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“Efficacia e Sicurezza a breve termine di XEN45 Gel Stent nel glaucoma scompensato: studio pilota” della U.O. Oculistica di Pisa dimostra come XEN45 Gel Stent sia in grado di guadagnare gli endpoints di efficacia e di sicurezza, valutati ad uno ed a 3 mesi, in pazienti affetti da glaucoma ad angolo aperto scompensato; e conferma le potenzialità del device e della metodologia chirurgica associata.

Lo Studio Pilota ha raggiunto il successo terapeutico prefissato – una IOP < 21 mmHg (pari a 13 ± 5.13 mmHg ad un mese e 12.88 ± 2.50 mmHg a 3 mesi) in assenza di terapia- nel 90% degli occhi ad un mese e nel 100% a 3 mesi, senza l’interferenza di complicanze maggiori ed irreversibili.

Lo Studio Pilota, dunque, si è sviluppato all’interno di un ambito innovativo ed in evoluzione, quello delle chirurgie mininvasive per Glaucoma (Microinvasive/ Minimally invasive Glaucoma Surgery, MIGS) ed in particolare, con XEN45 Gel Stent, delle Filtranti anteriori perforanti, rispetto al quale la letteratura è ancora esigua perché recente (per la tecnologia XEN non antecedente al 2014) ed in continuo aggiornamento (ultime pubblicazioni del 2017).

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7 BIBLIOGRAFIA

1. European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Chapter 2: Classification and terminologySupported by the EGS Foundation: Part 1: Foreword; Introduction; Glossary; Chapter 2 Classification and Terminology. The British journal of

ophthalmology 2017; 101(5): 73-127.

2. European Glaucoma Society E. Terminology and guidelines for glaucoma. 4th ed. Savona: Pubblicom; 2014.

3. Bowling B. Kanski's Clinical Ophthalmology. A Systematic Approach. 8th ed. Philadelphia: Elsevier Health Sciences; 2015.

4. Rossetti L, Digiuni M, Montesano G, et al. Blindness and Glaucoma: A Multicenter Data Review from 7 Academic Eye Clinics. PloS one 2015; 10(8): e0136632.

5. Quigley HA. Number of people with glaucoma worldwide. The British journal of

ophthalmology 1996; 80(5): 389-93.

6. Jacobs DS. Open-angle glaucoma: Epidemiology, clinical presentation, and diagnosis. In: Libman H, ed. UptoDate; 2017.

7. Kingman S. Glaucoma is second leading cause of blindness globally. Bulletin of the

World Health Organization 2004; 82(11): 887-8.

8. Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis.

Ophthalmology 2014; 121(11): 2081-90.

9. Gupta V, Somarajan BI, Gupta S, et al. The inheritance of juvenile onset primary open angle glaucoma. Clinical genetics 2016.

10. Hollander DA, Sarfarazi M, Stoilov I, Wood IS, Fredrick DR, Alvarado JA. Genotype and phenotype correlations in congenital glaucoma: CYP1B1 mutations, goniodysgenesis, and clinical characteristics. American journal of ophthalmology 2006; 142(6): 993-1004.

11. Turalba AV, Chen TC. Clinical and genetic characteristics of primary juvenile-onset open-angle glaucoma (JOAG). Seminars in ophthalmology 2008; 23(1): 19-25.

12. Prum BE, Jr., Rosenberg LF, Gedde SJ, et al. Primary Open-Angle Glaucoma Preferred Practice Pattern((R)) Guidelines. Ophthalmology 2016; 123(1): P41-p111.

13. Dielemans I, Vingerling JR, Wolfs RC, Hofman A, Grobbee DE, de Jong PT. The prevalence of primary open-angle glaucoma in a population-based study in The Netherlands. The Rotterdam Study. Ophthalmology 1994; 101(11): 1851-5.

14. Kapetanakis VV, Chan MP, Foster PJ, Cook DG, Owen CG, Rudnicka AR. Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. The British journal of ophthalmology 2016; 100(1): 86-93. 15. Friedman DS, Wolfs RC, O'Colmain BJ, et al. Prevalence of open-angle glaucoma among adults in the United States. Archives of ophthalmology (Chicago, Ill : 1960) 2004; 122(4): 532-8. 16. Le A, Mukesh BN, McCarty CA, Taylor HR. Risk factors associated with the incidence of open-angle glaucoma: the visual impairment project. Investigative ophthalmology & visual

science 2003; 44(9): 3783-9.

17. Czudowska MA, Ramdas WD, Wolfs RC, et al. Incidence of glaucomatous visual field loss: a ten-year follow-up from the Rotterdam Study. Ophthalmology 2010; 117(9): 1705-12. 18. Nemesure B, Honkanen R, Hennis A, Wu SY, Leske MC. Incident open-angle glaucoma and intraocular pressure. Ophthalmology 2007; 114(10): 1810-5.

19. Jiang X, Varma R, Wu S, et al. Baseline risk factors that predict the development of open-angle glaucoma in a population: the Los Angeles Latino Eye Study. Ophthalmology 2012;

86

20. Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Archives of ophthalmology (Chicago, Ill : 1960) 2002; 120(10): 1268-79.

21. Leske MC, Heijl A, Hyman L, Bengtsson B, Dong L, Yang Z. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology 2007; 114(11): 1965-72. 22. Bengtsson B, Leske MC, Hyman L, Heijl A. Fluctuation of intraocular pressure and glaucoma progression in the early manifest glaucoma trial. Ophthalmology 2007; 114(2): 205- 9.

23. Leske MC, Heijl A, Hyman L, Bengtsson B, Komaroff E. Factors for progression and glaucoma treatment: the Early Manifest Glaucoma Trial. Current opinion in ophthalmology 2004; 15(2): 102-6.

24. Sommer A, Tielsch JM, Katz J, et al. Racial differences in the cause-specific prevalence of blindness in east Baltimore. The New England journal of medicine 1991; 325(20): 1412-7. 25. Wolfs RC, Klaver CC, Ramrattan RS, van Duijn CM, Hofman A, de Jong PT. Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study. Archives of

ophthalmology (Chicago, Ill : 1960) 1998; 116(12): 1640-5.

26. Leske MC, Nemesure B, He Q, Wu SY, Fielding Hejtmancik J, Hennis A. Patterns of open-angle glaucoma in the Barbados Family Study. Ophthalmology 2001; 108(6): 1015-22. 27. Mitchell P, Hourihan F, Sandbach J, Wang JJ. The relationship between glaucoma and myopia: the Blue Mountains Eye Study. Ophthalmology 1999; 106(10): 2010-5.

28. Kuzin AA, Varma R, Reddy HS, Torres M, Azen SP. Ocular biometry and open-angle glaucoma: the Los Angeles Latino Eye Study. Ophthalmology 2010; 117(9): 1713-9.

29. Xu L, Wang Y, Wang S, Wang Y, Jonas JB. High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology 2007; 114(2): 216-20.

30. Grodum K, Heijl A, Bengtsson B. Refractive error and glaucoma. Acta ophthalmologica

Scandinavica 2001; 79(6): 560-6.

31. Wong TY, Klein BE, Klein R, Knudtson M, Lee KE. Refractive errors, intraocular pressure, and glaucoma in a white population. Ophthalmology 2003; 110(1): 211-7.

32. Perera SA, Wong TY, Tay WT, Foster PJ, Saw SM, Aung T. Refractive error, axial dimensions, and primary open-angle glaucoma: the Singapore Malay Eye Study. Archives of

ophthalmology (Chicago, Ill : 1960) 2010; 128(7): 900-5.

33. Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B. Risk factors for incident open- angle glaucoma: the Barbados Eye Studies. Ophthalmology 2008; 115(1): 85-93.

34. Gordon MO, Beiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Archives of

ophthalmology (Chicago, Ill : 1960) 2002; 120(6): 714-20; discussion 829-30.

35. Zhao D, Cho J, Kim MH, Friedman DS, Guallar E. Diabetes, fasting glucose, and the risk of glaucoma: a meta-analysis. Ophthalmology 2015; 122(1): 72-8.

36. Zhao D, Cho J, Kim MH, Guallar E. The association of blood pressure and primary open- angle glaucoma: a meta-analysis. American journal of ophthalmology 2014; 158(3): 615-27.e9. 37. McMonnies CW. Glaucoma history and risk factors. Journal of optometry 2017; 10(2): 71-8.

38. Fechtner RD, Weinreb RN. Mechanisms of optic nerve damage in primary open angle glaucoma. Survey of ophthalmology 1994; 39(1): 23-42.

39. Yan DB, Coloma FM, Metheetrairut A, Trope GE, Heathcote JG, Ethier CR. Deformation of the lamina cribrosa by elevated intraocular pressure. The British journal of ophthalmology 1994; 78(8): 643-8.

40. Flammer J. The vascular concept of glaucoma. Survey of ophthalmology 1994; 38

87

41. Flammer J, Orgul S, Costa VP, et al. The impact of ocular blood flow in glaucoma. Prog

Retin Eye Res 2002; 21(4): 359-93.

42. Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, de Vincentiis M. Emerging Concepts in Glaucoma and Review of the Literature. The American journal of medicine 2016;

129(9): 1000.e7-.e13.

43. Arora T, Bali SJ, Arora V, Wadhwani M, Panda A, Dada T. Diurnal versus office-hour intraocular pressure fluctuation in primary adult onset glaucoma. Journal of optometry 2015;

8(4): 239-43.

44. Goñi FJ, Maja K. Standard Automated Perimetry. In: Ferreras A, ed. Glaucoma Imaging. Cham: Springer International Publishing; 2016: 1-26.

45. Hodapp E, Parrish RK, Anderson DR. Clinical decisions in glaucoma: Mosby; 1993. 46. Peters D, Bengtsson B, Heijl A. Factors associated with lifetime risk of open-angle glaucoma blindness. Acta ophthalmologica 2014; 92(5): 421-5.

47. Johnson DH. Progress in glaucoma: early detection, new treatments, less blindness.

Ophthalmology 2003; 110(4): 634-5.

48. Chen PP. Blindness in patients with treated open-angle glaucoma. Ophthalmology 2003; 110(4): 726-33.

49. Mallick J, Devi L, Malik PK, Mallick J. Update on Normal Tension Glaucoma. Journal of

ophthalmic & vision research 2016; 11(2): 204-8.

50. Shetgar AC, Mulimani MB. The central corneal thickness in normal tension glaucoma, primary open angle glaucoma and ocular hypertension. Journal of clinical and diagnostic

research : JCDR 2013; 7(6): 1063-7.

51. Iwase A, Suzuki Y, Araie M, et al. The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmology 2004; 111(9): 1641-8.

52. Phelps CD, Corbett JJ. Migraine and low-tension glaucoma. A case-control study.

Investigative ophthalmology & visual science 1985; 26(8): 1105-8.

53. Henry E, Newby DE, Webb DJ, O'Brien C. Peripheral endothelial dysfunction in normal pressure glaucoma. Investigative ophthalmology & visual science 1999; 40(8): 1710-4.

54. Bengtsson B, Leske MC, Yang Z, Heijl A. Disc hemorrhages and treatment in the early manifest glaucoma trial. Ophthalmology 2008; 115(11): 2044-8.

55. Gramer E, Althaus G, Leydhecker W. [Site and depth of glaucomatous visual field defects in relation to the size of the neuroretinal edge zone of the optic disk in glaucoma without hypertension, simple glaucoma, pigmentary glaucoma. A clinical study with the Octopus perimeter 201 and the optic nerve head analyzer]. Klinische Monatsblatter fur

Augenheilkunde 1986; 189(3): 190-8.

56. Chauhan BC, Mikelberg FS, Artes PH, et al. Canadian Glaucoma Study: 3. Impact of risk factors and intraocular pressure reduction on the rates of visual field change. Archives of

ophthalmology (Chicago, Ill : 1960) 2010; 128(10): 1249-55.

57. Comparison of glaucomatous progression between untreated patients with normal- tension glaucoma and patients with therapeutically reduced intraocular pressures. Collaborative Normal-Tension Glaucoma Study Group. American journal of ophthalmology 1998; 126(4): 487-97.

