Andrea Di Giuseppe
PERSONAL DETAILS
Place and date of birth: L’Aquila (Italy), January 12th, 1981
Address: Via Vetoio 67100 (Coppito 2) Coppito (AQ), Italy
Phone: +39 0862433312
e-mail: andrea.digiuseppe@univaq.it
DIGITAL SCIENTIFIC IDENTIFIERS
ORCID: 0000-0002-3666-5800
ResearcherID: B-4730-2013
ScopusID: 26534068800
BIBLIOMETRIC INDICATORS (Scopus)
Total publications: 25 (5 as corresponding author, + 2 submitted) Sum of Times Cited: 762 (average citation per article 30,48)
h-index: 17
CURRENT POSITION
University of L’Aquila L’Aquila, Italy
– Researcher (RTD-B) 11/2020-Present
EDUCATION
- University of L’Aquila, Department of Chemistry L’Aquila, Italy -Ph.D. degree in Environmental and Cultural Heritage
Chemistry.
PhD thesis: “Homogeneous Catalysis for Fine Chemical Production:
Vanadium and Rhodium-Catalyzed Carbon-Heteroatom and Carbon- Carbon Bond Formation”. Supervisor: Prof. Marcello Crucianelli, Prof. Francesco De Angelis.
2008-2012
- M.Phil. degree in Chemical Sciences (Summa cum laude).
Master degree thesis: “Novel application for oxidative catalysis: use of methyltrioxorhenium supported on polymeric matrices”.
Supervisor: Prof. Francesco De Angelis, Prof. Marcello Crucianelli.
2004-2007
- B.Sc. degree in Chemistry (Summa cum laude).
Bachelor degree thesis: “New insights in β–lactam antibiotics field:
“dual action” cephalosporins having potential anti-inflammatory and elastase inhibitory activity”. Supervisor: Prof. Francesco De Angelis, Nicoletta Spreti.
2000-2004
PRIZES, GRANTS AND QUALIFICATIONS - Italian National Scientific Qualification to Associate Professor on
"Fondamenti delle Scienze Chimiche e Sistemi Inorganici-03-B1" by Ministry of Education, University and Research (MIUR).
2018 - 2024
- Italian National Scientific Qualification to Associate Professor on
"Fondamenti Chimici delle tecnologie-03-B2" by Ministry of Education, University and Research (MIUR).
2018 - 2024
- Italian National Scientific Qualification to Associate Professor on
"Chimica Organica-03-C1" by Ministry of Education, University and Research (MIUR).
2018 - 2024
- Postdoctoral Fellowship “Juan de la Cierva - Incorporación” by the Spanish Ministry of Economy and Competitiveness.
2017-2019 - Postdoctoral Fellowship “Subprograma de Formación Postdoctoral”
by the Spanish Ministry of Economy and Competitiveness.
2015-2016
- Parmaliana Award for the best Italian PhD Thesis in catalysis. 2013 - Award for the best poster presentation at XIX EuCOMC 2011,
Toulouse (France).
2011
- Undergraduate Studenship by the Italian Ministry of Education, University and Research.
2000-2003
RESEARCH EXPERIENCE University of L’Aquila, Department of Physical and Chemical sciences.
L’Aquila, Italy
Researcher (RTD-B) 11/2020- Present
Development and mechanistic studies on homogeneous and heterogeneous catalytic systems based on earth abundant metals for the selective introduction of functional groups and more complex structural units into organic substrates
University of California Berkeley, College of Chemistry. Berkeley, USA Assistant Project Scientist; Supervisor: Polly L. Arnold. 2/2020- Present Synthesis and analysis of f-block element species, in particular Group 3 and lanthanide complexes with unusual electronic structures and potential photocatalytic activity.
University of Edinburgh, School of Chemistry. Edinburgh, UK Postdoctoral Research Associate; Supervisor: Polly L. Arnold. 3/2019- 12/2019 Synthesis of new frustrated Lewis pair systems developed from f-block-centers bearing a hemilable NHC ligand. Studies of their catalytic properties for the heterofunctionalization of cheap and abundant organic starting materials.
