Patch testing is a relatively safe and reasonably reli- able method for identifying contact allergens in pa- tients with contact dermatitis. It has been clearly shown that patch testing is necessary in the majority of patients with eczema [1]. The technique of patch testing is described in Chap. 22.
All patients are tested with the European standard series, containing the most frequent contact allergens in European countries (Table 1). Often, standard se- ries patch testing is not enough, and additional aller- gens or potential allergens need to be tested, based on the patient’s history and clinical examination. Ex- amples are products and chemicals to which the pa- tient is exposed occupationally or in his or her home environment. Test series containing the most fre- quent allergens in certain products (preservatives, fragrances, dental materials, plastics and glues, me- dicaments) or in certain occupations (hairdressing, pesticides, oil and cooling fluid) are very helpful. Ap- proximately 510 patch test materials are commercial- ly available from Hermal (Reinbek, Germany, www.
hermal.de), Chemotechnique Diagnostics (Malmö, Sweden, www.chemotechnique.se) and Brial Allergen (Greven, Germany, www.brial.com).
For other chemicals and products, the investigator must decide how to apply them as a patch test. Chem- icals usually need to be diluted, and it is of the utmost importance to use an appropriate patch test concen- tration and vehicle to avoid both false-negative and false-positive (irritant) reactions. The most useful reference source for documented test concentrations and vehicles of chemicals, groups of chemicals and products is the book Patch testing. Test concentra- tions and vehicles for 3700 chemicals [2]. Other useful lists are provided in recent textbooks on contact der- matitis [3–6].
Guidelines for testing the patient’s own contact materials are provided in Chap. 50.
Table 2 lists alphabetically all chemicals men- tioned in this book with their test concentrations and vehicles (sometimes two concentrations are suggest- ed when insufficient data are available) as suggested by the various authors. All allergens commercially available are also listed with their supplier(s), their test concentrations, and vehicles as supplied. It should be appreciated that for a considerable num- ber of allergens, the concentrations vary between suppliers. Table 3 provides a list of test concentra- tions for groups of chemicals as suggested by various authors in this book. Table 4 finally is an alphabetical listing of commonly used abbreviations and their full chemical synonyms.
References
1. Rycroft RJG (1990) Is patch testing necessary? In:
Champion RH, Pye RJ (eds) Recent advances in dermatol- ogy, vol 8. Churchill Livingstone, Edinburgh, pp 101–111 2. De Groot AC (1994) Patch testing. Test concentrations and
vehicles for 3700 chemicals, 2nd edn. Elsevier, Amsterdam 3. Rietschel RL, Fowler JF Jr (eds) (1995) Fisher’s contact der-
matitis, 4th edn. Williams and Wilkins, Baltimore, Md.
4. Adams RM (1990) Occupational skin disease, 2nd edn.
Saunders, Philadelphia, Pa.
5. De Groot AC, Weijland JW, Nater JP (1994) Unwanted effects of cosmetics and drugs used in dermatology, 3rd edn. Elsevier, Amsterdam
6. Kanerva L, Elsner P, Wahlberg JE, Maibach HI (eds) (2000) Handbook of occupational dermatology. Springer, Berlin Heidelberg New York
and Vehicles
for Testing Contact Allergens
Anton C. De Groot, Peter J. Frosch
Metals Cobalt chloride 1% pet.
Nickel sulfate 5% pet.
Potassium dichromate 0.5% pet.
Rubber chemicals Thiuram mix 1% pet.
Dipentamethylenethiuram disulfide (0.25%) Tetramethylthiuram disulfide (0.25%) Tetraethylthiuram disulfide (0.25%) Tetramethylthiuram monosulfide (0.25%)
N-Isopropyl-N´-phenyl-p-phenylenediamine 0.1% pet.
Mercapto mix 2% pet.
N-Cyclohexylbenzothiazyl sulfenamide (0.5%) Dibenzothiazyl disulfide (0.5%)
Mercaptobenzothiazole (0.5%)
Morpholinyl mercaptobenzothiazole (0.5%)
Mercaptobenzothiazole 2% pet.
Medicaments Budesonide 0.01% pet.
Benzocaine 5% pet.
Neomycin sulfate 20% pet.
Clioquinol® 5% pet.
Tixocortol pivalate 0.1% pet.
Cosmetic ingredients Balsam of Peru (Myroxylon pereirae) 25% pet.
5-Chloro-2-methylisothiazol-3-one/2-methylisothiazol-3-one (MCI/MI) 0.01% aq.
Colophonium (rosin) 20% pet.
Formaldehyde 1% aq.
Fragrance mix (incl. 5% sorbitan sesquioleate) 8% pet.
α-Amylcinnamaldehyde (1%) Cinnamal(dehyde) (1%) Cinnamyl alcohol (1%) Eugenol (1%) Geraniol (1%)
Hydroxycitronellal (1%) Iso-eugenol (1%)
Oak moss absolute (Evernia prunastri) (1%)
Paraben mix 16% pet.
Butylparaben (4%) Ethylparaben (4%) Methylparaben (4%) Propylparaben (4%)
p-Phenylenediamine free base 1% pet.
Quaternium-15 1% pet.
Wool wax alcohols (lanolin alcohol) 30% pet.
Hydroxymethylpentylcyclohexenecarboxaldehyde (Lyral®) 5% pet.
Miscellaneous p-tert-Butylphenol formaldehyde resin 1% pet.
Epoxy resin 1% pet.
Primin 0.01% pet.
Sesquiterpene lactone mix 0.1% pet.
Alantolactone (0.033%) Dehydrocostus lactone (0.033%) Costunolide (0.033%)
49
Allergen Test Concentration and vehicle Suppliers
Trolab Chemo Brial
Abietic acid (icr) 10% pet. + + +
Acebutolol hydrochloride 2% pet.
Aceclofenac 1% pet
Acetylsalicylic acid (icr) 10% pet.
Achillea millefolium (yarrow extract) 1% pet. + +
Acid black 48 (CI 65005) 1% pet.
Acid red 14 (azorubine) 0.1% alc.