58. Musch DC, Gillespie BW, Palmberg PF, Spaeth G, Niziol LM, Lichter PR. Visual field improvement in the collaborative initial glaucoma treatment study. American journal of

ophthalmology 2014; 158(1): 96-104.e2.

59. Cohen SL, Rosen AI, Tan X, Kingdom FA. Improvement of the visual field index in clinical glaucoma care. Canadian journal of ophthalmology Journal canadien d'ophtalmologie 2016;

51(6): 445-51.

60. Nardi M, Casini G, Guidi G, Figus M. Emerging surgical therapy in the treatment of glaucoma. Progress in brain research 2015; 221: 341-57.

88

61. Conlon R, Saheb H, Ahmed, II. Glaucoma treatment trends: a review. Canadian journal

of ophthalmology Journal canadien d'ophtalmologie 2017; 52(1): 114-24.

62. van der Valk R, Webers CA, Schouten JS, Zeegers MP, Hendrikse F, Prins MH. Intraocular pressure-lowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials. Ophthalmology 2005; 112(7): 1177-85.

63. Heijl A, Leske MC, Hyman L, Yang Z, Bengtsson B. Intraocular pressure reduction with a fixed treatment protocol in the Early Manifest Glaucoma Trial. Acta ophthalmologica 2011;

89(8): 749-54.

64. Heijl A, Peters D, Leske MC, Bengtsson B. Effects of argon laser trabeculoplasty in the Early Manifest Glaucoma Trial. American journal of ophthalmology 2011; 152(5): 842-8.

65. Bovell AM, Damji KF, Hodge WG, Rock WJ, Buhrmann RR, Pan YI. Long term effects on the lowering of intraocular pressure: selective laser or argon laser trabeculoplasty? Canadian

journal of ophthalmology Journal canadien d'ophtalmologie 2011; 46(5): 408-13.

66. Tzimis V, Tze L, Ganesh J, et al. Laser trabeculoplasty: an investigation into factors that might influence outcomes. Canadian journal of ophthalmology Journal canadien

d'ophtalmologie 2011; 46(4): 305-9.

67. The Glaucoma Laser Trial (GLT) and glaucoma laser trial follow-up study: 7. Results. Glaucoma Laser Trial Research Group. American journal of ophthalmology 1995; 120(6): 718- 31.

68. Chen PP, Lin SC, Junk AK, Radhakrishnan S, Singh K, Chen TC. The Effect of Phacoemulsification on Intraocular Pressure in Glaucoma Patients: A Report by the American Academy of Ophthalmology. Ophthalmology 2015; 122(7): 1294-307.

69. Perez-Torregrosa VT, Olate-Perez A, Cerda-Ibanez M, et al. Combined phacoemulsification and XEN45 surgery from a temporal approach and 2 incisions. Archivos de

la Sociedad Espanola de Oftalmologia 2016; 91(9): 415-21.

70. Prum BE, Jr., Lim MC, Mansberger SL, et al. Primary Open-Angle Glaucoma Suspect Preferred Practice Pattern((R)) Guidelines. Ophthalmology 2016; 123(1): P112-51.

71. Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Archives of ophthalmology (Chicago, Ill : 1960) 2002; 120(6): 701-13; discussion 829-30.

72. Miglior S, Zeyen T, Pfeiffer N, Cunha-Vaz J, Torri V, Adamsons I. Results of the European Glaucoma Prevention Study. Ophthalmology 2005; 112(3): 366-75.

73. Miglior S, Pfeiffer N, Torri V, Zeyen T, Cunha-Vaz J, Adamsons I. Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study. Ophthalmology 2007; 114(1): 3-9.

74. Ritch R, Schlotzer-Schrehardt U, Konstas AG. Why is glaucoma associated with exfoliation syndrome? Prog Retin Eye Res 2003; 22(3): 253-75.

