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INVERSE ASSOCIATION BETWEEN TRANS ISOMERIC AND LONG-CHAIN POLYUNSATURATED FATTY ACIDS IN ERYTHROCYTE MEMBRANE LIPIDS IN PREGNANT WOMEN

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INVERSE ASSOCIATION BETWEEN TRANS ISOMERIC AND LONG-CHAIN

POLYUNSATURATED FATTY ACIDS IN ERYTHROCYTE MEMBRANE LIPIDS IN PREGNANT WOMEN

A. Kovacs

1

, C. Campoy

2

, B. Koletzko

3

, T. Marosvölgyi

1

, E. Szabo

1

, M.

Jimenez

2

, H. Demmelmair

3

, T. Decsi

1

1

Department of Paediatrics, University of Pecs, Pecs, Hungary;

22

Department o o f Paediatrics, University of Granada, Granada, Spain;

3

Dr. von Haunersches Kinderspital, University of Munich, Munich, Germany

Methods:

Fatty acid composition of erythrocyte membrane phospatidylcholine lipids was investigated at the 20

th

week of gestation in pregnant women living in Germany (n = 23), Hungary (n = 34) and Spain (n = 44).

Results:

The sum of trans isomeric fatty acids was significantly (P < 0.01) higher in Spanish (0.71 [0.32], % wt/wt, median [IQR]) than in German (0.49 [0.24]) and Hungarian (0.56 [0.34]) mothers. In Spanish pregnant women, trans isomeric fatty acids were significantly inversely correlated to both arachidonic and docosahexaenoic acids (Table 1).

Conclusions:

This observation supports the concept that maternal trans fatty acid intake may be inversely associated to the long-chain polyunsaturated fatty acid status of the fetus.

Table 1 . Linear correlation coefficients between fatty acids in erythrocyte membrane phosphatidylcholine lipids in Spanish expecting women (n = 44). * = P < 0.05, ** = P < 0.01

Fatty acid C16:1t C18:1t Sum of trans

isomeric Linoleic -0.08 +0.28 +0.15

Arachidonic -0.47** -0.33* -0.48**

164

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ERYTHROCYTE MEMBRANE LIPIDS IN PREGNANT WOMEN 165

Fatty acid C16:1t C18:1t Sum of trans

isomeric

Alpha-linolenic +0.08 -0.02 +0.05

Docosahexaenoic -0.35* -0.45** -0.43**

The study was supported by EU grant QLK1-CT-1999-00888

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