• Non ci sono risultati.

Dal nostro lavoro si evince un discreto e significativo miglioramento estetico delle regioni corporee sottoposte al trattamento .

In tutti i casi presi in esame, a prescindere dagli stadi e dalle varianti di PEFS caratterizzanti le regioni glutee e posteriori delle cosce, si osserva una discreta attenuazione dell’inestetismo cutaneo: scompare la pelle a buccia d’arancia; le adiposità si risolvono in massima parte; si ripristina l’elasticità tegumentaria, la cute appare più omogenea e compatta; migliora la ritenzione idrica; diminuiscono le telengectasie; infine i micronoduli, che erano presenti nelle pazienti con PEFS di stadio avanzato (II/III stadio), non risultano più palpabili. Il miglioramento dell’aspetto cutaneo e delle caratteristiche istopatologiche tipiche della patologia sono comprovati dall’attenuazione del quadro clinico: le pazienti riferiscono attenuazione e scomparsa del dolore, del senso di gonfiore e del senso di pesantezza agli arti inferiori. Gli esami di laboratorio e le composizioni corporee eseguite all’inizio, a metà e al termine dei trattamenti non hanno evidenziato alterazioni patologiche, anzi, si è evidenziato un certo miglioramento dei parametri. Le impedenziometrie rivelano un ottimizzazione dei parametri di composizione corporea: incremento di massa magra e decremento di massa grassa; aumento del metabolismo basale; incremento dell’acqua intracellulare e riduzione dell’acqua extracellulare. Ciò dimostra il riassorbimento dell’edema

interstiziale determinato dalla strumentazione, che possiede effetti benefici sul microcircolo veno-linfatico.

Gli esami di laboratorio mostrano come l’apparecchiatura non incida sul metabolismo glucidico (la glicemia rimane invariata) e sulla funzionalità renale (uremia e creatininemia non subiscono alterazioni patologiche). Per quanto concerne il profilo lipidico si osserva durante l’esecuzione del trattamento un iniziale lieve incremento plasmatico di colesterolo LDL e trigliceridi; da attribuirsi alla lipolisi indotta dalla strumentazione e conseguente immissione in circolo di acidi grassi e glicerolo. In ogni caso con il prosieguo del trattamento si registra un decremento dei suddetti parametri, come conseguenza del potenziamento del drenaggio veno-linfatico.

Inoltre le ecografie evidenziano come lo spessore del tessuto adiposo sottocutaneo si riduca; le iperecogenicità si attenuino; il flusso sanguigno migliori e rimanga aumentato anche a distanza di tempo dalla cessazione del trattamento. Il ripristino circolatorio-metabolico è convalidato dalla scomparsa alla palpazione di regioni cutanee ipotermiche.

In conclusione pensiamo che tale metodica risulti essere priva di controindicazioni in ordine al metabolismo organico e agli esami chimici di laboratorio, nonché essere un protocollo efficace per i risultati finali ottenuti. La terapia rappresenta un mezzo di comprovata efficacia nella PEFS di stadio da I a III, e validissimi risultati possono venir conseguiti anche nello stadio IV in fase precoce. E’ importante considerare che seppur non costituisca un metodo invasivo, in

definitiva si è dimostrata capace di incidere favorevolmente sul profilo lipidico e sul flusso ematico cutaneo e ipodermico.

BIBLIOGRAFIA

1 Giralt M, Villarroya F. White, brown, beige/brite: different adipose cells for different functions? Endocrinology. 2013; 154(9): 2992-3000.

2. Kozak LP. Genetic variation in brown fat activity and body weight regulation in mice: lessons for human studies. Biochimica et biophysica acta. 2014; 1842(3): 370-6.

3 Nuutila P. Brown adipose tissue thermogenesis in humans. Diabetologia. 2013; 56(10): 2110-2.

4. Lecoultre V, Ravussin E. Brown adipose tissue and aging. Current opinion in clinical nutrition and metabolic care. 2011; 14(1): 1-6.

5. Konige M, Wang H, Sztalryd C. Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis. Biochimica et biophysica acta. 2014; 1842(3): 393-401.