University of Zaragoza, Department of Inorganic Chemistry. Zaragoza, Spain Postdoctoral Fellow; Supervisor: Luis A. Oro. 7/2012-12/2019 Design and mechanistic studies of new homogeneous catalytic systems based on rhodium-NHC complexes for the selective hydrofunctionalization of unsaturated hydrocarbons.
• Development of Rh(I)-NHC complexes with nitrogen-based ligands for the stereoselective synthesis of gem-vinylsulfide throw hydrothiolation of alkynes (JACS 2012; ACIE 2013; Catal. Sci. Technol. 2016; Organometallics 2017; Top. Organomet.
Chem. 2018).
• Synthesis, characterization and post-polymerization modification of innovative sulfur containing polymers obtained by rhodium-catalyzed thiol-yne click reaction (Polym.
Chem. 2018).
• Rh(I)-NHC based catalyst for C-C bond formation via direct C-H activation (Chem.
Eur. J. 2013; Chem. Eur. J. 2013; ACS Catal. 2014, ACS Catal. 2019, Chem. Eur. J.,
2020, ACS Catal. 2021, Eur. J. Inorg. Chem, 2021).
• First example of soft-metal based catalyst for the double hydrophosphination of alkynes (Chem. Commun. 2016).
• Structure/activity studies of Rh(III)-NHC complexes on the catalyzed H/D exchange reaction of olefins (Chem. Eur. J. 2014; C. R. Chim. 2015).
• Mechanistic studies on the aminocarbonylation of alkynes mediated by Rh(III)-NHC complexes (Paper in preparation).
• Synthesis of new Rh(I)-NHC complexes with labile ligands and study of their stereo/electronic properties (Organometallics 2013; Dalton Trans. 2015;
Organometallics 2018)
University of Zaragoza, Department of Inorganic Chemistry Zaragoza, Spain
Visiting student; Supervisor: Luis A. Oro 2009-2011
Synthesis and characterization of unsaturated Rh(I) and (III) complexes bearing an NHC ligand.
• Synthesis of a Rh(I)-NHC-alkylidene complex and its reactivity in alkene metathesis (Organometallics 2011).
• Rh(III)-NHC-hydride based catalyst for the selective H/D exchange of α-olefins (ACIE 2011).
University of L’Aquila, Department of Chemistry L’Aquila, Italy PhD student; Supervisor: Marcello Crucianelli and Francesco
De Angelis
2008-2012 Development of homogeneous and heterogeneous catalytic systems based on metal-oxide complexes for the oxyfunctionalization of organic substrates with mild and green oxidants.
• Synthesis of new oxovanadium(IV) complexes bearing acyl-pyrazolone ligands and study of their catalytic properties in the selective oxidation of olefins under homogeneous and heterogeneous conditions (Appl. Catal., A 2010; Catal. Today 2012;
Catal. Sci. Technol. 2013).
• Methyltrixorhenium based catalyst for the green oxidation of organic compounds in high relevant industrial transformations (Appl. Catal., B 2009, J. Catal. 2010).
University of L’Aquila, Department of Chemistry L’Aquila, Italy Undergraduate student, M.Phil and B.Sc. thesis; Supervisor:
Francesco De Angelis, Marcello Crucianelli and Nicoletta Spreti.
2004 and 2007
• Synthesis of new cephalosporins derivatized with a potential antiinflamatory moiety and their in vitro elastase inhibitory activity (B.Sc. thesis).
• Development of a new biopolymer based support for the heterogeneization of transition metal complexes (M.Phil thesis).
SKILLS AND COMPETENCES
• Synthesis and characterization of organic ligands and d and f block organometallic species from milligram to gram scale.
• Ability to carry out reactions under high temperature and/or pressure (Fisher-Porter and J. Young tubes) even using hazardous gases such as CO, NH
3, HCl and H
2S.
• Manipulation of highly air and moisture sensitive compounds (Schlenk techniques and glove box).
• Experienced in separation and purification by chromatographic column, preparative thin layer chromatography, distillation, crystallization, sublimation.