Acid red 118 (CI 26410) 5% pet. +
Acid red 359 5% pet. +
Acid violet 17 (CI 42650) 1% pet.
Acid yellow 36 (CI 13065, metanil yellow) 1% pet. + + +
Acid yellow 61 (CI 18968) 5% pet.
Actarit (phde) 1% pet
Aciclovir (fde) 5% pet.
Alantolactone (icr) 0.33% pet.
Alclometasone-17,21-dipropionate 1% alc. 1% pet.
Alcohol, ethyl (icr) 10% aq.
Alimemazine tartrate see Trimeprazine tartrate
Allantoin 0.5% aq.
Althiazide (phde) 10% pet. or aq.
Aluminum (icr) Pure
Aluminum chloride hexahydrate 2% pet.
Allylisopropylacetylurea See Apronalide
Amalgam 5% pet.
Amalgam alloying metals 20% pet. + +
Amalgam non gamma 2 5% pet.
Amcinonide 1% alc. 0.1% pet. 0.1% pet.
Amerchol ® L-101 See Lanolin alcohol and
paraffinum liquidum
Amethocaine See Tetracaine hydrochloride
Amikacin sulfate 20% pet.
4-Aminoantipyrine See Ampyrone
p-Aminoazobenzene (Solvent yellow 1, CI 11000) 0.25% pet 1% pet. + 1% pet.
ε-Aminocaproic acid 1% aq.
Amino-4-N, N-diethylaniline sulfate (TSS Agfa®) 1% pet.
2-2-(Aminoethoxy)ethanol See Diglycolamine
Amino-4-N-ethyl-N-(methanesulfon- 1% pet. + +
aminoethyl)-m-toluidine (CD 3)
Aminoglycosides (de) 20% pet.
m-Aminophenol 1% pet. + + +
p-Aminophenol (CI 76550) (icr) 1% pet. + + +
Aminophylline (fde) 10% pet.
Amitriptyline (phde) 5% pet.
Amlexanox (fde) 1% pet.
Ammoniated mercury 1% pet. + + +
Ammonium bituminosulfonate See Ichthammol
Ammonium heptamolybdate 1% aq.
Ammonium hexachloroplatinate (icr) 0.1% aq. +
Ammonium persulfate (icr) 2.5% pet. + + +
Ammonium tetrachloroplatinate (icr) 0.25% pet. + 0.25% aq. +
Ammonium thioglycolate 1% pet., fresh 2.5% aq. 1% pet.
Amorolfine 1% pet.
Ampicillin (icr) 5% pet. +
Ampiroxicam (phde) 1% pet.
Amprolium hydrochloride 10% aq.
Ampyrone (4-aminoantipyrine) (icr) 10% pet.
α-Amylcinnamaldehyde (icr) 2% pet. 1% pet. + 1% pet.
Amylocaine hydrochloride 5% pet +
Anethole 5% pet.
Aniline 1% pet. +
Antazoline 1% pet.
Anthemis nobilis (chamomilla romana) 1% pet.
Antipyrine (phenazone) (de) 5% pet.
Apronalide (allylisopropylacetylurea) (fed) 5% pet.
Arnica montana (arnica extract) 0.5% pet. + +
Arsanilic acid 10% pet.
Atenolol (de) 10% pet.
Atranorin (ph) 0.1% pet.
Atropine sulfate 1% aq. or pet + (aq.) + (aq.)
Azathioprine 1% pet.
Azidamfenicol 2% pet.
Azodicarbonamide 0.5% pet.
Azodiisobutyrodinitrile 1% pet.
Azorubine See Acid red 14
Bacitracin (icr) 20% pet. + 5% pet. +
Bacitracin zinc 20% pet.
Balsam of Peru See Myroxylon pereirae
Balsam of Tolu See Myroxylon toluiferum
Basic brown 1 See Bismarck Brown R
Basic red 46 1% pet.
Beech tar See Fagus sylvatica
Befunolol 1% aq.
Benomyl 0.1–1% pet.
Benoxinate See Oxybuprocaine
Benzaldehyde (icr) 5% pet. + +
Benzalkonium chloride (BAK) 0.01–0.1% aq. 0.1% pet. 0.1% aq. 0.1% pet.
Benzamine lactate 1% pet.
2-Benzimidazolethiol 1% pet.
(2-mercaptobenzimidazole)
Benzisothiazolinone (BIT) (ph) 0.1% pet. + 0.05% pet. +
Benzocaine (icr) (ph) 5% pet. + + +
Benzodiazepines (de) 1–5% aq. or pet.
Benzoic acid (icr) (ph) 5% pet. 5% pet.; 1%
alc./glyc.
Benzoin resin see Styrax benzoin
Benzophenone-3 (oxybenzone) (ph) 10% pet. + + +
Benzophenone-4 (sulisobenzone) (ph) (icr) 10% pet. + + +
Benzophenone-10 (mexenone) (ph) 10% pet. +
IH-Benzotriazole 1% pet. + + +
Benzyl benzoate 5% pet.
Benzoyl peroxide (icr) 1% pet. + + +
Benzydamine hydrochloride (ph) 5% pet. or aq.
Benzyl alcohol (icr) 1% pet. + + +
Benzyl cinnamate 5% pet.
Benzylhemiformal 1% pet.
Benzyl salicylate 1–5% pet. 1% pet. 2% pet. 1% pet.
Bergamot oil See Citrus bergamia
Beryllium chloride or sulfate 1% pet.
Betamethasone dipropionate 1% alc.
Betamethasone-17-valerate 1% alc. 0.12% pet. 1% pet. 0.12% pet.
Betaxolol hydrochloride 1% aq.
Betula alba (birch tar) 3% pet.
BHA (butylated hydroxyanisole) (icr) 2% pet. + + +; 2% alc.
BHT (butylated hydroxytoluene) (icr) 2% pet. + + +; 2% alc.
Bifonazole 1% alc.
49
Bioban ® CS-1135 1% pet. + + +
Bioban ® CS-1246 1% pet. + +
Bioban® P 1487 1% pet. 0.5% pet. 1% pet.
Biocheck 60 ® 0.2% aq.