6. Peirce V, Carobbio S, Vidal-Puig A. The different shades of fat. Nature. 2014; 510(7503): 76-83.

7. Pope M, Budge H, Symonds ME. The developmental transition of ovine adipose tissue through early life. Acta physiologica (Oxford, England). 2014; 210(1): 20-30.

8 Lewis GF. Devastating metabolic consequences of a life of plenty: focus on the dyslipidemia of overnutrition. Clinical and investigative medicine

Medecine clinique et experimentale. 2013; 36(5): E242-7.

9 Fodor M, Sofi G. [New perspectives on childhood obesity]. Orvosi hetilap. 2013; 154(32): 1256-60.

10 Lukaszewski MA, Eberle D, Vieau D, Breton C. Nutritional manipulations in the perinatal period program adipose tissue in offspring. American journal of physiology Endocrinology and metabolism. 2013; 305(10): E1195-207.

11. Hocking S, Samocha-Bonet D, Milner KL, Greenfield JR, Chisholm DJ. Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots. Endocrine reviews. 2013; 34(4): 463-500.

12. Previs SF, McLaren DG, Wang SP, Stout SJ, Zhou H, Herath K, et al. New methodologies for studying lipid synthesis and turnover: looking backwards to enable moving forwards. Biochimica et biophysica acta. 2014; 1842(3):402-13. 13. Sanchez-Gurmaches J, Guertin DA. Adipocyte lineages: tracing back the origins of fat. Biochimica et biophysica acta. 2014; 1842(3): 340-51.

14. Yu YH, Ginsberg HN. Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue. Circulation research. 2005; 96(10): 1042-52.

15. Ameer F, Scandiuzzi L, Hasnain S, Kalbacher H, Zaidi N. De novo lipogenesis in health and disease. Metabolism: clinical and experimental. 2014; 63(7): 895-902.

16. Mitrou P, Raptis SA, Dimitriadis G. Insulin action in morbid obesity: a focus on muscle and adipose tissue. Hormones (Athens, Greece). 2013; 12(2): 201-13.

17. Peckett AJ, Wright DC, Riddell MC. The effects of glucocorticoids on adipose tissue lipid metabolism. Metabolism: clinical and experimental. 2011; 60(11): 1500-10.

18. Filhoulaud G, Guilmeau S, Dentin R, Girard J, Postic C. Novel insights into ChREBP regulation and function. Trends in endocrinology and metabolism: TEM. 2013; 24(5): 257-68.

19. Iizuka K. Recent progress on the role of ChREBP in glucose and lipid metabolism. Endocrine journal. 2013; 60(5): 543-55.

20. Richard AJ, Stephens JM. The role of JAK-STAT signaling in adipose tissue function. Biochimica et biophysica acta. 2014; 1842(3): 431-9.

21. White UA, Tchoukalova YD. Sex dimorphism and depot differences in adipose tissue function. Biochimica et biophysica acta. 2014; 1842(3): 377-92. 22. Robic A, Larzul C, Bonneau M. Genetic and metabolic aspects of androstenone and skatole deposition in pig adipose tissue: a review. Genetics, selection, evolution : GSE. 2008; 40(1): 129-43.

23. Symonds ME, Pope M, Budge H. Adipose tissue development during early life: novel insights into energy balance from small and large mammals. The Proceedings of the Nutrition Society. 2012; 71(3): 363-70.

24. Moro C. Natriuretic peptides and fat metabolism. Current opinion in clinical nutrition and metabolic care. 2013; 16(6): 645-9.

25. Fonseca-Alaniz MH, Takada J, Alonso-Vale MI, Lima FB. [The adipose tissue as a regulatory center of the metabolism]. Arquivos brasileiros de

endocrinologia e metabologia. 2006; 50(2): 216-29

26. Morange PE, Alessi MC. Thrombosis in central obesity and metabolic syndrome: mechanisms and epidemiology. Thrombosis and haemostasis. 2013; 110(4): 669-80.

27. Malgorzewicz S, Dardzinska JA, Gnacinska M, Jankun J, Bryl E,

Sworczak K. Complex interaction between the immune system and adipose tissue (Review). International journal of molecular medicine. 2014; 33(1): 3-7.