• Design and development of homogeneous and heterogeneous catalysts.
• Experimental and theoretical (DFT calculation) study of the structural and electronic
properties of organometallic catalysts, ligand design and mechanistic elucidation.
• Proficient in the application of standard analytical techniques including 1D and 2D (VT) NMR spectroscopy, FTIR, MS (ESI, EI, MALDI), UV-Visible spectroscopy, GC, HPLC (and coupled techniques, GC-MS, LC-MS).
• Ability to organize and optimize laboratory tasks. Supervision and training of postgraduate and undergraduate students on instrumentation and advanced synthetic inorganic/organic chemistry techniques.
• Languages: Italian, Spanish, English and basic French.
PUBLICATIONS
1) Galiana-Cameo, Maria; Passarelli, Vincenzo; Perez-Torrente, Jesus J.; Di Giuseppe, Andrea; Castarlenas, Ricardo. Variation on the π-Accepor Ligand within a Rh
I-N- Heterocyclic Carbene Framework: Divergent Catalytic Outcomes for Phenylacetylene- Methanol Transformations. Paper submitted, Eur. J. Inorg. Chem, 2021.
2) Galiana-Cameo, Maria; Borraz , Marina; Zelenkova, Yaroslava; Passarelli, Vincenzo;
Lahoz, Fernando J.; Perez-Torrente, Jesus J.; Oro, Luis A.; Di Giuseppe, Andrea; Castarlenas, Ricardo. Rhodium(I)-NHC Metal-Ligand Cooperative Proton Transfer as an Efficient Trigger for Rhodium-NHC-Pyridonato Catalyzed gem-Specific Alkyne Dimerization. Paper submitted, ACS Catal., 2021.
3) Galiana-Cameo, Maria; Borraz , Marina; Zelenkova, Yaroslava; Passarelli, Vincenzo;
Lahoz, Fernando J.; Perez-Torrente, Jesus J.; Oro, Luis A.; Di Giuseppe, Andrea; Castarlenas, Ricardo. Rhodium(I)-NHC Complexes Bearing Bidentate Heteroacidato Ligands as gem- Selective Catalysts for Alkyne Dimerization. Chem. Eur. J., 2020, 26, 9598-9608
4) Azpíroz, Ramon; Di Giuseppe, Andrea; Urriolabeitia, Asier; Passarelli, Vincenzo; Polo, Victor; Perez-Torrente, Jesus J.; Oro, Luis A.; Castarlenas, Ricardo. Hydride–Rhodium(III)- N-Heterocyclic Carbene Catalyst for Tandem Alkylation/Alkenylation via C–H Activation.
ACS Catal., 2019, 9, 9372-9386.
5) Azpíroz, Ramon; Di Giuseppe, Andrea; Passarelli, Vincenzo; Perez-Torrente, Jesus J.; Oro, Luis A.; Castarlenas, Ricardo. Rhodium–N-Heterocyclic Carbene Catalyzed Hydroalkenylation Reactions with 2-Vinylpyridine and 2-Vinylpyrazine: Preparation of Nitrogen-Bridgehead Heterocycles. Organometallics, 2018, 37, 1695-1707.
6) Di Giuseppe, Andrea; Castarlenas, Ricardo; Oro, Luis A. Rhodium Catalysts for C–S Bond Formation. In: Claver C. (eds) Rhodium Catalysis. Top. Organomet. Chem., Springer, Cham, 2018, 61, 31-67.
7) Funes-Hernando, Daniel; Hermosilla, Pablo; Vispe, Eugenio; Di Giuseppe, Andrea;
Castarlenas, Ricardo; Oro, Luis A.; Perez-Torrente, Jesus J. Vinylidene-based polymers by Rh(I)-NHC catalyzed thiol-yne click polymerization: synthesis, characterization and post- polymerization modification. Polym. Chem., 2018, 9, 1298-1302.
8) Karataş, Mert Olgun; Di Giuseppe, Andrea; Passarelli, Vincenzo; Alıcı, Bülent; Pérez- Torrente, Jesús J.; Oro, Luis A.; Özdemir, Ismail; Castarlenas, Ricardo. Pentacoordinated Rhodium(I) Complexes Supported by Coumarin- Functionalized N‑Heterocyclic Carbene Ligands. Organometallics, 2018, 37, 191-202.
