2
Ch Gl Ga__
D
th Sc Fo Tr at pr ‘P La Th its em in ris in be m an di bo va bo gu an pr fia re on in po ph tio28
THAP
hair: G.Janss lobal Medical D astroenterolog________
Dr. Kieran
he Departme cience and ondazione E rento, Italy/V t University o rovided a lec Prebiotic Pro actulose’. he intestinal s metabolic merging as i human hea sk. Indeed, d teractions in een shown t markers of m nd immune iseases, mo olic syndrom ascular disea oth the com ut microbiot nd quantity o roduces app able by diet, esearch inter n developing gredients w otential to in hysiology (e on, inflammaRIL 2017
sen-van Solin Director y Portfolio, Ab_________
Tuohy
Fr ent of Food Nutrition at Edmund Mac Visiting profe of Ulster), cture on the operties of microbiota output are important pl alth and dise diet:microbe n the gut hav to influence any metabo related chro ost notably m me and card ase. Becaus mposition of t a and the p of metabolit pear to be m much recen rest has focu g foods and which have th nfluence hos .g. immune ation, glucos7
gen, bott.____
rom ch, essor e and layers ease e ve olic onic meta- io-se the rofile es it modi-nt used he st func-se/ Choleste cognitive microbiot Prebiotic class of f A prebiot selectivel gredient specific c composit vity of the microbiot benefit(s) (1, Gibson accepted d http://isapp ons/gibson definition-is Lactulose galactofr such pre long histo safety proAB
GA
Be
erol homeost e function) th ta modulatio cs are one su food ingredie tic is defined ly fermented that results changes in t tion and/or a e gastrointes ta, thus con ) upon host et al, 2010, IS definition pscience.org/p n-prebiotic-new sapp-10/). e, now calle uctose, is o biotic and h ory with a po ofile in clinicBBOTT “
ASTROE
irut, Leb
tasis, hrough on. uch ents. d as “a d in-in he acti-stinal nferring health” SAPP publicati w-d ne has a ositive cal“EXPER
ENTERO
banon,
Gastr
SUMM
On April 2 Gastroent organized was atten (gastroent medicine, Egypt, Gu Pakistan, During the were 4 le from Italy “Prebiotic Prof. Jyh-provided updates o ment”; Pr from Turk “Pancreat and Prof. Lebanon “Statistics On Day 2 lectures: P Belgium p “Highlight Prof. Ben provided ment of A Karim Ka lecture on Chronic C Osama Ab a lecture o Prokinetic and GERRT SOLU
OLOGY
28th &
roentero
MIT
28th & 29th 20 terology Sum d for the MEA nded by 150 p terologists, in , hepatologist ulf, Levant, Ke and Saudi A e summit, on ectures: Dr. K provided a le c properties o -Ming Liou fr a lecture on “ on H.pylori M rof . Prof. Cem key provided a tic Exocrine In Hani Tamin f provided a le s in Medicine , there were Prof. Tim Va provided a lec ts on Rome IV oit Coffin fro a lecture on “ Acute Diarrhe ammeruddin n “Manageme Constipation”, bo El Fotoh A on “The Role cs In Motility RD”.UTIONS
Y” – Sum
29th 2
ology
17, a mmit was AP region. It physicians nternal ts) from enya, rabia. Day 1, there Kieran Tuohy ecture on The of Lactulose” rom Taiwan “Recent Manage-m Kalayci, a lecture on nsufficiency”; from ecture on e”. also 4 nuytsel from cture on V Criteria”;. om France “Manage-ea”; and Prof. provided a ent of , and Prof. Aly provided e of DisordersS IN
mmit -
2017
e e ”. m .pr bo ta la pr ev la m m th ve Sa lo in Im w th da pe ap es an to w by th 1. 2. ractice for im owel functio ation discuss ctulose /gal rebiotic and vidence for i te both the metabolic out microbiota. It he recent he ed by the Eu afety Author ose contribut intestinal tra mportantly, t was judged to he general po aily dose of er day. Lact ppears to im specially cal nd has extra o this effect. will cover pos y which lact his effect in v Gibson, G. R. R. A., Tuohy, Dubert-Ferran Dietary prebio and new defin Technol. Bull. doi:10.1616/1 Scientific Opin substantiation related to lactu potentially pat gastro-intestin 806) and redu transit time (ID Article 13(1) of 1924/2006.