28. Pattrick M, Luckett J, Yue L, Stover C. Dual role of complement in adipose tissue. Molecular immunology. 2009; 46(5): 755-60.

29. Hausman GJ, Barb CR. Adipose tissue and the reproductive axis: biological aspects. Endocrine development. 2010; 19: 31-44.

30. Steel JH, White R, Parker MG. Role of the RIP140 corepressor in ovulation and adipose biology. The Journal of endocrinology. 2005; 185(1): 1-9. 31. Yildiz BO, Azziz R. Ovarian and adipose tissue dysfunction in polycystic ovary syndrome: report of the 4th special scientific meeting of the Androgen Excess and PCOS Society. Fertility and sterility. 2010; 94(2): 690-3.

32. Bergman RN, Kim SP, Hsu IR, Catalano KJ, Chiu JD, Kabir M, et al. Abdominal obesity: role in the pathophysiology of metabolic disease and

cardiovascular risk. The American journal of medicine. 2007; 120(2 Suppl 1): S3- 8; discussion S29-32.

33. Finelli C, Sommella L, Gioia S, La Sala N, Tarantino G. Should visceral fat be reduced to increase longevity? Ageing research reviews. 2013; 12(4): 996- 1004.

34. Kyrou I, Chrousos GP, Tsigos C. Stress, visceral obesity, and metabolic complications. Annals of the New York Academy of Sciences. 2006; 1083: 77- 110.

35. Govindarajan G, Alpert MA, Tejwani L. Endocrine and metabolic effects of fat: cardiovascular implications. The American journal of medicine. 2008; 121(5): 366-70.

36. Konter J, Baez E, Summer RS. Obesity: "priming" the lung for injury. Pulmonary pharmacology & therapeutics. 2013; 26(4): 427-9.

37. Lee HY, Despres JP, Koh KK. Perivascular adipose tissue in the pathogenesis of cardiovascular disease. Atherosclerosis. 2013; 230(2): 177-84. 38. Schafer K, Konstantinides SV. Update on the cardiovascular risk in obesity: endocrine and paracrine role of the adipose tissue. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2011; 52(4): 327-36. 39. Morelli M, Gaggini M, Daniele G, Marraccini P, Sicari R, Gastaldelli A. Ectopic fat: the true culprit linking obesity and cardiovascular disease?

Thrombosis and haemostasis. 2013; 110(4): 651-60.

40. Musso G, Paschetta E, Gambino R, Cassader M, Molinaro F. Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver. Trends in molecular medicine. 2013; 19(9): 522-35.

41. Zafrir B. Brown adipose tissue: research milestones of a potential player in human energy balance and obesity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2013; 45(11): 774-85. 42. Zhao J, Lawless MW. Stop feeding cancer: pro-inflammatory role of visceral adiposity in liver cancer. Cytokine. 2013; 64(3): 626-37.

43. Chen X, Hess S. Adipose proteome analysis: focus on mediators of insulin resistance. Expert review of proteomics. 2008; 5(6): 827-39.

44. Goossens GH. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiology & behavior. 2008; 94(2): 206-18. 45. Ishikawa K, Yokote K. [Cutting-edge of medicine; dysfunction of adipose tissue and insulin resistance]. Nihon Naika Gakkai zasshi The Journal of the Japanese Society of Internal Medicine. 2013; 102(10): 2691-8.

46. Beltowski J. Endogenous hydrogen sulfide in perivascular adipose tissue: role in the regulation of vascular tone in physiology and pathology. Canadian journal of physiology and pharmacology. 2013; 91(11): 889-98.

47. Borges R, Dominguez N, Smith CB, Bandyopadhyay GK, O'Connor DT, Mahata SK, et al. Granins and catecholamines: functional interaction in

chromaffin cells and adipose tissue. Advances in pharmacology (San Diego, Calif). 2013; 68: 93-113.

48. Frigolet ME, Torres N, Tovar AR. The renin-angiotensin system in adipose tissue and its metabolic consequences during obesity. The Journal of nutritional biochemistry. 2013; 24(12): 2003-15.

