• Non ci sono risultati.

Prevalenza delle principali diagnosi ottenute alla SCID-5 nel campione di studenti (N=178)

Disturbi d'ansia Disturbi del sonno

Disturbi depressivi Disturbi di spettro ossessivo-compulsivo Disturbi dell'alimentazione e della nutrizione Disturbi bipolari

56

Tabella 1

Confronto fra maschi e femmine sui punteggi AQ, AdAS, RRS, MOODS, TALS Maschi (N=93) Femmine (N=85) T sig. AQ Abilità Sociali 2.93 (2.55) 2.88 (2.51) .140 .889 Capacità di variare l’attenzione 4.43 (2.21) 4.62 (2.10) -.595 .553 Attenzione ai dettagli 4.73 (2.30) 4.78 (2.25) -.167 .868 Comunicazione 2.70 (2.13) 2.36 (1.88) 1.11 .268 Immaginazione 3.12 (1.77) 2.49 (1.54) 2.51 .013 AQ Totale 17.9 (7.0) 17.2 (6.3) .714 .476 AdAS Spectrum Infanzia/adolescenza 7.24 (3.73) 6.95 (4.34) .486 .628 Comunicazione Verbale 5.08 (2.96) 4.88 (2.88) .464 .643 Comunicazione non verbale 10.07 (4.76) 10.20 (4.79) -.174 .862 Empatia 2.80 (2.31) 2.47 (2.09) 1.01 .313 Routinarietà 13.19 (6.47) 13.67 (6.74) -.481 .631 Interessi ristretti/ruminazione 8.35 (4.20) 8.11 (4.04) .383 .702 Iper/ipo-reattività 3.55 (2.85) 3.77 (2.75) -.516 .607 AdAS Spectrum Totale 50.3 (21.8) 50.0 (21.3) .078 .938 MOODS-SR Umore depressivo 26.38 (10.91) 39.29 (15.87) -6.215 <001 Umore maniacale 10.89 (5.35) 9.19 (5.15) 2.137 .034 Energia depressiva 2.73 (2.39) 2.87 (2.42) -.394 .694 Energia maniacale 4.53 (2.86) 3.75 (2.62) 1.867 .064

57 Cognitività depressiva 8.35 (5.63) 8.76 (5.61) -.482 .630 Cognitività maniacale 7.66 (4.51) 6.18 (4.25) 2.230 .027 Ritmicità 7.54 (4.56) 11.05 (4.75) -4.981 <001 MOODS-SR Totale 68.0 (27.2) 81.0 (28.6) -3.070 .002 Score maniacale totale 23.0 (11.6) 19.1 (10.9) 2.313 .022 Score depressivo totale 37.4 (15.5) 50.9 (19.3) -5.052 <001 TALS-SR Eventi di perdita 2.79 (1.70) 3.38 (1.37) -2.505 .013

Reazione agli eventi

di perdita 7.68 (5.07) 9.77 (5.48) -2.623 .009 Eventi potenzialmente traumatici 2.82 (2.52) 2.58 (2.23) .666 .506 Reazione alla perdita o a eventi potenz. traumatici 4.59 (3.91) 5.35 (4.57) -1.189 .236 Rievocazione 1.82 (2.13) 2.42 (2.14) -1.867 .064 Evitamento e ottundimento delle emozioni 2.30 (2.43) 2.57 (2.81) -.665 .507 Comportamenti disadattivi .4945 (1.19) .4167 (1.08) .449 .654 Arousal .8352 (1.23) .9643 (1.41) -.644 .520 Caratteristiche di personalità/fattori di rischio 1.84 (1.54) 1.73 (1.43) .478 .633 TALS-SR Totale 25.1 (16.2) 29.2 (16.5) -1.618 .108

58

Tabella 2

Confronto fra maschi e femmine rispetto alle principali diagnosi riportate alla SCID-5 Maschi (N=93) Femmine (N=85) Chi2 Sig. Disturbi bipolari 6 (6.5%) 3 (3.5%) 0.790 .050 Disturbi depressivi 10 (10.8%) 20 (23.5%) 5.173 .028 Disturbi d’ansia 27 (29%) 38 (44.7%) 4.706 .042 Disturbi dello spettro ossesivo- compulsivo 12 (12.9%) 13 (15.3%) .210 .672