mproving on on. The pres sed the use actofructose presented t ts ability to composition tput of the g also discus alth claim, a uropean Foo rity2 , that “la
tes to a redu ansit time”. his health cl o be applica opulation at 10g of lactu ulose also mprove mine cium, absor a-European This presen ssible mecha ulose media vivo. , Scott, K. P., K. M., Hotchki ndon, A., et al. otics: current st nition. Food Sc Funct. Foods 476- 2137.15 nion on the n of health claim
ulose and decr thogenic gastro nal microorgan uction in intestin D 807) pursuan f Regulation (E n en-of e as a the modu-n amodu-nd gut ssed appro-od actu-uction laim able to t a ulose eral, rption claims ntation anisms ates Rastall, iss, A., (2010). tatus i. 7, 1–19. 880. ms reasing o-isms (ID nal nt to EC) No
Prof. J
from the University provided updates Managem Gastric c most com the third cancer re world. Th cancer re were 353 and 174, accountin of gastric world in 2 pylori (H. shown to tant caus cancer. E showed t of H. pylo ment of g intestinal reduce th adenoca of H. pyl recurrenc disease a the incide disease i Therefore recomme infected i offered e unless thJyh-Ming
National Ta y, Taipei, Ta a lecture on on H. pylor ment’. cancer rema mmon malig leading cau elated morta he numbers elated death 3,100 amon ,000 among ng for about c cancer dea 2012. Helico pylori) has o be the mos sal factor of Emerging ev that early er ori before th gastric atrop metaplasia he risk of ga rcinoma. Eralori may red
ce rate of pe and may eve ence of pep n the comm e, internation ended that H individuals s eradication th here are com
Liou
iwan aiwan
n ‘Recent
ri
ins the fifth gnancy and se of ality in the of gastric h in Asia g males g females, t two-third aths in the obacter s been st impor-gastric vidence adication he develop-phy or may astric adication duce the eptic ulcer en reduce ptic ulcer munity. nal experts H. pylori should be herapy, mpeting cons Cons The infec Asia syste analy over pylo CI 15 44% metr 15–2 3% ( llin, a tetra seve the e treat inclu treat the u proto cab four addi thera susc thera The thera third siderations in sensus. prevalence ction remains n countries. ematic revie ysis showed all prevalenc ri resistance 5–18%) for c % (95% CI 39 ronidazole, 1 22%) for fluo (95% CI 2–5 and 4% (95% acycline in As eral strategie efficacy in th tment of H. p uding extend tment length use of highe on pump inh vonoprazan drug regime tion of bism apy, and the ceptibility tes apy. use of effec apies in the -line treatme n the Kyoto of H. pylori s high in ma Our recent ew and meta d that the ce of primar e were 17% clarithromyc 9–48) for 18% (95% C oroquinolone 5%) for amox % CI 2–5%) sia. There a es to improv he first-line pylori, ding the h to 14 days er dosage of hibitor or the n, the use of ens, the muth to triple e use of sting guided ctive rescue second-line ent may also
any a-ry H. (95% cin, CI es, for re ve s, f e p-f d e or o
in er th di th
P
fro en Fl Is “P In Et in su lo (e in la re ob ad tic Zo Sy va Pa as ab bl m fic ap cr Se pr w th K) oc crease the c radication ra hat H. pylori seases may hrough theseProf. Cem
om Private P nterology De orence Nigh tanbul, prov Pancreatic E suffiency’. tiology of pa sufficiency ( ummarized i oss of pancre eg, chronic p adequate p tion (eg, pan esection), pa bstruction (e denocarcino c enzyme ina ollinger Elliso ymptoms du ary from mild atients with symptomatic bdominal dis loating with movements. C cant steatorr pproximately reatic functio evere PEI ca rotein maldig weight loss. M he fat soluble ) and vitamin ccur. Patien cumulative ates. It is hop associated y be eliminat e efforts.m Kalayci