49. Goossens GH. The renin-angiotensin system in the pathophysiology of type 2 diabetes. Obesity facts. 2012; 5(4): 611-24.

50. Jing F, Mogi M, Horiuchi M. Role of renin-angiotensin-aldosterone system in adipose tissue dysfunction. Molecular and cellular endocrinology. 2013; 378(1- 2): 23-8.

51. Marcus Y, Shefer G, Stern N. Adipose tissue renin-angiotensin-aldosterone system (RAAS) and progression of insulin resistance. Molecular and cellular endocrinology. 2013; 378(1-2): 1-14.

52. Romijn JA, Fliers E. Sympathetic and parasympathetic innervation of adipose tissue: metabolic implications. Current opinion in clinical nutrition and metabolic care. 2005; 8(4): 440-4.

53. Ronconi V, Turchi F, Bujalska IJ, Giacchetti G, Boscaro M. Adipose cell- adrenal interactions: current knowledge and future perspectives. Trends in endocrinology and metabolism: TEM. 2008; 19(3): 100-3.

54. Walker BR, Andrew R. Tissue production of cortisol by 11beta-

hydroxysteroid dehydrogenase type 1 and metabolic disease. Annals of the New York Academy of Sciences. 2006; 1083: 165-84. 22. Calabro P, Yeh ET. Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ. Sub-cellular biochemistry. 2007; 42: 63-91.

55. Herold C, Rennekampff HO, Engeli S. Apoptotic pathways in adipose tissue. Apoptosis : an international journal on programmed cell death. 2013; 18(8): 911-6.

56. Myre M, Imbeault P. Persistent organic pollutants meet adipose tissue hypoxia: does cross-talk contribute to inflammation during obesity? Obesity reviews : an official journal of the International Association for the Study of Obesity. 2014; 15(1): 19-28.

57. Ortega FJ, Fernandez-Real JM. Inflammation in adipose tissue and fatty acid anabolism: when enough is enough! Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2013; 45(13): 1009-19.

58. Park YM, Myers M, Vieira-Potter VJ. Adipose tissue inflammation and metabolic dysfunction: role of exercise. Missouri medicine. 2014; 111(1): 65-72. 59. Raschke S, Eckel J. Adipo-myokines: two sides of the same coin--

mediators of inflammation and mediators of exercise. Mediators of inflammation. 2013; 2013: 320724.

60. Ruskovska T, Bernlohr DA. Oxidative stress and protein carbonylation in adipose tissue - implications for insulin resistance and diabetes mellitus. Journal of proteomics. 2013; 92: 323-34.

61. Siriwardhana N, Kalupahana NS, Cekanova M, LeMieux M, Greer B, Moustaid-Moussa N. Modulation of adipose tissue inflammation by bioactive food compounds. The Journal of nutritional biochemistry. 2013; 24(4): 613-23. 62. Toubal A, Treuter E, Clement K, Venteclef N. Genomic and epigenomic regulation of adipose tissue inflammation in obesity. Trends in endocrinology and metabolism: TEM. 2013; 24(12): 625-34.

63. Chmielewska-Kassassir M, Wozniak LA, Ogrodniczek P, Wojcik M. [The role of peroxisome proliferator-activated receptors gamma (PPARgamma) in obesity and insulin resistance]. Postepy higieny i medycyny doswiadczalnej (Online). 2013; 67: 1283-99.

64. Juhasz A, Katona E, Csongradi E, Paragh G. [The regulation of body mass and its relation to the development of obesity]. Orvosi hetilap. 2007; 148(39): 1827-36.

65. Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective. Biochimica et biophysica acta. 2010; 1801(3): 338-49.

66. Adamczak M, Wiecek A. The adipose tissue as an endocrine organ. Seminars in nephrology. 2013; 33(1): 2-13.

67. Baudrand BR, Arteaga UE, Moreno GM. [Adipose tissue as an endocrine modulator: hormonal changes associated with obesity]. Revista medica de Chile. 2010; 138(10): 1294-301.

68. Berggren JR, Hulver MW, Houmard JA. Fat as an endocrine organ:

influence of exercise. Journal of applied physiology (Bethesda, Md : 1985). 2005; 99(2): 757-64.