Disturbi del sonno

26 (28.0%) 16 (18.8%) 2.05 .162

Disturbi della nutrizione e dell’alimentazione

59

Tabella 3

Matrice di correlazione fra AdAS Spectrum totale, punteggio MOODS-SR (depressivo e maniacale), eventi potenzialmente traumatici del TALS-SR e punteggio TALS-SR AdAS Spectrum Totale MOODS- SR Totale MOODS- SR Totale Depres. MOODS- SR Totale Maniac. TALS- SR Eventi Potenz. Traumat. TALS- SR Totale AdAS Spectrum Totale - 0.660** 0.498** 0.607** 0.359** 0.529** MOODS- SR Totale - 0.894** 0.712** 0.478** 0.583** MOODS- SR Tot. Depres. - 0.345** 0.312** 0.405** MOODS- SR Tot. Maniac. - 0.483** 0.543** TALS- SR Eventi Potenz. Traumat. - 0.661** TALS- SR Totale - **P<0,01

60

Tabella 3a

Matrice di correlazione fra AdAS Spectrum totale, punteggio MOODS-SR (depressivo e maniacale), eventi potenzialmente traumatici del TALS-SR e punteggio TALS-SR solo nel sottocampione maschile

AdAS Spectrum Totale MOODS- SR Totale MOODS- SR Totale Depres. MOODS- SR Totale Maniac. TALS- SR Eventi Potenz. Traumat. TALS- SR Totale AdAS Spectrum Totale - 0.695** 0.596** 0.601** 0.526** 0.620** MOODS- SR Totale - 0.895** 0.837** 0.645** 0.672** MOODS- SR Tot. Depres. - 0.524** 0.465** 0.477** MOODS- SR Tot. Maniac. - 0.641** 0.702** TALS- SR Eventi Potenz. Traumat. - 0.720** TALS- SR Totale - **P<0,01

61

Tabella 3b

Matrice di correlazione fra AdAS Spectrum totale, punteggio MOODS-SR (depressivo e maniacale), eventi potenzialmente traumatici del TALS-SR e punteggio TALS-SR solo nel sottocampione femminile

AdAS Spectrum Totale MOODS- SR Totale MOODS- SR Totale Depres. MOODS- SR Totale Maniac. TALS- SR Eventi Potenz. Traumat. TALS- SR Totale AdAS Spectrum Totale - 0.671** 0.502** 0.626** 0.148** 0.441** MOODS- SR Totale - 0.898** 0.729** 0.338** 0.475** MOODS- SR Tot. Depres. - 0.378** 0.249** 0.317** MOODS- SR Tot. Maniac. - 0.277* 0.442** TALS- SR Eventi Potenz. Traumat. - 0.621** TALS- SR Totale - **P<0.01 *P<0.05

62

Tabella 4

Analisi di mediazione nel campione totale di studenti

a. Effetto predittivo del totale AdAS Spectrum sul totale MOODS-SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale

0.877(0.076) 0.660 0.727-1.026 <0.01 0.463

b. Effetto predittivo del totale AdAS Spectrum sugli eventi potenzialmente

traumatici del TALS-SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale

0.040(0.008) 0.359 0.024-0.055 <0.01 0.129

c. Effetto predittivo degli eventi potenzialmente traumatici del TALS-SR sul totale MOODS-SR

B(SE) Beta 95%IC p R2

Eventi Potenz. Traum.

5.748(0.808) 0.478 4.153-7.342 <0.01 0.228

d. Modello di regressione multipla con totale AdAS Spectrum e eventi

potenzialmente traumatici del TALS-SR sul totale MOODS-SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale 0.748(0.077) 0.563 0.596-0.900 <0.01 0.503 Eventi Potenz. Traum. 3.292(0.697) 0.274 1.916-4.669 <0.01

63

Tabella 5

Analisi di mediazione nel campione totale di studenti

a. Effetto predittivo del totale AdAS Spectrum sul totale depressivo MOODS- SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale

0.431(0.057) 0.498 0.319-0.544 <0.01 0.248

b. Effetto predittivo del totale AdAS Spectrum sugli eventi potenzialmente

traumatici del TALS-SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale

0.040(0.008) 0.359 0.024-0.055 <0.01 0.129

c. Effetto predittivo degli eventi potenzialmente traumatici del TALS-SR sul totale MOODS-SR

B(SE) Beta 95%IC p R2

Eventi Potenz. Traum.

