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(1)33 Aim To study whether TEL modulates endothelial inflammation and oxidative cell damage induced by AII-independent stimuli in cultured HUVECs

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Academic year: 2021

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33

Aim

To study whether TEL modulates endothelial inflammation and oxidative cell damage induced by AII-independent stimuli in cultured HUVECs.

For this reason, we evaluated the effect of the drug on VCAM-1 and ICAM-1 expression in ECs stimulated with TNF-α 142, an AII-unrelated pro-inflammatory cytokine pathophysiologically involved in the development of human cardiovascular disease 143 and on ECs treated with H2O2, a ROS sensitive to TNF-α stimulation and an important signalling molecule in cardiovascular cells 144.

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