69. Chudek J, Adamczak M, Nieszporek T, Wiecek A. The adipose tissue as an endocrine organ--a nephrologists' perspective. Contributions to nephrology. 2006; 151: 70-90.

70. Fischer-Posovszky P, Wabitsch M, Hochberg Z. Endocrinology of adipose tissue - an update. Hormone and metabolic research = Hormon- und

Stoffwechselforschung = Hormones et metabolisme. 2007; 39(5): 314-21.

71. Fonseca-Alaniz MH, Takada J, Alonso-Vale MI, Lima FB. Adipose tissue as an endocrine organ: from theory to practice. Jornal de pediatria. 2007; 83(5 Suppl): S192-203.

72. Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Molecular and cellular endocrinology. 2010; 316(2): 129-39.

73. Garruti G, Cotecchia S, Giampetruzzi F, Giorgino F, Giorgino R. Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome. Journal of gastrointestinal and liver diseases : JGLD. 2008; 17(2): 193-8.

74. Gesmundo I, Gallo D, Favaro E, Ghigo E, Granata R. Obestatin: a new metabolic player in the pancreas and white adipose tissue. IUBMB life. 2013; 65(12): 976-82.

75. Gimeno RE, Klaman LD. Adipose tissue as an active endocrine organ: recent advances. Current opinion in pharmacology. 2005; 5(2): 122-8.

76. Hutley L, Prins JB. Fat as an endocrine organ: relationship to the

metabolic syndrome. The American journal of the medical sciences. 2005; 330(6): 280-9.

77. Laharrague P, Casteilla L. The emergence of adipocytes. Endocrine development. 2010; 19: 21-30.

78. McGown C, Birerdinc A, Younossi ZM. Adipose tissue as an endocrine organ. Clinics in liver disease. 2014; 18(1): 41-58.

79. Ntikoudi E, Kiagia M, Boura P, Syrigos KN. Hormones of adipose tissue and their biologic role in lung cancer. Cancer treatment reviews. 2014; 40(1): 22- 30.

80. Pravdova E, Fickova M. Alcohol intake modulates hormonal activity of adipose tissue. Endocrine regulations. 2006; 40(3): 91-104.

81. Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes. 2006; 55(6): 1537-45.

82. Schwetz V, Pieber T, Obermayer-Pietsch B. The endocrine role of the skeleton: background and clinical evidence. European journal of endocrinology / European Federation of Endocrine Societies. 2012; 166(6): 959-67.

83. Wozniak SE, Gee LL, Wachtel MS, Frezza EE. Adipose tissue: the new endocrine organ? A review article. Digestive diseases and

sciences. 2009; 54(9): 1847-56.

84. Baranova AV. [Adipokine genetics: unbalanced protein secretion by human adipose tissue as a cause of the metabolic syndrome]. Genetika. 2008; 44(10): 1338-55.

85. Wang P, Mariman E, Renes J, Keijer J. The secretory function of adipocytes in the physiology of white adipose tissue. Journal of cellular physiology. 2008; 216(1): 3-13.

86. Dunmore SJ, Brown JE.The role of adipokines in beta-cell failure of type 2 diabetes.The Journal of endocrinology.2013; 216(1):T37-45.

87. Collins S. A heart-adipose tissue connection in the regulation of energy metabolism. Nature reviews Endocrinology.2014; 10(3):157-63.

88. Fonseca-Alaniz MH, Takada J, Alonso-Vale MI, Lima FB. [The adipose tissue as a regulatory center of the metabolism]. Arquivos brasileiros de

endocrinologia e metabologia. 2006; 50(2): 216-29

89. Kim SC, Han DJ, Lee JY. Adipose tissue derived stem cells for

regeneration and differentiation into insulin-producing cells. Current stem cell research & therapy. 2010; 5(2): 190-4.

90. Muller MJ, Wang Z, Heymsfield SB, Schautz B, Bosy-Westphal A. Advances in the understanding of specific metabolic rates of major organs and tissues in humans. Current opinion in clinical nutrition and metabolic care. 2013; 16(5): 501-8.

