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UNDER THE PATRONAGE OF

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The 12^th"Milan Congress on Anticancer Innovative Therapy" Conference will involve leading international experts in the field of immuno-oncology and biologic therapy of cancer to im- prove the potential, opportunities and challenges of the new approaches.

The increasing knowledge of the molecular mechanisms responsible for neoplastic progression, the characterization of tumor microenvironment, and the immunological/angiogenetic me- chanisms regulating the tumor-host interaction, allowed us to identify and apply more effec- tive anti-cancer biogical and immunological treatments.

To date, the immuno-biotherapy is a continuously evolving treatment modality and it is cur- rently integrated into the treatment algorythms of several different tumor types. The role of tumor metabolism and diet in tumor evolution and their impact on the outcomes of patients undergoing immunotherapy will be focused on.

This conference explores topics that will appeal to clinicians, as well as, basic, translational, and clinical scientists ranging from academics to industry. As in the past, the meeting will pro- vide a highly interactive forum in which leading experts will discuss clinical and pre-clinical da- ta, providing the audience with a broad overview of the most recent achievements in cancer biologic and immunologic therapy.

Finally, a wide spectrum of evolving topics in cancer research such as epigenetic drugs, nano- particles and CART cell-based new constructs will be analyzed in view on introducing them to the clinical setting.

RATIONALE

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FILIPPO DE BRAUD (Milan, Italy) MICHELE DEL VECCHIO (Milan, Italy) MASSIMO DI NICOLA (Milan, Italy)

SCIENTIFIC HEADS

GIOVANNI APOLONE (Milan, Italy) FILIPPO DE BRAUD (Milan, Italy) MICHELE DEL VECCHIO (Milan, Italy) MASSIMO DI NICOLA (Milan, Italy) GIANPIETRO DOTTI (Chapel Hill, USA) SOLDANO FERRONE (Boston, USA) JOHN HISCOTT (Rome, Italy)

SCIENTIFIC BOARD

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•GIULIA BIANCHI, Milan, Italy

•CHIARA BONINI, Milan, Italy

•YVONNE CHEN, Los Angeles, USA

•FILIPPO DE BRAUD, Milan, Italy

•MICHELE DEL VECCHIO, Milan, Italy

•MASSIMO DI NICOLA, Milan, Italy

•ANNA DIMBERG, Uppsala, Sweden

•MAURO FERRARI, Menlo Park, California, USA

•SOLDANO FERRONE, Boston, USA

•JOHN HISCOTT, Rome, Italy

•TAMARA LASKOWSKI, Houston, USA

•MASSIMO MASSAIA, Cuneo, Italy

•LLUIS MOREY, Miami, USA

•MARIA RESCIGNO, Milan, Italy

•RYAN SULLIVAN, Boston, Italy

FACULTY

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January 2022 · Scientific Program

14:50 Introduction

Michele Del Vecchio (Milan, Italy)

I SESSION: Preclinical evidences and new targets Chairmen: Filippo de Braud (Milan, Italy) Soldano Ferrone (Boston, USA)

15.00-15.30 Translational results in melanoma clinical trials Ryan Sullivan (Boston, USA)

15.30-15.40 Discussion

15.40-16.10 Tumor vessels as gatekeepers for immune cells – implications for cancer immunotherapy Anna Dimberg (Uppsala, Sweden)

16.10-16.20 Discussion

16.20-16.50 Overcoming immune suppression with next-generation CAR-T cells Yvonne Chen (Los Angeles, USA)

16.50-17.00 Discussion

17.00-17.30 CAR-NK cells in solid tumors Tamara Laskowski (Houston, USA) 17.30-17.40 Discussion

Keynote Lecture

17.40-18.10 Cancer Nanomedicine and Transport Oncophysics Mauro Ferrari (Menlo Park, California, USA) Presented by Michele Del Vecchio (Milan, Italy)

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January 2022 · Scientific Program

Chairmen: Massimo Massaia (Cuneo, Italy), John Hiscott (Rome, Italy)

15.30-16.00 TCR-modified T cells for anticancer adoptive therapy Chiara Bonini (Milan, Italy)

16.00-16.10 Discussion

16.10-16.40 Defining the role of the CoREST complex in advanced breast cancer Lluis Morey (Miami, USA)

16.40-16.50 Discussion

16.50-17.20 Modulation of microbiota to fight cancer Maria Rescigno (Milan, Italy)

17.20-17.30 Discussion

17.30-18.00 CDK 4-6 inhibitors in breast cancer Giulia Bianchi (Milan, Italy)

18.00-18.10 Discussion

18.10-18.20 Conclusions

Massimo Di Nicola (Milan, Italy)

GENERAL INFORMATIONS

Thursday, 27 January 2022 from 14.50 to 18.40 Friday, 28 January 2022 from 15.30 to 18.10 Webinar Congress on Nadirex Platform:

www.nadirex.org

Registration instructions

Registration is free and can be made on-line at www.nadirex.org

The Congress is not by direct invitation of the Sponsor.

Officlal language English

CME Provider Nr. 265 Organizing Secretariat

Nadirex International Srl Via Riviera 39 · 27100 Pavia

Tel. +39.0382.525714/35 - Fax +39.0382.525736 [email protected]

www.nadirex.com

GENERAL INFORMATIONS

• Learning hours: 7

• Educational goal: Nr. 2 - Guidelines - Protocols - Procedures

• Addresses of the Congress

The Congress is addressed to the following figures:

• Physician

(Disciplines: Hematology, Infectious Diseases, Oncology, Internal Medicine, Transfusional Medicine)

• Biologist

• Biotechnologist

• Biomedical Laboratory Technician

• Pharmacist (Disciplines: Hospital Pharmacy)

• Chemist (Disciplines: Analytical Chemistry)

• Participants: 200

• RL (Remote Learning) product type: Live courses on dedicated multimedia platform (Virtual Classroom, Webinar) - Synchronous RL

• Participant Resources Required: email address (for registration), recent and updated web browser, Internet connection, devices to enable use of learning contents (pc, smartphone or tablet) with speakers (or earphones), microphone (only if the course calls for verbal interaction between teachers and participants).

GENERAL INFORMATIONS

Online multiple-choice questionnaire with double randomization.

To earn ECM credits for the event you must:

• attend 90% of the teaching activities

• give correct answers to at least 75% of the questions on the questionnaire (a maximum of five attempts to pass the test are allowed, subject to repetition of content activities for each attempt);

• fill out the “RL evaluation form” and the “quality and learning needs questionnaire” (not mandatory)

Attention: the questionnaire will be online for only 3 (three) days after the event has concluded.

Guidelines for Speakers and Chairmen

The Zoom room will be opened only for speakers and chairmen at:

27 January: 02.00 p.m. - 28 January: 03.00 p.m.

(For participants room opens at the beginning time of the Congress) The Official Language for the presentation of speakers is: English The Official Language for the slides of the speakers is: English The Official Language for chairmen is: English

Nadirex International assumes all responsibility for the contents, quality and ethical correctness of this ECM activity.

WITH THE UNRESTRICTED EDUCATIONAL GRANTS OF: