Percutaneous angioplasty of internal jugular and azygous veins in patients with chronic cerebrospinal venous insufficiency and multiple sclerosis: preliminary results for a randomized controlled trial

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Table II for clinical evaluation

Table IIa: Evaluation of improvement, between experimental group A and control group B,

Neurorehabilitative Tests

_N. patients

_evaluationClinical

p-value 18. Stroop’s Test, colour-word A 10 1,000 B 7 22. Verbal Fluidity’s Test, Phonemic A 7 1,000 B 8 23. Verbal Fluency’s, Categorical A 9 1,000 B 11 22. Frontal Assessment Battery A 5 0,417 B 7 27. Wisconsin Card Sorting Test A 5 1,000 B 9 31. Clinical evaluation of voiding disorders A 19 0,741 B 20 32. Expanded Disability Status Scale A 18 0,510 B 19 33. 10 m walk test A 12 1,000 B 8 34. 6 min walk test A 3 NM B 7 35. Timed Up & Go A 18 0,378 B 18 36. Tinetti Balance

equilibrium A 9 1,000 B 14 37. Tinetti Balance walk A 10 0,990 B 14 38. Fatique Severity Scale A 24 0,530 B 21 39. Visual Analogic Scale A 19 0,391 B 17 40. HADS:

Anxiety Clinical Scale A 10 0,361 B 11 41. HADS:

Depression scale A 15 0,990 B 20 42. Barthel Index A 11 0,990 B 7 43. MSQOL- 54 Fisics A 27 NM B 31 44. MSQOL- 54 Mental A 28 NM B 32

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Table IIb. Evaluation of improvement, between experimental group A and control group B,

Cinematics Test

_patients

N.

_evaluationClinical

p-value 45. Pointing Test Upper limb DX Err A 21 0,565 _B ₂₈ 46. Pointing Test Upper limb DX PVtang A 13 1,000 _B ₂₀ 47. Pointing Test Upper limb DX AsymL A 10 0,666 _B ₂₂ 48. Pointing Test Upper limb DX LinearL A 23 0,818 _B ₂₀ 49. Pointing Test Upper limb DX MovT A 14 0,385 _B ₁₄ _{50. Pointing Test} Upper limb SX Err A 18 0,694 _B ₁₂ 51. Pointing Test Upper limb SX PVtang A 14 0,456 _B ₁₇ 52. Pointing Test Upper limb SX AsymL A 11 0,670 _B ₁₀ 53. Pointing Test Upper limb SX LinearL A 21 0,497 _B ₂₅ 54. Pointing Test Upper limb SX MovT A 13 1,000 _B ₁₃

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Table IIc. Evaluation of worsening, between experimental group A and control group B,

Cinematics Test

N. patients

Clinical evaluation

p-value _{45. Pointing Test} Upper limb DX Err A 21 1,000 B 28 46. Pointing Test Upper limb DX PVtang A 13 0,172 B 20 47. Pointing Test Upper limb DX AsymL A 10 0,276 B 22 48. Pointing Test Upper limb DX LinearL A 23 0,386 B 20 49. Pointing Test Upper limb DX MovT A 14 0,252 B 14 _{50. Pointing Test} Upper limb SX Err A 18 0,105 B 12 51. Pointing Test Upper limb SX PVtang A 14 0,704 B 17 52. Pointing Test Upper limb SX AsymL A 11 0,048 B 10 53. Pointing Test Upper limb SX LinearL A 21 1,000 B 25 54. Pointing Test Upper limb SX MovT A 13 0,005 B 13

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Table IId. Evaluation of worsening, between experimental group and control group,

Neurofunctional

Test

Neurofunctional Tests N.

patients evaluation Clinical

p-value 17. Attentive matrices A 25 0,356 B 28 18. Test di Stroop, colour-word A 19 0,426 B 26 _{19. Trail making test A} A 25 0,967 B 26 20. Trail making test B A 25 NP B 28 21. Trail making test B-A A 27 0,193 B 33

_{22. Test di}

_{Verbal Fluidity ,}

_phonemic A 24 0,932

B 27 23. Test di

Verbal Fluidity ,

categorical A 22 0,291 B 24 _{24. WEIGL} A 28 0,322 B 29 _{25. Frontal Assessment Battery} A 26 0,939 B 28 _{26. DSST} A 27 0,362 B 33 _{27. Wisconsin Card Sorting Test} A 25 0,312 B 25 _{28. MMSE} A 30 0,271 B 32 _{29. Clinical evaluation of dysphagia} A 25 0,706 B 32 _{30. Clinical evaluation of dysarthria} A 30 0,157 B 31 31. Clinical evaluation of minority disorders A 11 0,990 B 15 _{32. Expanded Disability Status Scale} A 15 0,990 B 17 _{33. 10 m walk test} A 19 0,228 B 27 _{34. 6 min walk test} A 28 0,788 B 28 _{35. Timed Up & Go} A 11 0,476 B 10 _{36. Tinetti Balance equilibrium} A 19 0,472 B 17 _{37. Tinetti Balance wolk} A 18 NP B 17 _{38. Fatique Severity Scale} A 7 0,990 B 14 _{39. Visual Analogic Scale} A 12 0,990 B 17 40. HADS:

Anxiety Clinical Scale A 17 0,104 B 21 _{41. HADS:}

_{Depression scale} A 14 0,990 B 13 _{42. Barthel Index} A 19 0,562 B 28

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Table IIe. Evaluation of worsening, between experimental group and control group, PEV Test

PEV Test

N. patients

Clinical _evaluation

p-value 1. PEV OD 60’ A 19 0,598 B 25 2. PEV OS 60’ A 17 0,723 B 29 3. PEV OD 15’ A 19 0,432 B 23 4. PEV OS 15’ A 18 0,622 B 22 5. TCMC AS Dx A 22 0,777 B 29 6. TCMC AS Sx A 18 0,890 B 26 7. TCMC AI Sx A 12 0,702 B 16 8. TCMC AI Sx A 11 0,990 B 15 _{9. TCMC direct AS} Dx A 26 0,678 B 31 _{10. TCMC direct AS} Sx A 26 0,221 B 34 _{11. TCMC direct AI} Sx A 14 0,477 B 17 _{12. TCMC direct AI} Sx A 13 0,990 B 16 _{13. TCMC indirect AS} Dx A 13 0,990 B 17 _{14. TCMC indirect AS} Sx A 11 0,395 B 15 15. TCMC indirect AI Sx A 11 0,689 B 15 _{16. TCMC indirect AI} Sx A 7 0,346 B 14

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Table III for standardised results

Evaluation of the improvement, between experimental group and control group, in cynematic (f) and

Neurorehabilitative tests (g) and the deterioration in evoked potential (h), using z-score.

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Cinematic Tests N. Patients Difference z-score

Mean IC 95% DS p-value

1.

45. Pointing Test Upper limb DX Err

A 21 -0,204

-0,805 +0,089 0,866 0,114

2. B 28 0,153

3.

46. Pointing Test Upper limb DX PVtang

A 13 -0,221

-0, 937 +0,204 0,606 0,200

4. B 20 0,144

5.

47. Pointing Test Upper limb DX AsymL

A 10 0,178

-0,828 +1,511 1,27 0,550

6. B 22 -0,163

7.

48. Pointing Test Upper limb DX LinearL

A 23 0,178

-1,271 +0,522 1,69 0,404

8. B 20 0,195

9.

49. Pointing Test Upper limb DX MovT

A 14 -0,166

-0,965 +0,275 0,499 0,263

10. B 14 0,178

11.

50. Pointing Test Upper limb SX Err

A 18 -0,313

-2,090 +0,614 2,139 0,273

12. B 12 0,424

13.

51. Pointing Test Upper limb SX PVtang

A 14 0,106

-0,319 +0,556 0,489 0,583

14. B 17 -0,012

15.

52. Pointing Test Upper limb SX AsymL

A 11 -0,193

-1,767 +0,675 1,260 0,360

16. B 10 0,352

17.

53. Pointing Test Upper limb SX LinearL

A 21 -0,090

-1,045 +0,704 1,539 0,697

18. B 25 0,080

19.

