• Non ci sono risultati.

Group Medicinal Inorganic Chemistry

N/A
N/A
Info
Scarica
Protected

Academic year: 2021

Condividi "Group Medicinal Inorganic Chemistry"

Copied!
13
0
0

Caricamento.... (Visualizza il testo completo ora)

Scarica adesso ( 13 pagine )

Testo completo

(1)

Essential elements

Diagnostic agents for

MRI and X-ray

Chelation therapy Metallomics

(Genomics Proteomics)

ChemoTherapy

Radiopharmaceutical

(Diagnosis and s

Therapy) Enzyme inhibitors

Medicinal Inorganic Chemistry

Medicinal Inorganic Chemistry

Group

(2)

Ayurvedic medicine

Natural Curcuminoids

O HO

O

H OH

O HO

O

H OCH3 OCH3OH

O HO

O

H OCH3OH

O H OCH3

O

OCH3OH OH OCH3

O HO

O H OCH3

Curcuma longa L.

(Turmeric)

(3)

Bifunctional ligands

Nature Structural &

Molecular Biology 22, 499–505 (2015)

Radiopharmaceutical preparation

(4)

TO-DO LIST:

- Synthesis

- Thermodynamic stability - Study of Coordinating site - Stoichiometry

- Metal speciation - pH dependence

Techniques:

- NMR

- UV-spectroscopy - Mass spectrometry

(5)

MAINZ

KOŠICE

….work in progress…

…ERASMUS+……

ERASMUS+

(2 studenti/anno)

(6)

CONTATTI

Prof. Monica Saladini monica.saladini@unimore.it

Dr. Erika Ferrari erika.ferrari@unimore.it

Dr. Giulia Orteca giulia.orteca@unimore.it Dr. Luca Rigamonti

luca.rigamonti@unimore.it

(7)

PET Diagnosis

Radiopharmaceutical preparation is a medicinal product in a ready-to-use form suitable for human use that contains a radionuclide.

POSITRON EMISSION TOMOGRAPHY

(PET)

(8)

Fluorodeoxyglucose (18F) - FDG

Radioligand Approaches

(9)

Synthesis of free ligands

• Coupling Reaction

K2CO3, dry DMF, RT 48h

(10)

Synthesis of free ligands

• Coupling Reaction

AAZTA chelator

(11)

Synthesis of free ligands

• Coupling Reaction

(12)

Erasmus project

(13)

Radionuclides

• 64 Cu

• 68 Ga

• 44 Sc

• Al- 18 F

• 89 Zr

• 177 Lu

• 18 F

• 11 C

Diagnosis

Therapy

Riferimenti

Scarica adesso ( PDF - 13 pagine - 1.44 MB )

Documenti correlati

European Journal of Medicinal Chemistry

Encouraged by these findings and intrigued by the possibility of developing highly hydrophilic riminophenazine-based clofazimine analogues endowed with potentialities as

Positron Emission Tomography 5

Noninvasive quantification of regional myocardial blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging.. Gambhir SS, Schwaiger M, Huang

Positron emission tomography (PET) is an imaging modality that allows

PET imaging studies generally use tracer doses containing only very small amounts of the radiopharmaceutical (in the range of picograms to micrograms) which conform to true

European Journal of Medicinal Chemistry

Representative low-energy structure all-trans-3A (3, BnCO-Asp- b 2 -Pro- AMPUMP) consistent with ROESY analysis and calculated by restrained MD; alternative minor conformer

The Glitter of Carbon Nanostructures in Hybrid/Composite Hydrogels for Medicinal Use

Incorpora- tion of GO into a pNIPAAm hydrogel, previously function- alized with an RGD peptide to promote cell adhesion [99], is a useful means to obtain a gel that,

MEDICINAL INORGANIC CHEMISTRY GROUP

The impact of molecular imaging on clinical medicine has been extensive since it allows a physician to diagnose a patient’s illness, prescribe treatment, and monitor the efficacy

MEDICINAL INORGANIC CHEMISTRY MEDICINAL INORGANIC CHEMISTRY

The impact of molecular imaging on clinical medicine has been extensive since it allows a physician to diagnose a patient’s illness, prescribe treatment, and

Positron Emission Tomography

rivelazione di 2 fotoni in coincidenza in rivelatori diversi posti attorno al paziente, permette di individuare una LOR = Line Of Response lungo la quale si trovava il