Practice/Gas epartment o htingale Hos vided a lectu Exocrine ancreatic exo (PEI) can be n four categ eatic parenc pancreatitis), ancreatic st ncreatic surg ancreatic du eg, pancreas oma), or pan activation (e on syndrom ue to PEI ma d to severe. mild PEI ma c or have m scomfort an normal bow Clinically sig rhea occurs y 90% of pa on has been auses fat an gestion and Malabsorptio e vitamins (A n B12 may a ts with PEI m ped tedstro-of spital, ure on ocrine gories: chyma , imu-gical ct s ncrea-eg, e). ay ay be ild d wel gni-s when an-n lost. nd on of A, D, E, also may also com cramping Patients w pancreat calcificati enlargem and peri collection imaging ( Patients w cystic fib Diamond pancreat However cause of Direct an available PEI. Feca common diagnosti is in doub performe secretin t The main severe m torrhea d diet and Enzyme PERT ma patients w HIV, IBS Accordin enteric-c minimicro mplain of bloa g, and flatule with severe titis (CP) pre ions, ductal ment of the p pancreatic f ns on abdom (CT, MRI, US with advanc rosis, Shwa d syndrome tic atrophy o r, the most c atrophy is t nd indirect te
for the diag al elastase-1 nly performed ic test. If the bt direct tes ed (eg, endo test), if availa nstay of trea maldigestion due to PEI is PERT (Panc Replacemen ay also be in with celiac d and diabete ng to HaPan oated micro ospheres of ating, ence. chronic sent with dilatation, pancreas, fluid minal S). ced CP, achman-may have on imaging. common he aging. ests are gnosis of 1 is most d initial e diagnosis ts can be oscopic able. atment in and stea-s a low fat creas nt Therapy). ndicated in disease, es. EU, ospheres or less than . 2 mm tions prep with caps be ta to ta the b being mea A do is rec with of th symp rece pum effec Refe World Dig L Am J Gut. 1 Pancr UEGJ ____
Pro
from of Be the C prov ‘Stat m in size are s of choice f parations sho meals. If mo sule/tablet p aken, it may ake one part beginning w g distributed l. ose of 40,00 commended the main m hat dose withptoms persi ptor antago mp inhibitors ctive. erences d J Surg. 1998 iver Dis. 2015; Gastroenterol 1996;39(4):580 reas. 2008;37( Journal (supple ___________
of. Hani T
m the Americ eirut/Biostat Clinical Rese vided a lectu tistics in Me e the prepar or PEI. Enzy ould be take ore than one per meal mus y be beneficiof the dose with the rest
d during the 00–50,000 P d to be take eals, and ha h snacks. If st, adding H onists or prot is often 8;22:254. 47:1013-20. . 1997;92(5):8 0 (4):418 ement) 2017;1-___________
Tamim
can Un8ivers tistics unit at earch Institu ure on dicine’.a-yme en e st al e at PhU en alf H2 ton 67 -47 ____ sity t te,
An m an re Th w co th cr m (m m da in ca pr M du in re di va va n introductio mental conce nd their use esearch was he objective was to introdu oncepts in s heoretical co riptive statist measures of c mean, media measures of d ard deviation terquartile ra al representa resented. Moreover, the uced the co ference as a esearch, suc istributions, als, hypothe alues. on to the fun epts in statis in clinical s provided. e of the sess
uce the core statistics. Th oncepts in de
tics, includin central tend an, and mod dispersion (s n, range, an ange), and g ations were e session int oncept of sta applied in cl ch as: proba confidence esis testing, a nda-stics ion e e es-ng: dency de), stan-nd graphi- tro-atistical inical ability inter-and p- In additio tests freq ferential s ted, such ANOVA,
20
THA
Chair: Pro Departmen Division of American U Center (AU Middle Eas (M.E.I.H)/ C logist at Cle (CMC).Prof. T
from the Research intestinal Division o Hepatolo Leuven, B lecture o IV Criteria In 2016, criteria fo intestinal published ration be terology j Foundati launched reviews o May 201 on, different quently used statistics we h as chi-squ and correlatAPRIL 2