2.439(0.567) 0.312 1.319-3.558 <0.01 0.098

d. Modello di regressione multipla con totale AdAS Spectrum e eventi

potenzialmente traumatici del TALS-SR sul totale depressivo MOODS-SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale 0.383(0.061) 0.444 0.263-0.503 <0.01 0.269 Eventi Potenz. Traum. 1.181(0.549) 0.151 0.096-2.265 <0.01

64

Tabella 6

Analisi di mediazione nel sotto-campione di studenti di sesso maschile

a. Effetto preditttivo del totale AdAS Spectrum sul totale depressivo MOODS- SR

B (SE) Beta 95%IC p R2

AdAS Spectrum Totale

0.425(3.356) 0.596 0.305-0.546 <0.01 0.355

b. Effetto predittivo del totale AdAS Spectrum sugli eventi potenzialmente

traumatici del TALS-SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale

0.060(0.010) 0.526 0.040-0.081 <0.01 0.277

c. Effetto predittivo degli eventi potenzialmente traumatici del TALS-SR sul totale MOODS-SR

B(SE) Beta 95%IC p R2

Eventi Potenz. Traum.

2.863(0.580) 0.465 1.710-4.016 <0.01 0.217

d. Modello di regressione multipla con totale AdAS Spectrum e eventi

potenzialmente traumatici del TALS-SR sul totale depressivo MOODS-SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale 0.351(0.070) 0.492 0.211-0.491 <0.01 0.391 Eventi Potenz. Traum. 1.269(0.606) 0.206 0.065-2.472 <0.01

65

Tabella 7

Analisi di mediazione nel sotto-campione di studenti di sesso femminile a. Effetto predittivo del totale AdAS Spectrum sul totale depressivo MOODS- SR

B (SE) Beta 95%IC p R2

AdAS Spectrum Totale

0.452(0.086) 0.502 0.281-0.623 <0.01 0.252

b. Effetto predittivo del totale AdAS Spectrum sugli eventi potenzialmente

traumatici del TALS-SR

B(SE) Beta 95%IC p R2

AdAS Spectrum Totale

66

5. BIBLIOGRAFIA

Alarcon, M., Abrahams, B. S., Stone, J. L., Duvall, J. A., Perederiy, J. V., Bomar, J. M., . . . Geschwind, D. H. (2008). Linkage, association, and gene- expression analyses identify CNTNAP2 as an autism-susceptibility gene.

Am J Hum Genet, 82(1), 150-159. doi: 10.1016/j.ajhg.2007.09.005

American Psychiatric Association, APA. (1987). Diagnostic and Statistical

Manual: Mental Disorders, DSM-III-R. Washington, DC: American

Psychiatric Press.

American Psychiatric Association, APA. (1994). Diagnostic and Statistical Manual

of Mental Disorders, DSM-IV. Washington, DC.: American Psychiatric

Press.

American Psychiatric Association, APA. (2000). Diagnostic and Statistical Manual

of Mental Disorders: DSM-IV-TR.: American Psychiatric Association.

Anderson, Jeffrey S. (2014). Cortical Underconnectivity Hypothesis in Autism: Evidence from Functional Connectivity MRI. In Vinood B. Patel, Victor R. Preedy, & Colin R. Martin (Eds.), Comprehensive Guide to Autism (pp. 1457-1471). New York, NY: Springer New York.

Anney, R., Klei, L., Pinto, D., Regan, R., Conroy, J., Magalhaes, T. R., . . . Hallmayer, J. (2010). A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet, 19(20), 4072-4082. doi: 10.1093/hmg/ddq307

Asperger, Hans. (1944). Die „Autistischen Psychopathen” im Kindesalter. Eur Arch

Psychiatry Clin Neurosci, 117(1), 76-136.

Assaf, M., Jagannathan, K., Calhoun, V. D., Miller, L., Stevens, M. C., Sahl, R., . . . Pearlson, G. D. (2010). Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. Neuroimage, 53(1), 247-256. doi: 10.1016/j.neuroimage.2010.05.067

Association, American Psychiatric. (1968). Diagnostic and Statistical Manual:

Mental Disorders, DSM-II. Washington, DC.: American Psychiatric Press

Association, American Psychiatric. (1980). Diagnostic and Statistical Manual:

67

Assouline, S. G., Foley Nicpon, M., & Dockery, L. (2012). Predicting the academic achievement of gifted students with autism spectrum disorder. J Autism Dev

Disord, 42(9), 1781-1789. doi: 10.1007/s10803-011-1403-x

Assouline, Susan G, Nicpon, Megan Foley, & Doobay, Alissa. (2009). Profoundly Gifted Girls and Autism Spectrum Disorder A Psychometric Case Study Comparison. Gifted Child Quarterly, 53(2), 89-105.

August, G. J., Stewart, M. A., & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children. Br J Psychiatry, 138, 416- 422.

Auyeung, B., Baron-Cohen, S., Wheelwright, S., & Allison, C. (2008). The Autism Spectrum Quotient: Children's Version (AQ-Child). J Autism Dev Disord,

38(7), 1230-1240. doi: 10.1007/s10803-007-0504-z

Bailey, A., Palferman, S., Heavey, L., & Le Couteur, A. (1998). Autism: the phenotype in relatives. J Autism Dev Disord, 28(5), 369-392.