9) Palacios, Laura; Meheut, Yoann; Galiana-Cameo, María; Artigas, María José; Di Giuseppe,
Andrea; Lahoz, Fernando J.; Polo, Victor; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Oro,
Luis A. Design of Highly Selective Alkyne Hydrothiolation Rh
I‑NHC Catalysts: Carbonyl-
Triggered Nonoxidative Mechanism. Organometallics, 2017, 36, 2198-2207.
10) Palacios, Laura; Di Giuseppe, Andrea; Polo, Victor; Lahoz, Fernando J.; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Oro, Luis A. Mechanistic insight into the pyridine enhanced α-selectivity in alkyne hydrothiolation catalysed by quinolinolate–rhodium(I)–N-heterocyclic carbene complexes. Catal. Sci. Technol., 2016, 6, 8548-8561.
11) Di Giuseppe, Andrea; De Luca, Roberto; Castarlenas, Ricardo; Perez-Torrente, Jesus J.;
Crucianelli, Marcello; Oro, Luis A. Double Hydrophosphination of Alkynes Promoted by Rhodium: the Key Role of an N-Heterocyclic Carbene Ligand. Chem. Commun., 2016, 52, 5554-5557.
12) Di Giuseppe, Andrea; Castarlenas, Ricardo; Oro, Luis A. Mechanistic Considerations on Catalytic H/D Exchange Mediated by Organometallic Transition Metal Complexes. C. R.
Chim., 2015, 18, 713-741.
13) Palacios, Laura; Di Giuseppe, Andrea; Castarlenas, Ricardo; Lahoz, Fernando J.; Perez- Torrente, Jesus J.; Oro, Luis A. Pyridine versus Acetonitrile Coordination in Rhodium–N- Heterocyclic Carbene Square-Planar Complexes. Dalton Trans., 2015, 44, 5777-5789.
14) Di Giuseppe, Andrea; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Lahoz, Fernando J.;
Oro, Luis A. Hydride-Rhodium(III)-N-Heterocyclic Carbene Catalysts for Vinyl-Selective H/D Exchange: A Structure-Activity Study. Chem. Eur. J., 2014, 20, 8391-8404.
15) Azpiroz, Ramon; Rubio-Perez, Laura; Di Giuseppe, Andrea; Passarelli, Vincenzo; Lahoz, Fernando J.; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Oro, Luis A. Rhodium(I)-N- Heterocyclic Carbene Catalyst for Selective Coupling of N-Vinylpyrazoles with Alkynes via C-H Activation. ACS Catal., 2014, 4, 4244-4253.
16) Castarlenas, Ricardo; Di Giuseppe, Andrea; Perez-Torrente, Jesus J.; Oro, Luis A. The Emergence of Transition Metal-Mediated Hydrothiolation of Unsaturated Carbon-Carbon Bonds: A Mechanistic Outlook. Angew. Chem., Int. Ed., 2013, 52, 211-222.
17) Azpiroz, Ramon; Di Giuseppe, Andrea; Castarlenas, Ricardo; Perez-Torrente, Jesus J.;
Oro, Luis A. A New Access to 4 H-Quinolizines from 2-Vinylpyridine and Alkynes Promoted by Rhodium-N-Heterocyclic-Carbene Catalysts. Chem. Eur. J., 2013, 19, 3812-3816.
18) Palacios, Laura; Di Giuseppe, Andrea; Opalinska, Anna; Castarlenas, Ricardo; Perez- Torrente, Jesus J.; Lahoz, Fernando J.; Oro, Luis A. Labile Rhodium(I)-N-Heterocyclic Carbene Complexes. Organometallics, 2013, 32, 2768-2774.
19) Rubio-Perez, Laura; Azpiroz, Ramon; Di Giuseppe, Andrea; Polo, Victor; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Oro, Luis A. Pyridine-Enhanced Head-to-Tail Dimerization of Terminal Alkynes by a Rhodium N-Heterocyclic Carbene Catalyst. Chem. Eur. J., 2013, 19, 15304-15314.