91. Scheller EL, Rosen CJ. What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health. Annals of the New York Academy of Sciences. 2014; 1311: 14-30.

92. Umpaichitra V. Roles of adipose tissue-derived factors in obesity. Pediatric endocrinology reviews : PER. 2006; 3 Suppl 4: 537-43.

93. Yang J, Kang J, Guan Y. The mechanisms linking adiposopathy to type 2 diabetes. Frontiers of medicine. 2013; 7(4): 433-44.

94. Chaves VE, Junior FM, Bertolini GL. The metabolic effects of growth hormone in adipose tissue. Endocrine. 2013; 44(2): 293-302

95. Van de Voorde J, Pauwels B, Boydens C, Decaluwe K. Adipocytokines in relation to cardiovascular disease. Metabolism: clinical and experimental. 2013; 62(11): 1513-21.

96. Pal'tseva EM, Rodina AV, Konstantinova SV, Ermakov NV, Andreev DA, Syrkin AL, et al. [Prognostic, diagnostic, and therapeutic prospects of using adiponectine as a biomarker in cardiobascular diseases]. Rossiiskii

fiziologicheskii zhurnal imeni IM Sechenova / Rossiiskaia akademiia nauk. 2009; 95(10): 1024-40.

97. Harris RB. Direct and indirect effects of leptin on adipocyte metabolism. Biochimica et biophysica acta. 2014; 1842(3): 414-23.

98. Dollet L, Magre J, Cariou B, Prieur X. Function of seipin: new insights from Bscl2/seipin knockout mouse models. Biochimie. 2014; 96: 166-72. 99. Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, Kim SY, et al. Leptin in human physiology and pathophysiology. American journal of physiology Endocrinology and metabolism. 2011; 301(4): E567-84. 100. Tucholski K, Otto-Buczkowska E. The role of leptin in the regulation of carbohydrate metabolism. Endokrynologia Polska. 2011; 62(3): 258-62.

101. Barat P, Duclos M, Moisan MP, Mormede P. [Involvement of

hypothalamopituitary adrenal axis in abdominal obesity]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 2008; 15(2): 170-8.

102. Barb CR, Hausman GJ, Rekaya R. Gene expression in the brain-pituitary adipose tissue axis and luteinising hormone secretion during pubertal

development in the gilt. Society of Reproduction and Fertility supplement. 2006; 62: 33-44.

103. Chaldakov GN, Fiore M, Tonchev AB, Aloe L. Neuroadipology: a novel component of neuroendocrinology. Cell biology international. 2010; 34(10): 1051-3.

104. Yi CX, Tschop MH. Brain-gut-adipose-tissue communication pathways at a glance. Disease models & mechanisms. 2012; 5(5): 583-7.

105. Schaffler A, Binart N, Scholmerich J, Buchler C. Hypothesis paper Brain talks with fat--evidence for a hypothalamic-pituitary-adipose axis? Neuropeptides. 2005; 39(4): 363-7.

106. Penicaud L. The neural feedback loop between the brain and adipose tissues. Endocrine development. 2010; 19: 84-92.

107. Uddin S, Hussain AR, Khan OS, Al-Kuraya KS. Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014; 35(2): 871-9.

108. Duntas LH, Biondi B. The interconnections between obesity, thyroid function, and autoimmunity: the multifold role of leptin. Thyroid : official journal of the American Thyroid Association. 2013; 23(6): 646-53.

109. Pontikides N, Krassas GE. Basic endocrine products of adipose tissue in states of thyroid dysfunction. Thyroid : official journal of the American Thyroid Association. 2007; 17(5): 421-31.

110. Janusz P, Pawlak-Adamska E, Kochanowska IE, Daroszewski J. [The role of adipose tissue in the pathogenesis and clinical manifestation of Graves'

orbitopathy]. Postepy higieny i medycyny doswiadczalnej (Online). 2013; 67: 1173-81.

111. Funahashi T, Matsuzawa Y. Adiponectin and the cardiometabolic syndrome: an epidemiological perspective. Best practice & research Clinical endocrinology & metabolism. 2014; 28(1): 93-106.