Bis(aminopropyl)-lauramine 0.01–0.1–1% aq.
Bis(dibutyldithiocarbamato) zinc See Zinc dibutyldithiocarbamate Bis(diethyldithiocarbamato) zinc See Zinc diethyldithiocarbamate
BIS-EMA 1% pet. +
BIS-GMA 2% pet. + + +
BIS-MA 2% pet. +
Bismarck Brown (vesuvine brown, 0.5% pet. + +
basic brown 1, CI 21000)
Bismuth neodecanoate 1% pet.
Bisphenol A See 4,4´-isopropylidenediphenol
Bisphenol A dimethacrylate 2% pet.
Bithionol (ph) (icr) 1% pet. + + +
Black rubber mix (N-isopropyl-N-phenyl-p- 0.25% pet.
phenylenediamine,N-cyclohexyl-N-phenyl-p- phenylenediamine,N, N-diphenyl-p- phenylenediamine)
Boric acid 10% pet.
Brilliant black 0.1%
coca/glyc.
Brilliant lake red R (D&C red 31, CI 15800) 1% pet.
(ph) (icr)
5-Bromo-4´-chlorosalicylanilide (ph) 1% pet.
2-Bromo-2-nitropropane-1,3-diol (icr) 0.5% pet. 0.25% pet. 0.5% pet.
Budesonide 0.1% pet. + 0.01% pet. +
Bucillamine (de) 1% pet.
Bufexamac 5% pet. + +
Bupivacaine 1% pet.
Butacaine 5% pet.
1,4-Butanediol diacrylate (BUDA) 0.1% pet. +
1,4-Butanediol dimethacrylate (BUDMA) 2% pet. + +
Butethamine hydrochloride 5% pet.
Butyl acrylate (BA) 0.1% pet. + +
Butyl aminobenzoate 5% pet.
Butylated hydroxyanisole See BHA
Butylated hydroxytoluene see BHT
4-tert-Butylbenzoic acid 1% pet.
p-tert-Butylcatechol (PTBC) 0.25% pet + 1% pet.
Butyl glycidyl ether 0.25% pet.
t-Butyl hydroquinone 1% pet. + + +
n-Butyl methacrylate (BMA) 2% pet. +
Butyl methoxydibenzoylmethane (ph) 10% pet. + + +
Butylparaben (icr) 3% pet. + + +
p-tert-Butylphenol 1% pet. + + +
p-tert-Butylphenolformaldehyde resin (PTBP) 1% pet. + + +
Cadmium chloride (ph) 0.5% pet. 1% aq. +
Caine mix I (procaine hydrochloride, 3.5% pet
dibucaine hydrochloride).
Caine mix II (dibucaine hydrochloride, 10% pet.
lidocaine, tetracaine)
Caine mix III (benzocaine, dibucaine, tetracaine) 10% pet
Caine mix IV (amylocaine, lidocaine, prilocaine) 10% pet
Calcipotriol 2µg/ml alc.
Camphor (icr) 1% pet.
Camphoroquinone 1% pet.
Cananga odorata (cananga oil, ylang-ylang oil) 5% pet. 2% pet.
Captan 0.5% aq. or pet. 0.5% pet.
Captopril (de) 0.1–3% pet
Carbamazepine (de) (fde) (phde) 10% pet. or alc. / 0.01–10% pet.
Carba mix (N, N-diphenylguanidine, 3% pet. 3% pet.
zinc dibutyl dithiocarbamate, zinc diethyldithiocarbamate)
Carbenicillin (de) 5% aq.
Carprofen 5% pet.
Carteolol 1% aq.
Castor oil Pure
CD 2 (color developer 2) See Methyl-3-amino-4-N, N- diethyl-aniline
CD 3 (color developer 3) See Amino-4-N-ethyl-N-(methane- sulfonaminoethyl)-m-toluidine CD 4 (color developer 4) See 4-(N-Ethyl-N-2-hydroxyethyl)-
2-methylphenylenediamine sulfate
Cedarwood oil See Cedrus atlantica
Cedrus atlantica (cedarwood oil) (ph) 10% pet. + +
Celecoxib (de) 10% pet.
Cetalkonium chloride 0.1% pet. 0.1% pet.
Cetrimide See Cetrimonium bromide
Cetrimonium bromide (Cetrimide) 0.25% pet.
Cetyl alcohol (icr) 5% pet. +
Cetyl alcohol, stearyl alcohol 20% pet. + + +
Cetylpyridinium chloride 0.1% pet. + +
Chamomilla recutita (chamomile extract) (icr) 2.5% pet.
Chamomilla romana see Anthemis nobilis
Chlorambucil 2% pet.
Chloramine-T (icr) 0.05% aq.
Chloramphenicol (icr) 5% pet. + + 10% pet.
Chlorhexidine diacetate (ph, icr) 0.5% aq.
Chlorhexidine digluconate (ph) (icr) 0.5% aq. + + +
Chlormezanone (fde) 10% pet. or alc.
Chloroacetamide 0.2% pet. + + +
p-Chloro-m-cresol (PCMX) (icr) 1% pet. + + +
5-Chloro-2-methyl-4-isothiazolin-3-one 0.01–0.02% aq.
5-Chloro-2-methylisothiazol-3-one (MCI), 0.01% aq. + + +
2-methylisothiazol-3-one (MI)
5-Chloro-1-methyl-4-nitroimidazole 0.1% pet.
Chlorothalonil (icr) 0.001–0.01% acet.
Chloroxylenol 1% pet. 0.5% pet. 1% pet.
Chlorphenesin 1% pet.
Chlorpheniramine maleate 5% pet. +
Chlorpromazine hydrochloride (phde) (icr) 0.1–1% pet. or aq. 0.1% pet. 1% pet.
Chlorquinaldol (ph) 5% pet. + + +
Chlortetracycline hydrochloride 5% pet. 1% pet.
Chromic chloride 1% pet.
Chromic potassium sulfate 2% aq.
Chromic sulfate 0.5% pet.
Chrysanthemum cinerariaefolium 1% pet. +
(pyrethrum) (icr)
Chrysanthemum parthenium 1% pet.
