RIFERIMENTI
BIBLIOGRAFICI
BIBLIOGRAFIA
Abbott N.J., Rőnnbäck L. and Hansson E. (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nature Reviews, Vol 7, 41-53. Aebi H., (1984). Catalase in vitro. Methods Enzymology; 105, 121-126. Argon C.M.G. and Amit Z. (1992) The effect of 3-amino-1,2,4-triazole on
volontari ethanol consumption: Evidence for brain catalane involvement inthe mechanism of action. Neuropharmacology 31, 709-712.
Backes W.L. (1993) NADPH-Cytochrome P450 Reductase: function. Da
Cytochrome P450. Editori Schenkman J.B. and Helmut G.
Springer-Verlag, 105, 15-34.
Baes M., Gulick T., Choi H.S., Martinoli M.G., Simha D. and Moore D.D. (1994) A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol. Cell. Biol. 14: 1544-52.
Baron J. and Voigt J. (1990) Localization, distribution and induction of xenobiotic metabolizing enzymes and arylhydrocarbon hydroxylase activity within lung. Pharmacol. Ther. 47: 419-445.
Black S.D. (1993) NADPH-Cytochrome P450 Reductase: function. Da
Cytochrome P450. Editori Schenkman J.B. and Helmut G.
Springer-Verlag, 105, 155-168.
Bogaards J.J.P., Bertrand M., Jackson P., Oudshoorn M.J., Weaver R.J.,van Bladeren P.J. and Walther B. (2000) Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 30: 1131-1152.
Desille M., Corcos L., L’Helgoualc’h A., Fremond B., Campion J-P., Guillouzo A. and Clement B. (1999) Detoxifying activity in pig livers and hepatocytes intended for xenotherapy. Transplantation 68, 1437-1443.
Djordjevi V. B. (2004). “Free radicals in cell biology.” International
Donato M.T., Castell J.V. and Gomez-Lechon M.J. (1999) Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models. J. Hepatol. 31: 542-549.
Farin F.M., Omiecinski C.J. (1993) Regiospecific expression of cytochrome P-450s and microsomal expoxide hydrolase in human brain tissue. J
Toxicol Environ Health 40, 317-535.
Faucette S.R., Sueyoshi T., Smith C.M., Negishi M., LeCluyse E.L. and Wang H. (2006) Differential regulation of hepatic CYP2B6 and CYP3A4 genes by Constitutive Androstane Receptor but not Pregnane X Receptor. J. Pharmacol. Exp. Ther. 317, 1200-1209.
Flohe L. and Gunzler W.A., (1984). Assay of glutathione peroxidase.
Methods Enzymology; 105, 114-121.
Forman B.M., Tzameli I., Choi H.S., Chen J., Simha D., Seol W., Evans R.M. and Moore D. (1998) Androstane metabolites bind to and deactive the nuclear receptor CAR-β Nature 395: 612-615.
Gaunt G.L. and de Duve C.(1976) Subcellular distribution oh D-amino acid oxidase and catalane in rat brain. J. Neurochemistry 26, 749-759. Ghersi-Egea J. F., Minn A. and Siest G. (1988) A new aspect of the
protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessel. Life Sciences, Vol 42, 2515-2523.
Ghersi-Egea J.F., Leininger-Muller B., Cecchelli R., Fenstermacher J.D. (1995) Blood-brain interfaces: relevance to cerebral drug metabolism.
Toxicology Letters, 82/83, 645-653.
Gill K., Menez J.F., Lucas D. and Deitrich R.A. (1992) Enzymatic production of acetaldehyde from ethanol in rat brain tissue.
Alcoholism: Clin. Exper. Res. 16, 910-915.
Gonzales F. J. and Nebert D. W. (1990) Evolution of the P450 superfamily: animal-plant “warfare”, molecular drive, and human genetic differences in drug oxidation. Trends Genet. 6, 182-186.
Goodwin B. and Moore J.T. (2004) CAR: detailing new models. Trends
Guengerich F.P. (1993) Metabolic reactions: types of reactions of Cytochrome P450 enzymes. Da Cytochrome P450. Editori Schenkman J.B. and Helmut G. Springer-Verlag, 105, 89-103.