54. Pointing Test Upper limb SX MovT

A 13 -0,381

-1,533 +1,771 0,701 0,016

20. B 13 0,474

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_{Neurorehabilitative Tests}

N.

patients Difference z-score

19. Stroop’s Test, colour-word A 10 -0,457 -0,857 +0,635 0,865 0,755 _B ₇ _0,065 _{24. Verbal Fluidity’s Test, Phonemic} _A ₇ _-0,177 _-1,172 _+0,505 _0,843 _0,406 B 8 0,155 25. Verbal Fluency’s, Categorical A 9 -0,100 -0,814 +0,450 0,484 0,553 B 11 0,081 25. Frontal Assessment Battery A 5 0,248 -1,053 +1,903 0,822 0,536 B 7 -0,177 28. Wisconsin Card Sorting Test A 5 -1,802 -1,77 +0,653 0,806 0,334 _B ₉ _0,600 45. Expanded Disability Status Scale A 18 -0,072 -0,282 -0,001 0,157 0,048 _B ₁₉ _0,069 46. 10 m walk test A 12 -0,085 -0,639 +0,082 0,282 0,118 _B ₈ _0,192 47. 6 min walk test A 3 -0,079 -0,748 +0,510 0,075 0,668 _B ₇ _0,039 48. Timed Up & Go A 18 -0,145 -0,445 +0,055 0,484 0,124 _B ₁₈ _0,090 49. Tinetti Balance equilibrium A 9 0,026 -0,181 +0,295 0,350 0,631 _B ₁₄ _-0,030 50. Tinetti Balance wolk A 10 0,011 -0,330 +0,377 0,433 0,893 _B ₁₄ _-0,011 51. Fatique Severity Scale A 24 -0,166 -0,875 +0,163 1,001 0,174 _B ₂₁ _0,189 52. Visual Analogic Scale A 19 -0,269 -1,413 +0,270 1,215 0,177 _B ₁₇ _0,301 53. HADS: Anxiety Clinical Scale A 10 -0,062 -0,889 +0,648 0,898 0,748 _B ₁₁ _0,057 54. HADS: Depression scale A 15 -0,258 -1,109 +0,203 0,830 0,169 _B ₂₀ _0,194 55. Barthel Index A 11 0,0583 -0,173 +0,473 0,338 0,340 _B ₇ _-0,091 56. MSQOL- 54 Fisics A 27 0,105 -0,177 +0,057 0,909 0,297 _B ₃₁ _-0,092 57. MSQOL- 54 Mental A 28 0,162 -0,140 +0,750 0,953 0,176 _B ₃₂ _-0,142

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Difference

z-score

_PEV Test

_N. patients

1. PEV OD 60’ A 19 1,794 -1,384 0,563 0,487 0,598 B 25 1,409 2. PEV OS 60’ A 17 1,437 -1,056 0,635 0,419 0,723 B 29 1,299 3. PEV OD 15’ A 19 1,671 -0,831 0,923 0,433

0,432 B 23 1,050 4. PEV OS 15’ A 18 1,318 -1,363 0,195 0,385 0,622 B 22 1,118 5. TCMC AS dx A 22 1,132 -1,173 0,195 0,393 0,777 B 29 1,559 6. TCMC AS sx A 18 1,210 -0,877 0,636 0,375 0,890 B 26 1,231 7. TCMC AI dx A 12 1,190 -1,241 0,893 0,519 0,702 B 16 1,471 8. TCMC AI sx A 11 0,818 -2,153 -0,276 0,454 0,990 B 15 1,330 9. TCMC dir AS dx A 26 0,631 -0,676 0,366 0,252 0,678 B 31 0,233 10. TCMC dir AS sx A 26 -0,043 -0,948 0,150 0,274 0,221 B 34 0,335 11. TCMC dir AI dx A 14 1,328 -0,746 1,355 0,513 0,477 B 17 1,497 12. TCMC dir AI sx A 13 1,041 -2,006 -0,417 0,478 0,990 B 16 1,385 13. TCMC indir AS dx A 13 1,407 -1,852 0,211 0,504 0,990

B 17 1,371 14. TCMC indir AS sx A 11 -0,052 -1,490 1,302 0,675 0,395 B 15 0,041 15. TCMC indir AI dx A 11 -0,067 -1,359 1,119 0,599 0,689 B 15 0,052 16. TCMC indir AI sx A 7 -0,696 -2,298 0,309 0,620 0,346 B 14 0,298

(h)

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