112. Perez-Leighton CE, Billington CJ, Kotz CM. Orexin modulation of adipose tissue. Biochimica et biophysica acta. 2014; 1842(3):440-5.

113. Stastny J, Bienertova-Vasku J, Vasku A. Visfatin and its role in obesity development. Diabetes & met€abolic syndrome. 2012; 6(2): 120-4.

114. Rega-Kaun G, Kaun C, Wojta J. More than a simple storage organ: adipose tissue as a source of adipokines involved in cardiovascular disease. Thrombosis and haemostasis. 2013; 110(4): 641-50

115. Cao X, Liu XM, Zhou LH. Recent progress in research on the distribution and function of NUCB2/nesfatin-1 in peripheral tissues. Endocrine journal. 2013; 60(9): 1021-7.

116. Carmean CM, Cohen RN, Brady MJ. Systemic regulation of adipose metabolism. Biochimica et biophysica acta. 2014; 1842(3): 424-30.

117. Lee DE, Kehlenbrink S, Lee H, Hawkins M, Yudkin JS. Getting the message across: mechanisms of physiological cross talk by adipose tissue. American journal of physiology Endocrinology and metabolism. 2009; 296(6): E1210-29.

118. Chaldakov GN, Fiore M, Tonchev AB, Aloe L. Neuroadipology: a novel component of neuroendocrinology. Cell biology international. 2010; 34(10): 1051-3.

119. Giordano A, Smorlesi A, Frontini A, Barbatelli G, Cinti S. White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ. European journal of endocrinology / European Federation of Endocrine Societies. 2014; 170(5): R159-71.

120. Becerril S, Gomez-Ambrosi J, Martin M, Moncada R, Sesma P, Burrell MA, et al. Role of PRDM16 in the activation of brown fat programming. Relevance to the development of obesity. Histology and histopathology. 2013; 28(11): 1411-25.

121. Cerf ME. High fat programming of beta-cell failure. Advances in experimental medicine and biology. 2010; 654: 77-89.

122. Elbelt U, Hofmann T, Stengel A. Irisin: what promise does it hold? Current opinion in clinical nutrition and metabolic care. 2013; 16(5): 541-7.

123. Kozak LP. Genetic variation in brown fat activity and body weight regulation in mice: lessons for human studies. Biochimica et biophysica acta. 2014; 1842(3): 370-6.

124. Villarroya J, Cereijo R, Villarroya F. An endocrine role for brown adipose tissue? American journal of physiology Endocrinology and metabolism. 2013; 305(5): E567-72.

125. Lecoultre V, Ravussin E. Brown adipose tissue and aging. Current opinion in clinical nutrition and metabolic care. 2011; 14(1): 1-6.

126. Lee YH, Mottillo EP, Granneman JG. Adipose tissue plasticity from WAT to BAT and in between. Biochimica et biophysica acta. 2014; 1842(3): 358-69. 127. Vosselman MJ, van Marken Lichtenbelt WD, Schrauwen P. Energy dissipation in brown adipose tissue: from mice to men. Molecular and cellular endocrinology. 2013; 379(1-2): 43-50.

128. Palou A, Pico C, Bonet ML. Nutritional potential of metabolic remodelling of white adipose tissue. Current opinion in clinical nutrition and metabolic care. 2013; 16(6): 650-6.

129. Sammons MF, Price DA. Modulation of adipose tissue thermogenesis as a method for increasing energy expenditure. Bioorganic & medicinal chemistry letters. 2014; 24(2): 425-9.

130. Peschechera A, Eckel J. "Browning" of adipose tissue--regulation and therapeutic perspectives. Archives of physiology and biochemistry. 2013; 119(4): 151-60.

131. Yoneshiro T, Saito M. Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management. Current opinion in clinical nutrition and metabolic care. 2013; 16(6): 625-31.

132. Frayn KN, Tan GD, Karpe F. Adipose tissue: a key target for diabetes pathophysiology and treatment? Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2007; 39(10): 739-42.

133. Pavicic T, Borelli C, Korting HC.Cellulite--the greatest skin problem in

Documenti correlati