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REPORT SULLE ATTIVITÀ SVOLTE
Corso di dottorato in Scienze Chimiche e dei Materiali – Agonigi Gabriele
Titolo della tesi
Diiron complexes with derivatizable bridging hydrocarbyl ligands as potential bioactive agents
Presenza e contributo a congressi e scuole:
1- CNIF 2016 - Corso Nazionale di Fotochimica 6-10 June 2016 Bologna
2- XVLI Congresso Nazionale di Chimica Inorganica - 14-17 September 2016 Padova
Presented poster: “Synthesis and Anticancer Activity of Osmium Complexes Containing Ethacrynic Acid” 3- MYCS Merck Young Chemists Symposium - 25-27 October 2016 Rimini, presented poster: “Synthesis and Anticancer Activity of Osmium Complexes”
4- ISACS Challenges in Inorganic Chemistry (10-13 April 2017, Manchester, UK); presented poster “In Vitro Anticancer Activity of Diiron Vinyliminium Complexes”
5- 3rd Southern Dalton Meeting (28 June 2017, London, UK); oral presentation “Anticancer Activity of Diiron Carbonyl Complexes”
6- Chemistry for the Future 2017, Pisa (Italy), 5 – 7 July 2017
7- XXVI SCI Congress (10-14 September, Paestum, Italy); presented poster “Anticancer Behaviour of Diiron Carbonyl Complexes with Functionalysed Bridging Ligands”.
8- Biomet, Napoli, 16-17 Febbraio 2018 poster presentation “Tuning the Cytotoxicity of Diiron Dicarbonyl Dicyclopentadienide Complexes by Varying the Substituents on a Bridging Vinyliminium Ligand”
9- RSC Dalton Meeting 2018, Coventry (UK), 3 -5 april 2018, oral presentation: “Reactivity of Diiron Complexes with a Bridging Aminoalkylidyne Ligand, and Cytotoxicity Results”.
10- Chemistry for the Future 2018, Pisa (Italy), 4 – 6 July 2018, oral presentation: “Design, synthesis and evaluation of the Anticancer activity of new iron carbonyl complexes”.
11- 28th International Conference of Organometallic Chemistry (ICOMC), Firenze (Italy), 15 – 20th July 2018, oral presentation " Exploring the Anticancer Properties of Diiron Vinyliminium Complexes"
12- XVLI Congresso Nazionale di Chimica Inorganica - 10-13 September 2018 Bologna, poster presentation: “Versatility of C3 Ligand in Diiron Complex Across Different Oxidation Levels”.
Pubblicazioni
1) “Controlled Dissociation of Fe and Cp from a Diiron Complex with a Bridging C3-Ligand Triggered by One Electron Reduction”, G. Agonigi, G. Ciancaleoni, T. Funaioli, S. Zacchini, F. Pineider, C. Pinzino, G. Pampaloni, V. Zanotti,, F. Marchetti, Inorganic Chemistry, accepted.
2) “Regioselective Nucleophilic Additions to Diiron Carbonyl Complexes Containing a Bridging Aminocarbyne Ligand: A Synthetic, Crystallographic and DFT Study”, G. Agonigi, M. Bortoluzzi, F. Marchetti, G. Pampaloni, S. Zacchini, V. Zanotti, European Journal of Inorganic Chemistry, 2018, 8, 960-971.
2 3) “Gold (III) Alkyne Complexes: Bonding and Reaction Pathways”, L. Rocchigiani, J. Fernandez-Cestau, G. Agonigi, I. Chambrier, P. H. M. Budzelaar, M. Bochmann, Angewandte Chemie – International Edition, 2017, 56 (44), 13861-13865.
4) “Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity”, G. Agonigi, T. Riedel, M. P. Gay, L. Biancalana, E. Oñate, P. J. Dyson, G. Pampaloni, E. Păunescu, M. A. Esteruelas, F. Marchetti, Organometallics, 2016, 35, 1046-1056.