(feverfew flower extract)
Cimetidine (de) 1% aq.
Cinchocaine® See Dibucaine hydrochloride
Cinnamal (cinnamic aldehyde) (ph) (icr) 1% pet. + 2% pet. +
Cinnamic acid (icr) 5% pet.
Cinnamomum cassia (cinnamon oil) (ph)(icr) 0.5% pet.
Cinnamyl alcohol 1–5% pet. 1% pet. 2% pet. 1% pet.
Cinnoxicam 1% pet.
49
Ciprofloxacin (fde) 10% pet.
Citiolone (fde) 10% DMSO
Citronellal 2% pet.
Citrus aurantium dulcis (neroli oil) (ph) 2% pet. + +
Citrus bergamia (bergamot oil) (ph) 2% pet.
Citrus dulcis (orange oil) (ph) 2% pet.
Citrus limonum (lemon oil) (ph) 2% pet. + +
Clioquinol® (icr) 5% pet. + + +
Clarithromycin (fde) 10% aq.
Clindamycin phosphate (de) 1–20% aq. or pet.
Clobetasol-17-propionate (icr) 1% alc. 0.25% pet. 1% pet. 0.25% pet.
Clobetasone butyrate 1% alc.
Clomipramine (phde) 0.1% pet.
Clonidine 1% pet.
Cloprednol 1% alc.
Clotrimazole 5% pet./1% alc. + (pet.) + (pet)
Clove oil See Eugenia caryophyllus
Cloxacillin (de) (icr) Pure
Coal tar See Pix ex carbone
Cobalt chloride (ph) (icr) 1% pet. + + +
Cobaltous sulfate (ph) 2.5% pet.
Cocamide DEA 0.5% pet. + + +
Cocamidopropyl betaine 1% aq. + + 1%
alc./aq.
Codeine phosphate (de) 0.05% aq.
Cold cream Pure
Colophonium (rosin) (ph) (icr) 20% pet. + + +
Compositae mix (Tanacetum vulgare, 6% pet. 5% pet. 5% pet.
Arnica montana, parthenolide,
Chamomilla romana, Achillea millefolium)
Congo red 2% pet.
Copper oxide See Cupric oxide
Copper 8-quinolinate 1% pet.
Copper sulfate See Cupric sulfate
Corticosteroid mix (budesonide, tixocortol 2.1% pet.
pivalate, hydrocortisone-17-butyrate)
Coumarin (ph) 1% pet.
Coumarone indene resin 20% pet.
p-Cresol 1% aq.
Cresyl glycidyl ether (icr) 0.25% pet. + +
Croconazole 1% alc.
Cromoglicate sodium See Cromolyn
Cromolyn (cromoglicate sodium) (icr) 2% aq. 2% pet.
Crotamiton 3% pet.
Cupric oxide (copper oxide) 5% pet.
Cupric sulfate (copper sulfate) (icr) 1% pet. 2% pet. 1% aq.;
2% pet.
Cyclohexanone resin 1% pet.
Cycloheximide 1% pet.
N-Cyclohexylbenzothiazyl sulfenamide (CBS) 1% pet. + + +
N-Cyclohexyl-N-phenyl-p-phenylene-diamine 1% pet.
(CPPD)
Cyclohexyl thiophthalimide 1% pet. 0.5% pet. + +
Cyclomethycaine hydrochloride 1% pet.
Cyclopentolate hydrochloride 0.5% aq.
Cymbopogon schoenanthus (lemon grass oil) (ph) 2% pet. + +
Dandelion See Taraxacum officinale
Dazomet 0.1% pet.
D and C red 31 See Brilliant lake red R
D and C yellow 11 See Solvent yellow 33
DDT 1% pet. or acet.
Desketoprofen 1% pet.
Desonide 1% alc.
Desoximetasone (ph) 1% alc.
Dexamethasone 0.5% pet.
Dexamethasone acetate 1% alc.
Dexamethasone phosphate 1% alc.
Dexamethasone 21-phosphate disodium salt 1% pet.
Dexpanthenol See Panthenol
Diallyl disulfide 1% -5% pet. 1% pet.
4,4´-Diaminodiphenylmethane (ph) 0.5% pet. + + +
Diazolidinyl urea 2% pet. + + +
Dibenzothiazyl disulfide (MBTS) 1% pet. + + +
Dibenzthione (sulbentine) 3% pet.
1,2-Dibromo-2,4-dicyanobutane See Methyldibromo glutaronitrile
Dibromosalicylanilide (ph) 1% pet.
Dibucaine hydrochloride (Cinchocaine ®) (ph) 5% pet. + + +
Dibutyl phthalate 5% pet. + + +
Dibutylthiourea 1% pet. + + +
Dibutyl- and diethylthiourea mix 1% pet.
Dichlorophene (ph) 0.5% pet. + 1% pet. +
Diclofenac sodium 1% pet. 5% pet.
Dicyanodiamide 0.1% aq.
Dicyclohexylcarbodiimide 0.1% acet. and lower
Diethanolamine 2% pet. + +
Diethyleneglycol diacrylate (DEGDA) 0.1% pet. +
Diethylenetriamine (DETA) 1% pet. 0.5% pet. +
Di-2-ethylhexyl phthalate (DEHP) See Dioctyl phthalate
Diethyl phthalate 5% pet.
Diethylstilbestrol 1% pet.
Diethylthiourea 1% pet. +
Diflorasone diacetate 1% alc.
Diflucortolone pivalate 1% alc.
Difolatan 0.1% pet.
Diglycolamine [2-(2-aminoethoxy)ethanol] 1% pet.
Dihydroquinidine (de) Pulverized tablet, pure
Dihydrostreptomycin 0.1% pet.
4,4´-Dihydroxydiphenyl 0.1% pet. 0.1% pet.
Diisopropyl carbodiimide 0.1% acet. and lower
Diltiazem (de) 1% pet.
Dimethylaminoethyl ether 1% pet.
N, N-Dimethylaminoethyl methacrylate 0.2% pet.