of. Cecilio Azant of Internal M Gastroenterolo University of Be UBMC) /Head o st Insti-tute of H Consultant Gas emenceau Me
Tim Vanuy
Translationa h Center for Disorders (T of Gastoente ogy, Universi Belgium pro n “Highlifhts a”. the updated or Functiona Disorders w d. Through a tween the G journal and on, Rome IV d with a serie on FGIDs (pu 6). statistical d for in-ere presen-are, t-test, tion.017
ar, edicine, ogy, eirut Medical of GI Division Health stroentero-dical Centerytsel
al Gastro-TARGID)/ erology & ity Hospital ovided a s on Rome d Rome IV al Gastro-were a collabo- Gastroen-the Rome V was es of ublished in Sinc III alr mark in sc thes to an and In th defin syste eluci phys on Ir (IBS) (FD). A su betw was gene patie ____Pro
from Hôp tanc Gast e the public ready, there ked and exc cientific undee disorders, n improveme
treatment o
is lecture, th nition and cla em for FGID idated, as w siology with rritable Bowe ) and Functi . ummary of d ween Rome provided as eral approac ents with FG ___________
of. Benoit
m the Gastroe ital Louis Mo e Publique-troenterolog cation of Rom has been a citing expans erstanding o , which has ent in diagn options. he operation assification Ds was furthe well as patho specific focu el Syndrome onal Dyspep ifferences III and Rom s well as a ch as to care GIDs. ___________Coffin
enterology U ourier, Assis Hôpitaux/ gy, Denis me a sion of led osis nal er o-us e psia e IV e of ____ Units-D Pa le “M di W (A of es yo M en sp da th Ra di in ni an po Th th ad m lite co fro ad ag Fo iderot-Paris aris, France cture on the Managemen iarrhea”. Worldwide, ac AD) constitut f morbidity a specially am oung or very Most AD case nteric infecti pontaneousl ays without herapy. acecadotril arrhoeal dru testinal antis sm of action ntimotility eff ositive safety he efficacy o he symptom dult AD was meta-analysis erature (MA ollected resu om articles t dequate liter ggregated th our randomi 7 University provided a e topic of nt of acute cute diarrho tes a major c and mortality mong the ver
y old patient es are cause ons but reso ly within a fe needing ant is an anti-ug with a pu secretory m n without an fect and wit y profile. of racecadot atic treatme s analyzed in s based on AL) findings t ults summar through an rature review he difference ized clinical y, oea cause y, ry s. ed by olve ew tibiotic ure echa-n h a tril for ent of n a hat ries w and es. trials were iden analysis w An Individ meta-ana to assess whatever placebo rhoea.Ind meta-ana level mixe the signif ment effe line cova Diarrhoea common clinical gl evaluated physician essential the outco placebo, minimum duced a recovere anytime ( [1.3, 2.5] increase proportio 3 days (p reduction and naus decrease 0.001). In pared to induced s effects, s diarrhoea of stools ntified follow with raw dat dual Patient alysis was c s racecadot r its dose, ve in adult acut dividual Patie alysis followi ed models t ficance of th ect adjusted riates. a duration w n main criteri lobal impres d at baseline n was found predictor in ome. As com the 100 mg m effective do 80% increas d patient pro (Hazard Rat , p < 0.001) of the respo on i.e. recove p < 0.001), a n of abdomin sea and an e of sick day n conclusion placebo, ra several sign such as redu a duration, t and associa wing this ta (n=669). Data onducted ril efficacy, ersus te diar-ent Data ing multi-esting of he treat-d for base-was the ia. The ssion e by the to be the nfluencing mpared to g dose, the ose, in-se of the oportion at io = 1.8 ), a 60% onder ery within a 47% nal pain overall 33% ys (p < n, as com-acecadotril ificant ucing the he number ated % symp prod The burd defin man focu antid ____
Pro
Kam