Baron-Cohen, S. (2002). The extreme male brain theory of autism. Trends Cogn

Sci, 6(6), 248-254.

Baron-Cohen, S. (2009). Autism: the empathizing-systemizing (E-S) theory. Ann N

Y Acad Sci, 1156, 68-80. doi: 10.1111/j.1749-6632.2009.04467.x

Baron-Cohen, S. (2010). Empathizing, systemizing, and the extreme male brain theory of autism. Prog Brain Res, 186, 167-175. doi: 10.1016/B978-0-444- 53630-3.00011-7

Baron-Cohen, S., Hoekstra, R. A., Knickmeyer, R., & Wheelwright, S. (2006). The Autism-Spectrum Quotient (AQ)--adolescent version. J Autism Dev Disord,

36(3), 343-350. doi: 10.1007/s10803-006-0073-6

Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord, 31(1), 5-17.

Baron-Cohen, Simon, Bolton, Patrick, Wheelwright, Sally, Scahill, Victoria, Short, Liz, Mead, Genevieve, & Smith, Alex. (1998). Autism occurs more often in families of physicists, engineers, and mathematicians. Autism, 2(3), 296- 301.

68

Ben‐Sasson, A, Cermak, SA, Orsmond, GI, Tager‐Flusberg, H, Kadlec, MB, & Carter, AS. (2008). Sensory clusters of toddlers with autism spectrum disorders: Differences in affective symptoms. Journal of Child Psychology

and Psychiatry, 49(8), 817-825.

Biondi, M. (2014). DSM-5. Manuale diagnostico e statistico dei disturbi mentali. Milano: Cortina Raffaello.

Bronicki, L. M., Redin, C., Drunat, S., Piton, A., Lyons, M., Passemard, S., . . . Aylsworth, A. S. (2015). Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A. Eur J

Hum Genet, 23(11), 1482-1487. doi: 10.1038/ejhg.2015.29

Callan, M. A., Cabernard, C., Heck, J., Luois, S., Doe, C. Q., & Zarnescu, D. C. (2010). Fragile X protein controls neural stem cell proliferation in the Drosophila brain. Hum Mol Genet, 19(15), 3068-3079. doi: 10.1093/hmg/ddq213

Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., . . . Levitt, P. (2006). A genetic variant that disrupts MET tra nscription is associated with autism. Proc Natl Acad Sci U S A, 103(45), 16834-16839. doi: 10.1073/pnas.0605296103

Castren, M., Tervonen, T., Karkkainen, V., Heinonen, S., Castren, E., Larsson, K., . . . Akerman, K. (2005). Altered differentiation of neural stem cells in fragile X syndrome. Proc Natl Acad Sci U S A, 102(49), 17834-17839. doi: 10.1073/pnas.0508995102

Chakrabarti, B., Dudbridge, F., Kent, L., Wheelwright, S., Hill-Cawthorne, G., Allison, C., . . . Baron-Cohen, S. (2009). Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Res, 2(3), 157-177. doi: 10.1002/aur.80

Cheng, T. L., & Qiu, Z. (2014). MeCP2: multifaceted roles in gene regulation and neural development. Neurosci Bull, 30(4), 601-609. doi: 10.1007/s12264- 014-1452-6

Chow, M. L., Pramparo, T., Winn, M. E., Barnes, C. C., Li, H. R., Weiss, L., . . . Courchesne, E. (2012). Age-dependent brain gene expression and copy

69

number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet, 8(3), e1002592. doi: 10.1371/journal.pgen.1002592

Christensen, D. L., Baio, J., Van Naarden Braun, K., Bilder, D., Charles, J., Constantino, J. N., . . . Prevention. (2016). Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years--Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012. MMWR Surveill Summ, 65(3), 1-23. doi: 10.15585/mmwr.ss6503a1 Constantino, J. N., Lajonchere, C., Lutz, M., Gray, T., Abbacchi, A., McKenna, K.,

. . . Todd, R. D. (2006). Autistic social impairment in the siblings of children with pervasive developmental disorders. Am J Psychiatry, 163(2), 294-296. doi: 10.1176/appi.ajp.163.2.294

Courchesne, E., Pierce, K., Schumann, C. M., Redcay, E., Buckwalter, J. A., Kennedy, D. P., & Morgan, J. (2007). Mapping early brain development in autism. Neuron, 56(2), 399-413. doi: 10.1016/j.neuron.2007.10.016

Dell'Osso, L., Armani, A., Rucci, P., Frank, E., Fagiolini, A., Corretti, G., . . . Cassano, G. B. (2002). Measuring mood spectrum: comparison of interview (SCI-MOODS) and self-report (MOODS-SR) instruments. Compr

Psychiatry, 43(1), 69-73.

