§ = confronto fra obesi prechirurgici e controlli : § = p<0.05 ; §§ = p< 0.01

Tabella 1. Dati demografici e clinici

+ = confronto fra obesi postchirurgici e controlli : + = p<0.05 ; §§ = p< 0.01

* = confronto fra gruppi di obesi : * = p<0.05 ; ** = p< 0.01

§ = confronto fra obesi prechirurgici e controlli : § = p<0.05 ; §§ = p< 0.01

Obesi Prechirurgici

(n= 13) Obesi Postchirurgici

(n= 13) Controlli

(n=13) ANOVA

Parametri Media SD Media SD Media SD P<

Età (anni) 31.2 6.1 == == 33.2 6.4 ns

Altezza (cm) 166.3 §§ 7.3 == == 172.6 7.4 0.001

Peso (kg) 126.4 §§ 20.3 93.6 ** + 16.3 74.8 8.2 0.001

Superficie Corporea (m

) 2.19§§ 0.3 1.88 *+ 0.2 1.85 0.2 0.001

BMI (kg/ m

) 47.0 §§ 8.1 36.0 ** + 5.0 22.8 2.8 0.001

SAP (mmHg) 128.2 13.7 120.6 8.5 120.2 4.3 ns

DAP (mmHg) 77.6 9.3 77.9 8.4 73.6 6.5 ns

MAP (mmHg) 97.4 § 4.8 92.7 4.5 85.4 7.6 0.05

HR (b/min) 81.5 §§ 8.7 67.7 * 8.2 69.9 11.2 0.001

SV (ml) 76.7§ 7.4 73.6 * 6.8 68.7 8.7 0.05

CO (l/min) 5.8 § 1.7 5.3 * + 1.5 5.02 1.3 0.05

Glicemia (mg/dL) 93.8*§ 7.3 81.2 6.8 80.8 7.5 0.05

Colesterolo Totale (mg/dL) 218.2*§ 15.3 198.5 10.2 176.3 9.8 0.05

Colesterolo HDL (mg/dL) 50.5 9.2 53.9 8.2 58.6 8.3 ns

Colesterolo LDL (mg/dL) 134.2 9.2 130.6 7.6 133.5 10.5 ns

Insulina 16.3 §§ 8.6 5.6 ** + 6.2 4.2 2.1 0.001

1

Tabella 2. Parametri ecocardiografici convenzionali

* = confronto fra gruppo di obesi : * = p<0.05 ; ** = p< 0.01

§ = confronto fra obesi prechirurgici e controlli : § = p<0.05 ; §§ = p< 0.01 + = confronto fra obesi postchirurgici e controlli : + = p<0.05 ; §§ = p< 0.01

Obesi Prechirurgici (n= 13)

Obesi Postchirurgici (n= 13)

Controlli

(n=13) ANOVA

Parametri

Media SD Media SD Media SD P<

Aortic root (mm) 31.7 3.1 30.9 2.7 31.9 2.6 ns

Left atrium (mm) 37.9 ^§§ 3.9 33.5 * 4.6 33.1 3.7 0.0001

EDD (cm) 5.3 4.3 47.7 4.0 47.4 3.8 ns

FS (%) 39.3 8.8 41.3 5.6 35.8 7.3 ns

EF (%) 72.5 § 9.9 70.6 + 8.8 66.3 8.6 0.03

DS

(mm) 11.3 §§ 1.9 8.6 ** 1.6 8.5 1.2 0.001

DPW

(mm) 9.9 §§ 1.5 8.2 ** 1.6 8.5 2.1 0.001

LVM

(g/m

) 56.2 §§ 12.2 41.8 ** 10.7 37.1 7.8 0.0001

LVM

(g/m

) 94.5 23.9 80.6 * 19.8 91.1 18.4 0.05

EDV(cm

) 85.2 ^§ 9.4 65.3 ** 13.7 75.8 5.8 00.05.00

ESV (cm

) 24.5 9.2 23.8 * 7.8 28.5 8.6 ns

Tabella 3. Parametri flusso transmitralico: velocità e tempi

* = confronto fra gruppo di obesi : * = p<0.05 ; ** = p< 0.01

§ = confronto fra obesi prechirurgici e controlli : § = p<0.05 ; §§ = p< 0.01 + = confronto fra obesi postchirurgici e controlli : + = p<0.05 ; §§ = p< 0.01

Obesi Prechirurgici (n= 13)

Obesi Postchirurgici

(n= 13) Controlli (n=13) ANOVA

Parametri Media SD Media SD Media SD P<

Peak E (cm/sec) 84.8 19.1 80.0 18.9 80.2 14.5 ns

Peak A (cm/sec) 75.1 §§ 13.7 64.5 ** 10.5 53.7 15.3 0.01

E/A ratio 1.18 §§ 0.4 1.3 * 0.4 1.4 0.5 0.01

Mitral Dec time (msec) 177.2 §§ 32.5 171.7 * + 23.9 155.5 31.9 0.01

IVRT (msec) 80.2 § 16.2 71.8 ** 9.6 77.8 16.8 0.05

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Tabella 4. Risultati PW-TDI .

