 263:H850-856.
Le Quoc K and Le Quoc D. Involvment of the ADP/ATP carrier in
calcium-induced perturbations of the mitochondrial inner membrane permeability: importance of the orientation of the nucleotide binding site. Arch. Biochem. Biophys. 1988; 265:249-
131
Li L, Bhatia M, Moore PK. Hydrogen sulfide: a novel mediator of
inflammation? Curr Opin Pharmacol 2006; 125-129.
Li GC, Vasquez JA, Gallagher KP, Lucchesi BR. “Myocardial
protection with preconditioning”, Circulation 1990; 82:609-619.
Li L, Hsu A, Moore PK, Actions and interactions of nitric oxide,
carbon monoxide and hydrogen sulphide in the cardiovascular and in inflammation a tale of three gases! Pharmacol Ther 2009;
123:386-400.
Li L and Moore PK. Putative biological roles of hydrogen sulfide
in health and disease: a breath of not so fresh air? Trends
Pharmacol Sci 2008; 29(2):84-90.
Li YF, Xiao CS, Hui RT. Calcium sulfide (CaS), a donor of
hydrogen sulfide (H2S): a new antihypertensive drug? Med
Hypotheses 2009; 73:445-447.
Liu GS, Thornton J, Van Winkle DM, Stanley AW, Olsson RA, Downey JM. Protection against infarction afforded by
preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation, 1991; 84(1):350-6.
Liu H, Zhang HY, Zhu X, Shao Z, Yao Z. Preconditioning blocks
cardiocyte apoptosis: role of K(ATP) channels and PKC-epsilon.
132
Liu Q, Takaoka A, Nakae I, Yamamoto K, Ito M, Kinoshita M.
Nicorandil improves ischemic changes in epicardial ECG during short-term coronary occlusion by opening ATP-sensitive potassium channels in pigs. Cardiovasc Drugs Ther. 1997; 11(6):757-66.
Liu Y, Gao WD, O'Rourke B, Marban E. Synergistic modulation of
ATP-sensitive K+ currents by protein kinase C and adenosine. Implications for ischemic preconditioning. Circ Res. 1996;
78(3):443-54.
Liu Y, Kalogeris T, Yusof M, Davis M, Korthuis R. Hydrogen
sulphide preconditioning attenuates ischemia/reperfusion-induces mitochondrial dysfunction in rat intestine by a BKCa
channel-dependent mechanism. FASEB J 2009; 23:763-766.
Liu Y, Sato T, O’Rourke B, Marban E. Mitochondrial
ATP-dependent potassium channels: novel effectors of
cardioprotection?. Circulation 1998; 97:2463-2469.
Lochner A, Marais E, Genade S, Moolman JA. Nitric oxide: a
trigger for classic preconditioning? Am J Physiol Heart Circ
Physiol. 2000; 279(6):H2752-65.
Lowicka E and Beltowski J. Hydrogen sulphide (H2S): the third
gas of interest for pharmacologists. Pharmacol Rep 2007; 59:4-24.
Lynch EA, Dinarello CA, Cannon JG. Gender differences in IL-1
133
mononuclear cells and urinary excretion. J Immunol. 1994;
153(1):300-6.
Mannhold R. KATP channel openers: structure-activity
relationships and therapeutic potential. Med Res Rev. 2004;
24(2):213-66.
Martelli A, Breschi MC, Calderone V, Pharmacodynamic hybrids
coupling established cardiovascular mechanism of action with additional nitric oxide releasing properties. Curr Pharma Des
2009; 15:614-636.
Martelli A, Rapposelli S, Calderone V, NO-releasing hybrids of
cardiovascular drugs. Curr Med Chem 2006; 13:609-625.
Martelli A, Testai L, Blandizzi C, Virdis A, Taddei S, Breschi MC, Calderone V. Hydrogen sulphide: biological functions, pharmacological implications and new opportunities for drug discovery. In Multifunctional Drugs: New chimeras in Medicinal
Chemistry, 2010, in press.
Meldrum DR. Tumor necrosis factor in the heart. Am J Physiol.
