vii
Contents
Preface ... v Contributors ... ix 1. Molecular Biology of Colon Cancer ... 1
William M. Grady
2. Chemoprevention of Colorectal Cancer ... 33 Yu-Ning Wong, Wen-Chi Chang, Margie Clapper,
and Paul F. Engstrom
3. Colorectal Cancer Screening and Surveillance ... 51 Arnold J. Markowitz
4. Cytotoxic Chemotherapy for Metastatic Colorectal Cancer ... 69 M. Wasif Saif, Richard Kim, and Edward Chu
5. Integration of Antiangiogenic Strategies Into Colorectal
Cancer Treatment ... 85 John M. Strother and Charles D. Blanke
6. The Role of EGFR Inhibition in Colorectal Cancer ... 99 Nabeel Shalan and Paulo M. Hoff
7. Second-Line Strategies in the Treatment of Patients
With Metastatic Colorectal Cancer ... 119 Anthony B. El-Khoueiry and Heinz-Josef Lenz
8. Adjuvant Chemotherapy for Colon Cancer ... 131 Bert H. O’Neil, Hanna Kelly, Michael A. Morse,
and Richard M. Goldberg
9. Management of Locally Advanced Rectal Cancer ... 155 Yu Jo Chua and David Cunningham
10. Rationale for Adjuvant and Neoadjuvant Chemotherapy
in the Resection of Liver Metastases ... 191 Axel Grothey and Steven A. Alberts
11. Percutaneous Radiofrequency Ablation in the Management
of Patients With Colorectal Cancer ... 205 Karen Brown
12. Colorectal Cancer Imaging ... 219 Sean D. Curran and Laurence H. Schwartz
13. Nursing Issues in Colorectal Cancer Chemotherapy ... 231 Ellen Hollywood and Deborah Semple
viii Contents
14. Pain Management in the Colorectal Cancer Patient ... 245 Vivek Tim Malhotra
15. Novel Agents and New Paradigms for Colorectal Cancer:
Beyond EGFR and VEGF ... 263 Chris Takimoto and Russell Kruzelock
Index ... 281