Dell'Osso, L., Carmassi, C., Rucci, P., Conversano, C., Shear, M. K., Calugi, S., . . . Cassano, G. B. (2009). A multidimensional spectrum approach to post- traumatic stress disorder: comparison between the Structured Clinical Interview for Trauma and Loss Spectrum (SCI-TALS) and the Self-Report instrument (TALS-SR). Compr Psychiatry, 50(5), 485-490. doi: 10.1016/j.comppsych.2008.11.006

Dell'osso, L., Carmassi, C., Stratta, P., Massimetti, G., Akiskal, K. K., Akiskal, H. S., . . . Rossi, A. (2012). Gender Differences in the Relationship between Maladaptive Behaviors and Post-Traumatic Stress Disorder. A Study on 900 L' Aquila 2009 Earthquake Survivors. Front Psychiatry, 3, 111. doi: 10.3389/fpsyt.2012.00111

Dell'Osso, L., & Dalle Luche, R. (2016). L'altra Marilyn. Psichiatria e psicoanalisi

70

Dell'Osso, L., Dalle Luche, R., & Maj, M. (2015). Adult autism spectrum as a transnosographic dimension. CNS Spectr, 1-3. doi: 10.1017/s1092852915000450

Dell'Osso, L., Dalle Luche, R., & Maj, M. (2016). Adult autism spectrum as a transnosographic dimension. CNS Spectr, 21(2), 131-133. doi: 10.1017/S1092852915000450

Dell'Osso , L., Dalle Luche, R.P., Carmassi, C. (2015). A New Perspective in Post- Traumatic Stress Disorder: Which Role for Unrecognized Autism Spectrum? International Journal of Emergency Mental Health and Human

Resilience, Vol. 17, No.2, , pp. 436-438.

Dell'Osso, L., Rucci, P., Cassano, G. B., Maser, J. D., Endicott, J., Shear, M. K., . . . Frank, E. (2002). Measuring social anxiety and obsessive-compulsive spectra: comparison of interviews and self-report instruments. Compr

Psychiatry, 43(2), 81-87.

Dell'osso, L., Shear, M. K., Carmassi, C., Rucci, P., Maser, J. D., Frank, E., . . . Cassano, G. B. (2008). Validity and reliability of the Structured Clinical Interview for the Trauma and Loss Spectrum (SCI-TALS). Clin Pract

Epidemiol Ment Health, 4, 2. doi: 10.1186/1745-0179-4-2

Dell’Osso, Liliana, Rucci, Paola, Ducci, Francesca, Ciapparelli, Antonio, Vivarelli, Laura, Carlini, Marina, . . . Cassano, Giovanni B. (2003). Social anxietyspectrum. Eur Arch Psychiatry Clin Neurosci, 253(6), 286-291. doi: 10.1007/s00406-003-0442-5

Eaves, Linda C, & Ho, Helena H. (1997). School placement and academic achievement in children with autistic spectrum disorders. Journal of

Developmental and Physical Disabilities, 9(4), 277-291.

Estes, A., Rivera, V., Bryan, M., Cali, P., & Dawson, G. (2011). Discrepancies between academic achievement and intellectual ability in higher- functioning school-aged children with autism spectrum disorder. J Autism

Dev Disord, 41(8), 1044-1052. doi: 10.1007/s10803-010-1127-3

Fletcher, P. C., Zafiris, O., Frith, C. D., Honey, R. A., Corlett, P. R., Zilles, K., & Fink, G. R. (2005). On the benefits of not trying: brain activity and

71

connectivity reflecting the interactions of explicit and implicit sequence learning. Cereb Cortex, 15(7), 1002-1015. doi: 10.1093/cercor/bhh201 Folstein, S., & Rutter, M. (1977). Infantile autism: a genetic study of 21 twin pairs.

J Child Psychol Psychiatry, 18(4), 297-321.

Fombonne, E. (2003). Epidemiological surveys of autism and other pervasive developmental disorders: an update. J Autism Dev Disord, 33(4), 365-382. Freeth, M., Sheppard, E., Ramachandran, R., & Milne, E. (2013). A cross-cultural comparison of autistic traits in the UK, India and Malaysia. J Autism Dev

Disord, 43(11), 2569-2583. doi: 10.1007/s10803-013-1808-9

Freitag, C. M. (2007). The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry, 12(1), 2-22. doi: 10.1038/sj.mp.4001896

Frith, Uta. (1989). Autism: Explaining the enigma.

