• Non ci sono risultati.

Imatinib-associated hyperpigmentation, a side effect that should be recognized

N/A
N/A
Protected

Academic year: 2021

Condividi "Imatinib-associated hyperpigmentation, a side effect that should be recognized"

Copied!
1
0
0

Testo completo

(1)

Imatinib-associated hyperpigmentation, a side effect that should be

recognized

Di Tullio F.1, Mandel V.D.1, Padalino C.1, Pellacani G.1

1Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant,

Oncological and Regenerative Medicine, Dermatology Unit; University of Modena and Reggio Emilia, Modena, Italy.

Introduction & Objectives: Imatinib mesylate is a tyrosine-kinase inhibitor used as the first-line treatment in chronic myeloid leukemia patients who are not candidate for allogeneic bone marrow transplantation. The most frequently reported drug-related side effects are edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea and rash.

Imatinib treatment is often associated with hypopigmentation, but only a few cases of mucocutaneous hyperpigmentation are described in literature. We are reporting an additional case of mucocutaneous blue hyperpigmentation in a patient affected by chronic myeloid leukemia and treated with imatinib since 2003.

Material & Methods: A review of the available literature regarding the hyperpigmentation related to imatinib was performed and one additional case was analysed.

Results: In our case imatinib therapy was well tolerated for several years and it led to an excellent hematological and cytogenetic response. However, the patient gradually developed an intense blue hyperpigmentation that involved the oral mucosa and part of the skin. Other causes of hyperpigmentation were excluded.

Conclusions: Since 2001, when imatinib was approved from Food and Drug Administration for chronic myeloid leukemia, some cases of secondary hyperpigmentation were reported. This rare side effect should be recognized by the physicians. Moreover, the patient should be informed about this benign event before starting the therapy. Currently, no treatment is required for this condition and there is not indication to discontinue imatinib treatment. Further insight into the mechanisms of the pigmentary alterations caused by this drug is suggested for better treatment and prevention of these manifestations.

Riferimenti

Documenti correlati

Si determini la foliazione associata alla distribuzione di piani generata dagli autovettori di cui al punto precedente3. Si calcoli la forma di Levi di T e se ne determini la

In accordance with the above, the aim of the present work is to assess an Early Intensive Intervention with Parent Involvement focusing on caregivers and dyadic outcomes through

A comparison of the classification accuracies achieved with the discriminant function model and k-nearest neighbor classification based on the TET metric indicates that TET

Use of all other works requires consent of the right holder (author or publisher) if not exempted from copyright protection by the applicable

Lock-free queues, multi-threading, multi-core, stream parallel programming, software pipeline, SCM, Smith-Waterman, local sequence alignment,

Lifetime and unspecified major depressive disorder were associated with severe migraine intensity among subjects with migraine with aura but not migraine without aura, while

L’Autorità di sistema portuale potrebbe essere condizionata già in partenza nel predisporre il piano regolatore dal consenso preventivo da parte dell’amministrazione centrale, per