Dimethylaminopropylamine 1% aq.
Dimethylaminopropyl ethyl carbodiimide 0.1% acet. and lower
Dimethyl dihydroxyethyleneurea 4.5% aq.
Dimethylol dihydroxyethyleneurea 5% aq.
4,4-Dimethyloxazolidine/3,4,4,trimethyl- See Bioban® CS-1135 oxazolidine
N, N´-Dimethyl-p-phenylenediamine 0.25% pet.
Dimethyl phthalate 5% pet. + +
Dimethylol propylene urea 5% aq.
N, N-Dimethyl-p-toluidine 2% pet. 5% pet. 2% pet.
N, N-di-β-Naphthyl-p-phenylenediamine 1% pet.
(DBNPD)
2,4-Dinitrochlorobenzene (DNCB) (icr) 0.01–0.1% aq. or acet.
Dioctyl phthalate (di-2-ethylhexyl phthalate) (icr) 5% pet. + 2% pet. +
Dipentamethylenethiuram disulfide 0.25% pet. 1% pet. 0.25% pet.
Dipentamethylenethiuram tetrasulfide 0.25% pet.
Dipentene (D-limonene) 2% pet. + 1% pet. +
Diperocaine 1% pet.
49
Diphenhydramine hydrochloride (ph) 1% pet. +
1,3-Diphenylguanidine (DPG) (icr) 1% pet. + + +
Diphenylmethane 4,4-diisocyanate (MDI) (icr) 2% pet. + 1% pet.
N, N’-Diphenyl-p-phenylenediamine (DPPD) 1% pet. 0.25% pet. 1% pet. 0.25% pet.
Diphenylthiourea (DPTU) 1% pet. + + +
Dipivalyl epinephrine hydrochloride 1% aq.
Dipyrone (metamizole) (fde) (icr) 10% pet. 1% pet.
Direct black 38 (CI 30235) 1% pet.
Direct orange 34 (CI 40215) 1% pet. 5% pet.
Disodium EDTA (edetic acid disodium salt) 1% pet. + + +
Disperse black 1 (CI 11365) 1% pet.
Disperse black 2 (CI 11255) 1% pet.
Disperse blue 1 (CI 64500) 1% pet. +
Disperse blue 3 (CI 61505) 1% pet. + + +
Disperse blue 7 (CI 62500) 1% pet.
Disperse blue 26 (CI 63305) 1% pet.
Disperse blue 35 (ph) 1% pet. +
Disperse blue 85 (CI 11370) 1% pet. +
Disperse blue 102 1% pet.
Disperse blue 106 (CI 111935) 1% pet. +
Disperse blue 124 1% pet. +
Disperse blue 153 1% pet. +
Disperse blue mix (124/106) 1% pet. + +
Disperse brown 1 (CI 11153) 1% pet. +
Disperse orange 1 (CI 11080) 1% pet. +
Disperse orange 3 (CI 11005) 1% pet. + + +
Disperse orange 13 (CI 26080) 1% pet.
Disperse orange 76 1% pet.
Disperse red 1 (CI 11110) 1% pet. + + +
Disperse red 11 (CI 62015) 1% pet. + +
Disperse red 17 (CI 11210) 1% pet. + + +
Disperse red 153 1% pet.
Disperse yellow 1 (CI 10345) 1% pet.
Disperse yellow 3 (CI 11855) 1% pet. + + +
Disperse yellow 9 (CI 10375) 1% pet. + + +
Disperse yellow 27 1% pet.
Disperse yellow 39 1% pet.
Disperse yellow 49 1% pet.
Disperse yellow 54 (CI 47020) 1% pet.
Disperse yellow 64 (CI 47023) 1% pet.
4,4´-Dithiodimorpholine 1% pet.
Dithranol 0.02% pet.
Di-o-tolyl biguanidine 1% pet.
Diurethane dimethacrylate 2% pet. 2% pet.
DMDM hydantoin 2% aq. + + +
Dodecyldi(aminoethyl)glycine (DDAG) 0.5% aq.
Dodecyl dimethyl ammonium chloride 0.01–0.1–1% aq (quaternium-12).
Dodecyl gallate (lauryl gallate) 0.3% pet. 0.25% pet. 0.3% pet.
Dodecyl mercaptan 0.1% pet. + +
Doxepin 5% pet.
Doxycycline (phde) (fde) 10% alc. or pet.
Drometrizole [2-(2´-hydroxy-5´-methyl- 1% pet.
phenyl)benzotriazole]
Echothiophate iodine 1% aq.
Econazole nitrate 1% alc. +
Edetic acid disodium salt See Disodium EDTA
Enilconazole 1% alc.
Eosine (ph) 5% pet. 50% pet.
Ephedrine hydrochloride (de) 5% aq. 1% pet.
Epichlorohydrin 0.1% pet.
Epinephrine 1% aq.
Epoxy acrylate 0.5% pet.
Epoxy resin (icr) 1% pet. + + +
Epoxy resin, cycloaliphatic 0.5% pet.
Erythromycin (base and salts) (de) 1% pet. + +
Erythrosine (ph) 0.25% pet.;
alc./glyc.
Estradiol 2% alc.
Ethacridine lactate monohydrate (Rivanol®) 2% pet.
Ethanolamine (monoethanolamine) 2% pet. 2% pet.
Ethenzamide (fde) 20% pet.
Ethoxyquin (ph) 1% pet. 0.5% pet.
Ethyl acrylate (EA) 0.1% pet. +
Ethyl alcohol 10% aq.
7-Ethylbicyclooxazolidine See Bioban® CS-1246
Ethylbutyl thiourea 1% pet.
Ethyl cyanoacrylate 5% pet. 10% pet.
Ethylenediamine dihydrochloride (ph) (icr) 1% pet. + + +
Ethyleneglycol dimethacrylate (EGDMA) 2% pet. + + +
Ethylene thiourea See 2-Imidazolidinethione
Ethylene urea See 2-Imidazolidinone
Ethyleneurea + melamine-formaldehyde 5% pet.