Habig W.H., Pabst M.J., Jakoby W.B. (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249(22), 7130-7139.
Hagemeyer C.E., rosenbrock H., Ditter M., Knoth R. and Volk B. (2003) Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain. Neuroscience 117, 521-529. Halliwell B. (1992). “Reactive oxygen species and the central nervous
system.” J. Neurochemistry; 59, 1609-1623.
Handischin C. and Meyer U.A. (2003) Induction of drug metabolism: the role of nuclear receptors. Pharmacol. Rev. 55, 649-673.
Hedlund E., Gustafsson J.A. and Warner M. (1998). Cytochrome P450 in the brain: 2B or not 2B. Trends Pharmacol. Sciences 19(3), 82-85. Hedlund E., Gustafsson J.-Å. and Warner M. (2001) Cytochrome P450 in
the Brain; A Review. Curr. Drug Metab. 2, 245-263.
Ioannides C. (2006) Cytochrome P450 expression in the liver of good-producing animals. Curr. Drug Metab. 7: 335-348.
Juchau M.R. (1990) Substrate specificities and functions of the P450 cytochromes. Life Sci. 47, 2385-2394.
Kato R. and Yamazoe Y. (1992) Sex-specific Cytochrome P450 as a cause of sex and species-related differences in drug toxicity. Toxicol.
Letters, 64/65, 661-667.
Knight T. R., Choudhuri S. and Klaassen C.D. (2007) Costitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice. Toxico.l Sciences 100, 513-524.
Kretschmer X.C. and Baldwin W.S. (2005) CAR and PXR: xenosensors of endocrine disrupers? Chem. Biol. Interac. 155: 111-128.
Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
Lamba V., Yasuda K., Lamba J.K., assem M., Davila J., Strom S. and Schuetz E.G. (2004) PXR (NR1I2): splice variants in human tissues,
including brain, and identification of neurosteroids and nicotine as PXR activators. Toxicol. Appl. Pharmacol. 199, 251-265.
Lee A.M., Miksys S., Palmour R. and Tyndale R.F. (2006) CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment. Neuropharmacology 50, 441-450.
Lewis D.F.V. (2001) The structure of Cytochrome P450. Da Guide to
Cytochrome P450 structure and function. Taylor and Francis 6,
140-159.
Lowry O.H., Rosebrough N.J., Farr A.L. and Randall R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 239, 2370-2378.
Lu C. and Li A.P. (2001) Species comparison in P450 induction: effects of dexametasone, omeprazolo and rifampicin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Spraque-Dawley rat, minipig and bearle dogs. Chem. Biol. Interact. 134: 271-181.
Ma J., Bradbury J. A., King L., Maronpot R., Davis L. S., Breyer M. D. and Zeldin D. C. (2002) Molecular cloning and characterization of mouse CYP2J6, an unstable cytochrome P450 isoform. Biochem.
Pharmacol., 64, 1447-1460.
Ma J., Ramachandran S., Fiedorek F. T. Jr. and Zeldin D. C. (1998) Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4. Genomics, 49, 152-155. Marini S., Grasso E., Longo V., Puccini P., Riccardi B. and Gervasi P.G.
(2003) 4-Biphenylaldehyde and 9-anthraldehyde: two fluorescent substrates for determinino P450 enzyme activities in rat and human.
Xenobiotica 33, 1-11.
Marini S., Nannelli A., Sodini D., Dragoni S., Valoti M., Longo V. and Gervasi P.G. (2007). Expression, microsomal and mitochondrial activieies of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits. Life Sciences 80, 910-917.
Marklund S.L. e Marklund G. (1974). Involvement of superoxide anion radical in the autooxidation of pyrogallol and convenient assay for superoxide dismutase. Eur. J. Biochem. 47, 469-474.
Masuyama H., Suwaki N., Tateishi Y., Nakatsukasa H., Segawa T. and Hiramatsu Y. (2005) The Pregnane X Receptor regulates gene expression in a ligand- and promoter- selective fashion. Mol.
Endocrinol. 19: 1170-80.