20) Di Giuseppe, Andrea; Di Nicola, Corrado; Pettinari, Riccardo; Ferino, Italo; Meloni, Daniela; Passacantando, Maurizio; Crucianelli, Marcello. Selective catalytic oxidation of olefins by novel oxovanadium(IV) complexes having different donor ligands covalently anchored on SBA-15: a comparative study. Catal. Sci. Technol., 2013, 3, 1972-1984.
21) Aschi, Massimiliano; Crucianelli, Marcello; Di Giuseppe, Andrea; Di Nicola, Corrado;
Marchetti, Fabio. Insights on the mechanistic features of catalytic oxidations of simple and
conjugated olefins promoted by VO(acac)
2/H
2O
2system, in acetonitrile: A computational
study. Catal. Today, 2012, 192, 56-62.
22) Di Giuseppe, Andrea; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Crucianelli, Marcello; Polo, Victor; Sancho, Rodrigo; Lahoz, Fernando J.; Oro, Luis A. Ligand-controlled regioselectivity in the hydrothiolation of alkynes by rhodium N-heterocyclic carbene catalysts.
J. Am. Chem. Soc., 2012, 134, 8171-8183.
23) Di Giuseppe, Andrea; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Lahoz, Fernando J.;
Polo, Victor; Oro, Luis A. Mild and selective H/D exchange at the β position of aromatic α- olefins by N-heterocyclic carbene-hydride-rhodium catalysts. Angew. Chem., Int. Ed., 2011, 50, 3938-3942.
24) Palacios, Laura; Miao, Xiaowei; Di Giuseppe, Andrea; Pascal, Simon; Cunchillos, Carmen; Castarlenas, Ricardo; Perez-Torrente, Jesus J.; Lahoz, Fernando J.; Dixneuf, Pierre H.; Oro, Luis A. Synthesis of a square-planar rhodium alkylidene N-heterocyclic carbene complex and its reactivity towards alkenes. Organometallics, 2011, 30, 5208-5213.
25) Di Giuseppe, Andrea; Crucianelli, Marcello; Passacantando, Maurizio; Nisi, Stefano;
Saladino, Raffaele. Chitin- and chitosan-anchored methyltrioxorhenium: An innovative approach for selective heterogeneous catalytic epoxidations of olefins. J. Catal., 2010, 276, 412-422.
26) Marchetti, Fabio; Pettinari, Claudio; Di Nicola, Corrado; Pettinari, Riccardo; Crispini, Alessandra; Crucianelli, Marcello; Di Giuseppe, Andrea. Synthesis and characterization of novel oxovanadium(IV) complexes with 4-acyl-5-pyrazolone donor ligands: Evaluation of their catalytic activity for the oxidation of styrene derivatives. Appl. Catal., A, 2010, 378, 211- 220.
27) Di Giuseppe, Andrea; Crucianelli, Marcello; De Angelis, Francesco; Crestini, Claudia;
Saladino, Raffaele. Efficient oxidation of thiophene derivatives with homogeneous and heterogeneous MTO/H
2O
2systems: A novel approach for, oxidative desulfurization (ODS) of diesel fuel. Appl. Catal., B, 2009, 89, 239-245.
CONTRIBUTION TO CONFERENCE
Poster presentation in XXXVI Congress of the Organometallic Chemistry Specialized Group of the Spanish Royal Society of Chemistry (XXXVI GEQO), 5-7
thSeptember 2018, Zaragoza (Spain).
Oral presentation in 28
thInternational Conference on Organometallic Chemistry (ICOMC- 2018), 15-20
thJuly 2018, Firenze (Italy).
Poster presentation in XXXIV Congress of the Organometallic Chemistry Specialized Group of the Spanish Royal Society of Chemistry (XXXIV GEQO), 7-9
thSeptember 2016, Girona (Spain).
