24 July 2021
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Original Citation:
BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS Mutant Colorectal Cancer
Published version:
DOI:10.1158/1078-0432.CCR-15-2664 Terms of use:
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Questa è la versione dell’autore dell’opera:
BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the
Endothelium in the Metastatic Spreading of KRAS Mutant Colorectal Cancer,
Bartolini A, Cardaci S, Lamba S, Oddo D, Marchiò C, Cassoni P, Amoreo CA, Corti G,
Cancer Res. 2016 May 3
Testori A, Bussolino F, Pasqualini R, Arap W, Corà D, Di Nicolantonio F, Marchio S,
Clin
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-15-The definitive version is available at:
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//clincancerres.aacrjournals.org/content/early/2016/05/03/1078-0432.CCR
2664.long
Downloaded from clincancerres.aacrjournals.org on May 20, 2016. © 2016 American Association for Cancer Research.
Author Manuscript Published OnlineFirst on May 3, 2016; DOI: 10.1158/1078-0432.CCR-15-2664 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.
Author Manuscript Published OnlineFirst on May 3, 2016; DOI: 10.1158/1078-0432.CCR-15-2664 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.
Author Manuscript Published OnlineFirst on May 3, 2016; DOI: 10.1158/1078-0432.CCR-15-2664 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.
Bartolini et al_Fig2
Mou s e m o del s Hum a n s a m p le sGenetic KRAS background
WT G12D G12V G13D BCAM/Bc a m 200 mm L A M A5 /L a m a5 BCAM LA MA5
A metastaseshepatic KRASWT me tas tase s h ep a ti c K R ASMuta n t B (%)area po sitive -BCAM 100 75 50 25 0 200 mm
C
(%) 100*** p<0.0001 Primary CRCs Matched metastases p=0.0644 ** p=0.0098 r e a 75 50 25 BC A M 0
WT Mutant WT Mutant WT Mutant
Gross Mallory’s Ki67 BCAM/Bcam LAMA5/Lama5 ) 2 500 HCT-116m (mutant KRAS) Control (m m 400 p=0.0126 p=0.0234 500 mm 200 mm 200 mm 200 mm a 300 Me ta st as is pep-BCAM1 200
* *
100 0 pep-BCAM2Control -BCAM1 - BCAM2
pep pep
Gross Mallory’s Ki67 BCAM/Bcam LAMA5/Lama5
) 2 400 DLD-1 (mutant KRAS) (mm p=0.0079 p=0.0389 300 ar e a 200 s 100
**
*
0 Control -BCAM1 - BCAM2 pep pep Control pep-BCAM1 pep-BCAM2Gross Mallory’s Ki67 BCAM/Bcam LAMA5/Lama5
) 2 400 HT-55 (WT KRAS) n.s. n.s. (mm 300 ar ea 200 100 Met a s tasi s 0 Control -BCAM1 - BCAM2 pep pep Control pep-BCAM1 pep-BCAM2
