Unit 2
SYSTEMATIC REVIEW
METHODS
1. Identify the components to address in
developing inclusion and exclusion criteria for a systematic review question about the effectiveness of an intervention.
2. Identify the components of a
comprehensive systematic review search strategy.
OBJECTIVES: UNIT 2
INCLUSION VS EXCLUSION CRITERIA
Inclusion
what a study need to address in order to be included in the review
Exclusion
situations and circumstances in which study will not be included in the review
INCLUSION/EXCLUSION:
CONSIDERATIONS
Review question
Broad vs. narrow
Consistent decisions
Reduce bias
Most robust design for the review question
Including non-randomized studies in Intervention Reviews
Limitations
Reasons
Based on review question
Lack of randomized studies
INCLUSION/EXCLUSION: STUDY DESIGN
Experimental study where participants are
allocated to interventions using methods that are not random
Non-randomized trial
Observational study with a control group
Use of different interventions is not allocated by the researcher
Controlled before-after study
Cohort study
Case-control study
Observational study without a control group
Cross-sectional study
Case series
Case reports
NON-RANDOMIZED STUDIES
Study designs for evaluating the effects of healthcare interventions
Comparison between interventions Systematically
collected data
Multiple measurements before and after
the intervention
Intervention data registered prior to outcome More than one
group studied
Interventions assigned by investigators
Interventions assigned randomly
Interventions assigned to
individuals
Randomised trial
Retrospective case-control study
Opinion paper
Prospective case-control study
Non-comparative study (e.g. Case series)
Groups defined by interventions
Cohort design Controlled before-after study
Both interventions
prospective
Prospective cohort study
Experimental intervention prospective
Non-concurrent cohort study
Retrospective cohort study
Before-after study
Interrupted time series study
Repeated measures study Repeated
measures in the same individuals
Non-randomised trial
Cluster randomised trial
Yes
Yes
No
No No No
No No
No
No No
Yes
Yes
Yes
Yes
Yes
Yes
Yes Yes
Yes
Yes
No
No Yes
(Shaded boxes are study designs that should be considered for inclusion in EPOC reviews.)
No
https://epoc.cochrane.org/sites/e poc.cochrane.org/files/public/uplo ads/EPOC%20Study%20Designs%
20About.pdf
If possible, include all languages
Reduces publication bias
Requires resources
INCLUSION/EXCLUSION: LANGUAGE
Intervention Review Question
Which of the many available microbial products improve healing in patients with chronic wounds
INCLUSION/EXCLUSION: EXAMPLE
Component Inclusion Criteria Exclusion Criteria
Population Adults with chronic wounds Other wounds Intervention • Systemic preparations
• Topical preparations Comparison • Placebo
• No antimicrobial
• Different antibiotics
Lack of comparison
Outcome Wound healing Wound healing not assessed Study Design Randomized trial Non-randomized trial
INCLUSION/EXCLUSION: EXAMPLE
Intervention Review Question
Are knowledge translation (KT) interventions
directed to nurses in tertiary care are effective for improving EBP knowledge, skills, behaviours, and, as a result, patient outcomes
Inclusion/Exclusion Criteria
IN-CLASS ACTIVIT Y
SEARCH STRATEGY
Identify search terms
Selection of relevant databases
Retrieval of citations from searches
As extensive as possible
Published
Unpublished
Aim for
comprehensiveness (high sensitivity)
Accept
large number of relevant results (low precision)
RESOURCES FOR SEARCHING
Internet access
Ability to obtain articles through inter-library loan
“Manpower” to retrieve hardcopy of articles and scan
e.g. EndNote, Reference Manager, RefWorks
Download
full record citation
key fields
Abstracts
Identifier
Accession number/unique identifier (PMID)
Digital object identifier (DOI)
Clinical trial number
Index terms/thesaurus terms/keywords
Language
Comments/corrections/errata/retrations/updates
BIBLIOGRAPHIC SOFT WARE
SEARCH TERMS
No agreed upon standard
Compile list of terms
Previous searches
Key words
Identify synonyms for the terms
Related terms
e.g. brain vs. head
Account for spelling variation
e.g. pediatric vs paediatric
COMBINING SEARCH TERMS
“or” “and” “or”
GENERAL SEARCH TIPS
Quotations and Parentheses
(“leg ulcer” or “varicose ulcer”) and chronic
Asterisk [*]
e.g. nurs*
searches for nurses, nursing, nurse
Wildcard [?]
e.g wom?n
searches for woman or women
MeSH
“medical subject heading”
Controlled terms used in MEDLINE to index citations
Cochrane Handbook
Other databases use “MeSH-like”
terms
Thesaurus or Index Structure
INDEXING OF CONTROLLED TERMS
OVID MEDLINE TIPS
$
Truncation
antibiotic$ will search for
antibiotics in general
different types of antibiotics, e.g. antibiotics,
aminoglycosides;
antiobiotics, lactam
Adj
Proximity and adjacency searching
chronic adj wounds$ will search for the
words next to each other
.tw
Textword search
skin adj ulcer.tw will search
for these adjacent
textwords in the title or abstracts
/
Medical subject heading (MeSH) search
diabetic foot/ will search
for MeSH in indesing terms
Khan, K., Kunz, R., Kleijnen, J., Antes, G. Systematic reviews to support evidence-based medicine, 2nd edition
Intervention Review Question
Which of the many available microbial products improve healing in patients with chronic wounds
Intervention Review Question
Are knowledge translation (KT) interventions directed to nurses in tertiary care are effective for improving EBP knowledge, skills, behaviours, and, as a result, patient outcomes
SEARCH TERMS: EXAMPLES
Search Terms
IN-CLASS ACTIVIT Y
Bibliographic databases
Journals and other non-bibliographic database sources
Unpublished and ongoing studies
SOURCES TO SEARCH
Subject specific
additional International/National/
Regional databases
Trial Registries
Citation Indexes
Dissertation and theses databases
Grey literature
BIBLIOGRAPHIC DATABASES
Handsearching
Electronic Journals
http://www.evidencebasednursing.it/riv iste.htm
Conference Proceedings
http://www.evidencebasednursing.it/as socia.htm
Reference Lists
Experts
JOURNALS/NON-BIBLIOGRAPHIC DATABASE SOURCES
Trial registers
http://www.alltrials.net/
UNPUBLISHED AND ONGOING STUDIES
Intervention Review Question
Which of the many available microbial products improve healing in patients with chronic wounds
Intervention Review Question
Are knowledge translation (KT) interventions directed to nurses in tertiary care are effective for improving EBP knowledge, skills, behaviours, and, as a result, patient outcomes
WHERE TO SEARCH: EXAMPLES
Where to Search
IN-CLASS ACTIVIT Y
Databases searched
Dates of the last search for each database
Period searched
Grey literature sources.
Individuals or organizations contacted
Journals searched
Electronically and/or handsearch
Conference proceedings
Other sources searched, e.g.
Reference lists
Internet
DOCUMENTING SEARCH
Number of records retrieved
PRISMA Flow Diagram
Full search strategies for each
database
Appendix
Additional File