Mei Q., Richards K., Strong-Basalyga K., Fauty S.E., Taylor A., Yamazaki M., Prueksaritanont T. and Lin J.H. (2004) Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2. J. Pharm. Sciences 93, 2488-2496.
Meyer R.P., Gehlhaus M., Knoth R. and Volk B. (2007) Expression and Funtion Of Cytochrome P450 in Brain Drug Metabolism. Curr. Drug
Metab. 8, 297-306.
Meyer R.P., Hagemeyer C.E., Knoth R., Kaufmann M.R. and Volk B. (2006) Anti-epileptic drug phenytoin enhances androgen metabolism and androgen receptor expression in murine hippocampus. J.
Neurochemistry 96, 460-472.
Miksys S., Hoffmann E., Tyndale R.F. (2000) Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment. Biochem Pharmacol 59:1501-1511.
Miksys S.L., Schoedel K.A., Mash D.C., Tyndale R.F. (2001) Nicotine metabolizing CYP2B6 enzyme in human brain regions: higher levels in smokers and smoking alcoholics. FASEB J. 15.A573.
Miksys Sharon L., Tyndale Racher F., (2002) Drug-metabolizing cytochrome P450s in the brain. J. Psychiatry Neurosci. 27 (6), 406-415.
Mitchell A.E., Morin D., Lakritz J. and Jones A.D. (1997) Quantitative profiling of tissue- and gender-related expression of glutathione S-transferase isoenzymes in the mouse. Biochem. J. 325, 207-216. Moore J.T., Moore L.B., Maglich J.M. and Kliewer S.A. (2003) Functional
and structural comparison of PXR and CAR. Biochim. Biophys. Acta 1619: 235-238.
Mršulja B.B., Mršulja B.J., Fujimoto T., Klatzo I. and Spatz M. (1976) Isolation of brain capillaries: a simplified technique. Brain Res.
Myers M.J., Farrell D.E., Howard K.D. and Kawaleck J.C. (2001) Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine. Drug Metab.
Dispos. 29. 908-915.
Nakahara K., Tanomoto T., Datano K. I., Usuda K. and Shoun H. (1993) Cytochrome P450 55A1 (P450dNIR) acts nitric oxide reductase employing NADH as yhe direct electron donor. J. Biol. Chem. 268, 8350-8355.
Nebert D. W. and Feyereisen R. (1994) Evolutionary argument for a connection between drug metabolism and signal trasduction. Ed. Lechner M. C. Da Cytochrome P450 8th
International conference.
John Libbery Eurotext, Paris 3-13.
Nebert D.W. and Gonzalez F.J. (1987) P450 genes: structure, evolution, and regulation. Annu. Rev. Biochem. 56, 945-993.
Nebert D.W., Nelson D.R., Coon H.J., Estabrook R.W., Feyereisen L.R., Fuji-Kuriyama Y., Gonzales F.J., Guengerich F.P., Gunsalus I.C., Johnson E.F., Loper J.C., Stato R., Weterman M.R. and Waxman D.J. (1991) The P450 superfamily: update on new sequences gene mapping and recommended nomenclature. DNA and Cell Biol., 10, 1-14.
Nelson D. R. (2003) http://drnelson.utmem.edu/CytochromeP450.html. Nelson D. R., Koyamans L., Kamataki T., Stegeman J. J., Feyereisen R.,
Waxman D. J., Waterman M. R., Gotoh O., Coon M. J., Estabrook R. W., Gunsalus I. C. and Nebert D. W. (1996) P450 superfamily: update new sequences, gene mapping, accession numbers and nomenclature.
Pharmacogenetics. 6, 1-42.
Nishimura M., Naito S. and Yokoi T. (2004) Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies. Drug
Metab. Pharmacokinet. 19: 135-149.
Omura T. and Sato R. (1964) The carbon monoxide-binding pigment of liver microsomes: solubilization, purification and properties. J. Biol
Chem. 239, 2379-85.
Ortiz de Montellano (1995) Cytochrome P450. Structure, mechanism and biochemistry. Plemium Press N. Y., London.
Parmar D., Dhawan A. and Seth P.K. (1998) Evidence for O-dealkylation of 7-pentoxyresorufin by cytochrome P450 2B1/2B2 isoenzymes in brain. Mol. Cell Biochem. 189, 201-205.