1998; 274(3 Pt 2):R577-95. Review.
Meldrum DR, Dinarello CA, Cleveland JC Jr, Cain BS, Shames BD, Meng X, Harken AH. Hydrogen peroxide induces tumor
necrosis factor alpha-mediated cardiac injury by a P38 mitogen-activated protein kinase-dependent mechanism. Surgery. 1998;
134
Mendelsohn ME and Karas RH. The protective effects of estrogen
on the cardiovascular system. N Engk J Med 1999; 340:1801-11.
McCully JD, Toyoda Y, Uematsu M, Stewart RD, Levitsky S.
Adenosine-enhanced ischemic preconditioning: adenosine receptor involvement during ischemia and reperfusion. Am. J. Physiol.
Heart Cic. Physiol., 2001; 280(2):H591-602.
Meier M, Janosik M, Kery V, Kraus JP, Burkhard P. Structure of
human cystathionine beta-synthase: a unique pyridoxal-5’-phosphate-dependent heme protein. EMBO J 2001; 20:3910-3916.
Minutolo F, Bellini R, Bertini S, Carboni I, Lapucci A, Pistolesi L, Prota G, Rapposelli S, Solati F, Tuccinardi T, Martinelli A, Stossi F, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Macchia M. Monoaryl-substituted salicylaldoximes as ligands for
estrogen receptor beta. J Med Chem. 2008; 51(5):1344-51.
Minutolo F, Bertini S, Granchi C, Marchitiello T, Prota G, Rapposelli S, Tuccinardi T, Martinelli A, Gunther JR, Carlson KE, Katzenellenbogen JA, Macchia M. Structural evolutions of
salicylaldoximes as selective agonists for estrogen receptor beta. J
Med Chem. 2009; 52(3):858-67.
Mironova GD, Grigoriev SM, Skarga YuYu, Negoda AE, Kolomytkin OV. ATP-dependent potassium channel from rat liver
mitochondria: inhibitory analysis, channel clusterization. Membr
135
Mishra PK, Tyagi N, Sen U, Givvimani S, Tyagi SC. H2S
ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure. Am J
Physiol Heart Circ Physiol 2010; 298(2):H451-456.
Mitsuhashi H, Yamashita S, Ikeuchi H, Kuroiwa T, Kaneko Y, Hiromura K, Ueki K, Nojima Y. Oxidative stress-dependent
conversion of hydrogen sulfide to sulfite by activated neutrophils.
Shock 2005; 24:529-534.
Mok YY, Atan MS, Yoke Ping C, Zhong Jing W, Bathia M, Moochhala SM, Moore PK. Role of hydrogen sulfide in
haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulfide biosynthesis. Br J Pharmacol 2004; 143:881-889.
Moore PK, Bathia M, Moochala S. Hydrogen sulphide: from the
smell of the past to the mediator of the future? Trends Pharmacol
Sci 2003; 24:609-611.
Mubagwa K and Flameng W. Adenosine, adenosine receptors and
myocardial protection: an updated overview. Cardiovasc Res.
2001; 52(1):25-39.
Murry CE, Jennings RB, Reimer KA. Preconditioning with
ischemia: a delay of lethal cell injury in ischemic myocardium.
136
Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic
preconditioning slows energy metabolism and delays
ultrastructural damage during a sustained ischemic episode. Circ.
Res., 1990; 66(4):913-31.
Nikolic I, Liu D, Bell JA, Collins J, Steenbergen C, Murphy E.
Treatment with an estrogen receptor-beta-selective agonist is cardioprotective. J Mol Cell Cardiol. 2007; 42(4):769-80.
Nicholls P and Kim JK. Sulphide as an inhibitor and electron
donor for the cytochrome c oxidase system. Can J Biochem 1982;
60:613-623.
Nichols CG. KATP channels as molecular sensors of cellular
metabolism. Nature 2006; 440:470-476.
Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor
potential cation channels in disease. Physiol Rev 2007;
87:165-217.
Noma A. ATP-regulated K+ channel in cardiac muscle. Nature
1983; 305(5930):147-8.