75. Arnarsson A, Jonasson F, Damji KF, Gottfredsdottir MS, Sverrisson T, Sasaki H. Exfoliation syndrome in the Reykjavik Eye Study: risk factors for baseline prevalence and 5-year incidence. The British journal of ophthalmology 2010; 94(7): 831-5.

76. Benitez-del-Castillo Sanchez J, Morion-Grande M, Marco-Garcia MC, Parron-Carreno T. Epidemiology of pseudoexfoliation syndrome: Demystifying legends and looking to the future.

Archivos de la Sociedad Espanola de Oftalmologia 2015; 90(10): 455-7.

77. Tarkkanen A, Kivela T. John G. Lindberg and the discovery of exfoliation syndrome.

Acta ophthalmologica Scandinavica 2002; 80(2): 151-4.

78. Jonasson F. From epidemiology to lysyl oxidase like one (LOXL1) polymorphisms discovery: phenotyping and genotyping exfoliation syndrome and exfoliation glaucoma in Iceland. Acta ophthalmologica 2009; 87(5): 478-87.

89

79. Topouzis F, Wilson MR, Harris A, et al. Prevalence of open-angle glaucoma in Greece: the Thessaloniki Eye Study. American journal of ophthalmology 2007; 144(4): 511-9.

80. Figus M, Taloni M, Posarelli C. Gonioscopy. In: Ferreras A, ed. Glaucoma Imaging. Cham: Springer International Publishing; 2016: 27-77.

81. Traverso CE, Spaeth GL, Starita RJ, Fellman RL, Greenidge KC, Poryzees E. Factors affecting the results of argon laser trabeculoplasty in open-angle glaucoma. Ophthalmic Surg 1986; 17(9): 554-9.

82. Niyadurupola N, Broadway DC. Pigment dispersion syndrome and pigmentary glaucoma--a major review. Clinical & experimental ophthalmology 2008; 36(9): 868-82.

83. Campbell DG. Pigmentary dispersion and glaucoma. A new theory. Archives of

ophthalmology (Chicago, Ill : 1960) 1979; 97(9): 1667-72.

84. Siddiqui Y, Ten Hulzen RD, Cameron JD, Hodge DO, Johnson DH. What is the risk of developing pigmentary glaucoma from pigment dispersion syndrome? American journal of

ophthalmology 2003; 135(6): 794-9.

85. Farrar SM, Shields MB, Miller KN, Stoup CM. Risk factors for the development and severity of glaucoma in the pigment dispersion syndrome. American journal of ophthalmology 1989; 108(3): 223-9.

86. Gottanka J, Johnson DH, Grehn F, Lutjen-Drecoll E. Histologic findings in pigment dispersion syndrome and pigmentary glaucoma. Journal of glaucoma 2006; 15(2): 142-51. 87. Liu L, Ong EL, Crowston J. The concave iris in pigment dispersion syndrome.

Ophthalmology 2011; 118(1): 66-70.

88. Carassa RG, Bettin P, Fiori M, Brancato R. Nd:YAG laser iridotomy in pigment dispersion syndrome: an ultrasound biomicroscopic study. The British journal of ophthalmology 1998;

82(2): 150-3.

89. Landers J, Martin K, Sarkies N, Bourne R, Watson P. A twenty-year follow-up study of trabeculectomy: risk factors and outcomes. Ophthalmology 2012; 119(4): 694-702.

90. Jacobs DS. Open-angle glaucoma: Treatment. In: Libman H, ed. UpToDate; 2017. 91. Reibaldi A, Uva MG, Longo A. Nine-year follow-up of trabeculectomy with or without low-dosage mitomycin-c in primary open-angle glaucoma. The British journal of ophthalmology 2008; 92(12): 1666-70.

92. Wilkins M, Indar A, Wormald R. Intra-operative mitomycin C for glaucoma surgery.

Cochrane database of systematic reviews (Online) 2005; (4).

93. Figus M, Posarelli C, Nasini F, Casini G, Martinelli P, Nardi M. Scleral Flap-Everting Suture for Glaucoma-filtering Surgery. Journal of glaucoma 2016; 25(1): 128-31.

94. Feyi-Waboso A, Ejere HO. Needling for encapsulated trabeculectomy filtering blebs.

The Cochrane database of systematic reviews 2012; (8): CD003658.

