THEORICAL SECTION
CHAPTER 1: PET and Radiopharmaceuticals……….Pag.1
Introduction
1.1. Positron Emission Tomography 1.2. Selection of a radiopharmaceutical 1.3. Traditional PET isotopes
1.4. Fluorine-18 radiopharmaceuticals
1.5. Design and synthesis of 2-deoxy-2-[18F]fluoro-D-glucose (18FDG)
1.6. First synthesis of 18F-FDG for animal and human studies
1.7. Improvements
1.8. 18F-FDG synthesis (1986 to present)
1.9. Mathematical 18F-FDG model
1.10. Lumped constant (LC)
1.11. Applications of 18F-FDG in PET
CHAPTER 2: Radionuclide generation and
synthesis automation………..Pag. 32
2.1. Production of fluorine-18 2.2. The cyclotron
2.3. Automation of synthetic processes
2.4. Development of automated radiotracer synthesis systems 2.5 Unit operations design
2.6. Role of feedback control
2.7. Real time control of unit operations 2.8. Sensor data
2.9. Modern automatic sinthesizers
2.10. Automation for the application of PET radiopharmaceuticals
CHAPTER 3: FDG as a radiopharmaceutical………Pag. 47
3.1 Radiopharmaceuticals as medicinal products 3.2 Quality Control of FDG
EXPERIMENTAL SECTION
CHAPTER 4
18F-FDG and
18F-SFB………..Pag. 55
4.1 The PETtrace System 4.2 Tracerlab Fx FDG
4.2.1 TRACERlab Fx FDG specifications
4.2.2 The TRACERlab Fx FDG software
4.2.3 Synthesis process description 4.2.4 Steps of the process
4.2.5 Preparation for the synthesis process. 4.3 Dispensing Unit 4.3.1 Diluter 4.3.2 Clean room 4.3.3 Sterilizer 4.3.4 Robot 4.3.5 Activimeter
4.3.6 Preparation for dispensing 4.3.7 Dispensing operations 4.3.8 Cleaning the dispenser 4.4 Matherials
4.4.1 Chemicals
4.4.2 Quality Control System 4.5 18F-SFB insulin
4.5.1 18F-SFB insulin manual synthesis 4.5.2 18F-SFB insulin automated synthesis 4.6 Conclusions