Nozawa Y, Miura T, Miki T, Ohnuma Y, Yano T, Shimamoto K.
Mitochondrial KATP channel-dependent and -independent phases of
ischemic preconditioning against myocardial infarction in the rat.
137
Ockaili R, Emani VR, Okubo S, Brown M, Krottapalli K, Kukreja RC. Opening of mitochondrial KATP channel induces early and
delayed cardioprotective effect: role of nitric oxide. Am J Physiol.
1999; 277(6 Pt 2):H2425-34.
O’Rourke F, Soons K, Flaumenhauft AR, Watras J, Baio-Larue C, Matthews E, Feinstein MB. Ca2+ release by inositol 1,4,5-trisphosphate is blocked by the K(+)-channel blockers apamin and tetrapentylammonium ion, and a monoclonal antibody to a 63 kDa membrane protein: reversal of blockade by K+ ionophores nigericin and valinomycin and purification of the 63 kDa antibody-binding protein. Biochem. J. 1994; 300:673-683.
Ohnuma, Y, Miura T, Miki T, Tanno M, Kuno A, Tsuchida A, Shimamoto K. Opening of mitochondrial K(ATP) channel occurs
downstream of PKC-epsilon activation in the mechanism of preconditioning. Am. J.Physiol. Heart Circ. Physioli., 2002;
283:H440-7.
Olson KR and Donald JA. Nervous control of circulation the role
of gasotransmitters, NO, CO and H2S. Acta Histochem 2009;
111:244-256.
Pedersen OL and Mikkelsen E. Comparison of the effects of a new
vasodilator pinacidil and nifedipine on isolated blood vessels. Acta
138
Pelzer T, Loza PA, Hu K, Bayer B, Dienesch C, Calvillo L, Couse JF, Korach KS, Neyses L, Ertl G. Increased mortality and
aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction. Circulation. 2005;
111(12):1492-8.
Penna C, Cappello S, Mancardi D, Raimondo S, Rastaldo R, Gattullo D, LosanoG, Pagliaro P. Postconditioning reduces infarct
size in the isolated rat heart: Role of coronary flow and pressure and the nitric oxide/cGMP pathway. Basic Res. Cardiol. 2006;
101:168-179.
Petit PX, Goubern M, Diolez P, Susin SA, Zamzani N, Kroemer G.
Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition. FEBS Lett. 1998; 426:111-116.
Pirotte B, De Tullio P, Lebrun P, Antoine MH, Fontaine J, Masereel B, Schynts M, Dupont L, Herchuelz A, Delarge J.
3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers? J Med Chem. 1993;
36(21):3211-3.
Porter P, Grishaver MS, Jones OW. Characterization of human
cystathionine beta-synthase: evidence for the identity of human L-serine dehydratase and cystathionine beta-synthase. Biochem
139
Pun PB, Lu J, Kan EM, Moochhala S. Gases in the mitochondria. Mitochondrion 2010; 10(2):83-93.
Rakhit RD, Edwards RJ, Marber MS. Nitric oxide, nitrates and
ischaemic preconditioning. Cardiovasc Res. 1999; 43(3):621-7.
Rapposelli S, Coi A, Bianucci AM, Calderone V, Testai L, Digiacomo M, Balsamo A. Predictive models, based on
classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers. Bioorg
Med Chem. 2009; 17(15):5565-71.
Reimer KA and Jennings RB. The bwavefront phenomenonQ of
myocardial ischemic cell death: II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 1979; 40:633–44.
Richard V, Karffer N, Tron C, Thuillez C. Ischemic
preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion. Circulation 1994;
89:1254-61.
Robert K, Vialard F, Thiery E, Toyama K, Sinet PM, Janel N, London J. Expression of the cystathionine beta-synthase (CBS)
gene during mouse development and immunolocalization in adult brain. J Histochem Cytochem 2003; 51:363-371.
Rodrigo GC, Davies NW, Standen NB. Diazoxide causes early
140
inhibition by an indirect mechanism. Cardiovasc Res. 2004;
61(3):570-9.
