Subjects Age
in years Gender Vonsattel et al.’s Grade
CAG
repeats Brain weight (g)
Clinical diagnosis of
HD
TGF-beta 1 immunoreactivity*
Cerebral White Caudate cortex matter nucleus
1 59 F 0 - 1456 - 2 0 2
2 73 M 0 - 1389 - 2 0 1
3 66 F 0 - 1463 - 3 0 2
4 61 M 0 - 1510 - 3 0 1
5 68 F 0 - 1478 - 2 0 1
6 67 M 0 - 1470 - 2 0 1
7 59 F 0 - 1480 - 3 0 1
8 64 M 0 - 1420 - 2 0 2
Mean+SEM 64.6+1.8 2.4+0.2 1.4+0.2
9 67 M III 9/43 1185 + 1 2 3
10 61 F III 22/44 1070 + 1 2 4
11 60 F III-IV 20/46 825 + 2 3 3
12 61 F III 25/44 800 + 1 3 3
13 59 M III 19/42 1330 + 2 2 4
14 67 M III-IV 20/45 1160 + 1 2 4
Mean+SEM 62.5+1.6 1.3+0.2 2.3+0.2 3.5+0.2
15 39 F 0 ND# ND At risk 0 1
TABLE 2 - Pathological, genetic, clinical data and expression of TGF-1 in cerebral cortex, white matter and caudate nucleus of eight control subjects, six patients with original pathological diagnosis of Huntington’s disease and one asymptomatic subjects.
Subjects 1-8 = Healthy controls; subjects 9-14 = Symptomatic HD subjects, subject 15 = asymptomatic subjects (positive genetic test of HD and unreported CAG size #). HD = Huntington disease; (0) = negative; (1) = light; (2) = moderate; (3) = strong. *P<0.05 (Student’s t test) HD vs. non-HD patients.