Med Kara the t chro It wa patio but a asso such Diag porta patie Cons com plain elder can Cons amo child safet of pa Two exist ptoms, lead ductivity. lecture focu den of acute nitions, guide agement wi s on raceca diarrhoeal m ___________of. Karim
mmerudd
d University, achi provided topic of “Ma onic constipa as outlined t on itself is no a symptom. ociated with h as hypothy gnosis is ther ant aspect in ents. stipation is o mon gastro nts among w rly, although be affected. stipation is v ongst pregna dren, which m ty profile of aramount im definitions o t; the patient ding to less lo used on the diarrhea, elines and ith particular adotril as nov edication. ___________in,
from Ba Nazimabad d a lecture o anagement o ation”. hat consti-ot a disease It may be some disea yroidism etc refore an im n constipate one of the m intestinal co women and t h all age gro. very commo ant women a makes the any treatme mportance. of constipat t definition a ost r vel ____ aqai , on of e ases, . m-ed most om-the ups on and ent ion and
th pa pa bo be ge to pe to an (3 O di se ev Va m of m C cu la su of te la __ he clinical de atient definit ation is a pe owel habit o ehavior by p enerally des oms as strain ellet-like sto o defecate w nd infrequen 33%). Other reviews ifficulty durin ensation of i vacuation. arious treatm mended for th f constipatio ment includes • A change in • An increase – 30 g per da • An increase x 200 ml glas • Additional e onsidering t ulties involve sting lifestyle uccess of su ften unsatisf emporary. Co xatives are f ___________ efinition. The tion of const erceived cha or defecatory patients, who cribe their s ning (52%, h ols (44%), In when desired nt defecation s include pa ng defecatio ncomplete r ments are re he managem on. Baseline s: n lifestyle and e in dietary fib ay) e in fluid intak sses per day) exercise
the major dif ed in achievi e change, th uch measure factory and onsequently frequently us ___________ e ti-ange in y o ymp-hard, nability d (34%) n. in or on, or a rectal ecom-ment treat-d treat-diet ber (20 ke (~ 8 ) ffi-ng a he es is y, sed. ______
______
Prof. O
Fotoh A
Departm Medicine Ain Sham Egypt, pr the topic prokinetic and GER The upda culminati criteria pu provide v the class and man gastroint (FGDs)._________
Osama Ab
Aly
from th ent of Intern e, Faculty of ms University rovided a lec of “The role cs in motility RD”. ated Rome c ng in the Ro ublished in 2 valuable insig sification, dia agement of estinal disor________
bo El
e nal Medicine, y, Cairo, cture on e of y disorders criteria, ome IV 2016, ghts into agnosis functional rders Rom sis o Func being synd pain than drom ackn phag and (IBS) tiona This chan tion conc sia in IV, a gast phag Curr optio me IV places on the differe ctional Dysp g postprand drome (PDS) syndrome ( focussing o me as a who nowledge th geal reflux d irritable bow ) can be par al dyspepsia lecture add nges regardi and diagnos cerning Func n particular ( and also focuroparesis an geal reflux d
rent and futu ons were sh further emp ent subtypes pepsia (FD), dial distress ) and epigas (EPS), rathe on the syn-ole and at gastroeso isease (GER wel syndrom rt of the func a spectrum. ressed the ing the defin stic criteria ctional Dysp (FD) in Rom ussed on nd gastroeso isease (GER ure treatmen ared with th pha-s of stric r o-RD) me c- ni- pep-e o-RD). nt he
au on th di Re de __ udience, wit n the efficac he managem isorders. ecent advan ed new insig ___________ h specific fo cy of prokine ment of these nces have p ghts and ope ___________ ocus etics in e rovi-ened ___________ up the po different t ___________ otential for n treatment o ___________ new and ptions. ______________________________________________