Rostovtseva T and Colombini M. VDAC channels mediate and
gate the flow of ATP: implications for the regulation of mitochondrial function. Biophys J. 1997; 72(5):1954-62.
Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J; Writing Group for the Women's Health Initiative Investigators. Risks and benefits of
estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002; 288(3):321-33.
Sanada S, Kitakaze M, Asanuma H, Harada K, Ogita H, Node K, Takashima S, Sakata Y, Asakura M, Shinozaki Y, Mori H, Kuzuya T, Hori M. Role of mitochondrial and sarcolemmal K(ATP) channels
in ischemic preconditioning of the canine heart. Am. Physiol.
Heart Circ. Physiol. 2001; 280:H256-H263.
Salkoff L, Butler A, Ferreira G, Santi C, Wei A. High-conductance
potassium channels of the SLO family. Nat Rev Neurosci 2006;
7:921-931.
Sasaki N, Murata M, Guo Y, Jo SH, Ohler A, Akao M, O’Rourke B, Xiao RP, Bolli R, Marban E. MCC-134, a single
141
blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation 2003; 107:1183-1188.
Sato T, Sasaki N, Seharaseyon J, O'Rourke B, Marbán E. Selective
pharmacological agents implicate mitochondrial but not sarcolemmal K(ATP) channels in ischemic cardioprotection.
Circulation. 2000; 101(20):2418-23.
Sato T, Costa AD, Saito T, Ogura T, Ishida H, Garlid KD, Nakaya H. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP
channels, blocks sarcolemmal KATP channels, and confers
cardioprotection. J Pharmacol Exp Ther. 2006; 316(1):182-8.
Schlattner U, Dolder M, Wallimann T, Tokarska-Schlattner M.
Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium. J
Biol Chem. 2001; 276(51):48027-30.
Schulz R, Rose J, Heusch G. Involvement of activation of
ATP-dependent potassium channels in ischemic preconditioning in swine. Am J Physiol. 1994; 267(4 Pt 2):H1341-52.
Schulz R, Rose J, Post H, Heusch G. Involvement of endogenous
adenosine in ischaemic preconditioning in swine. Pflugers Arch.
1995; 430(2):273-82.
Searcy DG and Lee SH. Sulfur reduction by human erythrocytes. J Exp Zool 1998; 282:310-322.
142
Serviddio G, Di Venosa N, Federici A, D’agostino D, Rollo T, Prigigallo F, Altomare E, Fiore T, Vendemiale G. Brief hypoxia
before normoxic reperfusion (postconditioning) protects the heart against ischemia-reperfusion injury by preventing mitochondria peroxyde production and glutathione depletion. FASEB J. 2005;
19:1006-1010.
Shibuya N, Mikami Y, Kimura Y, Nagahara N, Kimura H.
Vascular endothelium expresses 3-mercaptopyruvate
sulfurtransferase and produces hydrogen sulfide. J Biochem 2009;
146:623-626.
Shiki K and Hears DJ. Preconditioning of ischemic myocardium:
reperfusion-induced arrhythmias. Am. J. Physiol., 1987;
253:H1470-6.
Shott RJ, Rohmann S, Braun ER, Schaper W. Ischemic
preconditioning reduces infarct size in swine myocardium. Circ.
Res., 1990; 66:1133-1142.
Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit JF, Bonnefoy E, Finet G, André-Fouët X, Ovize M.
Postconditioning the human heart. Circulation. 2005
;112(14):2143-8.
Standen NB, Quayle JM, Davies NW, Brayden JE, Huang Y, Nelson MT. Hyperpolarizing vasodilators activate ATP-sensitive
143
Stipanuk MH and Beck PW. Characterization of the enzymic
capacity for cysteine desulphydration in liver and kidney of the rat.
Biochem J 1982; 206:267-277.
Sun YG, Cao YX, Wang WW, Ma SF, Yao T, Zhu YC. Hydrogen
sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes. Cardiovasc Res 2008;
79:632-641.