Poster presentation in 7
thCaRLa Winter School in Homogeneous Catalysis, 22-28
thFebruary 2014, Heidelberg (Germany)
Invited oral presentation in XVII National Congress of Catalysis (GIC 2013), 16-18
thSeptember 2013, Riccione (Italy).
Invited oral presentation in XXXI Convegno Interregionale Toscana Umbria Marche Abruzzo
(TUMA-XXXI), 18-20
thJune 2012, Francavilla (Italy).
Oral presentation in XXV International Conference on Organometallic Chemistry (ICOMC 25), 2-7
thSeptember 2012, Lisboa (Portugal).
Poster presentation in 19
thEuCheMS International Conference on Organometallic Chemistry (XIX EuCOMC), 3-7
thJuly 2011, Toulouse (France).
Oral presentation in Giornata di incontro Università – Aziende del territorio Aquilano sulla Chimica e Scienza dei materiali, 7
thJune 2010, L’Aquila (Italy).
Poster presentation in IX Congresso del Gruppo Interdivisionale di Chimica Organometallica (CoGICO-IX), 8-11
thJune 2010, Firenze (Italy).
Oral presentation in inGAP NANOCAT Catalysis Summer School 2009, 21-26
thJune 2009, Trondheim (Norway).
Oral presentation in XXVII Convegno Interregionale Toscana Umbria Marche Abruzzo (TUMA-XXVII), 23-25
thJune 2008, L’Aquila (Italy).
SPECIALISED TRAININGS
-Cryogens Safety by University of California 2020
-Fundamentals of Laboratory Safety by University of California 2020 -Radiation Safety Training for Users of Radioactive Materials and
Radiation Producing Machines (RPM) by University of California
2020 -Advanced Course in Nuclear Magnetic Resonance by Spanish
National Research Council (CSIC)
2013
-School of high resolution inductively coupled plasma mass spectrometry by Gran Sasso National Laboratory (LNGS)
2011
PARTICIPATION IN FUNDED RESEARCH PROJECTS
• “Dotación Adicional Ayuda Juan de la Cierva Incorporación (18840 IJCI-2015-27029)” 2017- 2019. Financed by Ministry of Economy and Competitiveness (Spain), 6.000,00 €. PI: Di Giuseppe, Andrea
• “Grupo de Referencia Catálisis Homogénea por Compuestos Organometálicos (18852
E42_17R)” 2017-2019. Financed by Aragón Government (Spain), 38.529,00 €. PI: Pérez Torrente, Jesús Julián
• “Grupo Consolidado E07 Catálisis Homogénea por compuestos Organometálicos (18824/3
E07)” 2016. Financed by Aragón Government (Spain), 16.666,00 €. PI: Oro Giral, Luis Antonio
• “Grupo Consolidado E07 Catálisis Homogénea por compuestos Organometálicos (18824/2
E07)” 2015. Financed by Aragón Government (Spain), 17.627,00 €. PI: Oro Giral, Luis Antonio
• “Grupo Consolidado E07 Catálisis Homogénea por compuestos Organometálicos (18824/1
E07)” 2014. Financed by Aragón Government (Spain), 22.623,00 €. PI: Oro Giral, Luis Antonio
• “Desarrollo de Catalizadores más Eficientes para el Diseño de Procesos Químicos Sostenibles y
Producción Limpia de Energía (MULTICAT) (18817 CSD2009-00050)” 2013-2016. Financed by Spanish National Research Council (CSIC) (Spain), 374.929,00 €. PI: Oro Giral, Luis Antonio
• “Grupo Consolidado E07 Catálisis Homogénea por compuestos Organometálicos (18819/3 E07)” 2013. Financed by Aragón Government (Spain), 16.410,00 €. PI: Oro Giral, Luis Antonio
• “Síntesis, Reactividad y Aplicaciones en Catálisis de Complejos de Metales de Transición con
Ligandos Polidentados (17074 CTQ2010-15221)” 2012-2013. Financed by Ministry of Economy
and Competitiveness (Spain), 173.030,00 €. PI: Pérez Torrente, Jesús Julián
• “PRIN 2008 Caratterizzazione strutturale mediante spettrometria di massa soft di polimeri