Gerdts, J., & Bernier, R. (2011). The broader autism phenotype and its implications on the etiology and treatment of autism spectrum disorders. Autism Res

Treat, 2011, 545901. doi: 10.1155/2011/545901

Grelotti, D. J., Klin, A. J., Gauthier, I., Skudlarski, P., Cohen, D. J., Gore, J. C., . . . Schultz, R. T. (2005). fMRI activation of the fusiform gyrus and amygdala to cartoon characters but not to faces in a boy with autism.

Neuropsychologia, 43(3), 373-385. doi: 10.1016/j.neuropsychologia.2004.06.015

Hanley, M., Riby, D. M., Carty, C., Melaugh McAteer, A., Kennedy, A., & McPhillips, M. (2015). The use of eye-tracking to explore social difficulties in cognitively able students with autism spectrum disorder: A pilot investigation. Autism, 19(7), 868-873. doi: 10.1177/1362361315580767 Happe, F., & Vital, P. (2009). What aspects of autism predispose to talent? Philos

Trans R Soc Lond B Biol Sci, 364(1522), 1369-1375. doi:

10.1098/rstb.2008.0332

Happé, Francesca, & Frith, Uta. (2006). The weak coherence account: detail- focused cognitive style in autism spectrum disorders. J Autism Dev Disord,

72

Hoekstra, R. A., Bartels, M., Cath, D. C., & Boomsma, D. I. (2008). Factor structure, reliability and criterion validity of the Autism-Spectrum Quotient (AQ): a study in Dutch population and patient groups. J Autism Dev Disord,

38(8), 1555-1566. doi: 10.1007/s10803-008-0538-x

Hofvander, B., Delorme, R., Chaste, P., Nyden, A., Wentz, E., Stahlberg, O., . . . Leboyer, M. (2009). Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders. BMC Psychiatry, 9, 35. doi: 10.1186/1471-244X-9-35

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (2013). Lancet, 381(9875), 1371-1379. doi: 10.1016/s0140-6736(12)62129-1

Irwin, S. A., Patel, B., Idupulapati, M., Harris, J. B., Crisostomo, R. A., Larsen, B. P., . . . Greenough, W. T. (2001). Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination. Am J Med Genet, 98(2), 161-167.

Jaworski, J., Spangler, S., Seeburg, D. P., Hoogenraad, C. C., & Sheng, M. (2005). Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt- mammalian target of rapamycin pathway. J Neurosci, 25(49), 11300-11312. doi: 10.1523/JNEUROSCI.2270-05.2005

Jeste, S. S., & Geschwind, D. H. (2014). Disentangling the heterogeneity of autism spectrum disorder through genetic findings. Nat Rev Neurol, 10(2), 74-81. doi: 10.1038/nrneurol.2013.278

Kana, R. K., Uddin, L. Q., Kenet, T., Chugani, D., & Muller, R. A. (2014). Brain connectivity in autism. Front Hum Neurosci, 8, 349. doi: 10.3389/fnhum.2014.00349

Kanne, S. M., Christ, S. E., & Reiersen, A. M. (2009). Psychiatric symptoms and psychosocial difficulties in young adults with autistic traits. J Autism Dev

Disord, 39(6), 827-833. doi: 10.1007/s10803-008-0688-x

Kanne, S. M., Wang, J., & Christ, S. E. (2012). The Subthreshold Autism Trait Questionnaire (SATQ): development of a brief self-report measure of subthreshold autism traits. J Autism Dev Disord, 42(5), 769-780. doi: 10.1007/s10803-011-1308-8

73

Kato, K., Mikami, K., Akama, F., Yamada, K., Maehara, M., Kimoto, K., . . . Matsumoto, H. (2013). Clinical features of suicide attempts in adults with autism spectrum disorders. Gen Hosp Psychiatry, 35(1), 50-53. doi: 10.1016/j.genhosppsych.2012.09.006

Keown, C. L., Shih, P., Nair, A., Peterson, N., Mulvey, M. E., & Muller, R. A. (2013). Local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders. Cell Rep,

5(3), 567-572. doi: 10.1016/j.celrep.2013.10.003

King, Robert, & Desaulnier, Cindy L. (2011). Commentary: Complex Post- Traumatic Stress Disorder. Implications for Individuals with Autism Spectrum Disorders--Part II. Journal on Developmental Disabilities, 17(1). Koczat, D. L., Rogers, S. J., Pennington, B. F., & Ross, R. G. (2002). Eye

movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands. J Autism Dev Disord, 32(6), 513- 518.