Pascussi J.M., Gerbal-Chaloin S., Drocourt L., Assenat E., Larrey D., Pichard-Garcia L., Vilarem M.J. and Maurel P. (2004) Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences. Xenobiotica 34: 633-664. Perrin R., Minn A., Ghersi-Egea J. F., Grassiot M. and Siest G. (1990)
Distribution of cytochrome P450 activities towards alkoxyresorufin derivates in rat brain regions, subcellular fractions and isolated cerebral microvessels. Biochemical Pharmacology. 40, 2145-2151. Platt K.L., Molitar E., Dohemer J., Dogra S. and Oesch F. (1989)
Genetically engineered V79 chinese hamster cell expression of purified cytochrome P450IIB1 monooxygenase activity. J. Biochem.
Toxicol. 4, 1-6.
Rein H. and Jung C. (1993) Metabolic reaction: mechanism of substrate oxygenation. Da Cytochrome P450. Editori Schenkman J.B. and Helmut G. Springer-Verlag 105, 105-122.
Roos P.H., Tschirbs S., Hack A., Welge P. and Wilhelm M. (2004) Different mechanism of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contamined soils.
Xenobiotica 34: 781-795.
Ryan D.E. and Lewin W. (1990) Cytochrome P450 Purification and characterization of Cytochrome P450. Pharmac. Ther. 45, 153-239. Samson J., Devi R.S., Ravindran R. and Senthilvelan M. (2005) Effect of
noise stress on free radical scavenging enzymes in brain. Environ.
Toxicol. and Pharmacol. 20, 142-148.
Savas Ü., Wester M.R., Griffin K.J. and Johnson E.F. (2000) Rabbit Pregnane X Receptor is activated by rifampicin. Drug Metab. Dispos. 28: 529-537.
Schilter B., Anderson MR.., Acharya C., Omiecinski C.J. (2000) Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-
Seliskar M. et Rozman D. (2007) Mammalian cytocromes P450. Importance of tissue specificity. Biochim. et Biophys. Acta 1770, 458-466.
Shilter B. and Omiecinski J. (1993) Regional Distribution and Expression Modulation of Cytochrome P-450 and Epoxide Hydrolase mRNAs in the Rat Brain. Molecular Pharmacol. 44, 990-996.
Sims N.R. (1990) Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation.
J. Neurochem. 55, 698-707.
Skaanild M.T. (2006) Porcine cytochrome P450 and metabolism. Curr.
Pharmacol. Disp. 12: 1421-1427.
Skaanild M.T. and Friis C. (1999) Cytocrome P450 sex differences in minipigs and conventional pigs. Pharmacol. Toxicol. 85: 174-180. Skaanild M.T. and Friis C. (2005) Porcine CYP2A polymorphisms and
activity. Basic Clin. Pharmacol. Toxicol. 97: 115-121.
Soucek P. and Gut I. (1992) Cytochrome P450 in rats: Structures, functions, properties and relevant human forms. Xenobiotica, 22, 83-103.
Soucek P., Zuber R., Anzebacherovà E., Amzebacher P. and Guengerich F.P. (2001) Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs BMC. Pharmacology 1: 11. Souidi M., Gueguen Y., Linard C., Dudoignon N., Grisou S., Baudelin C.,
Marquette C., Gourmelon P., Aigueperse J. and Dublineau I. (2005) In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat.
Toxicology 214, 113-122.
Strobel H.W., Thompson C.M., Antonovic L. (2001) Cytochrome P450 in brain: function and significance. Curr Drug Metab 2, 199-214.
Swales K. and Negishi M. (2004) CAR, driving into the future Mol.
Endocrinol. 18: 1589-1598.
Swindle M.M. and Smith A.C. (1998) Comparative anatomy and physiology of the pig. Scand. J.Lab. Anim. Sci. Suppl. 25: 11-22
Szotáková B., Baliharova V., Lamka J., Nožinova E., Wsól V., Velik J., Machala M., Neca J., Souček P., Susova S. and Skálová L. (2004) Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep. Res. Vet. Sci. 76: 43-51.
