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5. “Le basi patologiche delle malattie” di Robbins e Cotran

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10. https://ghr.nlm.nih.gov/gene/GATA1#location

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13. Nikolaev S, Santoni F, Vannier A, Falconnet E, Giarin E, Basso G, et al. Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome. Blood. 2013;122:554–61.

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16. Roberts I, Alford K, Hall G, Juban G, Richmond H, Norton A, et al. GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of prospective multi-centre Oxford Imperial Down syndrome cohort study which showed the high frequency of acquired GATA1 mutations in neonates with Down syndrome and described Silent TAM for the first time.

17. Rao A, Hills R, Stiller C, Gibson B, et al. Treatment for myeloid leukaemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials. Br J Haematol. 2006;132:576–83. 46. Webb D, Roberts I, Vyas P. Haematology of Down syndrome. Arch Dis Child Fetal Neonatal Ed. 2007;92:503–7.

83 18. Acute leukemias in children with Down syndrome- Laura Seewald, Jeffrey W. Taub, Kelly W.

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22. The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with down syndrome P Lee, R Bhansali, S Izraeli, N Hijiya, J D Crispino

23. K.W. Maloney, W.L. Carroll, A.J. Carroll, M. Devidas, M.J. Borowitz, P.L. Martin, J. Pullen, J.A. Whitlock, C.L. Willman, N.J. Winick, B.M. Camitta, S.P. Hunger, Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology Group, Blood 116 (2010) 1045–1050

24. C.H. Pui, S.C. Raimondi, M.J. Borowitz, V.J. Land, F.G. Behm, D.J. Pullen, M.L. Hancock, J.J. Shuster, C.P. Steuber, W.M. Crist, et al., Immunophenotypes and karyotypes of leukemic cells in children with Down syndrome and acute lymphoblastic leukemia, J. Clin. Oncol. 11 (1993) 1361–1367. 25. S. Izraeli, The acute lymphoblastic leukemia of Down Syndrome – Genetics and Pathogenesis,

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27. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia Daniel A. Arber, Attilio Orazi, Robert Hasserjian, J¨urgen Thiele, Michael J. Borowitz, Michelle M. Le Beau, Clara D. Bloomfield, Mario Cazzola and James W. Vardiman

28. “Pediatria” di Nelson

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30. Pharmacokinetics of Chemotherapeutic Drugs in Pediatric Patients With Down Syndrome and Leukemia Erik Hefti, PharmD, MS and Javier G. Blanco, PhD

31. S. Malinge, S. Izraeli, J.D. Crispino, Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome, Blood 113 (2009) 2619–2628.

32. http://www.ospedalebambinogesu.it/leucemia-acuta-mieloide#.WppS9VTOVPY

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38. www.wikipedia.com-Antracicline

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40. Down Syndrome, Drug Metabolism, and Chromosome 21 Jeffrey W. Taub1,2,3* and Yubin Ge1 41. Anthracycline-Related Cardiotoxicity in Patients with Acute Myeloid Leukemia and Down Syndrom: A

Literature Review Erik Hefti and Javier G. Blanco*. Department of Pharmaceutical Sciences, The School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America

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43. SEEWALD - Acute leukemias in children with down syndrome 44. https://en.wikipedia.org/wiki/Fludarabine

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47. How I treat ALL in Down’s syndrome: pathobiology and management Shai Izraeli,1 Ajay Vora,2 C. Michel Zwaan,3 and James Whitlock4

48. W. Stock, D. Yu, B. Sanford, G. Lozanski, R. Vij, J.C. Byrd, B.L. Powell, M. Wetzler, D. Sher, C. Edwards, M. Kelly, S.M. Richards, C. Sung, G. Malnassy, E. Hoke, C.D. Bloomfield, R.A. Larson, Alemtuzumab can be Incorporated into Front-line Therapy of Adult Acute Lymphoblastic Leukemia (ALL): Final Phase I Results of a Cancer and Leukemia Group B Study (CALGB 10102) ASH Annual Meeting Abstracts, 51st ASH Annual Meeting and Exposition, 2009.

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50. Fonte di alcune immagini: Google immagini

51. The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia; Claudia Scholl Richard F. Schlenk Karina Eiwen Hartmut Döhner Stefan Fröhling Konstanze Döhner for the AML Study Group