2-Ethylhexyl acrylate (EHA) 0.1% pet. + +
2-Ethylhexyl-p-dimethylaminobenzoate See Octyl dimethyl PABA 2-Ethylhexyl-p-methoxycinnamate see Octyl methoxycinnamate
4-(N-Ethyl-N-2-hydroxyethyl)-2-methyl- 1% pet. + +
phenylenediamine sulfate (CD 4)
Ethyl methacrylate (EMA) 2% pet. +
Ethylparaben (icr) 3% pet. + + +
Ethyl sebacate 2% alc.
N-Ethyl-4-toluenesulfonamide 0.1% pet.
Etofenamate (icr) 2% pet.
Eucalyptus globulus (eucalyptus oil) 2% pet. + +
Eucerin, anhydrous (lanolin) Pure +
Eugenia caryophyllus (clove oil) 2% pet. + +
Eugenol (icr) (ph) 2% pet. 1% pet. + 1% pet.
Euxyl ® K 400 1% pet. 1% pet. 1% pet.
Evernia prunastri (oak moss absolute) (ph) 1% pet. + + +
Evernic acid (ph) 0.1% pet.
Fagus sylvatica (beech tar) 3% pet.
Famciclovir 10% aq.
Feneticillin (de) Pure
Fenoprofen 5% pet.
Fentichlor (ph) 1% pet.
Fenticonazole 1% alc.
Feprazone 5% pet.
Ferrous chloride 2% alc./
glyc.
Ferrous sulfate 5% pet.
Feverfew flower extract See Chrysanthemum parthenium
Fluazinam 0.5% pet.
Fludrocortisone acetate 1% alc.
Flufenamic acid 1% pet.
Flumethasone acetate 1% alc.
Fluocinolone acetonide 1% alc.
Fluocinonide 1% alc.
Fluocortolone 1% alc.
Fluorouracil 1% pet.
Flurbiprofen 5% pet.
49
Flutamide (phde) 1–20% acet. or pet.
Fluticasone propionate 1% alc.
Folpet 0.1% pet.
Formaldehyde (ph) (icr) 1% aq. + + +
Formic acid 1% aq.
Fragrance mix (ph) (cinnamic alcohol, 8% pet. + + +
cinnamal, hydroxy citronellal, α-amyl-cinnamal, geraniol, eugenol, iso-eugenol, oakmoss absolute)
Framycetin (neomycin B) 20% pet. 10% pet.
Fusidic acid sodium salt 2% pet. + +
Gallium oxide 1% pet.
Ganciclovir 20% aq.
Gentamicin sulfate (icr) 20% pet. + + +
Geraniol (icr) 2% pet. 1% pet. 1% pet. 1% pet.
Geranium oil, Bourbon 2% pet.
Glutaral 0.2–0.3% pet. 0.3% pet. 0.2% pet. 0.3% pet.
Glyceryl thioglycolate (icr) 1% pet. + + +
Glyoxal 1% pet./aq. + (pet) + (pet)
Glyphosate 1–10% aq.
Gold sodium thiomalate (de) (icr) 5% pet.
Gold sodium thiosulfate (icr) 0.25% pet. 2% pet.
Griseofulvin (phde) 1% pet.
Grotan® BK See 1,3,5-Tris(2-hydroxyethyl)-
hexahydrotriazine
Halcinonide 1% alc.
Haloprogin 1% pet.
Halomethasone 1% alc.
Hexachlorophene (ph) 1% pet. + + +; 0.5%
pet.
Hexamethylene diisocyanate (HDI) 0.1% pet. +
Hexamethylenetetramine See Methenamine
Hydroxymethylpentylcyclohexene- 5% pet.
carboxaldehyde (Lyral®)
1,6-Hexanediol diacrylate (HDDA) 0.1% pet. +
Hexylresorcinol 0.25% pet. + +
Homosalate (homomenthyl salicylate) 5% pet.
Homatropine 1% aq.
Hydrangenol 0.1% pet.
Hydrazine sulfate 1% pet. + +
Hydroabietyl alcohol 10% pet + +
Hydrochlorothiazide (phde) 1–10% pet.
Hydrocortisone (ph) 1% alc./pet. + (pet.) + (pet.)
Hydrocortisone aceponate 1% alc.
Hydrocortisone acetate 1% alc.
Hydrocortisone buteprate 1% alc.
Hydrocortisone-17-butyrate 1% alc. 0.1% pet. + 0.1% pet.
Hydrogen peroxide 3% aq.
Hydromorphone (de) 2% aq.
Hydroquinone (HQ) 1% pet. + + +
Hydroquinone monobenzylether See Monobenzone
Hydroxycitronellal (ph) 1–5% pet. 1% pet. 1% pet. 1% pet.
2-Hydroxyethyl acrylate (2-HEA) 0.1% pet + +
2-Hydroxyethyl methacrylate (HEMA) 2% pet. 1% pet. + 1% pet.
Hydroxyisohexyl-3-cyclohexenecarboxaldehyde See Hydroxymethylpentylcyclo- hexenecarboxaldehyde
Hydroxylammonium chloride 0.1% aq.
Hydroxylammonium sulfate 0.1% aq.
2-Hydroxymethyl-2-nitro-1,3-propanediol See Tris(hydroxymethyl)nitro- methane
2-(2´-Hydroxy-5´-methylphenyl)benzotriazole See Drometrizole
Hydroxymethylpentylcyclohexene- 5% pet. 5% pet.
carboxaldehyde (Lyral®)
2-Hydroxypropyl acrylate (HPA) 0.1% pet. +
2-Hydroxypropyl methacrylate (HPMA) 2% pet. + +
2-Hydroxy-4-trifluoromethylbenzoic acid See Triflusal
Hypericum perforatum (hypericum oil) 0.5% pet.
Ibuprofen (fde) 5–10% pet.
Ibuproxam (ph) 2.5% pet.
Ichthammol (ammonium bituminosulfonate) 10% pet. +
Idoxuridine 1% pet. +
2-Imidazolidinethione (ethylene thiourea) 1% pet.
2-Imidazolidinone (ethylene urea) 1% pet.
Imidazolidinyl urea 2% pet. + + +
Indium (III) chloride 1% pet.