Tindberg N. and Ingelman-Sundberg M. (1996) Expression, catalytic activity and inducibility of cytochrome P450 2E1 (CYP2E1) in the Rat Central Nervous System. J. Neurochem. 67, 2066-2073.
Tirona R.G., Lee W., Leake B.F., Cline C.B., Lamba V., Parviz F., Duncan S.A., Inoue Y., Gonzalez F.J., Schuetz E.G. and Kim R.B. (2003) The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat. Med. 9: 220-224. Towbin H., Stachelin P. and Gordon J. (1979) Electrophoretic transfer of
proteins from polyacrylamide gels to nitro-cellulose sheets. Procedure and some applications. Proc. Nat. Acad. Sci. USA 76, 4350-4354. Upadhya S.C., Chinta S.J., Pai H.V., Boyd M.R. and Ravindranath V.
(2002) Toxicological consequences of differential regulation of cytochrome p450 isoforms in rat brain regions by phenobarbital.
Archives of Biochemistry and Biophysics 399, 56-65.
Wang H., Faucette S., Sueyoshi T., Moore R., Ferguson S., Negishi M. and LeCluyse E.L. (2003) A novel distal enhancer module regulated by Pregnane X Receptor/Constitutive Androstane Receptor is essential for the maximal induction of CYP2B6 gene expression. J.Biol. Chem. 278: 14146-14152.
Watkins R.E., Wisely G.B., Moore L.B., Collins J.L., Lambert M.H., Williams S.P., Willson T.M., Kliewer S.A. and Redimbo M.R. (2001) The human nuclear xenobiotic receptor PXR: structural determinants of direct promiscuità. Science 292: 2329-2333.
Wei Q., Bradbury J.A., Cheng-Chung Tsao, Maronpot R., Harry G.J., Parker C.E., Davis L. S., Breyer M.D., Waalkes M.P., Falck J.R., Chen J., Rosenberg R.L. and Zeldin D.C. (2001) Cytochrome P4502J9, a new mouse arachidonic acid ω-1 hydroxylase predominantly expressed in brain. The J. of Biol. Chem. 276, 25467-25479.
Wheeler C.R., Salzman J.A., Elsayed N.M., Omayed S.T., Korte D.W. (1990). Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Anal.
White J. A., Ramshaw H., Taimi M., Stangle W., Zhang A., Everingham S., Creighton S., Tam S. P., Jones G. and Petkovich M. (2000) Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. Proc. Natl. Acad. Sci USA 97, 6403-6408.
Wu S., Chen W., Murphy E., Gabel S., Tomer K.B., Foley J., Steenbergen C., Falck J.R., Moomaw C.R. and Zeldin D.C. (1997) Molecular cloning, expression and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J. Biol. Chem. 272, 12551-12559.
Wu S., Moomaw C.R., Tomer K.B., Falck J.R. and Zeldin D.C. (1996) Molecular cloning and expression of CYP 2J2. a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J. Biol.
Chem. 271, 3460-3468.
Yadav S., Dhawan A., Seth P.K., Singh R.L. and Parmar D. (2006) Cytochrome P4503A: Evidence for mRNA expression and catalytic activity in rat brain. Mol. Cell. Biochem. 287, 91-99.
Zeldin D. C., Foley J., Goldsworthy S. M., Coook M. E., Boyle J. E., Ma J., Moomaw C. R., Tomer K. B., Steenbergen C. and Wu S. (1997) Cyp2J subfamily citochrome P450s in the gastrointestinal tract: expression, localization and potential functional significance. Mol.
Pharmacol., 51, 931-943.
Zhang Q. Y., Ding X., Dunbar D., Cao L. and Kaminsky L. S. (1999) Induction of rat small intestinal cytochrome P450 2J4. Drug Metab.
Disp., 27, 1123-1127.
Zimatkin S.M. and Lindros K.O. (1996) Distribution of catalase in rat brain: aminergic neurons as possible targets for ethanol effects. Alcohol &
Alcoholism 31, 167-174.
Zuber R., Anzenbacherovà E. and Anzebacher P. (2002) Cytochromes P450 and experimental models of drug metabolism. J. Cell. Mol. Med. 6: 189-198.