Susumu Seino and Takashi Miki. Physiological and pathophysiological roles of ATP-sensitive K+ channels. Prog
Biophys Mol Biol. 2003; 81(2):133-76.
Szewczyk A. The ATP-regulated K+ channel in mitochondria: five years after its discovery. Acta Biochim Pol. 1996; 43(4):713-9.
Tan BH, Wong PT-H, Bian JS. Hydrogen sulphide: a novel
signaling molecule in the central nervous system. Neurochem Int
2010; 56:3-10.
Tang G, Wu L, Wang R. Interaction of hydrogen sulfide with ion
channels. Clinical and Experimental Pharmacology and
Physiology 2010; 37:753-763.
Testai L, Rapposelli S, Calderone V. Cardiac ATP-sensitive
Potassium Channels: A Potenzial target for Anti-Ischemic Pharmacological Strategy. Cardiovascular and Hematological
144
Thornton JD, Thornton CS, Downey JM. Effect of adenosine
receptor blockade: preventing protective preconditioning depends on time of initiation. Am J Physiol. 1993; 265(2 Pt 2):H504-8.
Tunstall-Pedoe H, Morriso C, Woodward M, Fitzpatrick B, Watt G. Sex differences in myocardial infarction and coronary deaths in
Scottisch MONICA population of Glasgow 1985 to 1991. Presentation, diagnosis, treatment, and 28-day case fatality of 3991 events in men and 1551 events in women. Circulation 1996;
93:1981-92.
Vanden Hoek TL, Becker LB, Shao Z, Li C, Schumacker PT.
Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem.
1998; 273(29):18092-8.
Vinten-Johansen J, Zhao ZQ, Jiang R, Zatta AJ. Myocardial
protection in reperfusion with postconditioning. Expert Rev
Cardiovasc Ther. 2005; 3(6):1035-45.
Vinten-Johansen J, Zhao ZQ, Zatta AJ, Kin K, Halkos ME, Kerendi F. Postconditioning. A new link in nature’s armor against
myocardial ischemia reperfusion injury. Basic Res. Cardiol. 2005;
100:295-310.
Wang GY, Wu S, Pei JM, Yu XC, Wong TM. Kappa- but not
delta-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats. Am. J. Physiol. Heart Circ.
145
Wang M, Crisostomo P, Wairiuko GM, Meldrum DR. Estrogen
receptor-α mediates acute myocardial protection in females”; Am.
J. Physiol. Rev. 2006; 290:H2204-2209.
Wang M, Tsai BM, Reiger KM, Brown JW, Meldrum DR.
17-beta-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia. J Mol Cell
Cardiol. 2006; 40(2):205-12.
Wang P, Gallagher KP, Downey JM, Cohen MV. Pretreatment
with endothelin-1 mimics ischemic preconditioning against infarction in isolated rabbit heart. J Mol Cell Cardiol. 1996;
28(3):579-88.
Wang R. Singnal transduction and the gasotransmitter: NO, CO,
H2S in Biology & Medicine. Human Press 2004, New Jersey, USA.
Wang R. Two’s company, three’s crowd: can H2S be the third
endogenous gaseous transmitter? FASEB J 2002; 16:1792-1798.
Waring M, Drappatz J, Weichel O, Seimetz P, Sarri E, Böckmann I, Kempter U, Valeva A, Klein J. Modulation of neuronal
phospholipase D activity under depolarizing conditions. FEBS
Lett. 1999; 464(1-2):21-4.
Weil J, Eschenhagen T, Fleige G, Mittmann C, Orthey E, Scholz H. Localization of preproenkephalin mRNA in rat heart: selective
gene expression in left ventricular myocardium. Am J Physiol.
146
Weston AH and Edwards G. Recent progress in potassium channel
openers pharmacology. Biochem. Pharmacol. 1992; 43(1):47-54.
Whiteman M, Armstrong JS, Chu SH, Siau J-L, Cheung NS, Halliwell B, Moore PK. The novel neuromodulator hydrogen
sulfide: an endogenous peroxynitrite “scavenger”? J Neurochem
2004; 90:765-768.