Kunihira, Y., Senju, A., Dairoku, H., Wakabayashi, A., & Hasegawa, T. (2006). 'Autistic' traits in non-autistic Japanese populations: relationships with personality traits and cognitive ability. J Autism Dev Disord, 36(4), 553- 566. doi: 10.1007/s10803-006-0094-1

Kwon, C. H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., . . . Parada, L. F. (2006). Pten regulates neuronal arborization and social interaction in mice. Neuron, 50(3), 377-388. doi: 10.1016/j.neuron.2006.03.023

Lai, M. C., Lombardo, M. V., & Baron-Cohen, S. (2014). Autism. Lancet,

383(9920), 896-910. doi: 10.1016/S0140-6736(13)61539-1

Lai, Meng-Chuan, Lombardo, Michael V., Pasco, Greg, Ruigrok, Amber N. V., Wheelwright, Sally J., Sadek, Susan A., . . . Consortium, Mrc Aims. (2011). A Behavioral Comparison of Male and Female Adults with High Functioning Autism Spectrum Conditions. PLoS One, 6(6), e20835. doi: 10.1371/journal.pone.0020835

Lainhart, J. E., Bigler, E. D., Bocian, M., Coon, H., Dinh, E., Dawson, G., . . . Volkmar, F. (2006). Head circumference and height in autism: a study by

74

the Collaborative Program of Excellence in Autism. Am J Med Genet A,

140(21), 2257-2274. doi: 10.1002/ajmg.a.31465

Levy, S. E., Mandell, D. S., & Schultz, R. T. (2009). Autism. Lancet, 374(9701), 1627-1638. doi: 10.1016/S0140-6736(09)61376-3

Li, Y., Wang, H., Muffat, J., Cheng, A. W., Orlando, D. A., Loven, J., . . . Jaenisch, R. (2013). Global transcriptional and translational repression in human- embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell, 13(4), 446-458. doi: 10.1016/j.stem.2013.09.001

Lonnqvist, L., Loukusa, S., Hurtig, T., Makinen, L., Siipo, A., Vayrynen, E., . . . Ebeling, H. (2016). How young adults with autism spectrum disorder watch and interpret pragmatically complex scenes. Q J Exp Psychol (Hove), 1-16. doi: 10.1080/17470218.2016.1233988

Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: a comparison across parents of multiple- and single-incidence autism families. Am J Med Genet B Neuropsychiatr Genet,

147B(4), 424-433. doi: 10.1002/ajmg.b.30612

Matsuo, J., Kamio, Y., Takahashi, H., Ota, M., Teraishi, T., Hori, H., . . . Kunugi, H. (2015). Autistic-like traits in adult patients with mood disorders and schizophrenia. PLoS One, 10(4), e0122711. doi: 10.1371/journal.pone.0122711

Mayes, S. D., & Calhoun, S. L. (2005). Test of the definition of learning disability based on the difference between IQ and achievement. Psychol Rep, 97(1), 109-116. doi: 10.2466/pr0.97.1.109-116

Mayes, S. D., & Calhoun, S. L. (2007). Learning, attention, writing, and processing speed in typical children and children with ADHD, autism, anxiety, depression, and oppositional-defiant disorder. Child Neuropsychol, 13(6), 469-493. doi: 10.1080/09297040601112773

McPartland, J. C., Reichow, B., & Volkmar, F. R. (2012). Sensitivity and specificity of proposed DSM-5 diagnostic criteria for autism spectrum disorder. J Am

Acad Child Adolesc Psychiatry, 51(4), 368-383. doi: 10.1016/j.jaac.2012.01.007

75

Meikle, L., Talos, D. M., Onda, H., Pollizzi, K., Rotenberg, A., Sahin, M., . . . Kwiatkowski, D. J. (2007). A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci, 27(21), 5546-5558. doi: 10.1523/JNEUROSCI.5540-06.2007

Meltzer, A., & Van de Water, J. (2016). The Role of the Immune System in Autism Spectrum Disorder. Neuropsychopharmacology. doi: 10.1038/npp.2016.158

Meyer, Jessica A. (2002). Cognitive patterns in autism spectrum disorders.

Assessment for Effective Intervention, 27(1-2), 27-35.

Mottron, L., Dawson, M., Soulieres, I., Hubert, B., & Burack, J. (2006). Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception. J Autism Dev Disord, 36(1), 27-43. doi: 10.1007/s10803-005- 0040-7

Narzisi, A., Muratori, F., Calderoni, S., Fabbro, F., & Urgesi, C. (2013). Neuropsychological profile in high functioning autism spectrum disorders.

