MEDICINAL INORGANIC CHEMISTRY GROUP

Metallo

MEDICINAL INORGANIC CHEMISTRY GROUP

Prof. Monica Saladini, Dr. Erika Ferrari

Medicinal Inorganic Chemistry

Essential elements

Diagnostic agents for

MRI and X-ray

Enzyme inhibitors

Chelation therapy Metallomics

(Genomics Proteomics)

Therapy

Radiopharmaceuticals (Diagnosis and

Therapy)

PET

positron emission tomography

The impact of molecular imaging on clinical medicine has been extensive since it allows a physician to diagnose a patient’s illness, prescribe treatment, and monitor the efficacy of that treatment non-invasively.

Nuclear Medicine

Chem. Rev. 2010, 110, 2858–2902

- Coordinating site - Stoichiometry - Metal speciation - pH dependence

- Thermodynamic stability

- Kinetics (transchelation, transmetallation)

-ADME (Adsorption, Distribution, Metabolism, Excretion)

M

M M

Ayurvedic medicine

Natural Curcuminoids

O HO

O

H OH

O HO

O H

OCH₃ OCH₃

OH

O HO

O

H OCH₃

OH

O H

OCH₃

O

OCH₃ OH

OH OCH₃ O HO

O H

OCH₃

Curcuma longa L.

(Turmeric)

…applications…

 early diagnosis

 pharmaco-kinetics

 drug delivery

 therapy

PET TOMOGRAPHY

(medicina nucleare e diagnostica)

Curcumin-Ga(III) Congo red

Progetti di tesi:

- Caratterizzazione termodinamica di metallo-complessi a base di gallio per applicazioni diagnostiche

-Sintesi e caratterizzazione di nuovi chelanti

bifuzionali per applicazioni diagnostiche in patologie

neurodegenerative.

OH O

NH O

N N N N COOH

HOOC HOOC

R₁ R₂

R₁

R₂

- Synthesis

- Coordinating site - Stoichiometry - Metal speciation - pH dependence

- Thermodynamic stability - Kinetics (transchelation, transmetallation)

-ADME

Durante il periodo di tesi verranno approfondite le

conoscenze di chimica

inorganica, metallo-organica, e numerose tecniche

strumentali

NMR

Potenziometria Sintesi

Inorganica Organica Spettroscopia UV-vis;

spettrofluorimetria