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Using the online DAVID tool (http://david.abcc.ncifcrf.gov/home.jsp) functional annotations of the up-regulated and down-regulated genes were we carried on. The data are reported in Supplementary Tables 1 and 2. Intriguingly, no significant increase in the expression of Gja1 gene which encodes Cx-43 was observed. This data has been discussed in the full paper.

Pathway analysis focused on these genes was carried on with KEGG tool (http://www.genome.jp/kegg/pathway.html) and is also reported in the Supplementary Tables 1 and 2.

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