* = confronto fra gruppo di obesi: * = p<0.05 ; ** = p< 0.01

§ = confronto fra obesi prechirurgici e controlli: § = p<0.05 ; §§ = p< 0.01 + = confronto fra obesi postchirurgici e controlli : + = p<0.05 ; §§ = p< 0.01

Obesi Prechirurgici (n= 13)

Obesi Postchirurgici (n= 13)

Controlli (n=13) ANOVA

Parametri Media ± SD Media±SD Media±SD P<

PW TDI S s 7.8 ± 1.6 8.3 ± 0.9 8.6 ± 1.6 ns

PW TDI E s 7.8 ± 2.9 §§ 8.7 ± 2.5 12.3 ± 2.3 0.001

PW TDI A s 9.9 ± 2.1 §§ 7.8 ± 2.2 ** 6.5 ± 1.9 0.001

PW TDI E/A s 0.81 ± 0.7 §§ 1.2 ± 0.6 ** 1.5 ± 0.6 0.001

PW TDI IVRT s 73.4 ± 11.7 §§ 67.8 ± 14.2 ** 75.4 ± 14.3 0.001

PW TDI S L 7.7 ± 1.7 § 10.0 ± 1.8 * 11.2 ± 2.1 0.01

PW TDI E L 11.5 ± 3.4 §§ 14.7 ± 4.8 16.7 ± 4.1 0.0001

PW TDI A L 10.8 ± 2.7 §§ 8.8 ± 1.9 8.3 ± 2.7 0.01

PW TDI E/A L 1.2 ± 0.4 §§ 1.7 ± 0.3 2.1± 0.5 0.002

PW TDI IVRT L 78.4 ± 19.8 59.5 ± 18.2 * 72.6 ± 17.8 0.05

E/Es 12.8 ± 1.9 §§ 7.8 ± 2.2 ** + 6.6 ± 1.6 0.0001

Table 5. Parametri CDMI (velocità regionali, strain and stain rate)

* = confronto fra gruppo di obesi : * = p<0.05 ; ** = p< 0.01

§ = confronto fra obesi prechirurgici e controlli : § = p<0.05 ; §§ = p< 0.01 + = confronto fra obesi postchirurgici e controlli : + = p<0.05 ; §§ = p< 0.01

5

Obesi Prechirurgici (n= 13)

Obesi Postchirurgici (n= 13)

Controlli (n=13)

ANOVA

Parametri Media SD Media SD Media SD P<

ε sys(S) -11.9 §§ 3.2 -20.4 ** 5.3 -23.4 9.4 0.001

SR sys (S) -0.5 §§ 0.2 -1.1 ** 0.3 -1.2 0.4 0.003

SR E (S) 0.8 §§ 0.4 1.2* 0.2 1.4 0.6 0.001

SR A (S) 0.8 0.3 0.5 0.3 0.5 0.4 Ns

ε sys(L) -10.5 §§ 3.7 -19.5 ** 4.7 -21.4 5.6 0.0001

SR sys (L) -0.6 §§ 0.3 -1.2 ** + 0.3 -1.7 1.7 0.0001

SR E (L) 1.1 §§ 0.4 1.3 * 0.6 1.3 0.5 0.001

SR A (L) 0.6 0.3 0.5 0.2 0.5 0.2 Ns

Tabella 6. Parametri IBS

* = confronto tra gruppo di obesi* = p<0.05 ; ** = p< 0.01

§ = confronto tra obesi prechirurgia e controlli : § = p<0.05 ; §§ = p< 0.01 + = confronto tra obesi postchirurgia e controlli : + = p<0.05 ; §§ = p< 0.01

Obesi prechirurgia (n= 13)

Obesi posrchirurgia (n= 13)

Controlli (n=13) ANOVA

Parametri Media SD Media SD Media SD P<

IBS p (dB) 47.1 5.6 47.5 5.5 48.2 4.9 ns

CVI

(%) 14.6 §§ 7.0 25.7**

1

1.2 36.2 9.1 0.0001

CVI

(%) 30.7 §§ 6.7 35.6 ** 9.5 42.0 8.6 0.001

IBS

(%) 55. 8 § 9.5 46.5 * + 8.8 43.0 8.0 0.04

IBS

(%) 34.6 §§ 5.9 27.7 * + 7.4 33.7 7.1 0.01

7