Indometacin 5% pet. 1% pet.
Iodoform 5% pet.
Iodopropynyl butylcarbamate 0.2% pet. 0.1% pet.
Isoamyl-p-methoxycinnamate (ph) 10% pet. + +
Isoconazole nitrate 1% alc.
Iso-eugenol 2% pet. 1% pet. + 1% pet.
Isophoronediamine (IPD) 0.1% pet. 0.5% pet. + 0.5% pet.
Isophorone diisocyanate (IPDI) 1% pet. +
Isopropyl dibenzoylmethane (ph) 2% pet.
4,4´-Isopropylidenediphenol (Bisphenol A) 1% pet. + +
Isopropyl myristate 10% pet. 20% pet. 10% pet.
N-Isopropyl-N´-phenyl-p-phenylenediamine 0.1% pet. + + +
(IPPD)
Jasminum officinale (jasmine absolute, synthetic) 5–10% pet. 2% pet.
Juniperus (juniper tar) 3% pet.
Kanamycin sulfate 10% pet. + + +
Ketoconazole (icr) 1% alc.
Ketoprofen (phde) (icr) 1% pet.
Ketotifen 2.5% pet./0.7% aq.
Lanette E ® 20% pet.
Lanette N ® 20% pet.
Lanoconazole 1% alc.
Lanolin Pure 30% pet.
Lanolin alcohol (wool wax alcohols) (icr) 30% pet. + + +
Lanolin alcohol and paraffinum liquidum 50% pet. + + +
(Amerchol® L 101)
Laurus nobilis (laurel oil) 2% pet. + +
Lauryl gallate See Dodecyl gallate
Lavandula angustifolia (lavender, absolute) (ph) 2% pet.
Lemon grass oil See Cymbopogon schoenanthus
Lemon oil See Citrus limonum
Levobunolol hydrochloride 1% aq.
Lichen acid mix (atranorin, evernic acid, 0.3% pet.
usnic acid)
Lidocaine hydrochloride (icr) 5% pet. 15% pet. + 15% pet.
D-Limonene See Dipentene
Lincomycin hydrochloride 1% aq.
Lindane (icr) 1% pet.
Lomefloxacin (phde) 1–10% pet.
Lyral® See Hydroxymethylpentylcyclo-
hexenecarboxaldehyde
Mafenide 10% pet. +
Malathion 0.5% pet.
Maneb (ph) 0.5–1% pet.
Mechlorethamine hydrochloride (icr) 0.02% aq.
49
Medroxyprogesterone acetate 1% pet.
Mefenamic acid (fde) 1–10% pet.
Melaleuca alternifolia (tea tree oil) 5% pet.
Melamine formaldehyde 7% pet.
Mentha piperita (peppermint oil) (icr) 2% pet. + +
Menthol (icr) 1% pet. 2% pet. 1% pet.
Mepivacaine 1% pet. +
Merbromin (mercurochrome) 2% aq. or pet.
2-Mercaptobenzimidazole See 2-Benzimidazolethiol
Mercaptobenzothiazole (MBT) (icr) 2% pet. + + +
Mercapto mix (mercaptobenzothiazole 1% pet. + + +
dibenzothiazyl disulfide, morpholinyl mercaptobenzothiazole,N-cyclohexyl-benzo- thiazyl sulfenamide)
Mercuric chloride 0.1% pet. +
Mercurochrome See Merbromin
Mercury (icr) 0.5% pet. + +
Mesulfen 5% pet.
Metamizol See Dipyrone
Metanil yellow See Acid yellow 36
Methenamine (hexamethylenetetramine) 2% pet 1% pet. + 1% pet.
Methyl-3-amino-4-N, N-diethyl-aniline (CD 2) 1% pet. 1% pet.
p-Methylaminophenol sulfate (Metol®)(icr) 1% pet. 1% pet.
Methyl anthranilate 5% pet.
4-Methylbenzylidene camphor (ph) 10% pet. + + +
Methylcoumarin (6-MC) (ph) 1% pet.
Methyldibromo glutaronitrile (1,2-dibromo-2,4- 0.3% pet. + + 0.1% pet.
dicyanobutane)
Methyldichlorobenzene sulfonate 0.1% pet.
N, N-Methylenebisacrylamide (MBAA) 1% pet. +
Methylene-bis(methyloxazolidine) 1% pet.
α-Methylene-γ-butyrolactone (tulipalin) 0.001% alc. 0.01% pet.
Methylhydroquinone (MHQ) 1% pet.
2-Methyl-4-isothiazolin-3-one 0.01–0.02% aq.
Methyl methacrylate (MMA) 2% pet. + + +
N-Methylolchloroacetamide 0.1% pet.
Methyl orange 2% pet.
Methylparaben (icr) 3% pet. + + +
Methylprednisolone aceponate 1% alc.
Methylprednisolone acetate 1% alc.
Methyl salicylate (icr) 2% pet. +
3-Methyl thiazolidone 2-thion 1% pet.
Methyl-p-toluene sulfonate 0.1% pet.
Methyl violet 0.5% pet.
Metipranolol 2% aq.
Metol ® Seep-Methylaminophenol sulfate
Metoprolol (de) 3% aq. / 10% pet.
Metronidazole (fde) 1% pet., 50% pet. 1% pet.
Mexenone See Benzophenone-10
Miconazole nitrate 1% alc. +
Minoxidil 5% in aq. + 20% prop. glyc.
Mitomycin C 0.1% pet.
Mofebutazone 1% pet.
Mometasone furoate 1% alc.
Monobenzone (monobenzylether of 1% pet. + + +
hydroquinone)
Monobenzylether of hydroquinone See Monobenzone
Monoethanolamine See Ethanolamine
2-Monomethylol phenol 1% pet.
Morpholinyl mercaptobenzothiazole (MOR) (icr) 0.5% pet. + 1% pet. 1% pet.
Mupirocin 10% pet.
Musk ambrette (ph) 5% pet. +
Musk ketone (ph) 1% pet.
Musk mix (xylene, tibetene, moskene, ketone) 3% pet.