5) “Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic Acid-Modified Pyridine- and Triphenylphosphine-Ligands”, G. Agonigi, T. Riedel, S. Zacchini, E. Păunescu, G. Pampaloni, N. Bartalucci, P. J. Dyson, F. Marchetti, Inorg. Chem., 2015, 54, 6504–6512.
Attività di tutoraggio e didattica integrativa
1. “Produzione di etilene ossido”, 1h, corso di Catalisi (T.Funaioli) – 11 Novembre 2016
2. “Laboratorio di Chimica Organica I” (Corso di Laurea in Chimica), Supporto alla Didattica, 20h – Marzo 2016 / Aprile 2016
3. “Laboratorio di Chimica Inorganica I” (Corso di Laurea in Chimica per l’Industria e per l’Ambiente), Supporto alla Didattica, 20h – Aprile 2016 / 18 Maggio 2016
4. “Laboratorio di Chimica Organica I” (Corso di Laurea in Chimica), Supporto alla Didattica, 20h – Marzo 2018 / Aprile 2018
Attività Formative
I anno di corso Corsi del dottorato:Radiochemistry (P. Salvadori, 8 h) Academic English (A. Wallwork, 20 h) Altri corsi:
Metallorganica (P. Leoni, 48 h) Seminari di ricerca:
1. Stefano Zacchini - Molecular Metal Carbonyl Nanoclusters, 3h
2. Marcin Gòrecki - Circular Dichroism as assistant for solving structural problems in sol. and s. state, 3h 3. Francesco Pineider - Molecole e nanostrutture per la magnetoplasmonica, 2h
4. Hiroshi Nakazawa - Selective Strong Bond Cleavage Catalyzed by Transition Metal Complexes, 2h 5. Marco Bandini - Catalytic Manipulation of Indole in Bologna, 2h
II anno di corso Corsi del dottorato:
Chemiometria (M. Calderisi, 8 h)
Tecniche di Laboratorio in Elettrochimica (T. Funaioli, 8 h) Magnetic Molecular Materials (G. Poneti, 6 h)
Seminari di ricerca:
3 2. D.Perego, “Integrated Li-ion microbatteries”, 3h
3. G. Ciancaleoni, “Synergy between NMR Spectroscopy and Computational Methods”, 2h 4. F. Picchioni, “Polymeric Materials for Enhanced Oil Recovery”, 2h
5. C. Landis, “Methods for Operando Studies of Catalysts”, 2h 6. C. Landis, “Valency and Bonding as revealed by NBO methods”, 2h
III anno di corso Corsi del dottorato:
Radiochemistry for Life Sciences applications (G. Pascali, 4 h)
What happens at the interface, does not stay at the interface and meet polymer chemistry (P. Raffa, 6 h) Fundamental reaction types in Organometallic Chemistry (D. Maiti, 2h)
Molecular chemistry (V. Sokolova, 2h) Altri corsi:
Academic english (S. Smith, 30 h) Seminari di ricerca:
1. L. Biancalana, “Synthesis, characterization and Cytotoxicity of New Ruthenium(II) Arene Compounds as Potential Anticancer Drugs”, PhD Thesis Dissertation (1 February 2018), 2h
2. E. Guazzelli, “Functional materials containing single-chain folding polymers” PhD Thesis Dissertation (3 march 2018) 2h
3. D. Barsi “New materials based on Janus particles: preparation and characterization” PhD Thesis Dissertation (20 may 2018) 2h
4. F. Barzagli, “Innovative methods for efficient CO2 capture and its reuse for the synthesis of useful chemical” (23 July 2018), 2h
Esperienze di ricerca presso altre strutture
Dal 20/02/2017 al 20/08/2017 ospite presso “University of East Anglia” (Norwich, UK) presso il gruppo del Prof. Manfred Bochmann, dove ho lavorato sulla reattività di complessi di Au (III) con substrati insaturi e sintesi di nuovi complessi luminescenti di Au (III).