95. Olayanju JA, Hassan MB, Hodge DO, Khanna CL. Trabeculectomy-related complications in Olmsted County, Minnesota, 1985 through 2010. JAMA ophthalmology 2015; 133(5): 574- 80.

96. Ang GS, Varga Z, Shaarawy T. Postoperative infection in penetrating versus non- penetrating glaucoma surgery. The British journal of ophthalmology 2010; 94(12): 1571-6. 97. Patel HY, Danesh-Meyer HV. Incidence and management of cataract after glaucoma surgery. Current opinion in ophthalmology 2013; 24(1): 15-20.

98. Vera VI, Horvath C. XEN Gel Stent: The Solution Designed by AqueSys®. In: Samples JR, Ahmed IIK, eds. Surgical Innovations in Glaucoma. New York, NY: Springer New York; 2014: 189-98.

99. Lewis RA. Ab interno approach to the subconjunctival space using a collagen glaucoma stent. Journal of cataract and refractive surgery 2014; 40(8): 1301-6.

100. Singh D. Conjunctival lymphatic system [1]. Journal of cataract and refractive surgery 2003; 29(4): 632-3.

90

101. Yücel YH, Johnston MG, Ly T, et al. Identification of lymphatics in the ciliary body of the human eye: A novel "uveolymphatic" outflow pathway. Experimental eye research 2009; 89(5): 810-9.

102. Yu DY, Morgan WH, Sun X, et al. The critical role of the conjunctiva in glaucoma filtration surgery. Progress in Retinal and Eye Research 2009; 28(5): 303-28.

103. Galal A, Bilgic A, Eltanamly R, Osman A. XEN Glaucoma Implant with Mitomycin C 1- Year Follow-Up: Result and Complications. Journal of ophthalmology 2017; 2017: 5457246. 104. Pinto Ferreira N, Abegao Pinto L, Marques-Neves C. XEN Gel Stent Internal Ostium Occlusion: Ab-Interno Revision. Journal of glaucoma 2017; 26(4): e150-e2.

105. Singh M, Aung T, Tun TA. Quantitative analysis of the change in bleb morphology over time after successful trabeculectomy [abstract]. Invest Ophthalmol Vis Sci 2009; 50.

106. Theelen T, Wesseling P, Keunen JEE, Klevering BJ. A pilot study on slit lamp-adapted optical coherence tomography imaging of trabeculectomy filtering blebs. Graefe's Archive for

Clinical and Experimental Ophthalmology 2007; 245(6): 877-82.

107. Addicks EM, Green WR, Robin AL, Quigley HA. Histologic Characteristics of Filtering Blebs in Glaucomatous Eyes. Archives of Ophthalmology 1983; 101(5): 795-8.

108. Labbé A, Dupas B, Hamard P, Baudouin C. In vivo confocal microscopy study of blebs after filtering surgery. Ophthalmology 2005; 112(11): 1979.e1-.e9.

109. Guthoff R, Klink T, Schlunck G, Grehn F. In vivo confocal microscopy of failing and functioning filtering blebs: Results and clinical correlations. Journal of glaucoma 2006; 15(6): 552-8.

110. Messmer EM, Zapp DM, Mackert MJ, Thiel M, Kampik A. In vivo confocal microscopy of filtering blebs after trabeculectomy. Archives of Ophthalmology 2006; 124(8): 1095-103. 111. Schmitt JM, Knuttel A, Yadlowsky M, Eckhaus MA. Optical-coherence tomography of a dense tissue: Statistics of attenuation and backscattering. Physics in Medicine and Biology 1994; 39(10): 1705-20.

112. De Gregorio A, Pedrotti E, Russo L, Morselli S. Minimally invasive combined glaucoma and cataract surgery: clinical results of the smallest ab interno gel stent. International

ophthalmology 2017.

113. Francis BA, Hong B, Winarko J, Kawji S, Dustin L, Chopra V. Vision loss and recovery after trabeculectomy: risk and associated risk factors. Archives of ophthalmology (Chicago, Ill :

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