J Autism Dev Disord, 43(8), 1895-1909. doi: 10.1007/s10803-012-1736-0

Nevison, C. D. (2014). A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors. Environ Health,

13, 73. doi: 10.1186/1476-069X-13-73

Nicpon, Megan Foley, Doobay, Alissa F, & Assouline, Susan G. (2010). Parent, teacher, and self perceptions of psychosocial functioning in intellectually gifted children and adolescents with autism spectrum disorder. J Autism Dev

Disord, 40(8), 1028-1038.

Osterweil, E. K., Chuang, S. C., Chubykin, A. A., Sidorov, M., Bianchi, R., Wong, R. K., & Bear, M. F. (2013). Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome.

Neuron, 77(2), 243-250. doi: 10.1016/j.neuron.2012.01.034

Ozonoff, Sally, & Griffith, Elizabeth McMahon. (2000). Neuropsychological function and the external validity of Asperger syndrome. Asperger

76

Peled, A. (2013). Brain "Globalopathies" cause mental disorders. Med Hypotheses,

81(6), 1046-1055. doi: 10.1016/j.mehy.2013.09.032

Peled, A., & Geva, A. B. (2014). "Clinical brain profiling": a neuroscientific diagnostic approach for mental disorders. Med Hypotheses, 83(4), 450-464. doi: 10.1016/j.mehy.2014.07.013

Persico, A.M.; Sacco, R. (2014). Endophenotypes in autism spectrum disorders.

Comprehensive Guide to Autism, pp 77-95. doi: 10.1007/978-1-4614-4788-

7_1

Pfaff, D. W., Rapin, I., & Goldman, S. (2011). Male predominance in autism: neuroendocrine influences on arousal and social anxiety. Autism Res, 4(3), 163-176. doi: 10.1002/aur.191

Pine, D. S., Guyer, A. E., Goldwin, M., Towbin, K. A., & Leibenluft, E. (2008). Autism spectrum disorder scale scores in pediatric mood and anxiety disorders. J Am Acad Child Adolesc Psychiatry, 47(6), 652-661. doi: 10.1097/CHI.0b013e31816bffa5

Pisula, E., Kawa, R., Szostakiewicz, L., Lucka, I., Kawa, M., & Rynkiewicz, A. (2013). Autistic traits in male and female students and individuals with high functioning autism spectrum disorders measured by the Polish version of the Autism-Spectrum Quotient. PLoS One, 8(9), e75236. doi: 10.1371/journal.pone.0075236

Pisula, E., & Ziegart-Sadowska, K. (2015). Broader Autism Phenotype in Siblings of Children with ASD--A Review. Int J Mol Sci, 16(6), 13217-13258. doi: 10.3390/ijms160613217

Piven, J., Palmer, P., Jacobi, D., Childress, D., & Arndt, S. (1997). Broader autism phenotype: evidence from a family history study of multiple-incidence autism families. Am J Psychiatry, 154(2), 185-190. doi: 10.1176/ajp.154.2.185

Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. (2014). MMWR Surveill Summ, 63(2), 1-21.

Ronald, A., Butcher, L. M., Docherty, S., Davis, O. S., Schalkwyk, L. C., Craig, I. W., & Plomin, R. (2010). A genome-wide association study of social and

77

non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples. Behav Genet, 40(1), 31-45. doi: 10.1007/s10519-009- 9308-6

Rossignol, D. A., Genuis, S. J., & Frye, R. E. (2014). Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry, 4, e360. doi: 10.1038/tp.2014.4

Rowe, Ellen W, Kingsley, Jessica M, & Thompson, Dawna F. (2010). Predictive ability of the General Ability Index (GAI) versus the Full Scale IQ among gifted referrals. School Psychology Quarterly, 25(2), 119.

Rutter, M.; Thapar, A. . (2014). Genetics of autism spectrum disorders. In R. Volkmar, Rogers, S.J., Paul, R., Pelphrey, K.A. (Ed.), Handbook of Autism

and Pervasive Developmental Disorders 4th ed. (Vol. 1, pp. 411–423). NJ,

USA,: Wiley & Sons: New Jersey.

Rynkiewicz, Agnieszka, Schuller, Björn, Marchi, Erik, Piana, Stefano, Camurri, Antonio, Lassalle, Amandine, & Baron-Cohen, Simon. (2016). An investigation of the ‘female camouflage effect’ in autism using a computerized ADOS-2 and a test of sex/gender differences. Mol Autism,

7(1), 10. doi: 10.1186/s13229-016-0073-0

Santini, E., Huynh, T. N., MacAskill, A. F., Carter, A. G., Pierre, P., Ruggero, D., . . . Klann, E. (2013). Exaggerated translation causes synaptic and