Musk moskene (ph) 1% pet.
Musk xylene (ph) 1% pet.
Myristyl alcohol 5% pet.
Myroxylon pereirae (balsam of Peru) (ph) (icr) 25% pet. + + +
Myroxylon toluiferum (balsam of Tolu) 20% pet. 10% alc. 20% pet.
Naftifine hydrochloride 5% alc.
1-Naphthalenethiourea (ANTU) 1% pet.
Naphthol AS (CI 37505) 1% pet. + +
Naphthyl mix (N, N-di-β-naphthyl-p-phenylene- 1% pet.
diamine,N-phenyl-2-naphthy-lamine)
Naproxen 5% pet.
Narcissus absolute 2% pet.
Neomycin sulfate (icr) 20% pet. + + +
Neroli oil See Citrus aurantium dulcis
Neticonazole 1% alc.
Nickel sulfate (icr) 5% pet. + + +
Nicotine (icr) 10% pet.
Nifuroxazide (de) 0.001–1% aq./10% pet.
Nigrosine 1% pet. +
Nimesulide (fde) 1–10% pet.
(Nitrobutyl)morpholine/(ethylnitrotrimethylen) see Bioban®
dimorpholine
Nitrofurazone 1% pet. + +
Nitroglycerin (icr) 1% pet.
2-Nitro-p-phenylenediamine (ONPPD) 1% pet. + +
Nonoxynol 5% aq.
Nordihydroguaiaretic acid 2% pet.
Norethisterone acetate 1% alc.
Nystatin (de) 2% pet. + +
Oak moss absolute See Evernia prunastri
Octyl dimethyl PABA (2-ethylhexyl-p-dimethyl- 10% pet. + + +
aminobenzoate) (ph)
Octyl gallate 0.3% pet. 0.25% pet. 0.3% pet.
Octylisothiazolinone 0.1% pet. 0.025% pet. +
Octyl methoxycinnamate (2-ethylhexyl-p- 10% pet. + + +
methoxycinnamate) (ph)
Octyl phthalate 5% pet.
Octyl triazone (ph) 10% pet.
Ofloxacin (fde) 20% pet.
Olaquindox (ph) 1% pet.
Olea europaea (olive oil) Pure
Oleamidopropyl dimethylamine 0.1% aq.
Oleyl alcohol 30% pet.
Oligotriacrylate 480 0.1% pet. +
Olive oil See Olea europaea
Orange oil See Citrus dulcis
Orthocaine 1% pet.
Oxiconazole 1% alc.
Oxprenolol (de) 10% pet.
Oxybenzone See Benzophenone-3
Oxybuprocaine (benoxinate) 1% pet.
Oxyphenbutazone (de) (icr) 1–5% pet. 10% pet.
Oxytetracycline 3% pet. + +
PABA (ph) 10% pet. + + +
49
Palladium chloride (icr) 1% pet. + 2% pet. +
Panthenol (dexpanthenol) (icr) 50% aq. 5% pet. 5% pet.
Papain 1% pet. 1% pet.
Paraben mix (butyl, ethyl, methyl, propyl- 16% pet. 16% pet. 16% pet
paraben) (icr).
Paracetamol 10% pet.
Paraquat 0.1% pet.
Paromomycin 10% pet.
Parthenolide 0.1% pet.
Pecilocin 1% pet.
PEG 6 (and) PEG 32 (polyethylene glycol Pure + +
ointment)
PEG 400 (icr) Pure
Penbutolol sulfate 2% aq.
Penethamate 1% pet.
D-Penicillamine 1% aq.
Penicillin G (de) (icr) 100,000 U/g aq. or pet.
Pentachloronitrobenzene 1% pet.
Pentaerythritol triacrylate (PETA) 0.1% pet. +
Peppermint oil See Mentha piperita
Perfume mix (cinnamic alcohol, cinnamal, 6% pet.
hydroxycitronellal, eugenol, iso-eugenol, geraniol)
Petrolatum, white (icr) Pure + + +
Phenacetin 10% pet.
Phenazone See Antipyrine
Phenidone ® See 1-Phenyl-3-pyrazolidinone
Phenobarbital (de) 1–20% pet.
Phenol-formaldehyde resin (P-F-R-2) 5% pet. 1% pet. 5% pet.
Phenolphthalein 0.5% pet.
Phenoxyethanol (icr) 1% pet. + + +
Phenyl-azo-2-naphthol (PAN) 0.1% pet.
Phenylbenzimidazole sulfonic acid (ph) 10% pet. + + +
Phenylbutazone (de) (icr) 1–5% pet. 10% pet.
p-Phenylenediamine dihydrochloride 0.5% pet.
p-Phenylenediamine free base (ph) (icr) 1% pet. + + +
Phenylephrine hydrochloride 10% aq. + 10% coca
Phenyl glycidyl ether (icr) 0.25% pet. 0.25% pet
Phenylhydrazine 1% pet.
α-Phenylindole 2% pet.
Phenyl isocyanate 0.1% pet.
Phenylmercuric acetate (icr) 0.01% aq. 0.05% pet. + 0.05% pet.
Phenylmercuric borate 0.05% pet.
Phenylmercuric nitrate (icr) 0.05% pet. 0.01% pet.
Phenyl-β-naphthylamine (PBN) 1% pet. + +
o-Phenylphenol (ph) (icr) 1% pet.
Phenyl-p-phenylenediamine 0.25% pet.
1-Phenyl-3-pyrazolidinone (Phenidone®) 1% pet. + +
Phenyl salicylate 1% pet. + + +
Phosphorus sesquisulfide (icr) 0.5% pet.
Picric acid 1–2% pet.
Piketoprofen 2.5% pet.
Pilocarpine hydrochloride (icr) 1% pet. 1% aq. 1% alc./
glyc.
Pindolol 2% pet.
Pinus (pine tar) 3% pet. + +
Piperazine (de) 1% pet. or aq.
Piroxicam (phde) (de) 1–10% pet.
Pix ex carbone (coal tar) (ph) (icr) 5% pet. + +
Polidocanol 3% pet. + +