Whiteman M, Cheung NS, Zhu YZ, Chu SH, Siau J-L, Wong BS, Armstrong JS, Moore PK. Hydrogen sulphide: a novel inhibitor of
hypochlorous acid-mediated oxidative damage in the brain?
Biochem Byophys Res Commun 2005; 326:794-798.
Xu M, Wang Y, Ayub A, Ashraf M. Mitochondrial K(ATP) channel
activation reduces anoxic injury by restoring mitochondrial membrane potential. Am. J. Physiol. Heart Circ. Physiol. 2001;
281:H1295-H1303.
Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, Kurachi Y. Sulfanylurea receptor 2B and Kir 6.form a
sulfanylurea-sensitive but ATP-insensitive K+ channel. J. Physiol.
1997; 499(part3):715-720.
Yamanishi T and Tuboi S. The mechanism of the L-cysteine
cleavage reaction catalyzed by rat liver gamma-cystathionase. J
147
Yang S, Hu S, Choudhry MA, Rue LW 3rd, Bland KI, Chaudry IH.
Anti-rat soluble 6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage. J
Mol Cell Cardiol. 2007; 42(3):620-30.
Yang X-M, Proctor JB, Cui L, Krieg T, Downey JM, Cohen MV.
Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signalling pathways. J. Am.
Coll. Cardiol. 2004; 44:1103-1110.
Yang Z, Zingarelli B, Szabó C. Crucial role of endogenous
interleukin-10 production in myocardial ischemia/reperfusion injury. Circulation. 2000; 101(9):1019-26.
Yao Z and Gross GJ. Effects of the KATP channel opener bimakalim
on coronary blood flow, monophasic action potential duration, and infarct size in dogs. Circulation. 1994; 89(4):1769-75.
Yap S, Naughten ER, Wilcken B, Wilcken DE, Boers GH.
Vascular complications of severe hyperhomocysteinemia in patients homocystinuria due to cystathionine beta-synthase deficiency: effects homocysteine lowering therapy. Semin Thromb
Hemost 2000; 26:335-340.
Yu HP, Shimizu T, Choudhry MA, Hsieh YC, Suzuki T, Bland KI, Chaudry IH. Mechanism of cardioprotection following
trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteins. J Mol Cell Cardiol. 2006; 40(1):185-94.
148
Zhang S-Z, Gao Q, Cao C-M, Bruce IC, Xia Q. Involvement of the
mitochondrial calcium uniporter in cardioprotection by ischemic preconditioning. Life Sci. 2006; 78:738-745.
Zhang WM, Jin WQ, Wong TM. Multiplicity of kappa opioid
receptor binding in the rat cardiac sarcolemma. J. Mol. Cell.
Cardiol. 1996; 28(7):1547-54.
Zhao W, Ndisang JF, Wang R. Modulation of endogenous
production of H2S in rat tissues. Can J Physiol Pharmacol 2003;
81:848-853.
Zhao W and Wang R. H2S-induced vasorelaxation and underlying
cellular and molecular mechanism. Am J Physiol Heart Circ
Physiol 2002; 283:H474-H480.
Zhao W, Zhang J, Lu Y, Wang R. The vasorelaxant effect of H2S
as a novel endogenous gaseous KATP channel opener. EMBO J
2001; 20:6008-6016.
Zhao ZQ, Sato H, Williams MW, Fernandez AZ, Vinten-Johansen J. Adenosine A2-receptor activation inhibits neutrophil-mediated
injury to coronary endothelium. Am. J. Physiol. 1996;
271:H1456-H1464.
Zhao ZQ, Sun H-Y, Wang N-P, Kin H, Guyton RA, Vinten-Johansen J. Hypoxic postconditioning attenuates cardiomyiocyte
149
apoptosis via inhibition of jnk and p38 kinases pathway. J. Mol.
Cell. Cardiol. 2005; 38:870.
Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA. Vinten-Johansen J. Inhibition of myocardial injury by
ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am. J. Physiol. Heart Circ. Physiol.
2003; 285:579-588.
Zhao ZQ and Vinten-Johansen J. Postconditioning: reduction of